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11.发明授权
公开(公告)号：US5290703A
公开(公告)日：1994-03-01
申请号：US990592
申请日：1992-12-14
Applicant: Chen-Jung Hsu , Robert C. Payne , James A. Profitt
Inventor： Chen-Jung Hsu , Robert C. Payne , James A. Profitt
CPC classification number: G01N1/405 , G01N33/491 , G01N33/92 , G01N2800/044 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
Abstract: A method for separating high density lipoproteins from blood serum or plasma. The method involves contacting the blood sample with an absorbant material comprising porous silica or silicate to adsorb the high density lipoprotein in preference to other lipoproteins in the blood sample. When combined with means for removing very low density lipoproteins and chylomicrons from the blood sample, the remaining low density lipoproteins can be measured directly.
Abstract translation: 从血清或血浆中分离高密度脂蛋白的方法。 该方法包括使血液样品与包含多孔二氧化硅或硅酸盐的吸收剂材料接触，以优先于血液样品中的其它脂蛋白吸附高密度脂蛋白。 当结合用于从血液样品中除去非常低密度脂蛋白和乳糜微粒的方法时，可以直接测量剩余的低密度脂蛋白。
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公开(公告)号：US4771069A
公开(公告)日：1988-09-13
申请号：US13519
申请日：1987-02-11
Applicant: Helen H. Ong , Vernon B. Anderson , James A. Profitt
Inventor： Helen H. Ong , Vernon B. Anderson , James A. Profitt
IPC: C07D337/14 , A61K31/38 , C07D409/12
CPC classification number: C07D337/14
Abstract: Novel aminoalkylthiodibenzothiepins and related compounds, physiologically tolerable acid addition salts thereof, a method of preparing same, pharmaceutical and veterinary preparations including same and methods of treating by administering same are disclosed. These compounds are useful as antidepressant, analgetic, and anticonvulsant agents.
Abstract translation: 公开了新型氨基烷基硫代二苯并硫蛋白及其相关化合物，其生理上可耐受的酸加成盐，其制备方法，包括其的药物和兽用制剂以及通过施用方法进行治疗。 这些化合物可用作抗抑郁药，止痛剂和抗惊厥剂。
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公开(公告)号：US4408050A
公开(公告)日：1983-10-04
申请号：US332178
申请日：1981-12-18
Applicant: Helen H. Ong , James A. Profitt
Inventor： Helen H. Ong , James A. Profitt
IPC: C07D211/64 , C07D471/10
CPC classification number: C07D471/10 , C07D211/64
Abstract: Novel spiro[indoline-3,4'-piperidine]s and related compounds and methods of preparing same are described. These compounds are useful as antidepressants, anticonvulsants and tranquilizers. Also described is a novel method of preparing indoline rings.
Abstract translation: 描述了新的螺[二氢吲哚-3,4'-哌啶]和相关化合物及其制备方法。 这些化合物可用作抗抑郁药，抗惊厥药和镇定剂。 还描述了制备二氢吲哚环的新方法。
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公开(公告)号：US4379933A
公开(公告)日：1983-04-12
申请号：US332175
申请日：1981-12-18
Applicant: Helen H. Ong , James A. Profitt
Inventor： Helen H. Ong , James A. Profitt
IPC: C07D211/64 , C07D471/10
CPC classification number: C07D471/10 , C07D211/64
Abstract: Novel spiro[indoline-3,4'-piperidine]s and related compounds and methods of preparing same are described. These compounds are useful as antidepressants, anticonvulsants and tranquilizers. Also described is a novel method of preparing indoline rings.
Abstract translation: 描述了新的螺[二氢吲哚-3,4'-哌啶]和相关化合物及其制备方法。 这些化合物可用作抗抑郁药，抗惊厥药和镇定剂。 还描述了制备二氢吲哚环的新方法。
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公开(公告)号：US4379932A
公开(公告)日：1983-04-12
申请号：US332174
申请日：1981-12-18
Applicant: Helen H. Ong , James A. Profitt
Inventor： Helen H. Ong , James A. Profitt
IPC: C07D211/64 , C07D471/10
CPC classification number: C07D471/10 , C07D211/64
Abstract: Novel spiro[indoline-3,4'-piperidine]s and related compounds and methods of preparing same are described. These compounds are useful as antidepressants, anticonvulsants and tranquilizers. Also described is a novel method of preparing indoline rings.
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Patent Agency Ranking
公开(公告)号：US09439630B2
公开(公告)日：2016-09-13
申请号：US12674944
申请日：2008-08-27
Applicant: Chris T. Zimmerle , Michael J. Pugia , James A. Profitt
Inventor： Chris T. Zimmerle , Michael J. Pugia , James A. Profitt
IPC: G01N33/543 , A61B10/00 , G01N33/558 , G01N35/00
CPC classification number: A61B10/007 , A61B90/90 , A61B90/96 , G01N33/558 , G01N35/00732 , G01N2035/00752 , G01N2035/00772
Abstract: Sample media for the analysis of analytes in a fluid test sample includes a carrier, at least one test field on the surface of the carrier including at least one reagent reactive with the analytes and capable of providing a detectable response. A non-visible bar code formed by at least two distinct non-visible marker fields is located on the carrier. The marker fields are configured to reflect electro-magnetic (EM) radiation within one or more ranges of non-visible wavelengths to form a coded sequence of reflectances correlated to identification of the sample media.
Abstract translation: 用于分析流体测试样品中的分析物的样品介质包括载体，载体表面上的至少一个测试场包括至少一种与分析物反应的试剂并且能够提供可检测的反应。 由至少两个不同的不可见标记字段形成的不可视条形码位于载体上。 标记场被配置为在不可见波长的一个或多个范围内反映电磁（EM）辐射，以形成与样本介质的识别相关的反射的编码序列。
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公开(公告)号：US08361782B2
公开(公告)日：2013-01-29
申请号：US12598141
申请日：2008-03-14
Applicant: Michael J. Pugia , James A. Profitt
Inventor： Michael J. Pugia , James A. Profitt
IPC: C12M1/36
CPC classification number: B01L3/502738 , B01L3/0268 , B01L3/50273 , B01L2200/0621 , B01L2300/0636 , B01L2300/0825 , B01L2400/0406 , B01L2400/0688 , B01L2400/086 , Y10T436/118339
Abstract: Assays in which samples of biological fluids are dispensed into the inlet port of a microfluidic device are improved in the accuracy and repeatability by dispensing the biological sample and/or associated liquids in small droplets and at timed intervals to control the operation of the microfluidic device.
Abstract translation: 通过以小液滴和定时的间隔分配生物样品和/或相关液体来控制微流体装置的操作，通过将生物流体的样品分配到微流体装置的入口端口的分析物的精度和重复性得到改善。
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公开(公告)号：US20110262304A1
公开(公告)日：2011-10-27
申请号：US12674941
申请日：2008-08-27
Applicant: James A. Profitt , Chris T. Zimmerle
Inventor： James A. Profitt , Chris T. Zimmerle
CPC classification number: G01N33/525
Abstract: Migration of liquid samples on diagnostic test strips is prevented by dividing the test strips into reagent-containing pads spaced about 0.3 to 3 mm apart with a laser.
Abstract translation: 通过用激光将测试条划分成间隔约0.3至3毫米的含试剂垫来防止液体样品在诊断测试条上的迁移。
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公开(公告)号：US20110111522A1
公开(公告)日：2011-05-12
申请号：US12674944
申请日：2008-08-27
Applicant: Chris T. Zimmerie , Michael J. Pugia , James A. Profitt
Inventor： Chris T. Zimmerie , Michael J. Pugia , James A. Profitt
CPC classification number: A61B10/007 , A61B90/90 , A61B90/96 , G01N33/558 , G01N35/00732 , G01N2035/00752 , G01N2035/00772
Abstract: Sample media for the analysis of analytes in a fluid test sample includes a carrier, at least one test field on the surface of the carrier including at least one reagent reactive with the analytes and capable of providing a detectable response. A non-visible bar code formed by at least two distinct non-visible marker fields is located on the carrier. The marker fields are configured to reflect electro-magnetic (EM) radiation within one or more ranges of non-visible wavelengths to form a coded sequence of reflectances correlated to identification of the sample media.
Abstract translation: 用于分析流体测试样品中的分析物的样品介质包括载体，载体表面上的至少一个测试场包括至少一种与分析物反应的试剂并且能够提供可检测的反应。 由至少两个不同的不可见标记字段形成的不可视条形码位于载体上。 标记场被配置为在不可见波长的一个或多个范围内反映电磁（EM）辐射，以形成与样本介质的识别相关的反射的编码序列。
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公开(公告)号：US20100239137A1
公开(公告)日：2010-09-23
申请号：US12681180
申请日：2008-10-06
Applicant: Michael J. Pugia , James A. Profitt , Chris T. Zimmerle
Inventor： Michael J. Pugia , James A. Profitt , Chris T. Zimmerle
CPC classification number: G01N33/54366 , G01N21/274 , G01N21/8483 , G01N2201/062
Abstract: A system for reading an assay includes a camera and a processor. The assay is used as a test for the presence or absence of a reaction between a sample and a reagent. The assay is defined by a test area and a background area. The test area is, preferably, substantially circular with a diameter between about 0.1 mm and about 5 mm. The camera simultaneously captures a two-dimensional image of the test area and the background area. The processor determines a first color response from the background area and a second color response from the test area. The processor then calibrates the second color response according to the first color response and generates a result of the test according to the second color response. The system may also include a uniform field illuminator that provides a substantially uniform level of illumination across the assay.
Abstract translation: 用于读取测定的系统包括照相机和处理器。 该测定用作样品和试剂之间存在或不存在反应的测试。 测定由测试区域和背景区域定义。 测试区域优选为直径在约0.1mm至约5mm之间的大致圆形。 相机同时捕获测试区域和背景区域的二维图像。 处理器确定来自背景区域的第一颜色响应和来自测试区域的第二颜色响应。 然后处理器根据第一颜色响应校准第二颜色响应，并根据第二颜色响应生成测试结果。 该系统还可以包括统一的场照明器，其在整个测定中提供基本均匀的照明水平。
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