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11.Cyclized N-substituted-tetrahydropyridine compounds, useful in the treatment of cardiovascular disorders 失效
标题翻译: 环化的N-取代四氢吡啶化合物,可用于治疗心血管疾病公开(公告)号:US4788203A
公开(公告)日:1988-11-29
申请号:US802127
申请日:1985-11-26
申请人: George D. Hartman , Wasyl Halczenko
发明人: George D. Hartman , Wasyl Halczenko
IPC分类号: C07D401/06 , C07D405/06 , C07D409/06 , C07D471/14 , C07D491/14 , C07D491/147 , C07D495/14 , A61K31/38 , A61K31/335 , A61K31/395 , C07D471/12
CPC分类号: C07D401/06 , C07D405/06 , C07D409/06 , C07D471/14 , C07D491/14 , C07D495/14
摘要: Novel cyclized N-substituted tetrahydropyridine compounds are disclosed. The compounds have the property of inhibiting calcium induced contraction of the smooth muscle and are adaptable to being employed in the chemotherapeutic treatment of cardiovascular diseases.
摘要翻译: 公开了新的环化的N-取代的四氢吡啶化合物。 该化合物具有抑制钙诱导的平滑肌收缩的特性,适用于心血管疾病的化学治疗。
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公开(公告)号:US5889023A
公开(公告)日:1999-03-30
申请号:US841884
申请日:1997-05-05
IPC分类号: C07D401/14 , A61K31/445
CPC分类号: C07D401/14
摘要: A fibrinogen receptor antagonist which is 3(R)-�2-(Piperidin-4-yl)ethyl!-2-piperidon-1-ylacetyl-3(S)-(3-pyridyl)-.beta.-alanine.
摘要翻译: 3(R) - [2-(哌啶-4-基)乙基] -2-哌啶-1-基乙酰基-3(S) - (3-吡啶基)-β-丙氨酸的纤维蛋白原受体拮抗剂。
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公开(公告)号:US5719144A
公开(公告)日:1998-02-17
申请号:US391851
申请日:1995-02-22
IPC分类号: C07D217/04 , A61K31/403 , A61K31/404 , A61K31/405 , A61K31/47 , A61K31/472 , A61K31/495 , A61P7/02 , C07D207/46 , C07D209/34 , C07D209/46 , C07D217/24 , C07D401/12 , C07D217/22 , A61K31/55 , C07D215/12
CPC分类号: C07D401/12 , C07D207/46 , C07D209/46 , C07D217/24
摘要: Fibrinogen receptor antagonists having the formula ##STR1## where L is L is (CH.sub.2).sub.p, where p is 1 or 2; and Z is --CR.sup.1 .dbd.CR.sup.2 --; which are useful for inhibiting platelet aggregation for example ##STR2##
摘要翻译: 具有式(IMAGE)其中L为L的纤维蛋白原受体拮抗剂为(CH2)p,其中p为1或2; Z为-CR1 = CR2-; 其可用于抑制血小板聚集,例如
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公开(公告)号:US5294616A
公开(公告)日:1994-03-15
申请号:US857528
申请日:1992-03-25
申请人: Mark E. Duggan , Melissa S. Egbertson , Wasyl Halczenko , George D. Hartman , Laura M. Turchi , William L. Laswell
发明人: Mark E. Duggan , Melissa S. Egbertson , Wasyl Halczenko , George D. Hartman , Laura M. Turchi , William L. Laswell
IPC分类号: A61K31/155 , A61K31/16 , A61K31/18 , A61K31/19 , A61K31/215 , A61K31/265 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/395 , A61K31/397 , A61K31/40 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/435 , A61K31/495 , A61K31/496 , A61P7/02 , C07C229/34 , C07C233/47 , C07C233/51 , C07C233/83 , C07C237/12 , C07C271/10 , C07C271/22 , C07C279/04 , C07C317/28 , C07C317/32 , C07C325/02 , C07C327/22 , C07C327/30 , C07C327/48 , C07D205/04 , C07D207/08 , C07D211/22 , C07D215/12 , C07D233/22 , C07D241/04 , C07D263/48 , C07D295/08 , C07D295/088 , C07D307/66 , C07D333/20 , C07D401/12 , C07D401/14 , C07D409/14 , C07D413/14 , C07F9/38 , C07F9/58 , C07F9/60 , C07F9/6509 , C07F9/6558 , A61K31/675 , A61K31/445 , C07D295/00 , C07D211/30 , C07D277/62 , C07D307/02
CPC分类号: C07D295/088 , C07C271/22 , C07C317/28 , C07C325/02 , C07C327/22 , C07C327/48 , C07D211/22 , C07F9/3882 , C07F9/60 , C07F9/650958 , C07F9/65583 , C07F9/65586 , C07C2101/08 , C07C2101/14
摘要: A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.
摘要翻译: 作为纤维蛋白原IIb / IIIa受体的拮抗剂的一系列非肽衍生物,因此是可用于预防和治疗由血栓形成引起的疾病的血小板聚集化合物。
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15.Bridged pyridine compounds useful as calcium channel blockers and analgesics 失效
标题翻译: 桥连的吡啶化合物可用作钙通道阻滞剂和镇痛药公开(公告)号:US4587253A
公开(公告)日:1986-05-06
申请号:US635971
申请日:1984-07-30
申请人: Wasyl Halczenko , George D. Hartman
发明人: Wasyl Halczenko , George D. Hartman
IPC分类号: C07D221/22 , A61K31/44 , A61K31/47
CPC分类号: C07D221/22
摘要: Novel substituted and bridged pyridine compounds useful as calcium channel blockers and analgesics, pharmaceutical compositions thereof, and methods of treatment are disclosed.
摘要翻译: 公开了用作钙通道阻滞剂和止痛剂的新型取代和桥接的吡啶化合物,其药物组合物和治疗方法。
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公开(公告)号:US6040317A
公开(公告)日:2000-03-21
申请号:US221044
申请日:1998-12-28
申请人: Mark E. Duggan , Wasyl Halczenko , Melissa S. Egbertson , George D. Hartman , William L. Laswell
发明人: Mark E. Duggan , Wasyl Halczenko , Melissa S. Egbertson , George D. Hartman , William L. Laswell
IPC分类号: C07D211/30 , A61K31/185 , A61K31/195 , A61K31/215 , A61K31/255 , A61K31/265 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/435 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/451 , A61K31/452 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/55 , A61K31/66 , A61P7/02 , A61P43/00 , C07C311/02 , C07C311/06 , C07C311/13 , C07C311/19 , C07C313/06 , C07C313/20 , C07C323/59 , C07C327/12 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/26 , C07D207/273 , C07D209/12 , C07D209/30 , C07D211/18 , C07D211/22 , C07D211/32 , C07D211/46 , C07D213/75 , C07D223/08 , C07D233/02 , C07D233/64 , C07D237/08 , C07D239/04 , C07D239/26 , C07D241/04 , C07D241/12 , C07D249/04 , C07D249/08 , C07D263/46 , C07D267/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D453/02 , C07D453/06 , C07D471/08 , C07D487/08 , C07F9/38 , C07F9/40
CPC分类号: C07C311/06 , C07C311/13 , C07D211/22 , C07D409/12
摘要: A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet anti-aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.
摘要翻译: 作为纤维蛋白原IIb / IIIa受体的拮抗剂的一系列非肽衍生物,因此是可用于预防和治疗由血栓形成引起的疾病的血小板抗聚集化合物。
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公开(公告)号:USRE36481E
公开(公告)日:2000-01-04
申请号:US188158
申请日:1998-11-04
申请人: Edward S. Inamine , Otto D. Hensens , David R. Houck , Ta J. Lee , Robert L. Smith , Wasyl Halczenko , George D. Hartman , Gerald E. Stokker
发明人: Edward S. Inamine , Otto D. Hensens , David R. Houck , Ta J. Lee , Robert L. Smith , Wasyl Halczenko , George D. Hartman , Gerald E. Stokker
IPC分类号: C07C69/732 , C07D309/30 , A61K31/335 , C07D315/00
CPC分类号: C07D309/30 , C07C69/732
摘要: Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) and (II): ##STR1##
摘要翻译: 新型3-羟基-3-甲基戊二酰辅酶A(HMG-CoA)还原酶抑制剂可用作抗高血胆固醇血症药,并由以下一般结构式(I)和(II)表示:
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公开(公告)号:US5721253A
公开(公告)日:1998-02-24
申请号:US717952
申请日:1996-09-23
IPC分类号: C07D333/54 , A61K31/34 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/415 , A61K31/4184 , A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61P7/02 , C07D209/10 , C07D209/14 , C07D235/28 , C07D263/58 , C07D277/68 , C07D307/79 , C07D307/80 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , A61K31/445
CPC分类号: C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06
摘要: Fibrinogen receptor antagonists of the formula: ##STR1## are disclosed for use in inhibiting the binding of fibrinogen to blood platelets and for inhibiting the aggregation of blood platelets.
摘要翻译: 公开了用于抑制纤维蛋白原与血小板结合和抑制血小板聚集的下式的纤维蛋白原受体拮抗剂:
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公开(公告)号:US5665723A
公开(公告)日:1997-09-09
申请号:US460372
申请日:1995-06-02
IPC分类号: C07D217/04 , A61K31/403 , A61K31/404 , A61K31/405 , A61K31/47 , A61K31/472 , A61K31/495 , A61P7/02 , C07D207/46 , C07D209/34 , C07D209/46 , C07D217/24 , C07D401/12 , A61K31/40 , C07D403/00 , C07D405/00
CPC分类号: C07D401/12 , C07D207/46 , C07D209/46 , C07D217/24
摘要: Fibrinogen receptor antagonists having the formula ##STR1## for example ##STR2##
摘要翻译: 具有式
的纤维蛋白原受体拮抗剂例如 -
公开(公告)号:US5098931A
公开(公告)日:1992-03-24
申请号:US587598
申请日:1990-09-24
IPC分类号: C07C69/732 , C07D309/30
CPC分类号: C07D309/30 , C07C69/732 , Y10S514/824
摘要: Novel HMG-CoA reductase inhibitors are useful as antihypercholesterolemic agents and are represented by structural formulae (I) and (II): ##STR1##
摘要翻译: 新型HMG-CoA还原酶抑制剂可用作抗高胆固醇血症药物,并由结构式(I)和(II)表示:(I)
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