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    MEDICAL COPOLYMERS
    11.
    发明申请
    MEDICAL COPOLYMERS 有权
    医用共聚物

    公开(公告)号：US20090324679A1

    公开(公告)日：2009-12-31

    申请号：US12491467

    申请日：2009-06-25

    申请人： J. Thomas Ippoliti ,  Scott Schewe ,  Robert W. Warner ,  Michele Zoromski

    发明人： J. Thomas Ippoliti ,  Scott Schewe ,  Robert W. Warner ,  Michele Zoromski

    IPC分类号： A61F2/00 ,  A61K9/14

    CPC分类号： C08G61/08 ,  A61L31/06 ,  A61L31/10 ,  C08G61/12 ,  C08G2261/147 ,  C08G2261/3324 ,  C08G2261/3342 ,  C08G2261/418

    摘要： According to an aspect of the present invention, medical copolymers are provided which comprise (a) a polymer backbone comprising (i) a plurality of —C═C— groups within the polymer backbone, (ii) a plurality of -R9- groups within the polymer backbone, wherein R9 comprises a radical-substituted C2-C10 cyclic or heterocyclic group, or (iii) both a plurality of —C═C— groups and a plurality of -R9- groups within the polymer backbone (b) a plurality of hydrocarbon-based pendant groups along the polymer backbone that comprise a saturated or unsaturated carbon chain of at least four carbons in length, and (c) a plurality of zwitterionic pendant groups along the polymer backbone that comprise a positively charged quaternary ammonium group and a negatively charged phosphate group. Further aspects of the invention, among others, relate to methods of forming such copolymers, medical products that contain such copolymers, and methods of making such medical products.

    摘要翻译： 根据本发明的一个方面，提供了医用共聚物，其包含（a）聚合物主链，其包含（i）聚合物主链内的多个-CC-基团，（ii）聚合物内的多个-R9-基团 骨架，其中R9包含自由基取代的C 2 -C 10环状或杂环基团，或（iii）聚合物主链（b）中的多个-CC-基团和多个-R9-基团，多个烃基 沿聚合物主链的侧基包含长度为至少四个碳原子的饱和或不饱和碳链，以及（c）沿聚合物主链的多个两性离子侧基，其包含带正电荷的季铵基和带负电荷的磷酸基 。 本发明的其它方面尤其涉及形成这种共聚物的方法，含有这种共聚物的医药产品，以及制备这种医药产品的方法。

    MEDICAL DEVICES HAVING ELECTRODEPOSITED COATINGS
    12.
    发明申请
    MEDICAL DEVICES HAVING ELECTRODEPOSITED COATINGS 审中-公开
    具有电沉积涂层的医疗器械

    公开(公告)号：US20090297581A1

    公开(公告)日：2009-12-03

    申请号：US12472234

    申请日：2009-05-26

    申请人： Liliana Atanasoska ,  Wayne Falk ,  Michele Zoromski ,  Robert W. Warner

    发明人： Liliana Atanasoska ,  Wayne Falk ,  Michele Zoromski ,  Robert W. Warner

    IPC分类号： A61F2/06

    CPC分类号： A61L31/16 ,  A61L31/08 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/624 ,  A61L2420/04

    摘要： According to one aspect, the present invention provides implantable or insertable medical devices that comprise a conductive substrate and an electrodeposited coating over the substrate. The electrodeposited coating includes (a) one or more types of inorganic materials, (b) one or more types of polymeric materials and (c) optionally, one or more types of therapeutic agents. Still other aspects of the invention concern methods of making and using such devices.

    摘要翻译： 根据一个方面，本发明提供了可植入或可插入的医疗装置，其包括导电基底和在基底上的电沉积涂层。 电沉积涂层包括（a）一种或多种类型的无机材料，（b）一种或多种类型的聚合材料和（c）任选的一种或多种类型的治疗剂。 本发明的其它方面涉及制造和使用这些装置的方法。

    Fibrous electrode material
    17.
    发明授权
    Fibrous electrode material 有权
    纤维电极材料

    公开(公告)号：US07908016B2

    公开(公告)日：2011-03-15

    申请号：US12237121

    申请日：2008-09-24

    申请人： L. Liliana Atanasoska ,  J. Lee Shippy, III ,  James Q. Feng ,  Robert W. Warner

    发明人： L. Liliana Atanasoska ,  J. Lee Shippy, III ,  James Q. Feng ,  Robert W. Warner

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0565

    摘要： A biomimetic electrode material including a fibrous matrix including a conductive polymer and an ion conducting polymeric material is described. The biomimetic electrode material may be used in a number of body-implantable application including cardiac and neuro-stimulation applications. The biomimetic electrode material can be formed using electrospinning and other related processes. The biomimetic electrode may facilitate efficient charge transport from ionically conductive tissue to the electronically conductive electrode and may induce surrounding tissue to attach or interface directly to the implanted device, increasing the biocompatibility of the device.

    摘要翻译： 描述了包括包含导电聚合物和离子导电聚合材料的纤维基质的仿生电极材料。 仿生电极材料可用于许多可植入人体的应用，包括心脏和神经刺激应用。 仿生电极材料可以使用静电纺丝和其它相关工艺形成。 仿生电极可以促进从离子导电组织到电子导电电极的有效电荷转运，并且可以诱导周围组织直接附着或接合到植入装置，增加装置的生物相容性。

    MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENT IN CONJUNCTION WITH GALVANIC CORROSION
    18.
    发明申请
    MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENT IN CONJUNCTION WITH GALVANIC CORROSION 失效
    用于与治疗性腐蚀相关的用于输送治疗药物的医疗装置

    公开(公告)号：US20090326638A1

    公开(公告)日：2009-12-31

    申请号：US12489948

    申请日：2009-06-23

    申请人： Liliana Atanasoska ,  Jan Weber ,  Paul Grosso ,  Robert W. Warner ,  Kasyap V. Seethamraju

    发明人： Liliana Atanasoska ,  Jan Weber ,  Paul Grosso ,  Robert W. Warner ,  Kasyap V. Seethamraju

    IPC分类号： A61F2/06

    CPC分类号： A61L31/022 ,  A61L31/10 ,  A61L31/14 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00

    摘要： According to an aspect of the present invention, at least one ionic therapeutic agent is delivered from an implantable or insertable medical device that comprises an ion-conductive polymeric region that is disposed on a metallic region. The metallic region is in electrical contact with a dissimilar metallic region, such that a galvanic current is generated by the dissimilar metals when the device is implanted or inserted into a patient. Delivery of the ionic therapeutic agent from the ion-conductive polymeric region may be, for example, either accelerated or retarded by the galvanic current. According to another aspect of the present invention, implantable or insertable medical devices are provided which comprise: (a) a first metallic region having a first corrosion potential, (b) a second metallic region in electrical contact with the first metallic region and having a second corrosion potential that is greater than the first corrosion potential, and (c) a solid ion-conductive polymeric region, comprising an ion conducting polymer and an ionic therapeutic agent, disposed on the first metallic region, the second metallic region, or both.

    摘要翻译： 根据本发明的一个方面，至少一种离子治疗剂从可植入或可插入的医疗装置输送，其包括设置在金属区域上的离子导电聚合物区域。 金属区域与异种金属区域电接触，使得当器件植入或插入患者体内时，异种金属产生电流。 离子导电聚合物区域的离子治疗剂的递送可以例如由电流加速或延迟。 根据本发明的另一方面，提供了可植入或可插入的医疗装置，其包括：（a）具有第一腐蚀电位的第一金属区域，（b）与第一金属区域电接触的第二金属区域， 第二腐蚀电位大于第一腐蚀电位，和（c）固体离子传导聚合物区域，其包含离子导电聚合物和离子治疗剂，设置在第一金属区域，第二金属区域或两者上。