公开(公告)号：US07399269B2

公开(公告)日：2008-07-15

申请号：US10307355

申请日：2002-12-02

Applicant: Johann Kindlein ,  Leo Hovestadt

Inventor： Johann Kindlein ,  Leo Hovestadt

IPC: A61N5/00

CPC classification number: A61N5/103 ,  A61N5/1001 ,  A61N5/1007 ,  A61N5/1027 ,  A61N5/1048

Abstract: The invention relates to a process for brachytherapy by using a dose measuring system, wherein, in at least one point of an area subjected to radiation treatment, the individual radiation dose contribution from at least one dwell position of at least one radiation source is measured in real time, the thus obtained measured dose value is compared with the corresponding value calculated by a treatment planning system, and the further course of the treatment is adapted on the basis of the degree of agreement between the measured value and the calculated value. Furthermore, the invention relates to a control program, a treatment control system, a treatment planning system and a dose measuring system.

Abstract translation: 本发明涉及一种通过使用剂量测量系统进行近距离放射治疗的方法，其中在经受辐射治疗的区域的至少一个点处，对来自至少一个辐射源的至少一个停留位置的个体辐射剂量贡献在 将由此获得的测量剂量值与由治疗计划系统计算的相应值进行比较，并且根据测量值与计算值之间的一致程度来改变治疗的进一步的过程。 此外，本发明涉及控制程序，治疗控制系统，治疗计划系统和剂量测量系统。

公开(公告)号：US07016471B2

公开(公告)日：2006-03-21

申请号：US10878160

申请日：2004-06-29

Applicant: Johann Kindlein

Inventor： Johann Kindlein

IPC: H01J35/06

CPC classification number: A61N5/1001 ,  H01J35/20 ,  H01J35/32 ,  H01J2235/205

Abstract: A miniature X-ray source device connected to a distal end of a guiding wire for insertion towards a desired location within an animal body for effecting radiation thereby. The X-ray source device at least includes a vacuum tube containing a cathode and an anode spaced apart at a distance from each other; an emitter for emitting free electrons from the cathode; an electric field generator for applying a high-voltage electric field between the cathode and the anode for accelerating the emitted free electrons towards the anode; and a getter material located in a high-voltage electric field free region in the vacuum tube. The vacuum tube is at least partly transparent to X-ray radiation emitted by the anode.

Abstract translation: 连接到导丝的远端的微型X射线源装置，用于插入到动物体内的所需位置，从而实现辐射。 X射线源装置至少包括一个真空管，该真空管包含彼此间隔一定距离的阴极和阳极; 用于从阴极发射自由电子的发射器; 电场发生器，用于在阴极和阳极之间施加高压电场，用于加速向阳极发射的自由电子; 以及位于真空管中的高压无电场区域中的吸气剂材料。 真空管对于由阳极发射的X射线辐射至少部分透明。

公开(公告)号：US20060015166A1

公开(公告)日：2006-01-19

申请号：US11165128

申请日：2005-06-24

Applicant: Johann Kindlein ,  Hans Schot

Inventor： Johann Kindlein ,  Hans Schot

IPC: A61N1/06

CPC classification number: A61N5/1015

Abstract: The invention relates to a device for radiation treatment of proliferative tissue surrounding a cavity in an animal body comprising radiation delivering means for placing at least one energy emitting source at a desired position within said cavity for performing said radiation treatment. The invention also relates to an implant element to be implanted into a cavity in an animal body for radiation treatment of proliferative tissue surrounding said cavity. The invention aims to provide a device and method for radiation treatment of proliferative tissue surrounding a cavity in an animal body, wherein the radiation treatment is performed in a far more accurate and reproducible manner and wherein the device causes far less discomfort to the patient. According to the invention said device comprises an permanent implant element suitable for placement in said body cavity, said element being made from a non-deformable material and having an outer surface being conformal to the inner surface of said body cavity.

Abstract translation: 本发明涉及一种用于放射治疗包围动物体腔内的增生组织的装置，该装置包括用于将至少一个能量发射源放置在所述空腔内的所需位置以进行所述放射治疗的辐射递送装置。 本发明还涉及一种待植入动物体腔内的植入元件，用于辐射治疗围绕所述腔的增生组织。 本发明的目的在于提供一种用于放射治疗动物体内空腔周围的增生组织的装置和方法，其中以更准确和更可重复的方式进行放射治疗，并且其中该装置对患者的不舒适程度较小。 根据本发明，所述装置包括适于放置在所述体腔中的永久植入元件，所述元件由不可变形的材料制成并具有与所述体腔的内表面共形的外表面。

公开(公告)号：US20050177020A1

公开(公告)日：2005-08-11

申请号：US10674356

申请日：2003-10-01

Applicant: Johann Kindlein ,  Arie Visscher ,  Ulrike Lutz ,  Jeroen Schuurman ,  Mark Adam

Inventor： Johann Kindlein ,  Arie Visscher ,  Ulrike Lutz ,  Jeroen Schuurman ,  Mark Adam

IPC: G21K1/00 ,  A61M36/00 ,  A61M36/04 ,  A61M36/12 ,  A61N5/10 ,  A61N5/00

CPC classification number: A61N5/1007 ,  A61N2005/1011 ,  A61N2005/1023

Abstract: The invention relates to a device for implanting at least one row of X radioactive seeds and Y non-radioactive spacers with Xε[1, 2, . . . ] and Yε[0, 1, . . . ] in a desired configuration to a desired location in an animal body for effecting radiation therapy of cancerous tissue in said body, said device comprising: at least one elongated hollow needle with an open distal end to be inserted towards said desired location in the body and with a proximal end to be connected to a seed loading apparatus; and at least one pushing element for implanting during retraction of the elongated hollow needle said row of radioactive seeds and non-radioactive spacers from said seed loading apparatus through said hollow needle towards said location. The prior art rows of seeds/spacers have the disadvantage, that after insertion into the body or near to the tissue to be irradiated no physical relation between the inserted seeds and spacers exists other than through the tissue of the body, thus affecting the radiation treatment to be performed. Therefore in order to avoid mutual displacement of the seeds/spacers after insertion of the row into the body due to movements of the patient the device according to the invention further comprises at least one tube-shaped element with at least one open end to be inserted through said hollow needle towards said desired location; and at least one tube-shaped sleeve member with an open distal and open proximal end for inserting said tube-shaped element through said hollow needle towards said desired location, wherein said tube-shaped element serves to accommodate said row of radioactive seeds and non-radioactive spacers.

Abstract translation: 本发明涉及用Xepsilon [1,2]注入至少一行X放射性种子和Y型非放射性间隔物的装置。 。 。 ]和Yepsilon [0,1]。 。 。 ]以期望的配置到动物体内的所需位置，用于对所述体内的癌组织进行放射治疗，所述装置包括：至少一个细长的中空针头，其具有敞开的远端，以朝向身体中的所述期望位置插入;以及 其近端连接到种子装载装置; 以及至少一个推动元件，用于在所述细长中空针将所述放射性种子排和非放射性间隔物从所述种子装载装置通过所述中空针向所述位置缩回时进行植入。 现有技术的种子/隔离物排的缺点在于，在插入体内或靠近要照射的组织之后，插入的种子和间隔物之间​​不存在物理关系，而不是通过身体的组织而存在，从而影响放射治疗 被执行。 因此，为了避免由于患者的移动而将排插入体内的种子/间隔物的相互移位，根据本发明的装置还包括至少一个具有至少一个开放端插入的管状元件 通过所述中空针朝向所述所需位置; 以及至少一个管形套筒构件，其具有开放的远侧和近端近端，用于将所述管状元件穿过所述中空针头朝向所述期望位置插入，其中所述管状元件用于容纳所述一排放射性种子， 放射性隔片。

公开(公告)号：US07899517B2

公开(公告)日：2011-03-01

申请号：US10448311

申请日：2003-05-30

Applicant: Johann Kindlein ,  Dimos Baltas ,  Georgios Sakas ,  Frans Kuipers ,  Hans Martin Schot

Inventor： Johann Kindlein ,  Dimos Baltas ,  Georgios Sakas ,  Frans Kuipers ,  Hans Martin Schot

IPC: A61B5/05

CPC classification number: A61N5/1031 ,  A61N5/1001 ,  A61N5/1007 ,  A61N5/1039 ,  A61N2005/1012 ,  A61N2005/1032 ,  A61N2005/1074 ,  G06F19/00 ,  G06F19/3481

Abstract: A real time radiation treatment planning system for use in effecting radiation therapy of a pre-selected anatomical portion of an animal body. A processor is provided with a three-dimensional imaging algorithm and a three-dimensional image segmentation algorithm for at least the specific organs within the anatomical portion and the needles. The processor converts the image data into a three-dimensional image of the anatomical portion using at least one single or multi-objective anatomy based genetic optimization algorithm. The processor determines in real time the optimal number and position of the hollow needles, the position of the energy emitting source within each hollow needle and the dwell times of the energy emitting source at each position. For post planning purposes, the processor determines, based on three-dimensional image information in real time, the real needle positions and the dwell times of the energy emitting source for each position.

Abstract translation: 一种实时放射治疗计划系统，用于对动物体的预先选择的解剖部分进行放射治疗。 为处理器提供三维成像算法和至少在解剖部分和针内的特定器官的三维图像分割算法。 处理器使用至少一个基于单目标或多目标解剖学的遗传优化算法将图像数据转换成解剖部分的三维图像。 处理器实时确定中空针的最佳数量和位置，能量发射源在每个中空针内的位置以及在每个位置处的能量发射源的驻留时间。 对于后期规划目的，处理器基于实时的三维图像信息确定每个位置的能量发射源的实际针位置和停留时间。

公开(公告)号：US07749150B2

公开(公告)日：2010-07-06

申请号：US11165128

申请日：2005-06-24

Applicant: Johann Kindlein ,  Hans Martin Schot

Inventor： Johann Kindlein ,  Hans Martin Schot

IPC: A61N5/00

CPC classification number: A61N5/1015

Abstract: The invention relates to a device for radiation treatment of proliferative tissue surrounding a cavity in an animal body comprising a radiation delivering means for placing at least one energy emitting source at a desired position within the cavity for performing radiation treatment. The device includes at least one permanent implant element for placement in the body cavity that is made from a non-deformable material and has an outer surface around which the inner surface of the body cavity will adapt or conform itself. The invention aims to provide a device and method for radiation treatment of proliferative tissue surrounding a cavity in an animal body, wherein the radiation treatment is performed in a far more accurate and reproducible manner and wherein the device causes far less discomfort to the patient.

Abstract translation: 本发明涉及一种用于放射治疗包围动物体腔内的增生组织的装置，其包括用于将至少一个能量发射源放置在腔内的期望位置以进行辐射治疗的辐射递送装置。 该装置包括至少一个用于放置在体腔中的永久性植入元件，其由不可变形的材料制成并且具有外表面，身体腔的内表面围绕该外表面适应或适应自身。 本发明的目的在于提供一种用于放射治疗动物体内空腔周围的增生组织的装置和方法，其中以更准确和更可重复的方式进行放射治疗，并且其中该装置对患者造成的不舒服。

公开(公告)号：US20090292200A1

公开(公告)日：2009-11-26

申请号：US12193472

申请日：2008-08-18

Applicant: Johann Kindlein ,  Tim Thurn

Inventor： Johann Kindlein ,  Tim Thurn

IPC: A61B5/05

CPC classification number: A61N5/1049 ,  A61N2005/105 ,  A61N2005/1056

Abstract: The present invention is related to an apparatus for marking an irradiation field on the surface of the patient's body, which was produced by means of a virtual 3D model of a patient's body, with a laser system for determining the coordinates of at least two reference points on the surface of the patient's body in a local coordinate system assigned to the apparatus, with an analysing and control unit which is realised to determine a transformation matrix for the transformation of arbitrary coordinates from the virtual coordinate system into the local coordinate system from the coordinates of the reference points in the local coordinate system and from coordinates of the reference points in a virtual coordinate system of the virtual 3D model of the patient's body, and wherein the analysing and control unit is further realised to transform coordinates from the virtual coordinate system into the local coordinate system with the transformation matrix, and to provide the transformed coordinates to the laser system. In addition, the present invention is also related to a corresponding method.

Abstract translation: 本发明涉及一种利用用于确定至少两个参考点的坐标的激光系统来标记患者身体的表面上的照射场的装置，该装置是通过患者身体的虚拟3D模型产生的 在分配给该装置的局部坐标系中的患者身体的表面上，具有分析和控制单元，其被实现为确定用于从任意坐标从虚拟坐标系向坐标系变换到坐标系的坐标系的坐标系 在本地坐标系中的参考点和患者身体的虚拟3D模型的虚拟坐标系中的参考点的坐标之间，并且其中进一步实现分析和控制单元将坐标从虚拟坐标系变换为 本地坐标系具有转换矩阵，并提供转换协调 激光系统。 此外，本发明还涉及相应的方法。

公开(公告)号：US07252629B2

公开(公告)日：2007-08-07

申请号：US10301682

申请日：2002-11-22

Applicant: Johann Kindlein ,  Dennis Robert Schaart

Inventor： Johann Kindlein ,  Dennis Robert Schaart

IPC: A61N5/00

CPC classification number: A61N5/062 ,  A61N5/0601 ,  A61N5/1007 ,  A61N2005/1008

Abstract: A device for effecting radiation therapy in an animal body has a housing provided with at least one outlet channel, a guide tube connected at one end with the outlet channel and wherein the other end of the guide tube is positionable in the animal body near the site of the intended radiation therapy, one electro-magnetic radiation emitting source connected to a first end of a transport wire, and a transport device for moving the transport wire and the radiation emitting source via the outlet channel through the guide tube to and from the site of the intended radiation therapy in the body. The transport device has a rotatable drum, which is rotationally symmetric around a rotation axis. The drum is provided with two end surfaces, and a circumferential surface is provided with at least one winding groove for at least one transport wire.

Abstract translation: 用于在动物体内进行放射治疗的装置具有壳体，该壳体设置有至少一个出口通道，一端与出口通道连接的导管，并且其中引导管的另一端可定位在动物身体附近 的一个电磁辐射发射源连接到传输线的第一端，以及传输装置，用于通过导管将输送线和辐射源经由出口通道移动到和从该位置移动 的预期放射治疗在身体。 运输装置具有可旋转的滚筒，其围绕旋转轴线旋转对称。 滚筒设置有两个端面，并且圆周表面设置有用于至少一个输送线的至少一个卷绕槽。

公开(公告)号：US20050025285A1

公开(公告)日：2005-02-03

申请号：US10871055

申请日：2004-06-21

Applicant: Johann Kindlein

Inventor： Johann Kindlein

IPC: A61N5/00 ,  A61N5/10 ,  H01J35/06 ,  H01J35/12 ,  H01J35/32 ,  H01J35/14 ,  H01J35/10

CPC classification number: A61N5/1001 ,  A61N2005/005 ,  H01J35/065 ,  H01J35/12 ,  H01J35/32 ,  H01J2235/1204 ,  H01J2235/1212 ,  H01J2235/1216 ,  H01J2235/122 ,  H01J2235/127 ,  H01J2235/1275 ,  H01J2235/186

Abstract: The invention relates to a miniature X-ray source device connected to a distal end of a guiding wire for insertion towards a desired location within an animal body for effecting radiation therapy, said X-ray source device at least comprising a vacuum tube accommodated in said housing containing a cathode and an anode spaced apart at some distance from each other; electron freeing means for freeing electrons from the cathode; electric field means for applying during use a high-voltage electric field between said cathode and said anode for accelerating said free electrons; said vacuum tube being at least partly transparent to X-ray radiation emitted by said anode, as well as cooling means for cooling at least said anode. It is an object to provide a miniature X-ray source device having further limited constructional dimensions and an improved control of the working temperature of at least the anode and hence the working conditions of the miniature X-ray source device. According to the invention the miniature X-ray source device is hereto characterised in that said cooling means are cryogenic cooling means. More in particular in a specific embodiment of said miniature X-ray source device said cooling means comprise at least one supply passageway for supplying pressurized gas towards said anode and at least one exhaust passageway for exhausting said pressurized gas from said anode, said supply passageway and said exhaust passageway being interconnected by means of an expansion chamber surrounding at least partly said anode.

Abstract translation: 本发明涉及一种连接到导丝的远端的微型X射线源装置，用于向动物体内的所需位置插入以进行放射治疗，所述X射线源装置至少包括容纳在所述的X射线源装置中的真空管 壳体包含彼此间隔开一定距离的阴极和阳极; 用于从阴极释放电子的电子释放装置; 电场装置，用于在使用期间施加所述阴极和所述阳极之间的高压电场，用于加速所述自由电子; 所述真空管对于由所述阳极发射的X射线辐射至少部分透明，以及用于冷却至少所述阳极的冷却装置。 本发明的目的是提供一种具有进一步有限的结构尺寸的微型X射线源装置，以及对至少阳极的工作温度的改进控制以及微型X射线源装置的工作条件的改进。 根据本发明，微型X射线源装置的特征在于所述冷却装置是低温冷却装置。 更具体地在所述微型X射线源装置的具体实施例中，所述冷却装置包括用于向所述阳极供应加压气体的至少一个供应通道和用于从所述阳极排出所述加压气体的至少一个排气通道，所述供应通道和 所述排气通道通过至少部分地围绕所述阳极的膨胀室相互连接。

公开(公告)号：US06641519B1

公开(公告)日：2003-11-04

申请号：US09788265

申请日：2001-02-16

Applicant: Johann Kindlein ,  Edgar German Loffler ,  Arie Luite Visscher

Inventor： Johann Kindlein ,  Edgar German Loffler ,  Arie Luite Visscher

IPC: A61M3600

CPC classification number: A61N5/1007 ,  A61N2005/1008

Abstract: A drive device in a medical device for driving a wire through a guide tube from a first position with an end of the wire outside an animal body to a second position in which the end is inside the animal body. The drive device comprises first and second elements rotatable relative to each other. The first and second elements each have contact surfaces, that in each rotational position of the first and second elements relative to each other are in contact with each other in a contact area along a common contact plane. A storage space going about the axis is provided for the wire in the first element. The storage space is open along a length of it to the contact surface of the first element. The second element comprises a channel for the wire and is open to the contact plane.

Abstract translation: 一种医疗装置中的驱动装置，用于通过引导管从第一位置驱动电线，其中电线的端部在动物体外部延伸到第二位置，其中端部在动物体内。 驱动装置包括可相对于彼此旋转的第一和第二元件。 第一和第二元件各自具有接触表面，在第一和第二元件的相对于彼此的每个旋转位置中，沿着公共接触平面的接触区域中彼此接触。 为第一个元件中的导线提供围绕轴线的存储空间。 存储空间沿其长度打开到第一元件的接触表面。 第二元件包括用于导线的通道并且对接触平面开放。