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公开(公告)号:US08058297B2
公开(公告)日:2011-11-15
申请号:US12496902
申请日:2009-07-02
申请人: Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
发明人: Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
IPC分类号: A61K31/425
CPC分类号: C07D275/02 , A61K31/425 , A61K31/4439 , A61K31/506 , C07D417/04 , C07D417/10 , C07F9/6539 , C07F9/65586
摘要: The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
摘要翻译: 本发明涉及结构式(I)的化合物或其药学上可接受的盐,溶剂化物,包合物和前药,其中R a,R b和R 2在本文中定义。 这些化合物抑制微管蛋白聚合和/或靶向脉管系统,并且可用于治疗增殖性疾病如癌症。
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公开(公告)号:US08399435B2
公开(公告)日:2013-03-19
申请号:US13269042
申请日:2011-10-07
申请人: Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
发明人: Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
IPC分类号: A61K31/675 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61P35/00 , C07D275/02 , C07D261/08 , C07D417/10 , C07F9/09 , C12N5/07
CPC分类号: C07D275/02 , A61K31/425 , A61K31/4439 , A61K31/506 , C07D417/04 , C07D417/10 , C07F9/6539 , C07F9/65586
摘要: The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
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公开(公告)号:US07572821B2
公开(公告)日:2009-08-11
申请号:US11601590
申请日:2006-11-17
申请人: Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
发明人: Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
IPC分类号: A61K31/425 , C07D275/03
CPC分类号: C07D275/02 , A61K31/425 , A61K31/4439 , A61K31/506 , C07D417/04 , C07D417/10 , C07F9/6539 , C07F9/65586
摘要: The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
摘要翻译: 本发明涉及结构式(I)的化合物或其药学上可接受的盐,溶剂化物,包合物和前药,其中R a,R b和R 2在本文中定义。 这些化合物抑制微管蛋白聚合和/或靶向脉管系统,并且可用于治疗增殖性疾病如癌症。
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公开(公告)号:US20120040937A1
公开(公告)日:2012-02-16
申请号:US13269042
申请日:2011-10-07
申请人: Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
发明人: Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
IPC分类号: A61K31/675 , C07D275/02 , C07D261/08 , A61P35/00 , A61K31/4439 , A61K31/4709 , A61K31/4725 , C07F9/09 , C12N5/07 , C07D417/10
CPC分类号: C07D275/02 , A61K31/425 , A61K31/4439 , A61K31/506 , C07D417/04 , C07D417/10 , C07F9/6539 , C07F9/65586
摘要: The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
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公开(公告)号:US20070249661A1
公开(公告)日:2007-10-25
申请号:US11233224
申请日:2005-09-21
申请人: Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhi Xia
发明人: Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhi Xia
IPC分类号: A61K31/44 , A61K31/40 , A61K31/415 , A61P19/02 , A61P5/00 , C07D235/28 , C07D471/02 , C07D455/02 , C07D235/00 , A61P3/10 , A61P17/00 , A61K31/437
CPC分类号: A61K31/437 , A61K31/403 , A61K31/4184 , A61K31/4439 , A61K31/444 , A61K31/537 , C07D235/06 , C07D235/08 , C07D235/10 , C07D235/24 , C07D235/28 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/12 , C07D471/04 , Y02A50/422
摘要: The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions and immune disorders.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,溶剂合物,包合物或前药,其中X,Y,A,Z,L和n如本文所定义。 这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症和免疫疾病。
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公开(公告)号:US07709518B2
公开(公告)日:2010-05-04
申请号:US11233224
申请日:2005-09-21
申请人: Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhi Qiang Xia
发明人: Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhi Qiang Xia
IPC分类号: A61K31/415 , A01N43/52 , C07D235/00 , C07D235/18
CPC分类号: A61K31/437 , A61K31/403 , A61K31/4184 , A61K31/4439 , A61K31/444 , A61K31/537 , C07D235/06 , C07D235/08 , C07D235/10 , C07D235/24 , C07D235/28 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/12 , C07D471/04 , Y02A50/422
摘要: The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions and immune disorders.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,溶剂合物,包合物或前药,其中X,Y,A,Z,L和n如本文所定义。 这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症和免疫疾病。
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公开(公告)号:US20130142831A1
公开(公告)日:2013-06-06
申请号:US13652878
申请日:2012-10-16
申请人: Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhiqiang Xia
发明人: Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhiqiang Xia
IPC分类号: A61K31/437
CPC分类号: A61K31/437 , A61K31/403 , A61K31/4184 , A61K31/4439 , A61K31/444 , A61K31/537 , C07D235/06 , C07D235/08 , C07D235/10 , C07D235/24 , C07D235/28 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/12 , C07D471/04 , Y02A50/422
摘要: The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions and immune disorders.
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公开(公告)号:US20100311787A1
公开(公告)日:2010-12-09
申请号:US12718366
申请日:2010-03-05
申请人: Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhi Qiang Xia
发明人: Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhi Qiang Xia
IPC分类号: A61K31/437 , A61K31/4184 , A61K31/4439 , A61K31/433 , A61P37/00 , A61P35/00 , A61P17/06 , A61P1/04 , A61P3/10 , A61P19/02 , A61P11/00 , A61P25/28 , C12N5/0783
CPC分类号: A61K31/437 , A61K31/403 , A61K31/4184 , A61K31/4439 , A61K31/444 , A61K31/537 , C07D235/06 , C07D235/08 , C07D235/10 , C07D235/24 , C07D235/28 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/12 , C07D471/04 , Y02A50/422
摘要: The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions and immune disorders.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,溶剂合物,包合物或前药,其中X,Y,A,Z,L和n如本文所定义。 这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症和免疫疾病。
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公开(公告)号:US08314134B2
公开(公告)日:2012-11-20
申请号:US12718366
申请日:2010-03-05
申请人: Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhiqiang Xia
发明人: Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhiqiang Xia
IPC分类号: C07D235/00 , A01N43/52 , A61K31/415
CPC分类号: A61K31/437 , A61K31/403 , A61K31/4184 , A61K31/4439 , A61K31/444 , A61K31/537 , C07D235/06 , C07D235/08 , C07D235/10 , C07D235/24 , C07D235/28 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/12 , C07D471/04 , Y02A50/422
摘要: The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions and immune disorders.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,溶剂合物,包合物或前药,其中X,Y,A,Z,L和n如本文所定义。 这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症和免疫疾病。
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公开(公告)号:US08680100B2
公开(公告)日:2014-03-25
申请号:US13132106
申请日:2009-12-01
申请人: Jun Jiang , Teresa Kowalczyk-Przewloka , Stefan M. Schweizer , Zhi-Qiang Xia , Shoujun Chen , Christopher Borella , Lijun Sun
发明人: Jun Jiang , Teresa Kowalczyk-Przewloka , Stefan M. Schweizer , Zhi-Qiang Xia , Shoujun Chen , Christopher Borella , Lijun Sun
IPC分类号: A61K31/5375 , A61K31/4965 , A61K31/445 , A61K31/4409 , A61K31/426 , A61K31/421 , A61K31/402 , A61K31/381 , A61K31/357 , A61K31/341 , A61K31/27 , A61K31/16 , C07D295/215 , C07D241/28 , C07D211/98 , C07D213/78 , C07D277/56 , C07D263/34 , C07D207/12 , C07D333/68 , C07D317/46 , C07D307/68 , C07C333/12 , C07C327/18 , A61P35/00
CPC分类号: C07D295/195 , C07C327/56 , C07C333/12 , C07C335/40 , C07C337/02 , C07C337/06 , C07C2601/02 , C07C2601/04 , C07D211/72 , C07D213/86 , C07D213/87 , C07D241/24 , C07D277/56 , C07D295/155 , C07D307/68 , C07D317/68 , C07D333/38 , C07D333/68
摘要: The present invention is directed to compounds represented by structural formula (I), or a pharmaceutically acceptable salt or a transition metal chelate, coordinate or complex thereof or a transition metal chelate, coordinate or complex of a deprotonated form of the compound. Pharmaceutical composition and method of use for these compounds are also included.
摘要翻译: 本发明涉及由结构式(I)表示的化合物或其药学上可接受的盐或过渡金属螯合物,其配位体或络合物或过渡金属螯合物,化合物去质子化形式的配位体或络合物。 也包括这些化合物的药物组合物和使用方法。
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