公开(公告)号：US20060015166A1

公开(公告)日：2006-01-19

申请号：US11165128

申请日：2005-06-24

申请人： Johann Kindlein ,  Hans Schot

发明人： Johann Kindlein ,  Hans Schot

IPC分类号： A61N1/06

CPC分类号： A61N5/1015

摘要： The invention relates to a device for radiation treatment of proliferative tissue surrounding a cavity in an animal body comprising radiation delivering means for placing at least one energy emitting source at a desired position within said cavity for performing said radiation treatment. The invention also relates to an implant element to be implanted into a cavity in an animal body for radiation treatment of proliferative tissue surrounding said cavity. The invention aims to provide a device and method for radiation treatment of proliferative tissue surrounding a cavity in an animal body, wherein the radiation treatment is performed in a far more accurate and reproducible manner and wherein the device causes far less discomfort to the patient. According to the invention said device comprises an permanent implant element suitable for placement in said body cavity, said element being made from a non-deformable material and having an outer surface being conformal to the inner surface of said body cavity.

摘要翻译： 本发明涉及一种用于放射治疗包围动物体腔内的增生组织的装置，该装置包括用于将至少一个能量发射源放置在所述空腔内的所需位置以进行所述放射治疗的辐射递送装置。 本发明还涉及一种待植入动物体腔内的植入元件，用于辐射治疗围绕所述腔的增生组织。 本发明的目的在于提供一种用于放射治疗动物体内空腔周围的增生组织的装置和方法，其中以更准确和更可重复的方式进行放射治疗，并且其中该装置对患者的不舒适程度较小。 根据本发明，所述装置包括适于放置在所述体腔中的永久植入元件，所述元件由不可变形的材料制成并具有与所述体腔的内表面共形的外表面。

公开(公告)号：US08301228B2

公开(公告)日：2012-10-30

申请号：US13013051

申请日：2011-01-25

申请人： Johann Kindlein ,  Dimos Baltas ,  Georgios Sakas ,  Frans Kuipers ,  Hans Martin Schot

发明人： Johann Kindlein ,  Dimos Baltas ,  Georgios Sakas ,  Frans Kuipers ,  Hans Martin Schot

IPC分类号： A61B6/00

CPC分类号： A61N5/1031 ,  A61N5/1001 ,  A61N5/1007 ,  A61N5/1039 ,  A61N2005/1012 ,  A61N2005/1032 ,  A61N2005/1074 ,  G06F19/00 ,  G06F19/3481

摘要： The invention relates to a real time radiation treatment planning system for use in effecting radiation therapy of a pre-selected anatomical portion of an animal body using hollow needles. According to embodiments of the invention, the system may include a processing means processing means-configured to perform a three-dimensional imaging algorithm and a three-dimensional image segmentation algorithm, with respect to one or more specific organs within the pre-selected anatomical portion and with respect to the needles, for converting the image data obtained with an imaging means into a three-dimensional image of the anatomical portion, using at least one single or multi-objective anatomy-based genetic optimization algorithm. For pre-planning or virtual simulation purposes, the processing means is arranged to determine in real time the optimal number and position of at least one of the needles, positions of energy emitting sources within the needles, and the dwell times of the energy emitting sources at the positions. For post-planning purposes, the processing means is arranged to determine, based on three-dimensional image information, in real time the real needle positions and the dwell times of the energy emitting sources for the positions.

摘要翻译： 本发明涉及一种实时放射治疗计划系统，用于使用空心针对动物体的预先选择的解剖部分进行放射治疗。 根据本发明的实施例，系统可以包括处理装置处理装置，其被配置为相对于预先选择的解剖部分内的一个或多个特定器官执行三维成像算法和三维图像分割算法 并且相对于针，用于使用至少一个单目标或多目标基于解剖的遗传优化算法将用成像装置获得的图像数据转换成解剖部分的三维图像。 对于预先规划或虚拟模拟目的，处理装置被布置成实时确定针中的至少一个针的最佳数量和位置，针内的能量发射源的位置以及能量发射源的停留时间 在职位。 为了规划后的目的，处理装置被布置成基于三维图像信息实时确定位置的能量发射源的实际针位置和停留时间。

公开(公告)号：US20100246766A1

公开(公告)日：2010-09-30

申请号：US12665491

申请日：2008-06-17

申请人： Johann Kindlein ,  Evert Hendrik Agterhuis ,  Godefridus Hendricus Maria Gubbels ,  Frank Simonis

发明人： Johann Kindlein ,  Evert Hendrik Agterhuis ,  Godefridus Hendricus Maria Gubbels ,  Frank Simonis

IPC分类号： A61N5/10 ,  H01J35/06

CPC分类号： A61N5/1001 ,  H01J35/06 ,  H01J35/14 ,  H01J35/16 ,  H01J2235/062 ,  H01J2235/081 ,  H01J2235/087 ,  H01J2235/164 ,  H01J2235/165 ,  H01J2235/205

摘要： A miniature X-ray source device for effecting radiation therapy at least comprising a vacuum tube containing a cathode and an anode spaced apart at some distance from each other; emitting means for emitting free electrons from the cathode; electric field generating means for applying during use a high-voltage electric field between the cathode and the anode for accelerating the emitted free electrons towards the anode, as well as an exit window for X-ray radiation being generating at the anode. The present invention provides an improved miniature X-ray source device, that can also properly be used in treating skin cancer and which is easy to handle. The anode is provided with a flat X-ray emitting surface. In particular, the cathode exhibits a concave shaped surface having a center part surrounded by an upright circumferential edge, wherein the center part of the concave shaped surface is provided with an electron emitting material.

摘要翻译： 一种用于进行放射治疗的微型X射线源装置，至少包括一个真空管，该真空管包含彼此间隔一定距离的阴极和阳极; 用于从阴极发射自由电子的发射装置; 电场产生装置，用于在使用期间施加阴极和阳极之间的高电压电场，用于加速向阳极发射的自由电子，以及在阳极处产生X射线辐射的出射窗口。 本发明提供一种改进的微型X射线源装置，其也可以适当地用于治疗皮肤癌，并且易于处理。 阳极设置有平坦的X射线发射表面。 特别地，阴极具有凹形状的表面，其中心部分被直立的周向边缘包围，其中凹形表面的中心部分设置有电子发射材料。

公开(公告)号：US07288061B2

公开(公告)日：2007-10-30

申请号：US10674356

申请日：2003-10-01

申请人： Johann Kindlein ,  Arie Luite Visscher ,  Ulrike Lutz ,  Jeroen Schuurman ,  Mark Alexander Adam

发明人： Johann Kindlein ,  Arie Luite Visscher ,  Ulrike Lutz ,  Jeroen Schuurman ,  Mark Alexander Adam

IPC分类号： A61N5/00

CPC分类号： A61N5/1007 ,  A61N2005/1011 ,  A61N2005/1023

摘要： A device for implanting radioactive seeds and non-radioactive spacers in a desired configuration in an animal body for effecting radiation therapy. An elongated hollow needle is inserted in the body. A pushing element implants the row of seeds and spacers though the hollow needle towards the desired location. A tube shaped element receives the row of seeds and spacers. A lube shaped sleeve having open ends is used to insert the tube shaped element through the needle and toward the location. The pushing elements pushes the row of seeds and spacers into the desired location while still being carried in the tube shaped element.

摘要翻译： 用于在动物体内植入放射性种子和非放射性间隔物的装置，用于实现放射治疗。 细长的中空针插入体内。 推动元件通过中空针将所述种子和间隔物排排列到期望的位置。 管形元件接收一排种子和间隔物。 使用具有开口端的润滑脂套筒将管形元件穿过针头并朝向该位置。 推动元件将种子和间隔物排推入期望的位置，同时仍被携带在管状元件中。

公开(公告)号：US07229401B2

公开(公告)日：2007-06-12

申请号：US10301791

申请日：2002-11-22

申请人： Johann Kindlein

发明人： Johann Kindlein

IPC分类号： A61M36/12 ,  A61M31/00 ,  A61B19/00

CPC分类号： A61N5/1007 ,  A61N5/1027 ,  A61N2005/1011

摘要： The invention relates to a device and method for inserting a needle in an animal body for effecting radiation therapy in the body, including a template for positioning the needles to be inserted, needle drive structure for drive a needle through said template towards a desired location in the body, and real-time imaging structure for creating and presenting an image of the desired location and the position of said needle during the insertion of said needle. Due to the fact that the bevelled tip of a hollow needle cause the needle to diverge away from the “line of insertion or movement” and away from the actual desired position in the animal body adversely affecting the dosimetry quality of the implanted seeds a more accurate insertion of the needle is required. According to the invention the device is provided with adjusting structure for adjusting a movement of said needle towards said desired location during insertion.

摘要翻译： 本发明涉及一种用于将针插入动物身体中用于在体内进行放射治疗的装置和方法，包括用于定位待插入的针的模板，针驱动结构，用于通过所述模板朝向期望的位置驱动针 身体和实时成像结构，用于在插入所述针时产生和呈现期望位置的图像和所述针的位置。 由于中空针头的斜头使得针头离开“插入或移动线”而远离动物体内的实际所需位置，从而不利地影响植入的种子的剂量学质量更准确 需要插针。 根据本发明，该装置设置有用于在插入期间调节所述针朝向所述期望位置的运动的调节结构。

公开(公告)号：US07097609B2

公开(公告)日：2006-08-29

申请号：US10382511

申请日：2003-03-07

申请人： Johann Kindlein ,  Frits van Krieken ,  Arie Luite Visscher

发明人： Johann Kindlein ,  Frits van Krieken ,  Arie Luite Visscher

IPC分类号： A61N5/00 ,  G21F5/00

CPC分类号： G21F5/015 ,  A61N5/1007 ,  A61N2005/1008

摘要： The invention relates to an after loader apparatus for treatment of tumours in an animal body comprising a housing with at least one exchangeable radiation source connected to a first end of a transport wire, which wire is connected with its other end to transport means for advancing said transport wire and said radiation source through a guide tube to and from a tumour in said body, where at least the radiation source and the transport wire are mounted in an exchangeable radiation shielded after loader cartridge, which cartridge can be placed in a suitable receptable opening present in said housing.It is an object of the invention to provide an after loader apparatus wherein in a more safe manner to the environment a cartridge containing a radioactive source can be replaced by another cartridge containing a new radioactive source and according to the invention the after loader apparatus is characterized in that, for exchanging said radiation source after use an exchanging device is present for, in a first step, removing the cartridge with the used radiation source from said receptable opening and, in a second step, inserting a further cartridge containing a new radiation source in said receptable opening.The invention relates furthermore to a device for exchanging an after loader cartridge in an after loader apparatus according to the invention.

摘要翻译： 本发明涉及一种用于治疗动物体内的肿瘤的后装载装置，包括具有连接到输送线的第一端的至少一个可交换辐射源的壳体，该导线与其另一端连接到用于推进所述 输送线和所述辐射源通过导管连接到所述主体中的肿瘤，其中至少辐射源和输送线被安装在装载器盒之后屏蔽的可更换辐射中，所述可插入的辐射源可以放置在合适的可接收开口 存在于房屋内。 本发明的目的是提供一种后装载装置，其中以更安全的方式到达环境中，容纳放射源的筒可以被另一个包含新的放射源的筒代替，根据本发明，后装载装置的特征在于 其特征在于，为了在使用之后交换所述辐射源，存在交换装置，用于在第一步骤中用所述可接收的开口用所使用的辐射源去除所述盒，并且在第二步骤中，插入另外的包含新的辐射源的盒 在所述可接收的开口中。 本发明还涉及根据本发明的用于在后装载机装置中更换后装载机筒的装置。

公开(公告)号：US6137114A

公开(公告)日：2000-10-24

申请号：US983051

申请日：1998-03-26

申请人： Karl-Heinz Rohe ,  Johann Kindlein ,  Karl Weinlich ,  Wolfgang Schreckenberg

发明人： Karl-Heinz Rohe ,  Johann Kindlein ,  Karl Weinlich ,  Wolfgang Schreckenberg

IPC分类号： A61M36/04 ,  A61N5/10 ,  G21K5/10

CPC分类号： G21F5/00 ,  A61N5/1007 ,  G21F5/015 ,  A61N2005/1008

摘要： An irradiation apparatus has at least one exchangeable radiation source that may be moved by means of a transport cable between at least one rest position and at least one irradiation position and a long-distance transport container for radiation sources to be exchanged. In order to reduce the danger of control errors, the rest position is located inside the long-distance transport container and the transport container forms or may form an integral part of the irradiation apparatus. For that purpose, interface elements are provided on the transport container and other parts of the irradiation apparatus. By winding and unwinding the transport cable on and from a feeding drum with a cable-receiving groove at least partially covered by a pressing strip, particularly thin transport cables may be used, so that the width of the pressing strip substantially corresponds to the width of the cable-receiving groove. The pressing strip is helically wound in the cable-receiving groove around the feeding drum, in the axial or radial direction with respect to the feeding drum, and the cable-receiving groove is thus covered in a substantially uninterrupted manner. Means for lifting, preferably also for deflecting and lowering again the pressing strip, may be moved along the transport cable in relation to the feeding drum in order to let free an output joint for the transport cable from the feeding drum.

摘要翻译： PCT No.PCT / EP96 / 03047 Sec。 371日期：1998年3月26日 102（e）1998年3月26日PCT PCT 1996年7月11日PCT公布。 出版物WO97 / 03722 日期1997年2月6日照射装置具有至少一个可更换的辐射源，其可以通过运送电缆在至少一个静止位置和至少一个照射位置之间移动，以及用于要交换的辐射源的长途运输容器 。 为了减少控制误差的危险，休息位置位于长途运输集装箱内，运输容器形成或可形成照射装置的整体部分。 为此，在运送容器和照射装置的其它部分上设置界面元件。 通过将输送缆线卷绕和放出来自至少部分地被压条覆盖的电缆接收槽的进给滚筒上和从其上退绕，可以使用特别细的输送电缆，使得压条的宽度基本上对应于 电缆接收槽。 压带在相对于进料滚筒的轴向或径向方向上围绕进料滚筒螺旋缠绕在电缆接收槽中，因此电缆接收槽以基本不间断的方式被覆盖。 用于提升的装置，优选地也可以用于使压紧带偏转和降低，可以相对于进料滚筒沿着传送缆索移动，以便使输送缆线从进料滚筒释放出来。

公开(公告)号：US09387343B2

公开(公告)日：2016-07-12

申请号：US13367807

申请日：2012-02-07

申请人： Johann Kindlein ,  Arie Luite Visscher ,  Johan Henning ,  Wouter Peter Engels

发明人： Johann Kindlein ,  Arie Luite Visscher ,  Johan Henning ,  Wouter Peter Engels

IPC分类号： A61N5/10

CPC分类号： A61N5/1007 ,  A61N5/1075 ,  A61N2005/1008 ,  A61N2005/1012 ,  A61N2005/1094

摘要： A medical apparatus for effecting radiation treatment on a pre-selected anatomical portion of an animal body is disclosed. The medical apparatus may include a plurality of treatment channels configured to be positioned adjacent a body tissue and a plurality of delivery channels coupled to a corresponding number of treatment channels. The medical apparatus may also include a plurality of source channels configured to receive one or more energy sources, a tracking channel configured to receive a tracking element, and a connecting element configured to connect each delivery channel with either one of the plurality of sources channels or the tracking channel.

摘要翻译： 公开了一种用于对动物体的预先选择的解剖部分进行放射治疗的医疗装置。 医疗设备可以包括被配置为邻近身体组织定位的多个治疗通道以及耦合到相应数量的治疗通道的多个输送通道。 医疗设备还可以包括被配置为接收一个或多个能量源的多个源通道，被配置为接收跟踪元件的跟踪通道，以及被配置为将每个输送通道与多个源通道中的任一个连接的连接元件 跟踪通道。

公开(公告)号：US07697147B2

公开(公告)日：2010-04-13

申请号：US12132874

申请日：2008-06-04

申请人： Johann Kindlein

发明人： Johann Kindlein

IPC分类号： G01B11/24

CPC分类号： A61B6/08 ,  A61B6/032 ,  A61B6/548 ,  A61B2090/366 ,  A61N5/1049 ,  A61N2005/105 ,  A61N2005/1059

摘要： An apparatus for the representation of an area on the three-dimensional surface of a patient's body, with a control device which provides three-dimensional coordinates of at least one area to be represented on the surface of the patient's body, wherein the area pre-sets a desired intersection area of a radiation area on the surface of the patient's body, characterized in that at least one projection device featuring a laser is provided, by which the desired intersection area can be projected to the three-dimensional surface of the patient's body on the basis of the provided coordinates, while at least one laser beam generated by the laser can be guided along the contour of the desired intersection area sufficiently rapidly, so that the impression of a closed contour around the desired intersection area results.

摘要翻译： 一种用于表示患者身体的三维表面上的区域的装置，具有提供要表示在患者身体的表面上的至少一个区域的三维坐标的控制装置，其中， 设置患者身体表面上的辐射区域的期望的交叉区域，其特征在于，提供具有激光器的至少一个投影装置，通过该投影装置可以将期望的交叉区域投影到患者身体的三维表面 基于所提供的坐标，同时由激光器产生的至少一个激光束可以沿着期望的交叉区域的轮廓充分快速地被引导，从而导致围绕期望的交叉区域的封闭轮廓的印象。

公开(公告)号：US20090251709A1

公开(公告)日：2009-10-08

申请号：US12132874

申请日：2008-06-04

申请人： Johann Kindlein

发明人： Johann Kindlein

IPC分类号： G01B11/25 ,  G01B11/24

CPC分类号： A61B6/08 ,  A61B6/032 ,  A61B6/548 ,  A61B2090/366 ,  A61N5/1049 ,  A61N2005/105 ,  A61N2005/1059

摘要： An apparatus for the representation of an area on the three-dimensional surface of a patient's body, with a control device which provides three-dimensional coordinates of at least one area to be represented on the surface of the patient's body, wherein the area pre-sets a desired intersection area of a radiation area on the surface of the patient's body, characterised in that at least one projection device featuring a laser is provided, by which the desired intersection area can be projected to the three-dimensional surface of the patient's body on the basis of the provided coordinates, while at least one laser beam generated by the laser can be guided along the contour of the desired intersection area sufficiently rapidly, so that the impression of a closed contour around the desired intersection area results.

摘要翻译： 一种用于表示患者身体的三维表面上的区域的装置，具有提供要表示在患者身体的表面上的至少一个区域的三维坐标的控制装置，其中， 设置患者身体表面上的辐射区域的期望的交叉区域，其特征在于，提供具有激光器的至少一个投影装置，通过该投影装置可以将期望的交叉区域投影到患者身体的三维表面 基于所提供的坐标，同时由激光器产生的至少一个激光束可以沿着期望的交叉区域的轮廓充分快速地被引导，从而导致围绕期望的交叉区域的封闭轮廓的印象。