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    CORRELATION CONFOCAL MICROSCOPE
    12.
    发明申请
    CORRELATION CONFOCAL MICROSCOPE 有权
    相关协同显微镜

    公开(公告)号：US20140008525A1

    公开(公告)日：2014-01-09

    申请号：US13534600

    申请日：2012-06-27

    申请人： David Simon ,  Alexander Sergienko ,  Lee Edwin Goldstein ,  Robert H. Webb

    发明人： David Simon ,  Alexander Sergienko ,  Lee Edwin Goldstein ,  Robert H. Webb

    IPC分类号： G02B21/00

    CPC分类号： G02B21/0004 ,  G02B21/0056 ,  G02B21/0084

    摘要： A correlation confocal microscope uses correlated photon pairs to improve resolution. It employs a source of a light beam converging to a point location on a sample, and an objective that gathers light from the point location and generates an image beam. A modulator applies a spatial pattern of modulation to the source light beam to define spatially correlated photons whose spatial correlations are preserved in modulated light gathered from the sample. A filter applies a modulation-selective filter function to the image light beam to generate a filtered light beam of like-modulated photons. A coincidence detector detects temporally coincident photon pairs in the filtered light beam, generating a pulse output that indicates the magnitude of a light-detectable property (such as transmissivity or reflectivity) of the sample at the point location. The modulator may apply phase modulation and the filter may be a phase-sensitive component such as an interferometer.

    摘要翻译： 相关共焦显微镜使用相关的光子对来提高分辨率。 它采用会聚在样本上的点位置的光束的源，以及从点位置收集光并产生图像束的目标。 调制器将调制空间模式应用于源光束以限定空间相关光子，其空间相关性保留在从样本收集的调制光中。 滤波器将调制选择滤波器功能应用于图像光束以产生经过调制的光子的滤波光束。 符合检测器检测滤波光束中的时间上重合的光子对，产生指示样品在点位置处的可光可检测特性（例如透射率或反射率）的幅度的脉冲输出。 调制器可以进行相位调制，并且滤波器可以是诸如干涉仪之类的相敏元件。

    Gate Cannulation Apparatus and Methods
    14.
    发明申请
    Gate Cannulation Apparatus and Methods 审中-公开
    门管装置和方法

    公开(公告)号：US20090259296A1

    公开(公告)日：2009-10-15

    申请号：US12100587

    申请日：2008-04-10

    申请人： Gregory McIff ,  Dwayne S. Yamasaki ,  David Simon ,  Andrew Bzostek

    发明人： Gregory McIff ,  Dwayne S. Yamasaki ,  David Simon ,  Andrew Bzostek

    IPC分类号： A61F2/06

    CPC分类号： A61F2/07 ,  A61B5/06 ,  A61B5/062 ,  A61B6/12 ,  A61B2034/2051 ,  A61F2/89 ,  A61F2002/067 ,  A61F2250/0001 ,  A61F2250/0097

    摘要： A representation of a prosthesis opening is created and a device having a marker is tracked through the opening while monitoring the relative positions of the opening representation and the marker on a display. In one alternative, a representation is made on a display of the center of the contralateral stump opening and an electromagnetic marker coil that is secured to an endovascular delivery device, and the marker and delivery device are guided into the opening, while monitoring the relative positions of the opening center and the electromagnetic marker coil representations. In another alternative, one or more markers are positioned in the vicinity of the prosthesis opening and a device having a marker is tracked to the one or more markers and through the opening where the device is one of a guidewire and a catheter, while monitoring the relative position of the markers on a display.

    摘要翻译： 创建假体开口的表示，并且通过开口跟踪具有标记的装置，同时监视开口表示和标记在显示器上的相对位置。 在一个替代方案中，在对侧残端开口的中心的显示器上形成表示，以及固定到血管内输送装置的电磁标记线圈，并且将标记和输送装置引导到开口中，同时监测相对位置 的开口中心和电磁标记线圈表示。 在另一替代方案中，一个或多个标记位于假体开口附近，并且具有标记的装置被跟踪到一个或多个标记并通过开口，其中该装置是导丝和导管之一，同时监测 标记在显示器上的相对位置。

    Vascular Position Locating Apparatus and Method
    16.
    发明申请
    Vascular Position Locating Apparatus and Method 审中-公开
    血管位置定位装置及方法

    公开(公告)号：US20080140180A1

    公开(公告)日：2008-06-12

    申请号：US11608081

    申请日：2006-12-07

    申请人： Mark Dolan ,  David Simon

    发明人： Mark Dolan ,  David Simon

    IPC分类号： A61F2/06 ,  A61B6/00

    CPC分类号： A61F2/954 ,  A61B34/20 ,  A61B2034/105 ,  A61B2034/2051 ,  A61F2/07 ,  A61F2002/061 ,  A61F2002/067 ,  A61M2025/0166

    摘要： A branch vessel in a human patient is located using in vivo tracked field sensors where in one variation the sensor positions can be located by determining the positions of the sensors relative to a plurality of magnetic field sources of known location. This approach is used, for example, in locating the opening in a renal artery and positioning the proximal end of the AAA stent-graft adjacent to the opening. According to another embodiment, field sensors in combination with signal generators are placed in vivo to locate vasculature aspects. In a further embodiment, an in vivo sensor is positioned in a deployed prosthesis to create a reference for a prosthetic member having a sensor to track to during cannulation of the deployed prosthesis with the prosthetic member.

    摘要翻译： 使用体内跟踪的场传感器来定位人类患者的分支血管，其中在一个变化中，可以通过确定传感器相对于已知位置的多个磁场源的位置来定位传感器位置。 例如，该方法用于将肾动脉中的开口定位并将AAA支架移植物的近端定位成与开口相邻。 根据另一个实施例，与信号发生器组合的场传感器被放置在体内以定位脉管系统方面。 在另一实施例中，体内传感器定位在部署的假体中，以为具有传感器的假体构件创建参考，所述假体构件具有在假肢构件插入展开假体期间跟踪的传感器。

    Novel therapeutic uses for nalmefene
    17.
    发明申请
    Novel therapeutic uses for nalmefene 审中-公开
    奈美芬的新型治疗用途

    公开(公告)号：US20060235038A1

    公开(公告)日：2006-10-19

    申请号：US11397439

    申请日：2006-04-04

    申请人： David Simon

    发明人： David Simon

    IPC分类号： A61K31/485

    CPC分类号： A61K31/485 ,  A61K2300/00

    摘要： The present invention relates to novel compositions, methods and therapeutic uses for nalmefene, a unique opioid antagonist drug. The invention teaches administering nalmefene by means that function to produce optimal steady-state plasma or serum concentrations. These means plus functions are claimed for treating alcoholism and pathological gambling.

    摘要翻译： 本发明涉及纳美芬的新型组合物，方法和治疗用途，一种独特的阿片拮抗剂药物。 本发明教导了通过产生最佳稳态血浆或血清浓度的功能来施用纳美芬。 这些手段加上功能被要求用于治疗酒精中毒和病态赌博。

    Personal communication device with bar code reader for obtaining product information from multiple databases
    18.
    发明授权
    Personal communication device with bar code reader for obtaining product information from multiple databases 有权
    具有条形码阅读器的个人通信设备，用于从多个数据库获取产品信息

    公开(公告)号：US06974078B1

    公开(公告)日：2005-12-13

    申请号：US09407666

    申请日：1999-09-28

    申请人： David Simon

    发明人： David Simon

    IPC分类号： G06F17/00 ,  G06K15/00 ,  G06Q30/00

    CPC分类号： G06Q30/06

    摘要： A communication system including a personal communication device that allows a user to communicate over the Internet with a network of multiple remote databases and to search the databases for desired product-related information from any location. The communication device includes an input mechanism, such as a bar code scanner or OCR reader, for entering product information such as product codes from product labels. The communication device establishes a communication link with a communications server, and the product information is transmitted to the server, which interfaces with one or more product information libraries to determine a product identifier based on the input product information. The product identifier is used by the server to search various databases over the Internet for desired product-related information in response to a search query from the user.

    摘要翻译： 一种包括个人通信设备的通信系统，其允许用户通过互联网与多个远程数据库的网络通信，并且从任何位置搜索数据库以获得期望的产品相关信息。 通信设备包括诸如条形码扫描器或OCR读取器的输入机构，用于从产品标签输入诸如产品代码的产品信息。 通信设备与通信服务器建立通信链路，并将产品信息发送到与一个或多个产品信息库接口的服务器，以基于输入的产品信息来确定产品标识符。 服务器使用产品标识符来响应来自用户的搜索查询来通过因特网搜索各种数据库以获得期望的产品相关信息。

    Air management systems
    19.
    发明申请
    Air management systems 审中-公开
    空中管理系统

    公开(公告)号：US20050172924A1

    公开(公告)日：2005-08-11

    申请号：US11051902

    申请日：2005-02-04

    申请人： David Simon

    发明人： David Simon

    IPC分类号： F02M35/10

    CPC分类号： F02M35/10019 ,  F02M35/10196 ,  F02M35/10255 ,  F02M35/10262 ,  F02M35/162 ,  F02M35/165 ,  Y02T10/146

    摘要： An air management system for improved airflow within a vehicle carburetor or fuel injection throttle-body. The air management system comprises a divider plate positioned within the airflow passage of the carburetor or fuel injection throttle body. Several embodiments utilize air pressure equalizing apertures for equalizing fluid pressures above and below the divider plate.

    摘要翻译： 一种用于改善车辆化油器或燃料喷射节流阀体内气流的空气管理系统。 空气管理系统包括位于化油器或燃料喷射节流阀体的气流通道内的分隔板。 几个实施例利用空气压力均衡孔来平衡分隔板上方和下方的流体压力。

    Method and apparatus for electromagnetic navigation of a surgical probe near a metal object
    20.
    发明授权
    Method and apparatus for electromagnetic navigation of a surgical probe near a metal object 有权
    用于金属物体附近的外科探头的电磁导航的方法和装置

    公开(公告)号：US06636757B1

    公开(公告)日：2003-10-21

    申请号：US09873604

    申请日：2001-06-04

    申请人： Bradley Jascob ,  David Simon ,  Paul Kessman ,  Aaron Smith

    发明人： Bradley Jascob ,  David Simon ,  Paul Kessman ,  Aaron Smith

    IPC分类号： A61B505

    CPC分类号： A61B90/36 ,  A61B34/20 ,  A61B2017/00725 ,  A61B2034/2051 ,  A61B2034/2072 ,  A61B2090/0481 ,  A61B2090/376

    摘要： A method and apparatus for electromagnetic navigation of a surgical probe near a metal object. The electromagnetic navigation system includes a transmitter coil array and a shield. The transmitter coil array has a plurality of transmitter coils and is operable to generate the electromagnetic field to navigate the probe. The shield is positioned adjacent the metal object and is operable to shield the metal object from the electromagnetic field generated by the transmitter coil array, such that the shield substantially reduces distortion of the electromagnetic field by the metal object.

    摘要翻译： 一种用于在金属物体附近的外科探头的电磁导航的方法和装置。 电磁导航系统包括发射器线圈阵列和屏蔽。 发射器线圈阵列具有多个发射器线圈并且可操作以产生电磁场以导航探针。 屏蔽件邻近金属物体定位，并且可操作以将金属物体与由发射器线圈阵列产生的电磁场隔离，使得屏蔽件基本上减少金属物体的电磁场的变形。