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公开(公告)号：US20250054093A1
公开(公告)日：2025-02-13
申请号：US18926187
申请日：2024-10-24
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Shanti Shankar , John Thompson , Mark Beauchemin , Sean Zimmerman
Abstract: A method for user guided initiating of an instrument includes receiving a run plan via a user interface of the instrument; indicating on the user interface, based on the run plan, a consumable to be provided to the instrument; detecting the presence of the consumable using a vision system; and indicating the presence of the consumable via the user interface.
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Patent Agency Ranking
公开(公告)号：US10809226B2
公开(公告)日：2020-10-20
申请号：US15920387
申请日：2018-03-13
Applicant: Life Technologies Corporation
Inventor： Todd Rearick , Melville Davey , Mark Beauchemin
IPC: G01N27/416 , G16B30/00 , G01N27/414
Abstract: A method, computer program product, and system are provided to calibrate a sensor array with a plurality of sensors. The method can include sweeping a voltage of a reference electrode from a first voltage to a second voltage, where the reference electrode is in fluid communication with the sensor array. The output voltage of each of the plurality of sensors can be monitored at one or more voltages within the first and second voltages. An overall average gain of the plurality of sensors can be calculated at each of the one or more voltages. Further, an acquisition window for the sensor array can be determined. The acquisition window can include a maximum distribution of sensors that provides a maximal overall average gain at a particular reference electrode voltage.
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公开(公告)号：US10365321B2
公开(公告)日：2019-07-30
申请号：US14830391
申请日：2015-08-19
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Mark Beauchemin
IPC: G01R31/26 , G01R31/28 , G01N27/414 , G01N27/416
Abstract: An apparatus including an array of sensors including a plurality of chemical sensors and a plurality of reference sensors, each chemical sensor coupled to a corresponding reaction region for receiving at least one reactant, and each reference sensor comprising a field effect transistor having a gate coupled to a corresponding reference line and an access circuit for accessing the chemical sensors and the reference sensors and a controller to apply bias voltages to the reference lines to select corresponding reference sensors, acquire output signals from the selected reference sensors, and identify one or more defects in the access circuit based on differences between the acquired output signals and expected output signals.
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公开(公告)号：US09927393B2
公开(公告)日：2018-03-27
申请号：US14330756
申请日：2014-07-14
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Todd Rearick , Melville Davey , Mark Beauchemin
IPC: G01N27/416 , G01N27/414 , G06F19/22
CPC classification number: G01N27/4165 , G01N27/4145 , G06F19/22
Abstract: A method, computer program product, and system are provided to calibrate a sensor array with a plurality of sensors. The method can include sweeping a voltage of a reference electrode from a first voltage to a second voltage, where the reference electrode is in fluid communication with the sensor array. The output voltage of each of the plurality of sensors can be monitored at one or more voltages within the first and second voltages. An overall average gain of the plurality of sensors can be calculated at each of the one or more voltages. Further, an acquisition window for the sensor may can be determined. The acquisition window can include a maximum distribution of sensors that provides a maximal overall average gain at a particular reference electrode voltage.
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15.发明授权公开(公告)号：US09515676B2
公开(公告)日：2016-12-06
申请号：US13754566
申请日：2013-01-30
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Charles Sugnet , Simon Cawley , Mohit Gupta , Iztok Marjanovic , Todd Rearick , Mark Beauchemin , Earl Hubbell
Abstract: A compression method includes measuring a waveform associated with a chemical event occurring on a sensor array, wherein the waveform comprises at least one region associated with expected measured values and at least one region associated with unpredictable measured values; applying a first compression process to the waveform, the first compression process including an averaging of one or more frames in one or more portions of the waveform; and applying a second compression process to the waveform, the second compression process including a truncating of data corresponding to a portion of the waveform that is not related to a nucleotide incorporation component of the waveform.
Abstract translation: 压缩方法包括测量与传感器阵列上发生的化学事件相关联的波形，其中所述波形包括与预期测量值相关联的至少一个区域和与不可预测的测量值相关联的至少一个区域; 对所述波形应用第一压缩处理，所述第一压缩处理包括所述波形的一个或多个部分中的一个或多个帧的平均值; 以及对所述波形应用第二压缩处理，所述第二压缩处理包括对应于与所述波形的核苷酸掺入成分无关的所述波形的一部分的数据的截断。
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公开(公告)号：US20160187289A1
公开(公告)日：2016-06-30
申请号：US14926264
申请日：2015-10-29
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Todd REARICK , Mark Beauchemin
IPC: G01N27/414 , C12Q1/68 , G01N27/27
CPC classification number: G01N27/4145 , C12Q1/6869 , G01N27/27 , G01N27/4148 , G16B30/00
Abstract: A method is provided to sample a sensor array. The method can include measuring a waveform associated with a chemical event occurring on the sensor array. The waveform can include at least one region associated with expected measured values and at least one region associated with unpredictable measured values. The method can also include applying a first frame averaging to the at least one region associated with the expected measured values. Here, a first number of frames can be included in the first frame averaging. Further, the method can include applying a second frame averaging to the at least one region associated with the unpredictable measured values, where a second number of frames can be included in the second frame averaging. The second number of frames can be less than the first number of frames.
Abstract translation: 提供了一种对传感器阵列进行采样的方法。 该方法可以包括测量与传感器阵列上发生的化学事件相关联的波形。 波形可以包括与预期测量值相关联的至少一个区域和与不可预测的测量值相关联的至少一个区域。 该方法还可以包括将第一帧平均应用于与预期测量值相关联的至少一个区域。 这里，可以在第一帧平均中包括第一数量的帧。 此外，该方法可以包括将第二帧平均应用于与不可预测的测量值相关联的至少一个区域，其中可以在第二帧平均中包括第二数量的帧。 第二帧数可以小于第一帧数。
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