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    Systems and methods for improved imaging and fluorescence in flow cytometry and other applications
    11.
    发明授权
    Systems and methods for improved imaging and fluorescence in flow cytometry and other applications 有权

    公开(公告)号：US11788949B2

    公开(公告)日：2023-10-17

    申请号：US17548964

    申请日：2021-12-13

    Applicant: Life Technologies Corporation

    Inventor： Michael D Ward ,  Gregory Kaduchak ,  Dmitriy Strelkov

    IPC: G01N15/14 ,  G01N15/00

    CPC classification number: G01N15/1436 ,  G01N2015/0065 ,  G01N2015/1438 ,  G01N2015/1443

    Abstract: Provided are systems and methods that allow for brightfield imaging in a flow cytometer, allowing for collection of fluorescence and high-quality image date. The disclosed technology also gives rise to an illumination pattern that allows a user to create different oblique or structured illumination profiles within a static system. With the disclosed approach, a user can illuminate a sample from a first direction (e.g., with laser illumination configured to give rise to one or more of fluorescence information and scattering information), collect scattering information from a second direction, collect fluorescence information from a third direction, and capture an image of the sample from a fourth direction. (Two or more of the foregoing can be accomplished simultaneously.) Also as described elsewhere herein, an illumination used to illuminate the sample for visual image capture can be communicated to the same through a lens that also collects fluorescence from the sample.

    Methods and Systems for Controlling the Flow of Particles for Detection
    16.
    发明申请
    Methods and Systems for Controlling the Flow of Particles for Detection 有权
    用于检测颗粒流动的方法和系统

    公开(公告)号：US20130292582A1

    公开(公告)日：2013-11-07

    申请号：US13849456

    申请日：2013-03-22

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Gregory Kaduchak ,  Carleton Stewart ,  Michael D. Ward

    IPC: G01N21/64

    CPC classification number: G01N15/1404 ,  A61M1/3678 ,  G01N15/12 ,  G01N15/147 ,  G01N21/1702 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/645 ,  G01N27/447 ,  G01N29/222 ,  G01N33/56966 ,  G01N2015/1409 ,  G01N2015/1415 ,  G01N2015/142 ,  G01N2291/02416 ,  G01N2291/02809 ,  G01N2291/02836 ,  Y10T436/101666 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/25625 ,  Y10T436/2575

    Abstract: A method of focusing particles is provided. The method includes transiting a fluid containing particles therein through a channel at a flow rate and adjusting the flow rate for a desired transit time through an interrogation zone through which a light from an excitation source passes. The method further includes optically exciting the particles with the excitation source, detecting an optical signal from the particles, and analyzing the optical signal. The particles may be droplets. Further, the particles may transit the interrogation zone in single file. A system of focusing particles is also provided. The system includes a channel having an inlet for accepting a fluid containing particles. The system further includes a flow adjuster configured to adjust the flow rate for a desired transit time through an interrogation zone, a light source configured to optically excite the particles, and a detector configured to detect optical signals from the particles.

    Abstract translation: 提供聚焦颗粒的方法。 该方法包括以流速通过通道流过其中含有颗粒的流体，并通过询问区调整流速以达到期望的通过时间，通过该询问区来自激发源的光通过该询问区。 该方法还包括用激发源光学激发颗粒，检测来自颗粒的光信号，以及分析光信号。 颗粒可以是液滴。 此外，颗粒可以在单个文件中传递询问区。 还提供了聚焦颗粒的系统。 该系统包括具有用于接收含有颗粒的流体的入口的通道。 该系统还包括流量调节器，其被配置为通过询问区域调整所需流通时间的流速，配置为光学激发粒子的光源以及被配置为检测来自粒子的光信号的检测器。

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