公开(公告)号：US20060205824A1

公开(公告)日：2006-09-14

申请号：US11434037

申请日：2006-05-15

Applicant: John Davidson ,  Alexander Tatarintsev ,  Ali Turgiev ,  James Hildreth

Inventor： John Davidson ,  Alexander Tatarintsev ,  Ali Turgiev ,  James Hildreth

IPC: A61K31/105 ,  C07C321/02

CPC classification number: A61K31/105 ,  A61K31/10 ,  C07C323/65

Abstract: The invention provides enantiomers of ajoene and derivatives of Z(−)-ajoene. The derivative of Z(−)-ajoene are useful for modulating integrin-mediated functions, for treating disorders, diseases or conditions in which integrins play a role, and for treating tissues to improve their condition for a subsequent use, such as transplantation.

Abstract translation: 本发明提供了ajoene和Z（ - ） - ajoene衍生物的对映异构体。 Z（ - ） - ajoene的衍生物可用于调节整联蛋白介导的功能，用于治疗整合素起作用的疾病，疾病或病症，以及治疗组织以改善其后续使用如移植的状况。

公开(公告)号：US20060065080A1

公开(公告)日：2006-03-30

申请号：US10953470

申请日：2004-09-28

Applicant: John Davidson ,  George Charvat

Inventor： John Davidson ,  George Charvat

IPC: B25B13/46

CPC classification number: B25B15/04

Abstract: Ratcheting tools are described that include: (a) a tool body; (b) a driven element; (c) a ratchet mechanism coupling the driven element to the tool body, wherein the ratchet mechanism is configured for adjustment between a plurality of a forward configuration, a reverse configuration, and a neutral configuration; (d) an adjustable first biasing element coupled to the ratchet mechanism and configured to bias the ratchet mechanism to at least one of the forward, reverse, and neutral configurations; and (e) an adjustable second biasing element coupled to the ratchet mechanism and configured to bias the ratchet mechanism to at least one of the forward, reverse, and neutral configurations.

Abstract translation: 描述的棘轮工具包括：（a）工具体; （b）从动元件; （c）棘轮机构，其将所述被驱动元件联接到所述工具主体，其中所述棘轮机构构造成用于在多个正向配置，反向配置和中立配置之间进行调节; （d）可调节的第一偏置元件，其联接到所述棘轮机构并且构造成将所述棘轮机构偏压到所述正向，反向和中性构造中的至少一个; 和（e）可调节的第二偏置元件，其联接到所述棘轮机构并且构造成将所述棘轮机构偏置到所述前进，后退和中立构造中的至少一个。

公开(公告)号：US20050182037A1

公开(公告)日：2005-08-18

申请号：US11106446

申请日：2005-04-15

Applicant: Alan Fergusson ,  John Davidson

Inventor： Alan Fergusson ,  John Davidson

IPC: A61K31/202 ,  A61K31/56 ,  A61K31/575

CPC classification number: A61K31/202 ,  A61K31/56 ,  A61K31/575 ,  A61K2300/00

Abstract: A nutritional supplement composed of phytosterols, anti-oxidants, and other complexes, including hydrolysates of fatty acids, amino acids, peptides, proline rich polypeptides and digestive enzymes is described. The nutritional supplement may be used by individuals suffering from or at risk of developing immune system diseases; breast cancer, colon and prostate cancer; HIV infection; or enlarged prostate. In the preferred form, the invention comprises phytosterols and antioxidants, together with hydrolysates of fatty acids derived from fish, amino acids, short chain peptides, proline rich polypeptides and digestive enzymes, and a microcellulose filler.

Abstract translation: 描述了由植物甾醇，抗氧化剂和其它复合物组成的营养补充剂，包括脂肪酸，氨基酸，肽，富含脯氨酸的多肽和消化酶的水解产物。 营养补充剂可能由患有或有发展免疫系统疾病风险的个体使用; 乳腺癌，结肠和前列腺癌; 艾滋病毒感染; 或扩大的前列腺。 在优选形式中，本发明包括植物甾醇和抗氧化剂以及衍生自鱼，氨基酸，短链肽，富含脯氨酸的多肽和消化酶的脂肪酸的水解产物和微纤维素填料。

公开(公告)号：US06699193B2

公开(公告)日：2004-03-02

申请号：US09966366

申请日：2001-10-01

Applicant: Kevin Crutchfield ,  John Davidson ,  Robert Mozayeni ,  Simon Fitall

Inventor： Kevin Crutchfield ,  John Davidson ,  Robert Mozayeni ,  Simon Fitall

IPC: A61B802

CPC classification number: A61B5/02007 ,  A61B5/4076 ,  A61B5/411 ,  A61B5/7264 ,  A61B8/06 ,  A61B8/56 ,  G01S7/52036 ,  G01S15/8915 ,  G01S15/8979 ,  G06F19/00 ,  G06Q10/10 ,  G06Q50/22

Abstract: The present invention relates generally to systems and methods for assessing blood flow in blood vessels, for assessing vascular health, for conducting clinical trials, for screening therapeutic interventions for adverse effects, and for assessing the effects of risk factors, therapies and substances, including therapeutic substances, on blood vessels, especially cerebral blood vessels, all achieved by measuring various parameters of blood flow in one or more vessels and analyzing the results in a defined manner. The relevant parameters of blood flow include mean flow velocity, systolic acceleration, and pulsatility index. By measuring and analyzing these parameters, one can ascertain the vascular health of a particular vessel, multiple vessels and an individual. Such measurements can also determine whether a substance has an effect, either deleterious or advantageous, on vascular health. The present invention further provides an expert system for achieving the above.

Abstract translation: 本发明一般涉及用于评估血管中的血流量，用于评估血管健康，进行临床试验，筛选用于不良反应的治疗干预的系统和方法，以及用于评估危险因素，治疗和物质（包括治疗）的影响 物质，血管，特别是脑血管，都是通过测量一个或多个血管中的血液流动的各种参数而实现的，并以确定的方式分析结果。 血流相关参数包括平均流速，收缩期加速度和搏动指数。 通过测量和分析这些参数，可以确定特定血管，多个血管和个体的血管健康。 这样的测量还可以确定物质是否对血管健康具有有害或有利的作用。 本发明还提供了一种用于实现上述的专家系统。

公开(公告)号：US09868945B2

公开(公告)日：2018-01-16

申请号：US13984346

申请日：2012-02-08

Applicant: John Davidson ,  Theo Nikiforov ,  Guobin Luo

Inventor： John Davidson ,  Theo Nikiforov ,  Guobin Luo

IPC: C12N11/10 ,  C12N9/12 ,  C12Q1/68

CPC classification number: C12N11/10 ,  C12N9/1241 ,  C12Q1/68 ,  G01N2333/9126

Abstract: In some embodiments, the disclosure relates generally to methods as well as related compositions, systems, kits and apparatus comprising linking proteins to target compounds and/or to locations of interest using tethers. For example, the tether can be used to link the protein to a target compound, for example, to link an enzyme to a substrate. Similarly, the tether can be used to link the protein at or near a desired location on a surface. In one group of embodiments, the tether includes a polynucleotide and the target compound or location on the surface includes another polynucleotide that is capable of hybridizing to the tether. In such embodiments, the tether can be used to link the protein to the target compound or location using nucleic acid hybridization.

公开(公告)号：US20060117918A1

公开(公告)日：2006-06-08

申请号：US10520776

申请日：2002-10-10

Applicant: John Davidson

Inventor： John Davidson

IPC: B25B23/16 ,  B25G1/00

CPC classification number: B25G3/18 ,  B25B23/0035

Abstract: A tool of the type having a drive stud for receiving and releasing a tool attachment includes an opening in the drive stud and a locking pin movably mounted in the opening. The opening defines first and second ends, and the first end of the opening is located at a portion of the drive stud constructed for insertion into the tool attachment. An actuating member is movably positioned on the drive stud, and the actuating member defines a sliding surface that engages the pin. A first spring biases the sliding surface toward the pin, and a second, weaker spring biases the pin toward the sliding surface. The first spring reacts against a ring that is disposed between the spring and a shoulder formed on the tool. The shoulder extends away from the longitudinal axis of the drive stud by a lesser distance than the spring or the ring.

Abstract translation: 具有用于接收和释放工具附件的驱动螺柱的类型的工具包括驱动螺柱中的开​​口和可移动地安装在开口中的锁定销。 开口限定第一端和第二端，并且开口的第一端位于构造成用于插入工具附件中的驱动螺柱的一部分。 致动构件可移动地定位在驱动螺柱上，并且致动构件限定接合销的滑动表面。 第一弹簧将滑动面朝向销偏压，而第二较弱的弹簧将销朝向滑动面偏压。 第一弹簧与设置在弹簧和形成在工具上的肩部之间的环反应。 肩部距离驱动螺柱的纵向轴线远离弹簧或环延伸。

公开(公告)号：US06692443B2

公开(公告)日：2004-02-17

申请号：US09966360

申请日：2001-10-01

Applicant: Kevin Crutchfield ,  Robert Mozayeni ,  John Davidson ,  Simon Fitall

Inventor： Kevin Crutchfield ,  Robert Mozayeni ,  John Davidson ,  Simon Fitall

IPC: A61B502

CPC classification number: A61B5/02007 ,  A61B5/4076 ,  A61B5/411 ,  A61B5/7264 ,  A61B8/06 ,  A61B8/56 ,  G01S7/52036 ,  G01S15/8915 ,  G01S15/8979 ,  G06F19/00 ,  G06Q10/10 ,  G06Q50/22

Abstract: The present invention relates generally to systems and methods for assessing blood flow in blood vessels, for assessing vascular health, for conducting clinical trials, for screening therapeutic interventions for adverse effects, and for assessing the effects of risk factors, therapies and substances, including therapeutic substances, on blood vessels, especially cerebral blood vessels, all achieved by measuring various parameters of blood flow in one or more vessels and analyzing the results in a defined matter. The relevant parameters of blood flow include mean flow velocity, systolic acceleration, and pulsatility index. By measuring and analyzing these parameters, one can ascertain the vascular health of a particular vessel, multiple vessels and an individual. Such measurements can also determine whether a substance has an effect, either deleterious or advantageous, on vascular health. In one of many embodiments, the present invention further provides an expert system for achieving the above.

Abstract translation: 本发明一般涉及用于评估血管中的血流量，用于评估血管健康，进行临床试验，筛选用于不良反应的治疗干预的系统和方法，以及用于评估危险因素，治疗和物质（包括治疗）的影响 物质，血管，特别是脑血管，都是通过测量一个或多个血管中的血液流动的各种参数而实现的，并在确定的物质中分析结果。 血流相关参数包括平均流速，收缩期加速度和搏动指数。 通过测量和分析这些参数，可以确定特定血管，多个血管和个体的血管健康。 这样的测量还可以确定物质是否对血管健康具有有害或有利的作用。 在许多实施例中的一个实施例中，本发明还提供了一种用于实现上述的专家系统。

公开(公告)号：US06656122B2

公开(公告)日：2003-12-02

申请号：US09966367

申请日：2001-10-01

Applicant: John Davidson ,  Robert Mozayeni ,  Simon Fitall ,  Kevin Crutchfield

Inventor： John Davidson ,  Robert Mozayeni ,  Simon Fitall ,  Kevin Crutchfield

IPC: A61B802

CPC classification number: A61B5/02007 ,  A61B5/4076 ,  A61B5/411 ,  A61B5/7264 ,  A61B8/06 ,  A61B8/56 ,  G01S7/52036 ,  G01S15/8915 ,  G01S15/8979 ,  G06F19/00 ,  G06Q10/10 ,  G06Q50/22

Abstract: The present invention relates generally to systems and methods for assessing blood flow in blood vessels, for assessing vascular health, for conducting clinical trials, for screening therapeutic interventions for adverse effects, and for assessing the effects of risk factors, therapies and substances, including therapeutic substances, on blood vessels, especially cerebral blood vessels, all achieved by measuring various parameters of blood flow in one or more vessels and analyzing the results in a defined matter. The relevant parameters of blood flow include mean flow velocity, systolic acceleration, and pulsatility index. By measuring and analyzing these parameters, one can ascertain the vascular health of a particular vessel, multiple vessels and an individual. Such measurements can also determine whether a substance has an effect, either deleterious or advantageous, on vascular health. The present invention further provides an expert system for achieving the above.

Abstract translation: 本发明一般涉及用于评估血管中的血流量，用于评估血管健康，进行临床试验，筛选用于不良反应的治疗干预的系统和方法，以及用于评估危险因素，治疗和物质（包括治疗）的影响 物质，血管，特别是脑血管，都是通过测量一个或多个血管中的血液流动的各种参数而实现的，并在确定的物质中分析结果。 血流相关参数包括平均流速，收缩期加速度和搏动指数。 通过测量和分析这些参数，可以确定特定血管，多个血管和个体的血管健康。 这样的测量还可以确定物质是否对血管健康具有有害或有利的作用。 本发明还提供了一种用于实现上述的专家系统。

公开(公告)号：US5040005A

公开(公告)日：1991-08-13

申请号：US443780

申请日：1989-11-30

Applicant: Geoffrey Davidson ,  John Davidson

Inventor： Geoffrey Davidson ,  John Davidson

IPC: A63H9/00 ,  B29C51/00 ,  B29C51/08 ,  B29C51/10 ,  G03C9/08 ,  G09F19/12

CPC classification number: B29C51/00 ,  G09F19/12 ,  A63H9/00 ,  B29C2795/002 ,  B29C51/08 ,  B29C51/10 ,  B29L2031/722

Abstract: A method for producing a three-diemnsional display device comprising the steps of photographing multiple views of a three dimension object, projecting the multiple perspective photographic views of the original object onto a topographically correct surface, and vacuum forming an image to full relief of the original object with all visual information in its correct location and without distortion.

公开(公告)号：US20120202276A1

公开(公告)日：2012-08-09

申请号：US13036623

申请日：2011-02-28

Applicant: John Davidson ,  Wolfgang Hinz ,  Jonathan Rothberg ,  Richard Whitaker

Inventor： John Davidson ,  Wolfgang Hinz ,  Jonathan Rothberg ,  Richard Whitaker

IPC: C12M1/40

CPC classification number: C12Q1/6869 ,  C12N9/1252 ,  C12Y207/07007 ,  G01N27/4145

Abstract: Methods, compositions, systems, apparatuses and kits comprising modified proteins, particularly modified nucleic acid-binding proteins with altered buffering properties are provided. For example, in some embodiments, methods of forming modified proteins including one or more amino acid modifications to achieve desired pKa values are described. Furthermore, the invention provides methods for using such modified proteins in ion-producing reactions, such as ion-based nucleic acid sequencing reactions.

Abstract translation: 提供了包含修饰的蛋白质，特别是具有改变的缓冲性质的经修饰的核酸结合蛋白质的方法，组合物，系统，装置和试剂盒。 例如，在一些实施方案中，描述了形成包含一个或多个氨基酸修饰以获得所需pKa值的修饰蛋白质的方法。 此外，本发明提供了在离子产生反应中使用这些修饰蛋白质的方法，例如基于离子的核酸测序反应。