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公开(公告)号：US20100069606A1
公开(公告)日：2010-03-18
申请号：US12283908
申请日：2008-09-15
申请人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： C07K2/00 , C07K16/00 , C07H1/00 , C07H21/04 , C07D323/00 , C07C69/00 , C07C229/00 , C07C49/00 , C07C47/00 , C07C43/00 , C07K14/42
CPC分类号： C07K16/32 , A61K38/1703 , A61K38/1732 , A61K47/60 , A61K47/6871 , A61K47/6901 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B21/0648 , C01B32/168 , C01B32/174 , C01B2202/02 , C01B2202/34 , C01B2202/36 , C01P2004/13 , Y02A50/473 , Y10S977/743 , Y10S977/75 , Y10S977/762 , Y10S977/788 , Y10S977/795 , Y10S977/848 , Y10S977/896 , Y10S977/915
摘要： Devices, compositions, and methods are described which provide a tubular nanostructure targeted to a lipid bilayer membrane. The targeted tubular nanostructure can have a surface region configured to pass through a lipid bilayer membrane of a cell, a hydrophobic surface region flanked by two hydrophilic surface regions configured to form a pore in a lipid bilayer membrane of a cellular organelle, and at least one ligand configured to bind one or more cognates on the lipid bilayer membrane of the cellular organelle. The target cell can be, for example, a tumor cell, an infected cell, or a diseased cell in a subject. The tubular nanostructure can form a pore in the lipid bilayer membrane of the cellular organelle, e.g., mitochondria, which can permit transit or translocation of at least one compound across the membrane and cause cell death of the target cell.
摘要翻译： 描述了提供靶向脂质双层膜的管状纳米结构的装置，组合物和方法。 目标管状纳米结构可以具有被配置为穿过细胞的脂质双层膜的表面区域，侧壁有两个亲水性表面区域的疏水性表面区域，所述疏水性表面区域配置成在细胞器官细胞器的脂质双层膜中形成孔，以及至少一个 配体被配置为结合细胞器的脂质双层膜上的一个或多个同源物。 靶细胞可以是例如受试者中的肿瘤细胞，感染细胞或患病细胞。 管状纳米结构可以在细胞器（例如线粒体）的脂质双层膜中形成孔，其可以允许至少一种化合物跨过膜的转运或易位并导致靶细胞的细胞死亡。
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公开(公告)号：US20110177154A1
公开(公告)日：2011-07-21
申请号：US12283907
申请日：2008-09-15
申请人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： A61K9/127 , C07K7/64 , C07D321/00 , C07H21/00 , C07K14/00 , C07H7/00 , C07C229/00 , C08G63/48 , C07K16/00 , C12N9/14 , A61K9/14 , A61K38/02 , A61K38/16 , A61K31/335 , A61K31/7088 , A61K38/14 , A61K39/395 , A61K38/12 , A61P43/00 , B82Y5/00
CPC分类号： C07K16/32 , A61K38/1703 , A61K38/1732 , A61K47/60 , A61K47/6871 , A61K47/6901 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B21/0648 , C01B32/168 , C01B32/174 , C01B2202/02 , C01B2202/34 , C01B2202/36 , C01P2004/13 , Y02A50/473 , Y10S977/743 , Y10S977/75 , Y10S977/762 , Y10S977/788 , Y10S977/795 , Y10S977/848 , Y10S977/896 , Y10S977/915
摘要： Devices, compositions, and methods are described which provide a tubular nanostructure or a composite tubular nanostructure targeted to a lipid bilayer membrane. The tubular nanostructure includes a hydrophobic surface region flanked by two hydrophilic surface regions. The tubular nanostructure is configured to interact with a lipid bilayer membrane and form a pore in the lipid bilayer membrane. The tubular nanostructure may be targeted by including at least one ligand configured to bind to one or more cognates on the lipid bilayer membrane of a target cell.
摘要翻译： 描述了提供靶向脂质双层膜的管状纳米结构或复合管状纳米结构的装置，组合物和方法。 管状纳米结构包括侧面有两个亲水表面区域的疏水表面区域。 管状纳米结构被配置为与脂质双层膜相互作用并在脂质双层膜中形成孔。 管状纳米结构可以通过包括至少一种被配置成结合靶细胞的脂质双层膜上的一个或多个同源物的配体来靶向。
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公开(公告)号：US09069067B2
公开(公告)日：2015-06-30
申请号：US12924036
申请日：2010-09-17
申请人： Mahalaxmi Gita Bangera , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Elizabeth A. Sweeney , Clarence T. Tegreene , David B. Tuckerman , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人： Mahalaxmi Gita Bangera , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Elizabeth A. Sweeney , Clarence T. Tegreene , David B. Tuckerman , Lowell L. Wood, Jr. , Victoria Y. H. Wood
IPC分类号： G06Q30/00 , G01S13/02 , G01S7/41 , G01S13/04 , G06F3/01 , H04N21/422 , H04N21/442
CPC分类号： G01S13/0209 , G01S7/415 , G01S13/04 , G06F3/017 , H04N21/42201 , H04N21/44218
摘要： A computer or entertainment system is configured to respond to data received from a micro impulse radar configured to detect movement, physiology, posture, presence, and/or absence of a person in one or more regions near the computer or entertainment system.
摘要翻译： 计算机或娱乐系统被配置为响应从被配置为检测计算机或娱乐系统附近的一个或多个区域中的人的运动，生理，姿势，存在和/或不存在的微脉冲雷达接收的数据。
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公开(公告)号：US08884813B2
公开(公告)日：2014-11-11
申请号：US12930254
申请日：2010-12-30
申请人： Mahalaxmi Gita Bangera , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Elizabeth A. Sweeney , Clarence T. Tegreene , David B. Tuckerman , Thomas Weaver , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人： Mahalaxmi Gita Bangera , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Elizabeth A. Sweeney , Clarence T. Tegreene , David B. Tuckerman , Thomas Weaver , Lowell L. Wood, Jr. , Victoria Y. H. Wood
IPC分类号： G01S13/00 , G08B23/00 , A61B5/05 , G01S13/88 , G01S13/52 , G01S13/86 , G01S7/41 , A61B5/16 , G01S13/02 , A61B5/024 , A61B5/08 , A61B5/113 , A61B5/00
CPC分类号： A61B5/0507 , A61B5/024 , A61B5/0816 , A61B5/113 , A61B5/165 , A61B5/7253 , G01S7/412 , G01S7/415 , G01S13/0209 , G01S13/52 , G01S13/867 , G01S13/88 , G01S13/887
摘要： One or more computers are configured to determine a human stress condition corresponding to one or more physical or physiological parameters extracted from one or more micro-impulse radar (MIR) signals.
摘要翻译： 一个或多个计算机被配置为确定对应于从一个或多个微脉冲雷达（MIR）信号提取的一个或多个物理或生理参数的人类应激条件。
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公开(公告)号：US20120135527A1
公开(公告)日：2012-05-31
申请号：US12927972
申请日：2010-11-29
申请人： Mahalaxmi Gita Bangera , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Jordin T. Kare , Erez Lieberman , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR.
发明人： Mahalaxmi Gita Bangera , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Jordin T. Kare , Erez Lieberman , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR.
CPC分类号： G01N31/223 , D03D15/00 , D10B2401/20 , G08B21/245 , Y10T428/239
摘要： A multilayer material is described herein that includes a flexible inner layer and a flexible outer layer configured to enclose at least one signaling layer, the at least one signaling layer including at least one chemical compound. The multilayer material including the chemical compound within the at least one signaling layer is configured to release a gas-phase chemical compound to signal to a detector indicating a breach of the multilayer material. A multilayer material, a system, an article of clothing, or a method is described herein.
摘要翻译： 本文描述了一种多层材料，其包括柔性内层和柔性外层，其被配置为包围至少一个信号层，所述至少一个信号层包括至少一种化学化合物。 包括至少一个信号层内的化合物的多层材料被配置为释放气相化合物以向检测器发出信号，指示破坏多层材料。 本文描述了多层材料，系统，服装或方法。
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公开(公告)号：US20100056873A1
公开(公告)日：2010-03-04
申请号：US12231048
申请日：2008-08-27
申请人： Paul G. Allen , Edward S. Boyden , Mahalaxmi Gita Bangera , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Paul G. Allen , Edward S. Boyden , Mahalaxmi Gita Bangera , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
摘要： Systems and methods are described for configuring and using displays, speakers, or other output devices positioned by an article of clothing or other such structure wearable by a healthcare recipient, for example, in a clinic or residential care facility.
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公开(公告)号：US20100052915A1
公开(公告)日：2010-03-04
申请号：US12231050
申请日：2008-08-27
申请人： Paul G. Allen , Edward S. Boyden , Mahalaxmi Gita Bangera , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Paul G. Allen , Edward S. Boyden , Mahalaxmi Gita Bangera , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： G08B23/00
CPC分类号： A61B5/411 , A61B5/0013 , A61B2560/0412 , G06F19/00 , G16H40/20
摘要： Systems and methods are described for configuring and using displays, speakers, or other output devices positioned by an article of clothing or other such structure wearable by a healthcare recipient, for example, in a clinic or residential care facility.
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公开(公告)号：US20100052898A1
公开(公告)日：2010-03-04
申请号：US12231061
申请日：2008-08-27
申请人： Paul G. Allen , Edward S. Boyden , Mahalaxmi Gita Bangera , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Paul G. Allen , Edward S. Boyden , Mahalaxmi Gita Bangera , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： G08B1/08
CPC分类号： A61B5/6833 , A61B5/01 , A61B5/02007 , A61B5/04 , A61B5/0816 , A61B5/1112 , A61B5/202 , A61B5/411 , A61B5/4875 , A61B5/6804 , A61B5/681 , A61B5/6831
摘要： Systems and methods are described for configuring and using displays, speakers, or other output devices positioned by an article of clothing or other such structure wearable by a healthcare recipient, for example, in a clinic or residential care facility.
摘要翻译： 描述了用于配置和使用由衣物制品定位的显示器，扬声器或其他输出设备的系统和方法，例如在诊所或安老院设置中，医疗保健接收者可佩戴其他此类结构。
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公开(公告)号：US20120133507A1
公开(公告)日：2012-05-31
申请号：US12927968
申请日：2010-11-29
申请人： Mahalaxmi Gita Bangera , Roy P. Diaz , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Jordin T. Kare , Erez Lieberman , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR.
发明人： Mahalaxmi Gita Bangera , Roy P. Diaz , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Jordin T. Kare , Erez Lieberman , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR.
CPC分类号： G01N31/223 , D03D15/00 , D10B2401/20 , G08B21/245 , Y10T428/239
摘要： A multilayer material is described herein that includes at least one signaling layer configured to propagate at least one electromagnetic signal; and a flexible layer configured to enclose the at least one signaling layer, wherein the flexible layer is substantially impermeable to an environment and to the at least one electromagnetic signal. The multilayer material including the at least one signaling layer is configured to transmit a change in the at least one electromagnetic signal upon exposure of the signaling layer to the environment. A system, an article of clothing, or a method is described herein.
摘要翻译： 本文描述了多层材料，其包括被配置为传播至少一个电磁信号的至少一个信令层; 以及柔性层，其被配置为包围所述至少一个信令层，其中所述柔性层对于环境和所述至少一个电磁信号基本上不可渗透。 包括至少一个信令层的多层材料被配置为在信令层暴露于环境时传输至少一个电磁信号的变化。 本文描述了系统，服装或方法。
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公开(公告)号：US20120133504A1
公开(公告)日：2012-05-31
申请号：US13135369
申请日：2011-06-30
申请人： Mahalaxmi Gita Bangera , Roy P. Diaz , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Jordin T. Kare , Erez Lieberman , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR.
发明人： Mahalaxmi Gita Bangera , Roy P. Diaz , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Jordin T. Kare , Erez Lieberman , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR.
IPC分类号： G08B21/00
CPC分类号： G01N31/223 , D03D15/00 , D10B2401/20 , G08B21/245 , Y10T428/239
摘要： A multilayer material is described herein that includes at least one signaling layer configured to propagate at least one electromagnetic signal; and a flexible layer configured to enclose the at least one signaling layer, wherein the flexible layer is substantially impermeable to an environment and to the at least one electromagnetic signal. The multilayer material including the at least one signaling layer is configured to transmit a change in the at least one electromagnetic signal upon exposure of the signaling layer to the environment. A system, an article of clothing, or a method is described herein.
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