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公开(公告)号：US07056901B2
公开(公告)日：2006-06-06
申请号：US10401496
申请日：2003-03-28
申请人： Jean M. J. Frechet , Niren Murthy
发明人： Jean M. J. Frechet , Niren Murthy
IPC分类号： A61K48/00 , A61K37/715 , A61K39/00 , A61K9/14
CPC分类号： A61K9/5161 , A61K9/1635 , A61K9/1652 , A61K9/5192 , A61K31/70 , A61K39/39 , A61K2039/53 , A61K2039/55555 , B82Y5/00 , C08B37/0021
摘要： Novel microgels, microparticles and related polymeric materials capable of delivering bioactive materials to cells for use as vaccines or therapeutic agents. The materials are made using a crosslinker molecule that contains a linkage cleavable under mild acidic conditions. The crosslinker molecule is exemplified by a bisacryloyl acetal crosslinker. The new materials have the common characteristic of being able to degrade by acid hydrolysis under conditions commonly found within the endosomal or lysosomal compartments of cells thereby releasing their payload within the cell. The materials can also be used for the delivery of therapeutics to the acidic regions of tumors and sites of inflammation.
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公开(公告)号：US6013413A
公开(公告)日：2000-01-11
申请号：US30461
申请日：1998-02-25
申请人： Jean M. J. Frechet , Quingshan Niu
发明人： Jean M. J. Frechet , Quingshan Niu
CPC分类号： C08F32/08 , C08G61/04 , C08G61/08 , G03F7/039 , G03F7/0045
摘要： Alicyclic nortricyclene polymers and co-polymers suitable for deep ultraviolet microlithography applications.
摘要翻译： 适用于深紫外线微光刻应用的脂环族诺里克林聚合物和共聚物。
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13.发明授权
公开(公告)号：US5679748A
公开(公告)日：1997-10-21
申请号：US628416
申请日：1996-04-05
IPC分类号： C08F8/00 , C08F8/06 , C08F212/08
CPC分类号： C08F8/06 , C08F2800/10 , C08F2810/50
摘要： This invention provides a method by which an alkylstyrene containing polymer may be exclusively functionalized at the primary benzylic carbon site of the styrenic monomer. The process of this invention comprises the treatment of an alkylstyrene containing polymer dissolved in a non-polar liquid medium with an organic hydroperoxide oxidizing reagent in the presence of a catalytically sufficient amount of a chromium compound, to oxidize a portion of the aromatic alkyl groups of the polymer to an oxygen containing functional group.
摘要翻译： 本发明提供了一种含烷基苯乙烯的聚合物可以在苯乙烯类单体的伯苄基碳原子官能化官能化的方法。 本发明的方法包括在催化足够量的铬化合物存在下，用有机氢过氧化物氧化试剂处理溶解在非极性液体介质中的含烷基苯乙烯的聚合物，以氧化一部分芳族烷基 该聚合物与含氧官能团。
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公开(公告)号：US5589537A
公开(公告)日：1996-12-31
申请号：US485685
申请日：1995-06-07
IPC分类号： C08F2/44 , C08F230/04 , C08K3/10 , C08F30/04
CPC分类号： C08F2/44 , B82Y10/00 , B82Y30/00 , C08F230/04
摘要： Single phase solid materials containing metal clusters are produced by dissolving a metal cluster having chemically bound polymerizable organic ligands in a polymerizable organic solvent, homogeneously dispersing the metal cluster, and then copolymerizing the organic solvent and the chemically bound polymerizable organic ligands.
摘要翻译： 通过将具有化学键合的可聚合有机配体的金属簇溶解在可聚合的有机溶剂中，均匀分散金属簇，然后使有机溶剂和化学键合的可聚合的有机配体共聚而制备含有金属簇的单相固体材料。
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公开(公告)号：US5587446A
公开(公告)日：1996-12-24
申请号：US456540
申请日：1995-06-01
IPC分类号： C08F297/00 , C08G83/00 , C08F16/12 , C08F4/14
CPC分类号： C08G83/005 , C08F297/00
摘要： A process for preparing hyperbranched polymers from AB monomers using a self constructing approach is disclosed. Hyperbranched polymers of a living-like character produced by such process are also disclosed.
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16.发明授权Method of making microelectronic structures utilzing photoresists containing C.sub.3 C.sub.12 water soluble sugar crosslinking agents 失效利用含有C3C12水溶性糖交联剂的光致抗蚀剂制造微电子结构的方法
公开(公告)号：US5532113A
公开(公告)日：1996-07-02
申请号：US531429
申请日：1995-09-21
申请人： Jean M. J. Frechet , Sze-Ming Lee
发明人： Jean M. J. Frechet , Sze-Ming Lee
CPC分类号： G03F7/0045 , G03F7/038 , Y10S430/143 , Y10S430/167 , Y10S430/168
摘要： A photoresist is provided. The photoresist comprises a polymer, a photoactive agent, and a crosslinking agent. The crosslinking agent comprises a water soluble sugar. The present invention also provides a method of making microelectronic structures.
摘要翻译： 提供光致抗蚀剂。 光致抗蚀剂包括聚合物，光活性剂和交联剂。 交联剂包括水溶性糖。 本发明还提供了一种制造微电子结构的方法。
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17.发明授权
公开(公告)号：US4801517A
公开(公告)日：1989-01-31
申请号：US61053
申请日：1987-06-10
申请人： Jean M. J. Frechet , Sylvie Gauthier , William W. Limburg , Rafik O. Loutfy , Dasarao K. Murti , John W. Spiewak
发明人： Jean M. J. Frechet , Sylvie Gauthier , William W. Limburg , Rafik O. Loutfy , Dasarao K. Murti , John W. Spiewak
IPC分类号： C07C67/00 , C07C213/00 , C07C217/34 , C07C217/76 , C07C219/34 , C07C313/00 , C07C323/20 , C07C323/37 , C07D209/86 , C07D209/88 , C08G64/00 , C08G64/12 , C08G64/16 , C08G65/40 , C08G73/00 , G03G5/05 , G03G5/06 , G03G5/07 , G03G5/14
CPC分类号： G03G5/0618 , C08G64/1641 , G03G5/0517 , G03G5/0521 , G03G5/0575 , G03G5/0582 , G03G5/076
摘要： An electrostatographic imagining member and an electrophotographic imaging process for using the imaging member are disclosed in which the imaging member comprises a substrate and at least one electroconductive layer, the imaging member comprising a polymeric arylamine compound represented by the formula: ##STR1## wherein: n is between about 5 and 5,000,m is 0 or 1,Z is selected from certain specified aromatic and fused ring groups,Ar is selected from certain specified aromatic groups,R is selected from certain specified alkyl groups,Ar' is selected from certain specified aromatic groups, andR' and R" are independently selected from certain specified alkylene groups.
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18.发明授权Positive- and negative-working resist compositions with acid generating photoinitiator and polymer with acid labile groups pendant from polymer backbone 失效具有酸产生光引发剂的正性和负性抗蚀剂组合物和由聚合物主链悬挂的酸不稳定基团的聚合物
公开(公告)号：US4491628A
公开(公告)日：1985-01-01
申请号：US410201
申请日：1982-08-23
IPC分类号： C08K5/00 , C08F8/00 , C08L33/00 , C08L33/02 , G03F7/004 , G03F7/021 , G03F7/038 , G03F7/039 , G03F7/20 , G03F7/30 , H01L21/027 , G03C1/60 , G03C1/68
CPC分类号： G03F7/039 , G03F7/021 , Y10S430/109 , Y10S430/111 , Y10S430/115
摘要： Resists sensitive to UV, electron beam and X-ray radiation with positive or negative tone upon proper choice of a developer are formulated from a polymer having recurrent pendant groups such as tert-butyl ester or tert-butyl carbonates that undergo efficient acidolysis with concomitant changes in polarity (solubility) together with a photoinitiator which generates acid upon radiolysis. A sensitizer component that alters wavelength sensitivity may also be added.
摘要翻译： 正确选择显色剂后，对具有正或负色调的紫外线，电子束和X射线辐射敏感的抗体由具有复发性侧基的聚合物配制，所述聚合物具有经历有效酸解和伴随变化的叔丁酯或叔丁基碳酸酯 极性（溶解度）与光引发剂一起，其在辐射分解时产生酸。 还可以添加改变波长灵敏度的敏化剂组分。
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19.发明授权公开(公告)号：US08137700B2
公开(公告)日：2012-03-20
申请号：US12299506
申请日：2007-05-04
CPC分类号： A61K31/787 , A61K9/1641 , A61K47/34
摘要： Novel main chain acid degradable polymer backbones and drug delivery systems comprised of materials capable of delivering bioactive materials to cells for use as vaccines or other therapeutic agents are described. The polymers are synthesized using monomers that contain acid-degradable linkages cleavable under mild acidic conditions. The main chain of the resulting polymers readily degrade into many small molecules at low pH, but remain relatively stable and intact at physiological pH. The new materials have the common characteristic of being able to degrade by acid hydrolysis under conditions commonly found within the endosomal or lysosomal compartments of cells thereby releasing their payload within the cell. The materials can also be used for the delivery of therapeutics to the acidic regions of tumors and other sites of inflammation.
摘要翻译： 描述了由能够将生物活性物质递送至用作疫苗或其它治疗剂的细胞的材料组成的新型主链酸可降解聚合物主链和药物递送系统。 使用含有酸可降解键的单体在温和的酸性条件下可裂解来合成聚合物。 所得聚合物的主链在低pH下容易降解成许多小分子，但在生理pH下保持相对稳定和完整。 新材料具有在细胞的内体或溶酶体区室内通常发现的条件下能够通过酸水解降解的共同特征，从而释放其在细胞内的有效载荷。 这些材料也可以用于将治疗剂递送到肿瘤和其它炎症部位的酸性区域。
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公开(公告)号：US06887384B1
公开(公告)日：2005-05-03
申请号：US10251604
申请日：2002-09-20
申请人： Jean M. J. Frechet , Frantisek Svec , Cong Yu , Thomas Rohr
发明人： Jean M. J. Frechet , Frantisek Svec , Cong Yu , Thomas Rohr
IPC分类号： B01J20/26 , B01J20/32 , G01N30/00 , G01N30/08 , G01N30/34 , G01N30/52 , G01N30/56 , G01N30/60 , B01D15/08
CPC分类号： B01J20/261 , B01J20/26 , B01J20/265 , B01J20/28042 , B01J20/3242 , G01N30/6095 , G01N2030/009 , G01N2030/085 , G01N2030/347 , G01N2030/528 , G01N2030/567
摘要： Microfluidic devices comprising porous monolithic polymer for concentration, extraction or mixing of fluids. A method for in situ preparation of monolithic polymers by in situ initiated polymerization of polymer precursors within microchannels of a microfluidic device and their use for solid phase extraction (SPE), preconcentration, concentration and mixing.
摘要翻译： 微流体装置包括用于浓缩，提取或混合流体的多孔整体聚合物。 通过在微流体装置的微通道内的聚合物前体的原位引发聚合及其用于固相萃取（SPE），预浓缩，浓缩和混合的原位制备整体聚合物的方法。
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