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11.发明授权Assay buffer, compositions containing the same, and methods of using the same 有权测定缓冲液，含有该组合物的组合物及其使用方法公开(公告)号：US07288410B2
公开(公告)日：2007-10-30
申请号：US11054672
申请日：2005-02-09
申请人： Michael Tsionsky , Eli N. Glezer , Selen Altunata , George Sigal , Jonathan K. Leland , Mark A. Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
发明人： Michael Tsionsky , Eli N. Glezer , Selen Altunata , George Sigal , Jonathan K. Leland , Mark A. Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
CPC分类号： G01N33/573 , C12Q1/485 , G01N21/76 , G01N33/5306 , G01N33/54386 , G01N33/58 , G01N33/582 , G01N2333/91205 , G01N2458/30 , G01N2458/40 , Y10S435/967 , Y10S435/968 , Y10T436/10 , Y10T436/108331
摘要： Compositions, reagents, kits, systems, system components, and methods for performing assays. More particularly, the invention relates to the use of novel combinations of reagents to provide improved assay performance.
摘要翻译： 组合物，试剂，试剂盒，系统，系统组分和用于进行测定的方法。 更具体地说，本发明涉及使用新颖的试剂组合来提供改进的测定性能。
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公开(公告)号：US06919173B2
公开(公告)日：2005-07-19
申请号：US10238437
申请日：2002-09-10
申请人： Michael Tsionsky , Eli N. Glezer , Selen Altunata , George Sigal , Jonathan K. Leland , Mark A. Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
发明人： Michael Tsionsky , Eli N. Glezer , Selen Altunata , George Sigal , Jonathan K. Leland , Mark A. Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
IPC分类号： G01N33/53 , C12Q1/42 , C12Q1/48 , G01N21/76 , G01N33/531 , G01N33/543 , G01N33/58 , G01N33/68 , C12Q1/70 , C12Q1/68 , A61K39/395
CPC分类号： G01N33/573 , C12Q1/485 , G01N21/76 , G01N33/5306 , G01N33/54386 , G01N33/58 , G01N33/582 , G01N2333/91205 , G01N2458/30 , G01N2458/40 , Y10S435/967 , Y10S435/968 , Y10T436/10 , Y10T436/108331
摘要： Compositions, reagents, kits, systems, system components, and methods for performing assays. More particularly, the invention relates to the use of novel combinations of reagents to provide improved assay performance.
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公开(公告)号：US20120034645A1
公开(公告)日：2012-02-09
申请号：US13275398
申请日：2011-10-18
申请人： Mark A. Billadeau , Jeff D. Debad , Eli N. Glezer , Jonathan K. Leland , Charles A. Wijayawardhana
发明人： Mark A. Billadeau , Jeff D. Debad , Eli N. Glezer , Jonathan K. Leland , Charles A. Wijayawardhana
IPC分类号： C12Q1/02
CPC分类号： G01N33/543 , G01N33/523 , G01N33/54366 , Y10T436/106664 , Y10T436/117497 , Y10T436/25125 , Y10T436/25375
摘要： Disclosed are methods for conducting assays of samples, such as whole blood, that may contain cells or other particulate matter. Also disclosed are systems, devices, equipment, kits and reagents for use in such methods. One advantage of certain disclosed methods and systems is the ability to rapidly measure the concentration of an analyte of interest in blood plasma from a whole blood sample without blood separation and hematocrit correction.
摘要翻译： 公开了用于进行可能含有细胞或其它颗粒物质的样品例如全血的测定的方法。 还公开了用于这些方法的系统，装置，设备，试剂盒和试剂。 某些公开的方法和系统的一个优点是能够在没有血液分离和血细胞比容校正的情况下从全血样品中快速测量血浆中目标分析物的浓度。
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公开(公告)号：US20100267063A1
公开(公告)日：2010-10-21
申请号：US12831139
申请日：2010-07-06
申请人： Mark A. Billadeau , Jeff D. Debad , Eli N. Glezer , Jonathan K. Leland , Charles A. Wijayawardhana
发明人： Mark A. Billadeau , Jeff D. Debad , Eli N. Glezer , Jonathan K. Leland , Charles A. Wijayawardhana
IPC分类号： G01N33/53
CPC分类号： G01N33/543 , G01N33/523 , G01N33/54366 , Y10T436/106664 , Y10T436/117497 , Y10T436/25125 , Y10T436/25375
摘要： Disclosed are methods for conducting assays of samples, such as whole blood, that may contain cells or other particulate matter. Also disclosed are systems, devices, equipment, kits and reagents for use in such methods. One advantage of certain disclosed methods and systems is the ability to rapidly measure the concentration of an analyte of interest in blood plasma from a whole blood sample without blood separation and hematocrit correction.
摘要翻译： 公开了用于进行可能含有细胞或其它颗粒物质的样品例如全血的测定方法。 还公开了用于这些方法的系统，装置，设备，试剂盒和试剂。 某些公开的方法和系统的一个优点是能够在没有血液分离和血细胞比容校正的情况下从全血样品中快速测量血浆中目标分析物的浓度。
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公开(公告)号：US08641986B2
公开(公告)日：2014-02-04
申请号：US12244119
申请日：2008-10-02
申请人： Eli N. Glezer , Jonathan K. Leland , Mark A. Billadeau , Joseph M. Leginus , Bandele Jeffrey-Coker , Jeff D. Debad , Koustubh A. Phalnikar , Sriram Jambunathan
发明人： Eli N. Glezer , Jonathan K. Leland , Mark A. Billadeau , Joseph M. Leginus , Bandele Jeffrey-Coker , Jeff D. Debad , Koustubh A. Phalnikar , Sriram Jambunathan
CPC分类号： G01N21/76 , B01J19/0046 , B01J2219/00653 , B01J2219/00725 , B01J2219/0074 , B01L3/5027 , B01L3/502715 , B01L3/5029 , B01L9/527 , B01L2200/0684 , B01L2200/10 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/049 , B01L2400/0688 , B33Y80/00 , C12Q1/001 , C40B40/10 , G01N27/30 , G01N33/5438 , G01N2458/30 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.
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公开(公告)号：US08273566B2
公开(公告)日：2012-09-25
申请号：US12831139
申请日：2010-07-06
申请人： Mark A. Billadeau , Jeff D. Debad , Eli N. Glezer , Jonathan K. Leland , Charles A. Wijayawardhana
发明人： Mark A. Billadeau , Jeff D. Debad , Eli N. Glezer , Jonathan K. Leland , Charles A. Wijayawardhana
CPC分类号： G01N33/543 , G01N33/523 , G01N33/54366 , Y10T436/106664 , Y10T436/117497 , Y10T436/25125 , Y10T436/25375
摘要： Disclosed are methods for conducting assays of samples, such as whole blood, that may contain cells or other particulate matter. Also disclosed are systems, devices, equipment, kits and reagents for use in such methods. One advantage of certain disclosed methods and systems is the ability to rapidly measure the concentration of an analyte of interest in blood plasma from a whole blood sample without blood separation and hematocrit correction.
摘要翻译： 公开了用于进行可能含有细胞或其它颗粒物质的样品例如全血的测定的方法。 还公开了用于这些方法的系统，装置，设备，试剂盒和试剂。 某些公开的方法和系统的一个优点是能够在没有血液分离和血细胞比容校正的情况下从全血样品中快速测量血浆中目标分析物的浓度。
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公开(公告)号：US20120055809A1
公开(公告)日：2012-03-08
申请号：US13221427
申请日：2011-08-30
申请人： Eli N. Glezer , Jonathan K. Leland , Mark A. Billadeau , Joseph M. Leginus , Bandele Jeffrey-Coker , Jeff D. Debad , Koustubh A. Phalnikar , Sriram Jambunathan
发明人： Eli N. Glezer , Jonathan K. Leland , Mark A. Billadeau , Joseph M. Leginus , Bandele Jeffrey-Coker , Jeff D. Debad , Koustubh A. Phalnikar , Sriram Jambunathan
IPC分类号： G01N27/416
CPC分类号： G01N21/76 , B01J19/0046 , B01J2219/00653 , B01J2219/00725 , B01J2219/0074 , B01L3/5027 , B01L3/502715 , B01L3/5029 , B01L9/527 , B01L2200/0684 , B01L2200/10 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/049 , B01L2400/0688 , B33Y80/00 , C12Q1/001 , C40B40/10 , G01N27/30 , G01N33/5438 , G01N2458/30 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.
摘要翻译： 测定模块，优选测定盒，被描述为可用于控制模块操作的方面的读取器设备。 模块优选地包括具有集成电极的检测室，其可用于执行电极诱导的发光测量。 描述了以这种控制方式将测定试剂固定在这些电极和其它表面上的方法。 还描述了具有检测室，优选地具有集成电极的测定模块和盒，以及可以包括样品室，废物室，导管，通风口，气泡阱，试剂室，干试剂丸区等的其它流体组分。 在某些优选实施例中，这些模块适于接收和分析在施用器棒上收集的样品。
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公开(公告)号：US08852922B2
公开(公告)日：2014-10-07
申请号：US13221427
申请日：2011-08-30
申请人： Eli N. Glezer , Jonathan K. Leland , Mark A. Billadeau , Joseph M. Leginus , Bandele Jeffrey-Coker , Jeff D. Debad , Koustubh A. Phalnikar , Sriram Jambunathan
发明人： Eli N. Glezer , Jonathan K. Leland , Mark A. Billadeau , Joseph M. Leginus , Bandele Jeffrey-Coker , Jeff D. Debad , Koustubh A. Phalnikar , Sriram Jambunathan
CPC分类号： G01N21/76 , B01J19/0046 , B01J2219/00653 , B01J2219/00725 , B01J2219/0074 , B01L3/5027 , B01L3/502715 , B01L3/5029 , B01L9/527 , B01L2200/0684 , B01L2200/10 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/049 , B01L2400/0688 , B33Y80/00 , C12Q1/001 , C40B40/10 , G01N27/30 , G01N33/5438 , G01N2458/30 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.
摘要翻译： 测定模块，优选测定盒，被描述为可用于控制模块操作的方面的读取器设备。 模块优选地包括具有集成电极的检测室，其可用于执行电极诱导的发光测量。 描述了以这种控制方式将测定试剂固定在这些电极和其它表面上的方法。 还描述了具有检测室，优选地具有集成电极的测定模块和盒，以及可以包括样品室，废物室，导管，通风口，气泡阱，试剂室，干试剂丸区等的其它流体组分。 在某些优选实施例中，这些模块适于接收和分析在施用器棒上收集的样品。
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公开(公告)号：US20090066339A1
公开(公告)日：2009-03-12
申请号：US12244133
申请日：2008-10-02
申请人： Eli N. Glezer , Jonathan K. Leland , Mark A. Billadeau , Joseph M. Leginus , Bandele Jeffrey-Coker , Jeff D. Debad , Koustubh A. Phalnikar , Sriram Jambunathan
发明人： Eli N. Glezer , Jonathan K. Leland , Mark A. Billadeau , Joseph M. Leginus , Bandele Jeffrey-Coker , Jeff D. Debad , Koustubh A. Phalnikar , Sriram Jambunathan
CPC分类号： G01N21/76 , B01J19/0046 , B01J2219/00653 , B01J2219/00725 , B01J2219/0074 , B01L3/5027 , B01L3/502715 , B01L3/5029 , B01L9/527 , B01L2200/0684 , B01L2200/10 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/049 , B01L2400/0688 , B33Y80/00 , C12Q1/001 , C40B40/10 , G01N27/30 , G01N33/5438 , G01N2458/30 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.
摘要翻译： 测定模块，优选测定盒，被描述为可用于控制模块操作的方面的读取器设备。 模块优选地包括具有集成电极的检测室，其可用于执行电极诱导的发光测量。 描述了以这种控制方式将测定试剂固定在这些电极和其它表面上的方法。 还描述了具有检测室，优选地具有集成电极的测定模块和盒，以及可以包括样品室，废物室，导管，通风口，气泡阱，试剂室，干试剂丸区等的其它流体组分。 在某些优选实施例中，这些模块适于接收和分析在施用器棒上收集的样品。
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公开(公告)号：US08343526B2
公开(公告)日：2013-01-01
申请号：US13275398
申请日：2011-10-18
申请人： Mark A. Billadeau , Jeff D. Debad , Eli N. Glezer , Jonathan K. Leland , Charles A. Wijayawardhana
发明人： Mark A. Billadeau , Jeff D. Debad , Eli N. Glezer , Jonathan K. Leland , Charles A. Wijayawardhana
CPC分类号： G01N33/543 , G01N33/523 , G01N33/54366 , Y10T436/106664 , Y10T436/117497 , Y10T436/25125 , Y10T436/25375
摘要： Disclosed are methods for conducting assays of samples, such as whole blood, that may contain cells or other particulate matter. Also disclosed are systems, devices, equipment, kits and reagents for use in such methods. One advantage of certain disclosed methods and systems is the ability to rapidly measure the concentration of an analyte of interest in blood plasma from a whole blood sample without blood separation and hematocrit correction.
摘要翻译： 公开了用于进行可能含有细胞或其它颗粒物质的样品例如全血的测定的方法。 还公开了用于这些方法的系统，装置，设备，试剂盒和试剂。 某些公开的方法和系统的一个优点是能够在没有血液分离和血细胞比容校正的情况下从全血样品中快速测量血浆中目标分析物的浓度。
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