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公开(公告)号:US5939388A
公开(公告)日:1999-08-17
申请号:US788729
申请日:1997-01-23
CPC分类号: C12N15/85 , A61L24/043 , A61L27/227 , C07K14/51 , A61K38/00 , C12N2800/108 , C12N2840/20
摘要: Purified BMP-5 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
摘要翻译: 公开了纯化的BMP-5蛋白质及其生产方法。 蛋白质可用于治疗骨和/或软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号:US5631142A
公开(公告)日:1997-05-20
申请号:US118363
申请日:1993-09-07
CPC分类号: C07K14/51 , A61L24/043 , A61L27/227 , A61K38/00
摘要: Purified BMP-2 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
摘要翻译: 公开了纯化的BMP-2蛋白质及其生产方法。 蛋白质可用于治疗骨和软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号:US07300772B2
公开(公告)日:2007-11-27
申请号:US09804625
申请日:2001-03-09
CPC分类号: A61L27/227 , A61K38/00 , A61L24/043 , C07K14/51 , Y10S514/801 , Y10S514/90 , Y10S930/12 , C08L89/00
摘要: Purified BMP-2 and BMP-4 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
摘要翻译: 公开了纯化的BMP-2和BMP-4蛋白及其生产方法。 蛋白质可用于治疗骨和软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号:US5543394A
公开(公告)日:1996-08-06
申请号:US116425
申请日:1993-09-07
CPC分类号: C12N15/85 , A61L24/043 , A61L27/227 , C07K14/51 , A61K38/00 , C12N2800/108 , C12N2840/20
摘要: Purified BMP-5 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
摘要翻译: 公开了纯化的BMP-5蛋白质及其生产方法。 蛋白质可用于治疗骨和/或软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号:US5187076A
公开(公告)日:1993-02-16
申请号:US490033
申请日:1990-03-07
CPC分类号: C12N15/85 , A61L24/043 , A61L27/227 , C07K14/51 , A61K38/00
摘要: Purified BMP-6 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
摘要翻译: 公开了纯化的BMP-6蛋白质及其生产方法。 蛋白质可用于治疗骨和/或软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号:US5106748A
公开(公告)日:1992-04-21
申请号:US370547
申请日:1989-06-23
IPC分类号: A61K38/00 , A61L24/04 , A61L27/22 , C07K14/51 , C12N15/12 , C12N15/85 , C07H15/12 , A61K37/00 , C07K7/00 , C07K13/00 , C12N1/14 , C12N1/20 , C12N15/03 , C12N15/04 , C12N15/06 , C12P19/34 , C12P21/00 , C12P21/02
CPC分类号: C12N15/85 , A61L24/043 , A61L27/227 , C07K14/51 , A61K38/00
摘要: Purified BMP-5 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
摘要翻译: 公开了纯化的BMP-5蛋白质及其生产方法。 蛋白质可用于治疗骨和/或软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号:US07365052B2
公开(公告)日:2008-04-29
申请号:US11154826
申请日:2005-06-17
申请人: Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
发明人: Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
CPC分类号: C07K14/51 , A61K38/1875 , A61L27/227 , A61L27/386 , A61L27/54 , C07K2319/02
摘要: Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related tissue repair.
摘要翻译: 公开了具有肌腱/类韧带组织诱导活性的蛋白质组成。 该组合物可用于治疗腱炎和腱或韧带缺陷以及相关组织修复。
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公开(公告)号:US06984623B2
公开(公告)日:2006-01-10
申请号:US10779635
申请日:2004-02-18
申请人: Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
发明人: Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
CPC分类号: C07K14/51 , A61K38/1875 , A61L27/227 , A61L27/386 , A61L27/54 , C07K2319/02
摘要: Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related tissue repair.
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公开(公告)号:US06287816B1
公开(公告)日:2001-09-11
申请号:US08254353
申请日:1994-06-06
IPC分类号: C12P2100
CPC分类号: C07K14/51 , A61K38/1875 , A61K38/30 , A61L27/227 , C07K2319/02 , Y10S530/84 , Y10S930/12 , A61K2300/00
摘要: Purified bone morphogenetic protein-9 (BMP-9) proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
摘要翻译: 公开了纯化的骨形态发生蛋白-9(BMP-9)蛋白及其生产方法。 蛋白质可用于治疗骨和软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号:US6027919A
公开(公告)日:2000-02-22
申请号:US333576
申请日:1994-11-02
申请人: Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
发明人: Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
IPC分类号: C12N15/09 , A61K38/00 , A61K38/22 , A61K38/27 , A61L27/22 , A61L27/36 , A61P1/02 , A61P5/00 , A61P19/04 , A61P43/00 , C07H21/04 , C07K14/51 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/19 , C12R1/91 , C07K14/475
CPC分类号: A61L27/227 , A61L27/38 , C07K14/51 , A61K38/00 , C07K2319/02
摘要: The present invention relates to a novel family of purified proteins, and compositions containing such proteins, which compositions are useful for the induction of tendon/ligament-like tissue formation, wound healing and ligament and other tissue repair. The present invention further relates to DNA molecules, vectors and host cells useful for production of such proteins.
摘要翻译: 本发明涉及一种纯化蛋白质的新家族,以及含有这些蛋白质的组合物,该组合物可用于诱导腱/类韧带组织形成,伤口愈合和韧带以及其它组织修复。 本发明还涉及可用于生产这种蛋白质的DNA分子,载体和宿主细胞。
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