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77 条记录 (耗时 0.108 秒)

    Testis-specific tubulin tyrosine-ligase-like protein, BGS42
    11.
    发明授权
    Testis-specific tubulin tyrosine-ligase-like protein, BGS42 有权
    睾丸特异性微管蛋白酪氨酸连接酶样蛋白BGS42

    公开(公告)号：US07122358B2

    公开(公告)日：2006-10-17

    申请号：US10635977

    申请日：2003-08-07

    申请人： John N. Feder ,  Thomas C. Nelson ,  Shujian Wu

    发明人： John N. Feder ,  Thomas C. Nelson ,  Shujian Wu

    IPC分类号： C12N9/00 ,  C12N1/20 ,  C12N15/00 ,  C07K1/00

    CPC分类号： C12N9/93 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  C07K2319/00

    摘要： The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码BGS-42多肽的新型多核苷酸，其片段和同源物。还提供了用于产生所述多肽的载体，宿主细胞，抗体以及重组和合成方法。 本发明还涉及将这些新型BGS-42多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding three novel human cell surface proteins with leucine rich repeats and immunologobulin folds, BGS2, 3, and 4 and variants thereof
    12.
    发明授权
    Polynucleotides encoding three novel human cell surface proteins with leucine rich repeats and immunologobulin folds, BGS2, 3, and 4 and variants thereof 失效
    编码具有富含亮氨酸重复序列和免疫球蛋白折叠的三种新型人细胞表面蛋白的多核苷酸，BGS2,3和4及其变体

    公开(公告)号：US07223558B2

    公开(公告)日：2007-05-29

    申请号：US10193477

    申请日：2002-07-11

    申请人： Shujian Wu ,  Stanley R. Krystek ,  Liana Lee ,  John N. Feder ,  Janet D. Cheng

    发明人： Shujian Wu ,  Stanley R. Krystek ,  Liana Lee ,  John N. Feder ,  Janet D. Cheng

    IPC分类号： C12N15/12 ,  C12N5/10 ,  C12P21/02 ,  C07K14/47

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： The present invention provides novel polynucleotides encoding BGS-2, 3, and 4 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-2, 3, and 4 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码BGS-2,3和4多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型BGS-2,3和4多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Human histone deacetylase, HDAC9c
    13.
    发明授权
    Human histone deacetylase, HDAC9c 有权
    人组蛋白脱乙酰酶HDAC9c

    公开(公告)号：US07521044B2

    公开(公告)日：2009-04-21

    申请号：US11497205

    申请日：2006-08-01

    申请人： Donald G. Jackson ,  Matthew V. Lorenzi ,  Liana M. Lee ,  John N. Feder

    发明人： Donald G. Jackson ,  Matthew V. Lorenzi ,  Liana M. Lee ,  John N. Feder

    IPC分类号： A61K38/43 ,  C12N9/00 ,  C07K14/00

    CPC分类号： C12N9/16

    摘要： The present invention relates to newly discovered human histone deacetylases (HDACs), also referred to as histone deacetylase-like polypeptides. The polynucleotide sequences and encoded polypeptides of the novel HDACs are encompassed by the invention, as well as vectors comprising these polynucleotides and host cells comprising these vectors. The invention also relates to antibodies that bind to the disclosed HDAC polypeptides, and methods employing these antibodies. Also related are methods of screening for modulators, such as inhibitors or antagonists, or agonists. The invention also relates to diagnostic and therapeutic applications which employ the disclosed HDAC polynucleotides, polypeptides, and antibodies, and HDAC modulators. Such applications can be used with diseases and disorders associated with abnormal cell growth or proliferation, cell differentiation, and cell survival, e.g., neoplastic cell growth, and especially breast and prostate cancers or tumors.

    摘要翻译： 本发明涉及新发现的人类组蛋白脱乙酰酶（HDAC），也称为组蛋白脱乙酰酶样多肽。 本发明涵盖了新型HDAC的多核苷酸序列和编码多肽，以及包含这些多核苷酸的载体和包含这些载体的宿主细胞。 本发明还涉及结合所公开的HDAC多肽的抗体以及使用这些抗体的方法。 还涉及筛选调节剂的方法，例如抑制剂或拮抗剂或激动剂。 本发明还涉及使用所公开的HDAC多核苷酸，多肽和抗体以及HDAC调节剂的诊断和治疗应用。 这种应用可以用于与异常细胞生长或增殖，细胞分化和细胞存活相关的疾病和病症，例如肿瘤细胞生长，特别是乳腺癌和前列腺癌或肿瘤。

    Polynucleotides encoding the human citron kinase polypeptide, BMSNKC—0020/0021
    14.
    发明授权
    Polynucleotides encoding the human citron kinase polypeptide, BMSNKC—0020/0021 有权
    编码人柚子激酶多肽的多核苷酸BMSNKC-0020/0021

    公开(公告)号：US07326781B2

    公开(公告)日：2008-02-05

    申请号：US10412897

    申请日：2003-04-11

    申请人： Daniel B. Davison ,  John N. Feder ,  Liana M. Lee ,  Karl-Heinz Ott

    发明人： Daniel B. Davison ,  John N. Feder ,  Liana M. Lee ,  Karl-Heinz Ott

    IPC分类号： C07H21/04

    CPC分类号： C12N9/1205

    摘要： The present invention describes a novel human protein kinase related to citron kinase, and its encoding polynucleotide. Also described are expression vectors, host cells, antisense molecules, and antibodies associated with the protein kinase polynucleotide and/or polypeptide of this invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders or diseases associated with abnormal biological activity of the protein kinase are described, as are methods for screening for modulators, e.g., agonists or antagonists, of the protein kinase activity and/or function.

    摘要翻译： 本发明描述了与柚子激酶相关的新型人蛋白激酶及其编码多核苷酸。 还描述了与本发明的蛋白激酶多核苷酸和/或多肽相关的表达载体，宿主细胞，反义分子和抗体。 此外，描述了用于治疗，诊断，预防和筛选与蛋白激酶的异常生物活性相关的疾病或疾病的方法，以及用于筛选蛋白激酶活性的调节剂例如激动剂或拮抗剂的方法和/ 或功能。

    Polynucleotides encoding human histone deacetylase HDAC9c
    15.
    发明授权
    Polynucleotides encoding human histone deacetylase HDAC9c 有权
    编码人组蛋白脱乙酰酶HDAC9c的多核苷酸

    公开(公告)号：US07199227B2

    公开(公告)日：2007-04-03

    申请号：US10172094

    申请日：2002-06-14

    申请人： Donald G. Jackson ,  Matthew V. Lorenzi ,  Ricardo M. Attar ,  Marco Gottardis ,  Liana M. Lee ,  John N. Feder

    发明人： Donald G. Jackson ,  Matthew V. Lorenzi ,  Ricardo M. Attar ,  Marco Gottardis ,  Liana M. Lee ,  John N. Feder

    IPC分类号： C07H21/04

    CPC分类号： C12N9/16

    摘要： The present invention relates to newly discovered human histone deacetylases (HDACs), also referred to as histone deacetylase-like polypeptides. The polynucleotide sequences and encoded polypeptides of the novel HDACs are encompassed by the invention, as well as vectors comprising these polynucleotides and host cells comprising these vectors. The invention also relates to antibodies that bind to the disclosed HDAC polypeptides, and methods employing these antibodies. Also related are methods of screening for modulators, such as inhibitors or antagonists, or agonists. The invention also relates to diagnostic and therapeutic applications which employ the disclosed HDAC polynucleotides, polypeptides, and antibodies, and HDAC modulators. Such applications can be used with diseases and disorders associated with abnormal cell growth or proliferation, cell differentiation, and cell survival, e.g., neoplastic cell growth, and especially breast and prostate cancers or tumors.

    摘要翻译： 本发明涉及新发现的人类组蛋白脱乙酰酶（HDAC），也称为组蛋白脱乙酰酶样多肽。 本发明涵盖了新型HDAC的多核苷酸序列和编码多肽，以及包含这些多核苷酸的载体和包含这些载体的宿主细胞。 本发明还涉及结合所公开的HDAC多肽的抗体以及使用这些抗体的方法。 还涉及筛选调节剂的方法，例如抑制剂或拮抗剂或激动剂。 本发明还涉及使用所公开的HDAC多核苷酸，多肽和抗体以及HDAC调节剂的诊断和治疗应用。 这种应用可以用于与异常细胞生长或增殖，细胞分化和细胞存活相关的疾病和病症，例如肿瘤细胞生长，特别是乳腺癌和前列腺癌或肿瘤。

    Antibodies that bind to BGS-4
    16.
    发明申请
    Antibodies that bind to BGS-4 失效
    与BGS-4结合的抗体

    公开(公告)号：US20090088385A1

    公开(公告)日：2009-04-02

    申请号：US12283245

    申请日：2008-09-10

    申请人： Shujian Wu ,  Stanley R. Krystek ,  Liana Lee ,  John N. Feder ,  Janet D. Cheng

    发明人： Shujian Wu ,  Stanley R. Krystek ,  Liana Lee ,  John N. Feder ,  Janet D. Cheng

    IPC分类号： A61K38/16 ,  C07K16/00 ,  G01N33/68 ,  A61P37/00 ,  A61P29/00 ,  A61P35/00 ,  A61P9/00

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： The present invention provides novel polynucleotides encoding BGS-4 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing the polypeptides of the present invention. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-4 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码BGS-4多肽的新型多核苷酸，其片段和同源物。 还提供载体，宿主细胞，抗体，以及用于产生本发明多肽的重组和合成方法。 本发明还涉及将这些新型BGS-4多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotide encoding a TRP channel family member, TRP-PLIK2
    17.
    发明授权
    Polynucleotide encoding a TRP channel family member, TRP-PLIK2 有权
    编码TRP通道家族成员的多核苷酸TRP-PLIK2

    公开(公告)号：US07223557B2

    公开(公告)日：2007-05-29

    申请号：US10153244

    申请日：2002-05-22

    申请人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Han Chang ,  Liana M. Le ,  Michael A. Blanar ,  David Bol

    发明人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Han Chang ,  Liana M. Le ,  Michael A. Blanar ,  David Bol

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/02 ,  C12N5/06 ,  C07K14/705

    CPC分类号： C07K14/705

    摘要： The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel TRP-PLIK2, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码TRP-PLIK2多肽的新型多核苷酸，其片段和同源物。 本发明还提供分别编码TRP-PLIK2多肽，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d的变体和剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型TRP-PLIK2，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d多肽应用于诊断，治疗和/或预防与这些相关的各种疾病和/或病症的诊断和治疗方法 多肽。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Metalloprotease highly expressed in the testis, MMP-29
    19.
    发明授权
    Metalloprotease highly expressed in the testis, MMP-29 有权
    金属蛋白酶在睾丸中高度表达，MMP-29

    公开(公告)号：US07285633B2

    公开(公告)日：2007-10-23

    申请号：US11313356

    申请日：2005-12-21

    申请人： Shujian Wu ,  Jian Chen ,  John N. Feder ,  Liana Lee ,  Stanley R. Krystek

    发明人： Shujian Wu ,  Jian Chen ,  John N. Feder ,  Liana Lee ,  Stanley R. Krystek

    IPC分类号： A61K38/17

    CPC分类号： C12N9/6489

    摘要： The present invention provides novel polynucleotides encoding MMP-29 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MMP-29 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码MMP-29多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型MMP-29多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。