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公开(公告)号：US5880136A
公开(公告)日：1999-03-09
申请号：US130334
申请日：1998-08-06
申请人： Mark E. Duggan , Melissa S. Egbertson , Wasyl Halczenko , George D. Hartman , William L. Laswell
发明人： Mark E. Duggan , Melissa S. Egbertson , Wasyl Halczenko , George D. Hartman , William L. Laswell
IPC分类号： C07D211/30 , A61K31/185 , A61K31/195 , A61K31/215 , A61K31/255 , A61K31/265 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/435 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/451 , A61K31/452 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/55 , A61K31/66 , A61P7/02 , A61P43/00 , C07C311/02 , C07C311/06 , C07C311/13 , C07C311/19 , C07C313/06 , C07C313/20 , C07C323/59 , C07C327/12 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/26 , C07D207/273 , C07D209/12 , C07D209/30 , C07D211/18 , C07D211/22 , C07D211/32 , C07D211/46 , C07D213/75 , C07D223/08 , C07D233/02 , C07D233/64 , C07D237/08 , C07D239/04 , C07D239/26 , C07D241/04 , C07D241/12 , C07D249/04 , C07D249/08 , C07D263/46 , C07D267/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D453/02 , C07D453/06 , C07D471/08 , C07D487/08 , C07F9/38 , C07F9/40
CPC分类号： C07C311/06 , C07C311/13 , C07D211/22 , C07D409/12
摘要： A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet anti-aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.
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公开(公告)号：US06784190B2
公开(公告)日：2004-08-31
申请号：US09916977
申请日：2001-07-27
申请人： Ben C. Askew , Paul J. Coleman , Mark E. Duggan , Wasyl Halczenko , George D. Hartman , Cecilia A. Hunt , John H. Hutchinson , Robert S. Meissner , Michael A. Patane , Garry R. Smith , Jiabing Wang
发明人： Ben C. Askew , Paul J. Coleman , Mark E. Duggan , Wasyl Halczenko , George D. Hartman , Cecilia A. Hunt , John H. Hutchinson , Robert S. Meissner , Michael A. Patane , Garry R. Smith , Jiabing Wang
IPC分类号： A61K3147
CPC分类号： C07D401/06 , C07D401/12 , C07D471/04 , C07D495/04
摘要： The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors &agr;v&bgr;3, &agr;v&bgr;5, and/or &agr;v&bgr;6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, tumor growth, and metastasis.
摘要翻译： 本发明涉及其化合物及其衍生物，其合成及其作为整联蛋白受体拮抗剂的用途。 更具体地说，本发明的化合物是整联蛋白受体alphavbeta3，alphavbeta5和/或alphavbeta6的拮抗剂，可用于抑制骨吸收，治疗和预防骨质疏松，抑制血管再狭窄，糖尿病性视网膜病变，黄斑变性，血管生成，动脉粥样硬化 ，炎症，伤口愈合，病毒性疾病，肿瘤生长和转移。
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公开(公告)号：US6048861A
公开(公告)日：2000-04-11
申请号：US212082
申请日：1998-12-15
申请人： Ben C. Askew , Paul J. Coleman , Mark E. Duggan , Wasyl Halczenko , George D. Hartman , Cecilia A. Hunt , John H. Hutchinson , Robert S. Meissner , Michael A. Patane , Garry R. Smith , Jiabing Wang
发明人： Ben C. Askew , Paul J. Coleman , Mark E. Duggan , Wasyl Halczenko , George D. Hartman , Cecilia A. Hunt , John H. Hutchinson , Robert S. Meissner , Michael A. Patane , Garry R. Smith , Jiabing Wang
IPC分类号： C07D401/06 , C07D401/12 , C07D471/04 , C07D495/04 , C07D519/00 , A61K31/435 , A61K31/44
CPC分类号： C07D401/06 , C07D401/12 , C07D471/04 , C07D495/04
摘要： The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors .alpha.v.beta.3, .alpha.v.beta.5, and/or .alpha.v.beta.6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, tumor growth, and metastasis.
摘要翻译： 本发明涉及其化合物及其衍生物，其合成及其作为整联蛋白受体拮抗剂的用途。 更具体地说，本发明的化合物是整联蛋白受体αvβ3，αvβ5和/或αvβ6的拮抗剂，可用于抑制骨吸收，治疗和预防骨质疏松症，并抑制血管再狭窄， 糖尿病性视网膜病变，黄斑变性，血管生成，动脉粥样硬化，炎症，伤口愈合，病毒性疾病，肿瘤生长和转移。
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公开(公告)号：US5292756A
公开(公告)日：1994-03-08
申请号：US860747
申请日：1992-03-25
IPC分类号： C07D211/30 , A61K31/185 , A61K31/195 , A61K31/215 , A61K31/255 , A61K31/265 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/435 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/451 , A61K31/452 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/55 , A61K31/66 , A61P7/02 , A61P43/00 , C07C311/02 , C07C311/06 , C07C311/13 , C07C311/19 , C07C313/06 , C07C313/20 , C07C323/59 , C07C327/12 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/26 , C07D207/273 , C07D209/12 , C07D209/30 , C07D211/18 , C07D211/22 , C07D211/32 , C07D211/46 , C07D213/75 , C07D223/08 , C07D233/02 , C07D233/64 , C07D237/08 , C07D239/04 , C07D239/26 , C07D241/04 , C07D241/12 , C07D249/04 , C07D249/08 , C07D263/46 , C07D267/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D453/02 , C07D453/06 , C07D471/08 , C07D487/08 , C07F9/38 , C07F9/40 , C07D267/22
CPC分类号： C07C311/06 , C07C311/13 , C07D211/22 , C07D409/12
摘要： A series of non-peptide derivatives of the formula ##STR1## that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet anti-aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.
摘要翻译： 一系列式（IMAGE）的非肽衍生物
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公开(公告)号：US6040317A
公开(公告)日：2000-03-21
申请号：US221044
申请日：1998-12-28
申请人： Mark E. Duggan , Wasyl Halczenko , Melissa S. Egbertson , George D. Hartman , William L. Laswell
发明人： Mark E. Duggan , Wasyl Halczenko , Melissa S. Egbertson , George D. Hartman , William L. Laswell
IPC分类号： C07D211/30 , A61K31/185 , A61K31/195 , A61K31/215 , A61K31/255 , A61K31/265 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/435 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/451 , A61K31/452 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/55 , A61K31/66 , A61P7/02 , A61P43/00 , C07C311/02 , C07C311/06 , C07C311/13 , C07C311/19 , C07C313/06 , C07C313/20 , C07C323/59 , C07C327/12 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/26 , C07D207/273 , C07D209/12 , C07D209/30 , C07D211/18 , C07D211/22 , C07D211/32 , C07D211/46 , C07D213/75 , C07D223/08 , C07D233/02 , C07D233/64 , C07D237/08 , C07D239/04 , C07D239/26 , C07D241/04 , C07D241/12 , C07D249/04 , C07D249/08 , C07D263/46 , C07D267/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D453/02 , C07D453/06 , C07D471/08 , C07D487/08 , C07F9/38 , C07F9/40
CPC分类号： C07C311/06 , C07C311/13 , C07D211/22 , C07D409/12
摘要： A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet anti-aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.
摘要翻译： 作为纤维蛋白原IIb / IIIa受体的拮抗剂的一系列非肽衍生物，因此是可用于预防和治疗由血栓形成引起的疾病的血小板抗聚集化合物。
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公开(公告)号：US5098931A
公开(公告)日：1992-03-24
申请号：US587598
申请日：1990-09-24
IPC分类号： C07C69/732 , C07D309/30
CPC分类号： C07D309/30 , C07C69/732 , Y10S514/824
摘要： Novel HMG-CoA reductase inhibitors are useful as antihypercholesterolemic agents and are represented by structural formulae (I) and (II): ##STR1##
摘要翻译： 新型HMG-CoA还原酶抑制剂可用作抗高胆固醇血症药物，并由结构式（I）和（II）表示：（I）
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公开(公告)号：US5294616A
公开(公告)日：1994-03-15
申请号：US857528
申请日：1992-03-25
申请人： Mark E. Duggan , Melissa S. Egbertson , Wasyl Halczenko , George D. Hartman , Laura M. Turchi , William L. Laswell
发明人： Mark E. Duggan , Melissa S. Egbertson , Wasyl Halczenko , George D. Hartman , Laura M. Turchi , William L. Laswell
IPC分类号： A61K31/155 , A61K31/16 , A61K31/18 , A61K31/19 , A61K31/215 , A61K31/265 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/395 , A61K31/397 , A61K31/40 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/435 , A61K31/495 , A61K31/496 , A61P7/02 , C07C229/34 , C07C233/47 , C07C233/51 , C07C233/83 , C07C237/12 , C07C271/10 , C07C271/22 , C07C279/04 , C07C317/28 , C07C317/32 , C07C325/02 , C07C327/22 , C07C327/30 , C07C327/48 , C07D205/04 , C07D207/08 , C07D211/22 , C07D215/12 , C07D233/22 , C07D241/04 , C07D263/48 , C07D295/08 , C07D295/088 , C07D307/66 , C07D333/20 , C07D401/12 , C07D401/14 , C07D409/14 , C07D413/14 , C07F9/38 , C07F9/58 , C07F9/60 , C07F9/6509 , C07F9/6558 , A61K31/675 , A61K31/445 , C07D295/00 , C07D211/30 , C07D277/62 , C07D307/02
CPC分类号： C07D295/088 , C07C271/22 , C07C317/28 , C07C325/02 , C07C327/22 , C07C327/48 , C07D211/22 , C07F9/3882 , C07F9/60 , C07F9/650958 , C07F9/65583 , C07F9/65586 , C07C2101/08 , C07C2101/14
摘要： A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.
摘要翻译： 作为纤维蛋白原IIb / IIIa受体的拮抗剂的一系列非肽衍生物，因此是可用于预防和治疗由血栓形成引起的疾病的血小板聚集化合物。
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公开(公告)号：US5852045A
公开(公告)日：1998-12-22
申请号：US729968
申请日：1996-10-15
申请人： Ben C. Askew , George D. Hartman , Mark E. Duggan , Steven D. Young , John H. Hutchinson , John S. Wai , Melissa S. Egbertson , Laura M. Vassallo , Laura A. Libby , Amy E. Krause , Wasyl Halczenko , Nathan C. Ihle
发明人： Ben C. Askew , George D. Hartman , Mark E. Duggan , Steven D. Young , John H. Hutchinson , John S. Wai , Melissa S. Egbertson , Laura M. Vassallo , Laura A. Libby , Amy E. Krause , Wasyl Halczenko , Nathan C. Ihle
IPC分类号： C07D401/06 , C07D401/14 , C07D405/14 , C07D453/04 , C07D521/00 , C07K5/06 , A61K31/445 , A61K31/495
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/06 , C07D401/14 , C07D405/14 , C07D453/04 , C07K5/06026
摘要： Fibrinogen receptor antagonists having the structure, for example, of ##STR1## for example ##STR2##
摘要翻译： 具有例如
结构的纤维蛋白原受体拮抗剂，例如 -
公开(公告)号：US5814643A
公开(公告)日：1998-09-29
申请号：US861545
申请日：1997-05-22
申请人： Mark E. Duggan , Melissa S. Egbertson , Wasyl Halczenko , George D. Hartman , William L. Laswell
发明人： Mark E. Duggan , Melissa S. Egbertson , Wasyl Halczenko , George D. Hartman , William L. Laswell
IPC分类号： C07D211/30 , A61K31/185 , A61K31/195 , A61K31/215 , A61K31/255 , A61K31/265 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/435 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/451 , A61K31/452 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/55 , A61K31/66 , A61P7/02 , A61P43/00 , C07C311/02 , C07C311/06 , C07C311/13 , C07C311/19 , C07C313/06 , C07C313/20 , C07C323/59 , C07C327/12 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/26 , C07D207/273 , C07D209/12 , C07D209/30 , C07D211/18 , C07D211/22 , C07D211/32 , C07D211/46 , C07D213/75 , C07D223/08 , C07D233/02 , C07D233/64 , C07D237/08 , C07D239/04 , C07D239/26 , C07D241/04 , C07D241/12 , C07D249/04 , C07D249/08 , C07D263/46 , C07D267/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D453/02 , C07D453/06 , C07D471/08 , C07D487/08 , C07F9/38 , C07F9/40
CPC分类号： C07C311/06 , C07C311/13 , C07D211/22 , C07D409/12
摘要： A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet anti-aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.
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公开(公告)号：US5658929A
公开(公告)日：1997-08-19
申请号：US505417
申请日：1995-07-21
申请人： Mark E. Duggan , Melissa S. Egbertson , Wasyl Halczenko , George D. Hartman , William L. Laswell
发明人： Mark E. Duggan , Melissa S. Egbertson , Wasyl Halczenko , George D. Hartman , William L. Laswell
IPC分类号： C07D211/30 , A61K31/185 , A61K31/195 , A61K31/215 , A61K31/255 , A61K31/265 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/435 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/451 , A61K31/452 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/55 , A61K31/66 , A61P7/02 , A61P43/00 , C07C311/02 , C07C311/06 , C07C311/13 , C07C311/19 , C07C313/06 , C07C313/20 , C07C323/59 , C07C327/12 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/26 , C07D207/273 , C07D209/12 , C07D209/30 , C07D211/18 , C07D211/22 , C07D211/32 , C07D211/46 , C07D213/75 , C07D223/08 , C07D233/02 , C07D233/64 , C07D237/08 , C07D239/04 , C07D239/26 , C07D241/04 , C07D241/12 , C07D249/04 , C07D249/08 , C07D263/46 , C07D267/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D453/02 , C07D453/06 , C07D471/08 , C07D487/08 , C07F9/38 , C07F9/40
CPC分类号： C07C311/06 , C07C311/13 , C07D211/22 , C07D409/12
摘要： A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet anti-aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.
摘要翻译： 作为纤维蛋白原IIb / IIIa受体的拮抗剂的一系列非肽衍生物，因此是可用于预防和治疗由血栓形成引起的疾病的血小板抗聚集化合物。
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