公开(公告)号：US07682796B2

公开(公告)日：2010-03-23

申请号：US10809831

申请日：2004-03-26

申请人： Thomas R. Kozel ,  William J. Murphy ,  Suzanne Brandt ,  Peter Thorkildson ,  Ann Percival ,  Bruce R. Blazar ,  Julie A. Lovchik ,  C. Rick Lyons

发明人： Thomas R. Kozel ,  William J. Murphy ,  Suzanne Brandt ,  Peter Thorkildson ,  Ann Percival ,  Bruce R. Blazar ,  Julie A. Lovchik ,  C. Rick Lyons

IPC分类号： G01N33/53 ,  A61K39/07

CPC分类号： G01N33/56911 ,  G01N33/68 ,  G01N2333/32

摘要： Compositions and methods for the detection, prevention, or treatment of anthrax or other infectious diseases. In one aspect, the present invention provides methods for immunizing humans or animals against Bacillus anthracis or other capsulated pathogens. The methods include administering a capsular polypeptide of a pathogen of interest and a CD40 agonist to a human or animal. The capsular polypeptide or the CD40 agonist is administered in such an amount or frequency that an immunoprotective response can be elicited in the human or animal against the pathogen of interest. In another aspect, the present invention provides methods of using passive immunization with anti-capsular polypeptide antibodies to prevent or treat infections caused by Bacillus anthracis or other pathogens. In yet another aspect, the present invention provides methods useful for diagnosis of anthrax by detection of capsular polypeptide in serum or other biological samples.

摘要翻译： 用于检测，预防或治疗炭疽或其他传染病的组合物和方法。 一方面，本发明提供了用于免疫人或动物针对炭疽芽孢杆菌或其他包裹的病原体的方法。 所述方法包括向人或动物施用目的病原体的荚膜多肽和CD40激动剂。 荚膜多肽或CD40激动剂以可以在人或动物中针对感兴趣的病原体引起免疫保护反应的量或频率施用。 另一方面，本发明提供了使用被动免疫与抗荚膜多肽抗体来预防或治疗由炭疽芽孢杆菌或其他病原体引起的感染的方法。 另一方面，本发明提供了通过检测血清或其他生物样品中的荚膜多肽来诊断炭疽的方法。

公开(公告)号：US20090280513A1

公开(公告)日：2009-11-12

申请号：US10809831

申请日：2004-03-26

申请人： Thomas R. Kozel ,  William J. Murphy ,  Suzanne Brandt ,  Peter Thorkildson ,  Ann Percival ,  Bruce R. Blazar ,  Julie A. Lovchik ,  C. Rick Lyons

发明人： Thomas R. Kozel ,  William J. Murphy ,  Suzanne Brandt ,  Peter Thorkildson ,  Ann Percival ,  Bruce R. Blazar ,  Julie A. Lovchik ,  C. Rick Lyons

IPC分类号： G01N33/53 ,  C40B30/04

CPC分类号： G01N33/56911 ,  G01N33/68 ,  G01N2333/32

摘要： Compositions and methods for the detection, prevention, or treatment of anthrax or other infectious diseases. In one aspect, the present invention provides methods of immunizing humans or animals against Bacillus anthracis or other capsulated pathogens. The methods include administering a capsular polypeptide of a pathogen of interest and a CD40 agonist to a human or animal. The capsular polypeptide or the CD40 agonist is administered in such an amount or frequency that an immunoprotective response can be elicited in the human or animal against the pathogen of interest. In another aspect, the present invention provides methods of using passive immunization with anti-capsular polypeptide antibodies to prevent or treat infections caused by Bacillus anthracis or other pathogens. In yet another aspect, the present invention provides methods useful for diagnosis of anthrax by detection of capsular polypeptide in serum or other biological samples.

摘要翻译： 用于检测，预防或治疗炭疽或其他传染病的组合物和方法。 在一个方面，本发明提供了针对炭疽芽孢杆菌或其他包裹的病原体免疫人或动物的方法。 所述方法包括向人或动物施用目的病原体的荚膜多肽和CD40激动剂。 荚膜多肽或CD40激动剂以可以在人或动物中针对感兴趣的病原体引起免疫保护反应的量或频率施用。 另一方面，本发明提供了使用被动免疫与抗荚膜多肽抗体来预防或治疗由炭疽芽孢杆菌或其他病原体引起的感染的方法。 另一方面，本发明提供了通过检测血清或其他生物样品中的荚膜多肽来诊断炭疽的方法。

公开(公告)号：US07429318B2

公开(公告)日：2008-09-30

申请号：US11438059

申请日：2006-05-18

申请人： Ian A. Cody ,  William J. Murphy ,  Sylvain Hantzer ,  David W. Larkin ,  John E. Gallagher, Jr. ,  Jeenok T. Kim

发明人： Ian A. Cody ,  William J. Murphy ,  Sylvain Hantzer ,  David W. Larkin ,  John E. Gallagher, Jr. ,  Jeenok T. Kim

IPC分类号： C10G71/00 ,  C10G47/02

CPC分类号： B01J29/7461 ,  B01J29/041 ,  B01J29/068 ,  B01J29/74 ,  B01J37/12 ,  B01J2229/12 ,  B01J2229/34 ,  B01J2229/42 ,  C10G45/02 ,  C10G45/22 ,  C10G45/58 ,  C10G45/60 ,  C10G45/62 ,  C10G45/64 ,  C10G65/043

摘要： A process for preparing high VI lubricating oil basestocks comprising hydrotreating, hydrodewaxing and optionally hydrofinishing. The hydrotreated feedstock is hydrodewaxed using a dewaxing catalyst that has been selectively activated by oxygenate treatment. The hydrodewaxed product may then be hydrofinished.

摘要翻译： 一种制备高VI润滑油基础油料的方法，包括加氢处理，加氢脱蜡和任选加氢精制。 加氢处理的原料使用已经通过含氧化合物处理选择性活化的脱蜡催化剂进行加氢脱蜡。 然后将加氢脱蜡产品加氢处理。

公开(公告)号：US07282137B2

公开(公告)日：2007-10-16

申请号：US10678689

申请日：2003-10-03

申请人： Ian A. Cody ,  William J. Murphy ,  Sylvain Hantzer ,  David W. Larkin ,  John E. Gallagher, Jr. ,  Jeenok T. Kim

发明人： Ian A. Cody ,  William J. Murphy ,  Sylvain Hantzer ,  David W. Larkin ,  John E. Gallagher, Jr. ,  Jeenok T. Kim

IPC分类号： C10G45/00

CPC分类号： C10G45/08 ,  B01J29/041 ,  B01J29/74 ,  C10G45/12 ,  C10G45/62 ,  C10G45/64 ,  C10G65/043 ,  C10G69/00 ,  C10M171/02 ,  C10M2203/1006 ,  C10M2205/173 ,  C10N2220/022 ,  C10N2220/13 ,  C10N2230/02 ,  C10N2230/54 ,  C10N2230/74 ,  C10N2240/10 ,  C10N2260/02

摘要： A process for preparing high VI lubricating oil basestocks comprising hydrotreating, hydrodewaxing and optionally hydrofinishing. The hydrotreating step is under conditions such that the amount of conversion to 343° C. minus is less than 5 wt. % of the feedstock and the VI increase is less than 4 VI over the feedstock. Hydrodewaxing uses a low alpha catalyst and hydrofinishing is accomplished with a catalyst based on the M41S family.

摘要翻译： 一种制备高VI润滑油基础油料的方法，包括加氢处理，加氢脱蜡和任选加氢精制。 加氢处理步骤在使得转变为343℃负的量小于5重量％的条件下进行。 原料的百分比和VI的增加在原料上小于4 VI。 加氢脱蜡使用低α催化剂，加氢精制使用基于M41S系列的催化剂完成。

公开(公告)号：US07125818B2

公开(公告)日：2006-10-24

申请号：US10678433

申请日：2003-10-03

申请人： Ian A. Cody ,  William J. Murphy ,  Sylvain Hantzer

发明人： Ian A. Cody ,  William J. Murphy ,  Sylvain Hantzer

IPC分类号： B01J29/06

CPC分类号： B01J29/068 ,  B01J29/064 ,  B01J29/7461 ,  B01J37/20 ,  B01J2229/12 ,  B01J2229/14 ,  B01J2229/34 ,  C10G45/02 ,  C10G45/60 ,  C10G45/62 ,  C10G65/043

摘要： A dewaxing catalyst is selectively activated by treatment with an oxygenate. Selective activation is accomplished by treated the dewaxing catalyst with a carrier feed containing oxygenate. The selectively activated dewaxing catalyst when used to dewax waxy hydrocarbons results in improved yield of isomerate at equivalent pour point over a dewaxing catalyst which has not been oxygenate treated.

公开(公告)号：US06762121B2

公开(公告)日：2004-07-13

申请号：US09826036

申请日：2001-04-04

申请人： Jonathan D. Chapple-Sokol ,  Randy W. Mann ,  William J. Murphy ,  Jed H. Rankin ,  Daniel S. Vanslette

发明人： Jonathan D. Chapple-Sokol ,  Randy W. Mann ,  William J. Murphy ,  Jed H. Rankin ,  Daniel S. Vanslette

IPC分类号： C23C1434

CPC分类号： C23C28/00 ,  Y10T428/12

摘要： A method of ensuring against deterioration of an underlying silicide layer over which a refractory material layer is deposited by physical vapor deposition (PVD) or chemical vapor deposition (CVD) is realized by first providing a continuous polysilicon layer prior to the refractory material deposition. The continuous polysilicon layer, preferably no thicker than 50 Å, serves a sacrificial purpose and prevents interaction between any fluorine that is released during the refractory material deposition step from interacting with the underlying silicide.

摘要翻译： 通过首先在耐火材料沉积之前提供连续的多晶硅层，来实现通过物理气相沉积（PVD）或化学气相沉积（CVD）确保耐蚀材料层沉积在其下的硅化物层的劣化的方法。 连续多晶硅层，优选不大于50，用于牺牲目的，并且防止在耐火材料沉积步骤期间释放的任何氟与下面的硅化物相互作用的相互作用。

公开(公告)号：US06592748B2

公开(公告)日：2003-07-15

申请号：US09892384

申请日：2001-06-26

申请人： Ian A. Cody ,  William J. Murphy ,  John E. Gallagher ,  Joseph P. Boyle ,  Anne M. Zinicola ,  Christopher J. May ,  Jeenok T. Kim ,  John A. Groestch ,  Sylvain S. Hantzer

发明人： Ian A. Cody ,  William J. Murphy ,  John E. Gallagher ,  Joseph P. Boyle ,  Anne M. Zinicola ,  Christopher J. May ,  Jeenok T. Kim ,  John A. Groestch ,  Sylvain S. Hantzer

IPC分类号： C10G7302

CPC分类号： C10G67/0409 ,  C10G65/04 ,  C10G65/043 ,  C10G65/08 ,  C10G65/12 ,  C10G67/0418 ,  C10G67/0445 ,  C10G2400/10

摘要： A process for producing a high VI/low volatility lubricating oil basestock and a lubricating oil basestock prepared by said process. The process comprises subjecting the raffinate from a solvent extraction step to a two step, single stage hydroconversion process wherein the first step involves severe hydroconversion of the raffinate followed by a cold hydrofinishing step.

摘要翻译： 一种生产高VI /低挥发性润滑油基础油的方法和通过所述方法制备的润滑油基础油。 该方法包括使萃余液从溶剂萃取步骤进行到两步，单阶段加氢转化方法，其中第一步骤涉及萃余液的严格加氢转化，然后进行冷加氢精制步骤。

公开(公告)号：US6032705A

公开(公告)日：2000-03-07

申请号：US27040

申请日：1998-02-20

申请人： William J. Murphy ,  Leon M. Levy

发明人： William J. Murphy ,  Leon M. Levy

IPC分类号： B65D37/00 ,  B09B3/00 ,  B65B1/04

CPC分类号： B09B3/0075

摘要： A delivery system for dispensing controlled amounts of liquid or powder has two slidingly engaged parts which are held together as a single unit. The system is closed by pushing one of the two parts toward the other until a valve plug in the upper part of the system is received within an aperture of a valve seal membrane in the lower part of the system. The system is opened by pulling one part of the system away from the other using the sliding engagement means so that the valve plug exits the aperture in the valve seal membrane. Interior contoured walls prevent undesired collection of powder within the system, the relative orientation of the two parts of the system is adjustable to control the rate of flow of powder, and the system is particularly suitable for introducing powdered desiccants into medical waste containers without exposing the contents of the waste containers to the surrounding environment.

摘要翻译： 用于分配受控量的液体或粉末的输送系统具有两个作为单个单元保持在一起的滑动接合部分。 通过将两个部件中的一个朝向另一个部分将系统关闭，直到系统上部的阀塞被接收在系统下部的阀密封膜的孔内。 通过使用滑动接合装置将系统的一部分拉离另一个系统来打开系统，使得阀塞离开阀密封膜中的孔。 内部波纹壁防止系统内不期望的粉末收集，系统的两个部分的相对定向是可调节的，以控制粉末的流动速率，并且该系统特别适用于将粉末干燥剂引入医疗废物容器而不暴露 废物容器的内容物到周围环境。

公开(公告)号：US5886252A

公开(公告)日：1999-03-23

申请号：US963672

申请日：1997-10-31

申请人： George R. Lennert ,  Rick L. Collins ,  William J. Murphy

发明人： George R. Lennert ,  Rick L. Collins ,  William J. Murphy

IPC分类号： A61B5/1459 ,  A61B5/15 ,  G01N21/86 ,  G01N33/483 ,  G01N33/49 ,  G01N35/00 ,  G01N21/03

CPC分类号： G01N35/00712 ,  G01N21/8483 ,  G01N33/4905 ,  Y10T307/625 ,  Y10T307/735

摘要： An instrument for determining a characteristic of a biological fluid or a control comprises a radiation-reflective surface, a first source for irradiating the surface, a first detector for detecting radiation reflected from the surface, and a mechanism for determining the characteristic based on the detected radiation. A slide holds a sample of the biological fluid or control the characteristic of which is to be determined. The slide has two opposed walls transparent to the radiation. The first source and first detector are disposed adjacent a first one of the two opposed walls and the radiation reflective surface is disposed adjacent a second of the two opposed walls. A system is provided for supplying power and regulating supplied power from one of multiple power sources to the instrument. The system comprises first and second power sources, first coupling circuitry for selectively coupling the system to the first power source, second coupling circuitry for selectively coupling the system to the second power source, and circuitry for comparing a voltage supplied by the first power source to a voltage supplied by the second power source and for controlling the first coupling circuitry to decouple the system from the first power source when the voltage supplied by the second power source exceeds the voltage supplied by the first power source.

摘要翻译： 用于确定生物流体或控制物的特征的仪器包括辐射反射表面，用于照射表面的第一源，用于检测从表面反射的辐射的第一检测器，以及用于基于检测到的特性确定特性的机构 辐射。 载玻片保持生物流体的样品或其特性被确定的控制。 滑片具有两个对辐射透明的相对的壁。 第一源极和第一检测器被布置成与两个相对的壁中的第一个相邻，并且辐射反射表面邻近两个相对的壁中的第二个设置。 提供一种用于从多个电源之一向仪器供电和调节供电的系统。 该系统包括第一和第二电源，用于将系统选择性地耦合到第一电源的第一耦合电路，用于将系统选择性地耦合到第二电源的第二耦合电路，以及用于将由第一电源提供的电压与 由第二电源提供的电压，并且当第二电源提供的电压超过由第一电源提供的电压时，用于控制第一耦合电路以将系统与第一电源分离。

公开(公告)号：US5792944A

公开(公告)日：1998-08-11

申请号：US697019

申请日：1996-08-16

申请人： George R. Lennert ,  Rick L. Collins ,  William J. Murphy

发明人： George R. Lennert ,  Rick L. Collins ,  William J. Murphy

IPC分类号： A61B5/1459 ,  A61B5/15 ,  G01N21/86 ,  G01N33/483 ,  G01N33/49 ,  G01N35/00 ,  A61B5/60

CPC分类号： G01N35/00712 ,  G01N21/8483 ,  G01N33/4905 ,  Y10T307/625 ,  Y10T307/735

摘要： An instrument for determining a characteristic of a biological fluid or a control comprises a radiation-reflective surface, a first source for irradiating the surface, a first detector for detecting radiation reflected from the surface, and a mechanism for determining the characteristic based on the detected radiation. A slide holds a sample of the biological fluid or control the characteristic of which is to be determined. The slide has two opposed walls transparent to the radiation. The first source and first detector are disposed adjacent a first one of the two opposed walls and the radiation reflective surface is disposed adjacent a second of the two opposed walls. A system is provided for supplying power and regulating supplied power from one of multiple power sources to the instrument. The system comprises first and second power sources, first coupling circuitry for selectively coupling the system to the first power source, second coupling circuitry for selectively coupling the system to the second power source, and circuitry for comparing a voltage supplied by the first power source to a voltage supplied by the second power source and for controlling the first coupling circuitry to decouple the system from the first power source when the voltage supplied by the second power source exceeds the voltage supplied by the first power source.