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公开(公告)号：US06235740B1
公开(公告)日：2001-05-22
申请号：US09097338
申请日：1998-06-15
申请人： Joel C. Barrish , Ping Chen , Jagabandhu Das , Edwin J. Iwanowicz , Derek J. Norris , Ramesh Padmanabha , Jacques Y. Roberge , Gary L. Schieven
发明人： Joel C. Barrish , Ping Chen , Jagabandhu Das , Edwin J. Iwanowicz , Derek J. Norris , Ramesh Padmanabha , Jacques Y. Roberge , Gary L. Schieven
IPC分类号： C07D48704
CPC分类号： C07D487/04 , A61K31/4985 , C07D491/14
摘要： Novel imidazoquinoxalines and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic disorders.
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公开(公告)号：US08106021B2
公开(公告)日：2012-01-31
申请号：US12917367
申请日：2010-11-01
申请人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
发明人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
CPC分类号： C07H7/04 , C07D309/10 , C07D407/12
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译： 提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。 本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。
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公开(公告)号：US07838499B2
公开(公告)日：2010-11-23
申请号：US12197095
申请日：2008-08-22
申请人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
发明人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
CPC分类号： C07H7/04 , C07D309/10 , C07D407/12
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译： 提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。 本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。
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公开(公告)号：US20140011754A9
公开(公告)日：2014-01-09
申请号：US13158724
申请日：2011-06-13
申请人： Ge Xu , Binhua Lv , Brian Seed , Jacques Y. Roberge
发明人： Mengzhuang Cai , Qian Liu , Ge Xu , Binhua Lv , Brian Seed , Jacques Y. Roberge
IPC分类号： A61K31/7034 , C07H1/06 , A61P3/10 , A61P5/48 , A61P3/00 , A61P35/00 , A61P7/00 , A61P3/04 , A61P7/10 , A61P3/06 , A61P9/04 , A61P9/10 , C07H7/04 , A61P9/12
CPC分类号： C07H1/06 , C07D309/10 , C07H7/04
摘要： Provided are crystalline forms of a compound having an inhibitory effect on sodium-dependent glucose cotransporter SGLT2. The invention also provides pharmaceutical compositions, methods of preparing the crystalline compound, and methods of using the crystalline compound, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT or SGLT2 inhibition.
摘要翻译： 提供对钠依赖性葡萄糖转运体SGLT2具有抑制作用的化合物的结晶形式。 本发明还提供药物组合物，制备结晶化合物的方法，以及独立地或与其它治疗剂组合使用结晶化合物治疗受SGLT或SGLT2抑制影响的疾病和病症的方法。
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公开(公告)号：US20100063141A1
公开(公告)日：2010-03-11
申请号：US12503384
申请日：2009-07-15
申请人： Brian Seed , Binhua LV , Jacques Y. Roberge , Yuanwei Chen , Kun Peng , Jiajia Dong , Baihua Xu , Jiyan Du , Lili Zhang , Xinxing Tang , Ge Xu , Yan Feng , Min Xu
发明人： Brian Seed , Binhua LV , Jacques Y. Roberge , Yuanwei Chen , Kun Peng , Jiajia Dong , Baihua Xu , Jiyan Du , Lili Zhang , Xinxing Tang , Ge Xu , Yan Feng , Min Xu
IPC分类号： A61K31/35 , C07D315/00 , C07C15/16
CPC分类号： A61K45/06 , A61K31/35 , C07D309/10 , A61K2300/00
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions that are affected by SGLT inhibition.
摘要翻译： 提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。 本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用该化合物用于治疗受SGLT抑制影响的疾病和病症的方法。
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公开(公告)号：US20090118201A1
公开(公告)日：2009-05-07
申请号：US12197095
申请日：2008-08-22
申请人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
发明人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
IPC分类号： A61K31/7028 , C07H7/04 , C07H7/06 , A61P3/10
CPC分类号： C07H7/04 , C07D309/10 , C07D407/12
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译： 提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。 本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。
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公开(公告)号：US08987323B2
公开(公告)日：2015-03-24
申请号：US13158724
申请日：2011-06-13
申请人： Mengzhuang Cai , Qian Liu , Ge Xu , Binhua Lv , Brian Seed , Jacques Y. Roberge
发明人： Mengzhuang Cai , Qian Liu , Ge Xu , Binhua Lv , Brian Seed , Jacques Y. Roberge
IPC分类号： A01N43/16 , A61K31/35 , A01N43/02 , A61K31/335 , A01N43/00 , A61K31/33 , C07D315/00 , C07D309/10
CPC分类号： C07H1/06 , C07D309/10 , C07H7/04
摘要： Provided are crystalline forms of a compound having an inhibitory effect on sodium-dependent glucose cotransporter SGLT2. The invention also provides pharmaceutical compositions, methods of preparing the crystalline compound, and methods of using the crystalline compound, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT or SGLT2 inhibition.
摘要翻译： 提供对钠依赖性葡萄糖转运体SGLT2具有抑制作用的化合物的结晶形式。 本发明还提供药物组合物，制备结晶化合物的方法，以及独立地或与其它治疗剂组合使用结晶化合物治疗受SGLT或SGLT2抑制影响的疾病和病症的方法。
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公开(公告)号：US20120238510A1
公开(公告)日：2012-09-20
申请号：US13158724
申请日：2011-06-13
申请人： Mengzhuang Cai , Qian Liu , Ge Xu , Binhua Lv , Brian Seed , Jacques Y. Roberge
发明人： Mengzhuang Cai , Qian Liu , Ge Xu , Binhua Lv , Brian Seed , Jacques Y. Roberge
IPC分类号： A61K31/7034 , C07H1/06 , A61P3/10 , A61P5/48 , A61P3/00 , A61P35/00 , A61P7/00 , A61P3/04 , A61P7/10 , A61P3/06 , A61P9/04 , A61P9/10 , C07H7/04 , A61P9/12
CPC分类号： C07H1/06 , C07D309/10 , C07H7/04
摘要： Provided are crystalline forms of a compound having an inhibitory effect on sodium-dependent glucose cotransporter SGLT2. The invention also provides pharmaceutical compositions, methods of preparing the crystalline compound, and methods of using the crystalline compound, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT or SGLT2 inhibition.
摘要翻译： 提供对钠依赖性葡萄糖转运体SGLT2具有抑制作用的化合物的结晶形式。 本发明还提供药物组合物，制备结晶化合物的方法，以及独立地或与其它治疗剂组合使用结晶化合物治疗受SGLT或SGLT2抑制影响的疾病和病症的方法。
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19.发明授权Urea antagonists of P2Y1receptor useful in the treatment of thrombotic conditions 有权P2Y1受体的尿素拮抗剂可用于治疗血栓形成公开(公告)号：US07674828B2
公开(公告)日：2010-03-09
申请号：US12117005
申请日：2008-05-08
申请人： Hannguang J. Chao , Huji Tuerdi , Timothy F. Herpin , Jacques Y. Roberge , Yalei Liu , Michael R. Lawrence , Robert P. Rehfuss , Charles G. Clark , Jennifer X. Qiao , Timur Gungor , Patrick Y. S. Lam , Tammy C. Wang , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Gilles Bouthillier , Dora M. Schnur
发明人： Hannguang J. Chao , Huji Tuerdi , Timothy F. Herpin , Jacques Y. Roberge , Yalei Liu , Michael R. Lawrence , Robert P. Rehfuss , Charles G. Clark , Jennifer X. Qiao , Timur Gungor , Patrick Y. S. Lam , Tammy C. Wang , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Gilles Bouthillier , Dora M. Schnur
IPC分类号： A61K31/155 , C07C275/28
CPC分类号： C07D409/14 , C07C275/30 , C07C275/32 , C07D213/40 , C07D213/75 , C07D213/89 , C07D231/40 , C07D231/50 , C07D237/22 , C07D333/36 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07F7/1804
摘要： The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
摘要翻译： 本发明提供了作为人P2Y1受体的选择性抑制剂的新颖的吡啶基或苯基脲及其类似物。 本发明还提供了相同的各种药物组合物以及治疗对P2Y1受体活性调节作用的疾病的方法。
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公开(公告)号：US07470712B2
公开(公告)日：2008-12-30
申请号：US11038862
申请日：2005-01-19
申请人： Timothy F. Herpin , George C. Morton , Robert P. Rehfuss , R. Michael Lawrence , Michael A. Poss , Jacques Y. Roberge , Timur Gungor
发明人： Timothy F. Herpin , George C. Morton , Robert P. Rehfuss , R. Michael Lawrence , Michael A. Poss , Jacques Y. Roberge , Timur Gungor
IPC分类号： A61K31/4439 , C07D401/12
CPC分类号： C07D401/12 , C07D235/30 , C07D401/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/04 , C07D513/04
摘要： The present invention provides novel amino-benzazoles and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
摘要翻译： 本发明提供了新的氨基 - 苯并唑类似物，它们是人P2Y1受体的选择性抑制剂。 本发明还提供了相同的各种药物组合物以及治疗对P2Y1受体活性调节作用的疾病的方法。
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