公开(公告)号：US08175709B2

公开(公告)日：2012-05-08

申请号：US11668491

申请日：2007-01-30

申请人： Jie Lian ,  Hannes Kraetschmer ,  Dirk Muessig

发明人： Jie Lian ,  Hannes Kraetschmer ,  Dirk Muessig

IPC分类号： A61N1/362

CPC分类号： A61B5/04017 ,  A61B5/0402 ,  A61B5/04525 ,  A61B5/7232

摘要： A system for heart monitoring comprises an IEGM input for an intracardiac electrocardiogram (IEGM) that is connected to an active filtering stage that is adapted to transform an incoming IEGM into an output ECG signal. The active filtering stage is connected to a filter characterization stage that is adapted to process a recorded, patient specific IEGM template and a corresponding SECG template and to adapt the filter characteristics of said active filtering stage such that the filter characteristics best characterize the input-output relationship between the IEGM template and the corresponding SECG template. As a consequence, the active filtering stage is adapted to transform an incoming IEGM such that the output ECG signal closely resembles a morphology of a corresponding SECG.

摘要翻译： 用于心脏监测的系统包括用于心内心电图（IEGM）的IEGM输入，其连接到适用于将输入的IEGM变换为输出ECG信号的有源滤波级。 有源滤波级连接到滤波器表征阶段，其适于处理记录的，患者特异性IEGM模板和对应的SECG模板，并适应所述有源滤波级的滤波器特性，使得滤波器特性最好地表征输入 - 输出 IEGM模板与相应的SECG模板之间的关系。 因此，有源滤波阶段适于变换输入的IEGM，使得输出的ECG信号非常类似于对应的SECG的形态。

公开(公告)号：US07580748B2

公开(公告)日：2009-08-25

申请号：US11567753

申请日：2006-12-07

申请人： Garth Garner ,  Hannes Kraetschmer ,  Dirk Muessig ,  Indra B. Nigam

发明人： Garth Garner ,  Hannes Kraetschmer ,  Dirk Muessig ,  Indra B. Nigam

IPC分类号： A61N1/00

CPC分类号： A61N1/3712

摘要： A heart stimulator provides a reliable automatic capture threshold search feature. A stimulation pulse generator is connected to at least a ventricular stimulation electrode for delivering electric stimulation pulses to at least the ventricle of the heart. The stimulation pulses generated have a strength depending on a control signal. A sensing stage is connected to an electrode for picking up electric potentials inside at least said ventricle of a heart and a control unit connected to the sensing stage and to the stimulation pulse generator determines points of time for scheduling stimulation pulses, to trigger the stimulation pulse generator so as to deliver a stimulation pulse when scheduled and to put out control signals for controlling the strength of the stimulation pulse. The control unit is further adapted to perform a capture analysis which may take into account extraordinary events.

摘要翻译： 心脏刺激器提供可靠的自动捕获阈值搜索功能。 刺激脉冲发生器连接到至少一个心室刺激电极，用于将电刺激脉冲传送到至少心脏的心室。 产生的刺激脉冲具有取决于控制信号的强度。 感测级连接到用于拾取心脏的至少所述心室内的电位的电极和连接到感测级的控制单元，并且刺激脉冲发生器确定调度刺激脉冲的时间点，以触发刺激脉冲 发生器，以便在调度时传递刺激脉冲，并且输出用于控制刺激脉冲的强度的控制信号。 控制单元还适于执行可以考虑特殊事件的捕获分析。

公开(公告)号：US08843198B2

公开(公告)日：2014-09-23

申请号：US13603418

申请日：2012-09-05

申请人： Jie Lian ,  Volker Lang ,  Hannes Kraetschmer ,  Dirk Muessig

发明人： Jie Lian ,  Volker Lang ,  Hannes Kraetschmer ,  Dirk Muessig

IPC分类号： A61N1/368 ,  A61B5/04 ,  A61N1/365 ,  A61N1/362 ,  A61B5/0402

CPC分类号： A61N1/3627 ,  A61B5/0402 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3686

摘要： The present disclosure refers to a heart stimulator comprising a stimulation control unit, a stimulation unit, an impedance measurement unit and an impedance evaluation unit. The stimulation control unit is operatively connected to the stimulation unit to control timing of stimulation pulses by said stimulation unit. The impedance measurement unit is configured to determine an impedance signal reflecting intracardiac impedance. The impedance evaluation unit is operatively connected to the impedance measurement unit and to the stimulation control unit and is configured to evaluate the impedance signal so as to determine an isovolumic contraction time, an isovolumic relaxation time, an ejection time and a filling time from said impedance signal. The stimulation control unit is further configured to control timing of stimulation pulses depending on a performance index.

摘要翻译： 本公开涉及包括刺激控制单元，刺激单元，阻抗测量单元和阻抗评估单元的心脏刺激器。 刺激控制单元可操作地连接到刺激单元以控制所述刺激单元的刺激脉冲的定时。 阻抗测量单元被配置为确定反映心内阻抗的阻抗信号。 阻抗评估单元可操作地连接到阻抗测量单元和刺激控制单元，并被配置为评估阻抗信号，以便确定等容收缩时间，等容弛豫时间，喷射时间和来自所述阻抗的填充时间 信号。 刺激控制单元还被配置为根据性能指标来控制刺激脉冲的定时。

公开(公告)号：US20080183088A1

公开(公告)日：2008-07-31

申请号：US11668491

申请日：2007-01-30

申请人： Jie Lian ,  Hannes Kraetschmer ,  Dirk Muessig

发明人： Jie Lian ,  Hannes Kraetschmer ,  Dirk Muessig

IPC分类号： A61B5/0402

CPC分类号： A61B5/04017 ,  A61B5/0402 ,  A61B5/04525 ,  A61B5/7232

摘要： A system for heart monitoring comprises an IEGM input for an intracardiac electrocardiogram (IEGM) that is connected to an active filtering stage that is adapted to transform an incoming IEGM into an output ECG signal. The active filtering stage is connected to a filter characterization stage that is adapted to process a recorded, patient specific IEGM template and a corresponding SECG template and to adapt the filter characteristics of said active filtering stage such that the filter characteristics best characterize the input-output relationship between the IEGM template and the corresponding SECG template. As a consequence, the active filtering stage is adapted to transform an incoming IEGM such that the output ECG signal closely resembles a morphology of a corresponding SECG.

摘要翻译： 用于心脏监测的系统包括用于心内心电图（IEGM）的IEGM输入，其连接到适用于将输入的IEGM变换为输出ECG信号的有源滤波级。 有源滤波级连接到滤波器表征阶段，其适于处理记录的，患者特异性IEGM模板和对应的SECG模板，并适应所述有源滤波级的滤波器特性，使得滤波器特性最好地表征输入 - 输出 IEGM模板与相应的SECG模板之间的关系。 因此，有源滤波阶段适于变换输入的IEGM，使得输出的ECG信号非常类似于对应的SECG的形态。

公开(公告)号：US08868166B2

公开(公告)日：2014-10-21

申请号：US13455131

申请日：2012-04-25

申请人： Dirk Muessig ,  J. Christopher Moulder ,  Hannes Kraetschmer ,  Jeffrey A. Von Arx ,  Larry Stotts

发明人： Dirk Muessig ,  J. Christopher Moulder ,  Hannes Kraetschmer ,  Jeffrey A. Von Arx ,  Larry Stotts

IPC分类号： A61N5/04 ,  A61B5/00 ,  A61B5/0452 ,  A61N1/05 ,  A61B5/0464 ,  A61B5/046

CPC分类号： A61N1/05 ,  A61B5/0452 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/721

摘要： Implantable electromedical device or loop recorders or ILRs that solve the problem of very low arrhythmia detection specificities in, i.e., high number of false positives, based on detection and analysis of external noise, specifically muscle noise surrounding the electromedical device. Embodiments generally employ active detection of lead or device movement that induces signal artifacts indicative of external noise. One or more embodiments may detect lead or device movement through use of a piezoelectric transducer, for example located proximally to the device or in the lead of the electromedical.

摘要翻译： 基于外部噪声的检测和分析，特别是电动医疗装置周围的肌肉噪声，可植入的电疗装置或回路记录器或ILR，其解决非常低的心律失常检测特性（即，高数量的假阳性）的问题。 实施例通常采用引导或器件移动的主动检测，其引起指示外部噪声的信号伪影。 一个或多个实施例可以通过使用压电换能器来检测引线或器件的移动，例如位于设备的近侧或电子医疗的引线。

公开(公告)号：US08064998B2

公开(公告)日：2011-11-22

申请号：US11863375

申请日：2007-09-28

申请人： Xin Good ,  David F. Hastings ,  Hannes Kraetschmer ,  Dirk Muessig

发明人： Xin Good ,  David F. Hastings ,  Hannes Kraetschmer ,  Dirk Muessig

IPC分类号： A61N1/00

CPC分类号： A61N1/3702 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/053 ,  A61B5/0816 ,  A61B5/11 ,  A61B5/145 ,  A61N1/368 ,  A61N1/3682

摘要： Heart stimulating system for stimulating at least a ventricle of a heart including: stimulation pulse generator adapted to generate stimulation pulses and connected to a ventricular stimulation electrode for delivering stimulation pulses, atrial sensing stage connected to an electrode for picking up potentials inside an atrium and adapted to sense an excitation or contraction of atrial myocardium, ventricular sensing stage connected to an electrode for picking up potentials inside a ventricle and adapted to sense an excitation or contraction of ventricular myocardium, memory for AV-delay values, a control unit adapted to trigger said stimulation pulse generator to generate ventricular stimulation pulses timed based on AV-delay values stored in said memory and to acquire atrioventricular interval samples, and atrioventricular interval timing analyzing unit for receiving atrioventricular interval samples from said control unit and adapted to generate at least one histogram based on said atrioventricular interval samples and analyze said histograms.

摘要翻译： 用于刺激至少一个心脏心室的心脏刺激系统，包括：刺激脉冲发生器，其适于产生刺激脉冲并连接到心室刺激电极以传递刺激脉冲，心房感测级连接到电极，用于拾取心房内的电位并适应 感测心房心肌的激发或收缩，心室感测阶段连接到电极，用于拾取心室内的电位并且适于感测心室心肌的激发或收缩，用于AV延迟值的记忆，适于触发所述 刺激脉冲发生器，以产生基于存储在所述存储器中的AV延迟值定时并获取房室间隔样本的心室刺激脉冲，以及房室间隔定时分析单元，用于从所述控制单元接收房室间隔样本，并适于生成至少一个基于直方图 就说 房室间隔采样并分析所述直方图。

公开(公告)号：US08849425B2

公开(公告)日：2014-09-30

申请号：US13455136

申请日：2012-04-25

申请人： Hannes Kraetschmer ,  Dirk Muessig ,  Jeffrey A. Von Arx ,  Larry Stotts

发明人： Hannes Kraetschmer ,  Dirk Muessig ,  Jeffrey A. Von Arx ,  Larry Stotts

IPC分类号： A61N1/00 ,  A61B5/11 ,  A61N1/05 ,  A61B5/00 ,  A61B5/024 ,  A61B5/0452 ,  A61B5/04

CPC分类号： A61N1/0504 ,  A61B5/02405 ,  A61B5/0452 ,  A61B5/11 ,  A61B5/686 ,  A61B5/6867 ,  A61B5/721 ,  A61B2562/0219

摘要： Detects external noise using a motion sensor signal for example to increase the specificity of arrhythmia detections based on active muscle noise detection. Whenever a motion signal is present that is below or above a certain frequency, for example 5 Hz, or within a certain frequency range, for example 1 to 10 Hz, and/or above a certain amplitude, for example greater than 1 mg, or close to a known motion pattern, then the detection of fast ventricular arrhythmia is suspended. For the detection of slow arrhythmia, for example asystole or syncope, an episode is confirmed when a short lasting motion sensor signal occurs. Uses a motion sensor based signal, for example as obtained from an accelerometer on an implantable electrode lead and/or implantable device.

摘要翻译： 使用运动传感器信号检测外部噪声，例如以增加基于主动肌肉噪声检测的心律失常检测的特异性。 每当存在低于或高于某一频率（例如5Hz）或在一定频率范围内（例如1至10Hz）和/或高于某一幅度（例如大于1mg）的运动信号时，或 接近已知的运动模式，然后暂停检测快速心室心律失常。 为了检测慢性心律不齐，例如心搏停止或晕厥，当发生短暂的持续运动传感器信号时，确认发作。 使用基于运动传感器的信号，例如从可植入电极引线和/或可植入装置上的加速度计获得。

公开(公告)号：US08718751B2

公开(公告)日：2014-05-06

申请号：US11746156

申请日：2007-05-09

申请人： David F. Hastings ,  Xin Good ,  Hannes Kraetschmer ,  Dirk Muessig

发明人： David F. Hastings ,  Xin Good ,  Hannes Kraetschmer ,  Dirk Muessig

IPC分类号： A61B5/08 ,  A61B5/04 ,  A61B5/053 ,  A61B5/085

CPC分类号： A61N1/36521 ,  A61B5/0535 ,  A61B5/0809 ,  A61B5/4818 ,  A61N1/36114 ,  A61N1/36542 ,  A61N1/36585

摘要： A heart monitoring system comprises a ventricular sensing stage sensing excitation or contraction of ventricular myocardium, an activity sensor unit determining a signal reflecting a patient's physical activity, a ventricular impedance or conductance measuring module, said modules comprising a current source unit adapted to provide a sub-threshold excitation current to the myocardium and comprising an impedance or conductance measurement unit for measuring the resulting voltage on said electrode at the myocardium, a signal generator module, a filter module, a memory, a control unit adapted to derive single measures |ΣZ| of magnitude of impedance or conductance change over a preset sample time interval, determine the variability TARVI in the impedance or conductance change, compare this variability and the activity sensor output signal with a threshold and recent history, determine if sleep disturbed breathing (SDB) is present, and log the SDB episode in the memory device.

摘要翻译： 心脏监测系统包括心室感测阶段感测心室心肌的激发或收缩，活动传感器单元确定反映患者身体活动的信号，心室阻抗或电导测量模块，所述模块包括电流源单元，其适于提供子 并且包括用于测量心肌上的所述电极上产生的电压的阻抗或电导测量单元，信号发生器模块，滤波器模块，存储器，适于导出单个测量的控制单元。 Z | 在预设的采样时间间隔内测量阻抗或电导变化的大小，确定阻抗或电导变化中的变异性TARVI，将该变异性和活动传感器输出信号与阈值和最近历史进行比较，确定睡眠扰动呼吸（SDB）是否为 呈现并记录SDB剧集在内存设备中。

公开(公告)号：US20100100143A1

公开(公告)日：2010-04-22

申请号：US12254728

申请日：2008-10-20

申请人： Indra B. Nigam ,  Dirk Muessig ,  Hannes Kraetschmer

发明人： Indra B. Nigam ,  Dirk Muessig ,  Hannes Kraetschmer

IPC分类号： A61N1/39 ,  A61N1/365

CPC分类号： A61N1/3704 ,  A61B5/042 ,  A61B5/046 ,  A61B5/0468 ,  A61B5/6846 ,  A61N1/395

摘要： Device for classifying tachyarrhythmia that obtains pre-defined values, monitors atrial intervals and compares lengths of each interval with pre-defined value IL, stores length of atrial interval if length is shorter than IL, in case X of most recent Y number of atrial intervals have length shorter than IL, evaluates most recent =1 criteria, and controls a cardiac device depending on the classification. Atrial intervals are first evaluated by using the “X-out-of-Y” criterion and subsequently checked for stability after an atrial tachyarrhythmia is detected using “X-out-of-Y” criterion. For stability check, only intervals found shorter than the interval limit are used. Check is based on interval-to-interval comparison rather than as generally practiced, comparisons of individual intervals with the minimum or average of all intervals.

摘要翻译： 用于分类获得预定值的快速性心律失常的装置，监测心房间隔并且将每个间隔的长度与预定义值IL进行比较，如果长度短于IL，则存储心房间隔的长度，在最近的Y个心房间隔的情况下 长度短于IL，评估最近的<= N心房间隔，长度 = 1标准，则将心房快速性心律失常分类为稳定，并根据 分类。 首先通过使用“X-out-Y”标准来评估心房间隔，并随后在使用“X-out-of-Y”标准检测到房性快速性心律失常之后检查其稳定性。 对于稳定性检查，仅使用间隔时间间隔短于间隔限制。 检查是基于间隔间隔比较而不是通常实践的，将各个间隔与所有间隔的最小值或平均值进行比较。

公开(公告)号：US20080009910A1

公开(公告)日：2008-01-10

申请号：US11484336

申请日：2006-07-10

申请人： Hannes Kraetschmer ,  Xin Good

发明人： Hannes Kraetschmer ,  Xin Good

IPC分类号： A61N1/00

CPC分类号： A61N1/368 ,  A61N1/3688

摘要： Cardiac pacemaker, having at least one stimulation pulse generator to selectively generate stimulation pulses for delivery to an atrium or to an atrium and a ventricle of a heart in DDD mode, at least one sensing stage adapted to process electrical signals sensed by an atrial and ventricular sensing electrode to detect an atrial or ventricular event and to generate an atrial or ventricular sense signal upon event detection, a control unit connected to the generator and sensing stage and being adapted to trigger the generator in DDD mode, wherein the control unit is adapted to verify proper atrioventricular conduction and to switch from a regular (DDD) mode, wherein scheduled ventricular stimulation pulses having predetermined positive intensity is triggered unless inhibited to a ventricular pulse suppression mode (VPS mode) wherein no ventricular stimulation pulses or ventricular stimulation pulses of sub-threshold intensity are generated as long as proper atrioventricular conduction is verified.

摘要翻译： 心脏起搏器，具有至少一个刺激脉冲发生器，以选择性地产生刺激脉冲，用于递送至DDD模式的心房或心脏的心房和心室，至少一个感测级，适于处理由心房和心室感测的电信号 检测电极以检测心房或心室事件并且在事件检测时产生心房或心室感测信号;控制单元，其连接到所述发生器和感测级，并且适于以DDD模式触发所述发生器，其中所述控制单元适于 验证正常的房室传导并从常规（DDD）模式切换，其中触发具有预定正强度的预定心室刺激脉冲，除非被抑制到心室脉搏抑制模式（V S P S模式），其中无心室 只要适当的房室传导c就产生刺激脉冲或亚阈值强度的心室刺激脉冲 导弹被验证。