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    Process for preparing lactate
    12.
    发明授权
    Process for preparing lactate 失效
    制备乳酸盐的方法

    公开(公告)号：US5824818A

    公开(公告)日：1998-10-20

    申请号：US698478

    申请日：1996-08-15

    申请人： Takafumi Abe ,  Toshiyuki Gotoh ,  Takako Uchiyama ,  Hirofumi Higuchi ,  Yoshikazu Shima ,  Kazuto Ikemoto

    发明人： Takafumi Abe ,  Toshiyuki Gotoh ,  Takako Uchiyama ,  Hirofumi Higuchi ,  Yoshikazu Shima ,  Kazuto Ikemoto

    IPC分类号： C07C67/20 ,  C07C69/66

    CPC分类号： C07C67/20

    摘要： A process for preparing a lactate which includes: (a) preparing lactonitrile from prussic acid and acetaldehyde, (b) hydrating the lactonitrile to form lactamide, (c) forming the desired lactate and formamide from lactamide and formate (or methanol and carbon monoxide), (d) separating and collecting components, having a lower boiling point than that of lactate from the reaction liquid in step (c), by distillation under specified conditions, and (e) dehydrating formamide from step (d) to form prussic acid and recycling the prussic acid to step (a). Heretofore, lactates had been manufactured by forming lactonitrile (cyanohydrin) from acetaldehyde and prussic acid, and then esterifying lactonitrile with a mineral acid or the like. However, in this conventional process, ammonium salts were formed as by-products in an amount equal to that of the lactate. According to the present invention, a lactate can be efficiently manufactured on a commercial scale without forming a large amount of the ammonium salts as by-products. In particular, the yield of the lactate can be increased by controlling the formation of 2-formyloxy propionate and also a dimer of a lactate.

    摘要翻译： 一种制备乳酸的方法，其包括：（a）从丙二酸和乙醛制备乳腈，（b）使乳腈水合形成乳酰胺，（c）从乳酰胺和甲酸盐（或甲醇和一氧化碳）形成所需的乳酸盐和甲酰胺， ，（d）在步骤（c）中通过蒸馏从特定条件下蒸馏分离和收集沸点低于乳酸盐的组分，并且（e）从步骤（d）中将甲酰胺脱水形成二甲苯， 将重要的酸回收到步骤（a）。 迄今为止，已经通过从乙醛和氢溴酸形成乳腈（氰醇），然后用无机酸等使乳腈酯化来制造乳酸盐。 然而，在该常规方法中，形成铵盐，其量等于乳酸盐的副产物。 根据本发明，可以以商业规模有效地制造乳酸盐，而不会形成大量的作为副产物的铵盐。 特别地，通过控制2-甲酰氧基丙酸酯和乳酸二聚体的形成可以提高乳酸产率。

    Process for producing methyl .alpha.-hydroxyisobutyrate
    13.
    发明授权
    Process for producing methyl .alpha.-hydroxyisobutyrate 失效
    制备α-羟基异丁酸甲酯的方法

    公开(公告)号：US5391813A

    公开(公告)日：1995-02-21

    申请号：US135247

    申请日：1993-10-12

    申请人： Nobuyuki Muro ,  Takafumi Abe ,  Hirofumi Higuchi

    发明人： Nobuyuki Muro ,  Takafumi Abe ,  Hirofumi Higuchi

    IPC分类号： C07B61/00 ,  C07C67/20 ,  C07C69/675

    CPC分类号： C07C67/20

    摘要： There is disclosed a process for efficiently producing methyl .alpha.-hydroxyisobutyrate from .alpha.-hydroxyisobutyramide and methyl formate by means of reaction distillation which comprises feeding .alpha.-hydroxyisobutyramide and an alkali metal hydroxide in a continuous distillation column to prepare therein the dehydrated condensate of .alpha.-hydroxyisobutyramide with the alkali metal hydroxide as the catalyst and reacting remaining .alpha.-hydroxyisobutyramide with methyl formate in the presence of the dehydrated condensate as the catalyst.According to the above process, the objective methyl .alpha.-hydroxyisobutyrate is continuously obtained in high yield and high selectivity without any operational trouble.

    摘要翻译： 公开了一种通过反应蒸馏从α-羟基异丁酰胺和甲酸甲酯有效生产α-羟基异丁酸甲酯的方法，其中包括在连续蒸馏塔中加入α-羟基异丁酰胺和碱金属氢氧化物，以制备α-羟基异丁酰胺的脱水缩合物 与碱金属氢氧化物作为催化剂，并在脱水缩合物作为催化剂存在下使残余的α-羟基异丁酰胺与甲酸甲酯反应。 根据上述方法，以高产率和高选择性连续获得目标α-羟基异丁酸甲酯，没有任何操作故障。

    Process for production of carboxylic acid ester and formamide
    14.
    发明授权
    Process for production of carboxylic acid ester and formamide 失效
    羧酸酯和甲酰胺的生产方法

    公开(公告)号：US5312966A

    公开(公告)日：1994-05-17

    申请号：US944359

    申请日：1992-09-14

    申请人： Takafumi Abe ,  Yoshiyuki Nishide ,  Nobuyuki Muro ,  Hirofumi Higuchi

    发明人： Takafumi Abe ,  Yoshiyuki Nishide ,  Nobuyuki Muro ,  Hirofumi Higuchi

    IPC分类号： B01J31/08 ,  C07B61/00 ,  C07C67/20 ,  C07C67/36 ,  C07C69/14 ,  C07C69/54 ,  C07C69/675 ,  C07C231/08 ,  C07C233/03 ,  C07C69/34 ,  C07C69/68

    CPC分类号： C07C67/20

    摘要： There is disclosed a process for efficiently producing a carboxylic acid ester and formamide by reacting a carboxylic acid amide with a formic acid ester or with an alcohol and carbon monoxide in the presence of a strongly basic anion-exchange resin. By the use of the strongly basic anion-exchange resin as the catalyst, the process of the present invention enables the efficient production of the carboxylic acid ester as well as formamide from the Carboxylic acid amide and Formic acid ester, etc. with a high selectivity under mild reaction conditions and facilitates the separation of the catalyst from the reaction product, thereby greatly enhancing the industrial significance of itself.

    摘要翻译： 公开了在强碱性阴离子交换树脂存在下，使羧酸酰胺与甲酸酯或与醇和一氧化碳反应，有效地制备羧酸酯和甲酰胺的方法。 通过使用强碱性阴离子交换树脂作为催化剂，本发明的方法能够以高选择性从羧酸酰胺和甲酸酯等有效地制备羧酸酯以及甲酰胺 在温和的反应条件下，促进了催化剂与反应产物的分离，从而大大增强了其自身的工业意义。

    Process for producing methyl methacrylate
    15.
    发明授权
    Process for producing methyl methacrylate 失效
    生产甲基丙烯酸甲酯的方法

    公开(公告)号：US5371273A

    公开(公告)日：1994-12-06

    申请号：US135066

    申请日：1993-10-12

    申请人： Yoshikazu Shima ,  Takafumi Abe ,  Hirofumi Higuchi

    发明人： Yoshikazu Shima ,  Takafumi Abe ,  Hirofumi Higuchi

    IPC分类号： B01J29/08 ,  C07B61/00 ,  C07C67/327 ,  C07C69/54 ,  C07C67/00

    CPC分类号： C07C67/327

    摘要： There is disclosed a process for producing methyl methacrylate through gas-phase catalytic reaction of methyl .alpha.-hydroxyisobutyrate which comprises feeding methanol in an amount by weight of 0.1 to 3.0 times the methyl .alpha.-hydroxyisobutyrate in a reactor along therewith and proceeding with the reaction at a reaction temperature in the range of 230.degree. to 300.degree. C. by the use of a transition-type synthetic faujasite zeolite having a specific lattice constant and a specific Na content (Na/Al) as the catalyst. The process is capable of stably producing the objective product having excellent quality in high yield for a long period of time while preventing the problems of early deterioration of the catalyst and coloring of reaction product.

    摘要翻译： 公开了一种通过甲基α-羟基异丁酸甲酯的气相催化反应生产甲基丙烯酸甲酯的方法，该方法包括在反应器中沿着反应器进料甲醇的量为0.1-3.0倍的甲基α-羟基异丁酸甲酯，并进行反应 通过使用具有特定晶格常数和特定Na含量（Na / Al）作为催化剂的过渡型合成八面沸石，反应温度在230℃至300℃的范围内。 该方法能够长期稳定地生产高质量的高品质的目标产物，同时防止催化剂的早期劣化和反应产物的着色。

    Process for producing methacrylic acid
    16.
    发明授权
    Process for producing methacrylic acid 失效
    生产甲基丙烯酸的方法

    公开(公告)号：US5225594A

    公开(公告)日：1993-07-06

    申请号：US759468

    申请日：1991-09-13

    申请人： Yoshikazu Shima ,  Takafumi Abe ,  Hirofumi Higuchi

    发明人： Yoshikazu Shima ,  Takafumi Abe ,  Hirofumi Higuchi

    IPC分类号： B01J23/34 ,  B01J23/72 ,  B01J23/755 ,  C07B61/00 ,  C07C51/377 ,  C07C57/04 ,  C07C57/065 ,  C07C67/20

    CPC分类号： C07C51/377 ,  C07C67/20 ,  Y02P20/582

    摘要： A process for producing methacrylic acid which comprises: (I) producing acetonecyanohydrin from prussic acid and acetone; (II) hydrating the acetonecyanohydrin obtained in step (I) to form .alpha.-hydroxyisobutyric acid amide; (III) reacting the .alpha.-hydroxyisobutyric acid amide obtained in step (II) with methyl formate or with methanol and carbon monoxide to form methyl .alpha.-hydroxyisobutyrate and formamide; (IV) hydrolyzing the methyl .alpha.-hydroxyisobutyrate obtained in step (III) to form .alpha.-hydroxyisobutyric acid; (V) dehydrating the .alpha.-hydroxyisobutyric acid obtained in step (IV) to form methacrylic acid; and (VI) dehydrating the formamide separated from the products obtained in step (III) to form prussic acid and recycling the prussic acid to step (I) as a starting material. The process is capable of producing methacrylic acid from readily available starting materials with a high yield and selectivity, without forming undesirable by-product or waste materials, such as ammonium sulfate.

    ULTRASONIC SENSOR DEVICE
    17.
    发明申请
    ULTRASONIC SENSOR DEVICE 有权
    超声波传感器装置

    公开(公告)号：US20140157902A1

    公开(公告)日：2014-06-12

    申请号：US14117050

    申请日：2012-06-12

    申请人： Makiko Sugiura ,  Hirofumi Higuchi

    发明人： Makiko Sugiura ,  Hirofumi Higuchi

    IPC分类号： G01S15/50

    CPC分类号： G01S15/50 ,  B06B1/0666 ,  G01S7/521

    摘要： An ultrasonic sensor device includes a substrate, a piezoelectric vibrator, and a Q-factor adjuster. The piezoelectric vibrator includes a pair of detection electrodes that face each other in a thickness direction of the substrate and a piezoelectric body interposed between the electrodes. The piezoelectric vibrator provides a membrane structure which is formed on a surface of the substrate and has rigidity lower than that of a remaining portion of the substrate. An ultrasonic wave is transmitted by the piezoelectric vibrator, and its reflected wave is received by the same piezoelectric vibrator. The Q-factor adjuster adjusts a Q-factor of the piezoelectric vibrator so that the Q-factor can be larger during a transmission period where the piezoelectric vibrator transmits the ultrasonic wave than during a reception period where the piezoelectric vibrator receives the ultrasonic wave.

    摘要翻译： 超声波传感器装置包括基板，压电振动器和Q因子调节器。 压电振子包括在基板的厚度方向上彼此相对的一对检测电极和插在电极之间的压电体。 压电振动器提供形成在基板的表面上的膜结构，其刚性低于基板的剩余部分的刚度。 超声波由压电振子传递，其反射波被同一压电振子接收。 Q因子调节器调节压电振动器的Q因子，使得压电振动器发送超声波的传播期间的Q因子可以比在压电振动器接收超声波的接收时段期间更大。

    Humanized anti-human α9-integrin antibody
    18.
    发明授权
    Humanized anti-human α9-integrin antibody 有权
    人源化抗人α9整联蛋白抗体

    公开(公告)号：US08603476B2

    公开(公告)日：2013-12-10

    申请号：US12812341

    申请日：2009-01-09

    申请人： Kenji Uehara ,  Hirofumi Higuchi ,  Toshihiro Nakashima ,  Daisuke Ishikawa ,  Nobuchika Yamamoto ,  Hirotada Fujita ,  Fumihiko Sakai

    发明人： Kenji Uehara ,  Hirofumi Higuchi ,  Toshihiro Nakashima ,  Daisuke Ishikawa ,  Nobuchika Yamamoto ,  Hirotada Fujita ,  Fumihiko Sakai

    IPC分类号： A61K39/395

    CPC分类号： C07K16/2839 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

    摘要： The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to a donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:11 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:13 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:15 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:9, and a means for the prophylaxis or treatment of various diseases involving human α9 integrin in the pathogenesis, which uses the antibody.

    摘要翻译： 本发明提供与供体小鼠抗人α9整联蛋白抗体相比具有改善的活性和/或性质的人源化抗人α9整联蛋白抗体，即包含重链可变区的人源化抗人α9整联蛋白抗体，其包含 的SEQ ID NO：11所示的氨基酸序列和由SEQ ID NO：17所示的氨基酸序列组成的轻链可变区，含有重链可变区的人源化抗人α9整联蛋白抗体包含由 由SEQ ID NO：13所示的氨基酸序列和由SEQ ID NO：17所示的氨基酸序列组成的轻链可变区，含有重链可变区的人源化抗人α9整联蛋白抗体 由SEQ ID NO：15所示的氨基酸序列和由SEQ ID NO：9所示的氨基酸序列组成的轻链可变区，以及预防或治疗涉及 人类α9整联蛋白在发病机制中使用抗体。

    Physical quantity sensor
    19.
    发明申请
    Physical quantity sensor 审中-公开
    物理量传感器

    公开(公告)号：US20090100931A1

    公开(公告)日：2009-04-23

    申请号：US12232120

    申请日：2008-09-11

    申请人： Hirofumi Higuchi

    发明人： Hirofumi Higuchi

    IPC分类号： G01P15/125

    CPC分类号： G01P15/125 ,  G01P15/131

    摘要： A physical quantity sensor has a weight mass movable in a detection direction. Auxiliary capacitors are formed at both side ends of the weight mass in a non-detection direction by auxiliary movable electrodes and auxiliary fixed electrodes, respectively. When capacitances of the auxiliary capacitors change due to movement of the weight mass in the non-detection direction, a limiter circuit feedback-controls voltages applied to the auxiliary fixed electrodes to maintain the position of the weight mass unchanged. Thus, the weight mass is limited from moving in the non-detection direction thereby to improve accuracy in detection of the movement in the detection direction.

    摘要翻译： 物理量传感器具有在检测方向上可移动的重量。 辅助电容器分别通过辅助可动电极和辅助固定电极在非检测方向上形成在重量块的两侧。 当辅助电容器的电容由于重量质量在非检测方向的移动而变化时，限制器电路对施加到辅助固定电极的电压进行反馈控制，以保持重量质量的位置不变。 因此，重量质量被限制为在非检测方向上移动，从而提高检测方向上的运动的检测精度。