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11.发明授权Methods and apparatus for creating particle derivatives of HDL with reduced lipid content 有权用于产生脂质含量降低的HDL颗粒衍生物的方法和装置公开(公告)号：US08637460B2
公开(公告)日：2014-01-28
申请号：US13601131
申请日：2012-08-31
申请人： Marc Bellotti , H. Bryan Brewer, Jr. , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
发明人： Marc Bellotti , H. Bryan Brewer, Jr. , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
CPC分类号： C07K14/775 , A61K9/1275 , A61K31/685 , A61K38/1709 , B01D11/0492 , B01D15/00 , B01D15/426 , G01N33/92 , A61K2300/00
摘要： The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.
摘要翻译： 本发明涉及用于产生HDL的至少一种形式的衍生物而不显着影响LDL的系统，装置和方法。 HDL的这些衍生物是具有降低的脂质含量的颗粒，特别是降低的胆固醇含量。 这些颗粒具有结合胆固醇的能力，并且给予患者以增强细胞，胆固醇的流出并降低细胞，组织，器官和血管中的胆固醇水平。 本发明方法可用于治疗动脉粥样化性血管疾病，并且可与其他治疗如他汀类，胆固醇吸收抑制剂，烟酸，抗炎药，运动和饮食限制组合。
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12.发明授权Methods and apparatus for creating particle derivatives of HDL with reduced lipid content 有权用于产生脂质含量降低的HDL颗粒衍生物的方法和装置公开(公告)号：US08268787B2
公开(公告)日：2012-09-18
申请号：US13222287
申请日：2011-08-31
申请人： Marc Bellotti , H. Bryan Brewer, Jr. , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
发明人： Marc Bellotti , H. Bryan Brewer, Jr. , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
CPC分类号： C07K14/775 , A61K9/1275 , A61K31/685 , A61K38/1709 , B01D11/0492 , B01D15/00 , B01D15/426 , G01N33/92 , A61K2300/00
摘要： The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.
摘要翻译： 本发明涉及用于产生HDL的至少一种形式的衍生物而不显着影响LDL的系统，装置和方法。 HDL的这些衍生物是具有降低的脂质含量的颗粒，特别是降低的胆固醇含量。 这些颗粒具有结合胆固醇的能力，并且给予患者以增强细胞，胆固醇的流出并降低细胞，组织，器官和血管中的胆固醇水平。 本方法可用于治疗动脉粥样硬化性血管疾病，并可与其他疗法（如他汀类药物，胆固醇吸收抑制剂，烟酸，抗炎药，运动和饮食限制）结合使用。
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13.发明申请Modified Viral Particles with Immunogenic Properties and Reduced Lipid Content Useful for Treating and Preventing Infectious Diseases 审中-公开用于治疗和预防传染病的具有免疫原性和降低脂质含量的改性病毒颗粒公开(公告)号：US20080267997A1
公开(公告)日：2008-10-30
申请号：US12118335
申请日：2008-05-09
申请人： Bill E. Cham , Jo-Ann B. Maltais , Marc Bellotti
发明人： Bill E. Cham , Jo-Ann B. Maltais , Marc Bellotti
CPC分类号： A61K39/292 , A61K39/12 , A61K39/29 , A61K2039/5252 , A61K2039/55566 , A61K2039/57 , A61L2/0011 , A61L2/0088 , A61M1/3486 , C12N7/00 , C12N2730/10134 , C12N2730/10163 , C12N2740/15034 , C12N2740/15063 , C12N2770/20034 , C12N2770/24063 , C12N2770/24334 , C12N2770/24363
摘要： The present invention relates to a method for reducing the occurrence and severity of infectious diseases, especially infectious diseases in which lipid-containing infectious viral organisms are found in biological fluids, such as blood. The present invention employs solvents useful for extracting lipids from the lipid-containing infectious viral organism thereby creating modified viral particles with reduced infectivity and enhanced antigenicity. The present invention provides vaccine compositions, comprising these modified viral particles with reduced infectivity and enhanced antigenicity, optionally combined with a pharmaceutically acceptable carrier or an immunostimulant. The vaccine composition is administered to a patient to provide protection against the lipid-containing infectious viral organism. The vaccine compositions of the present invention include combination vaccines of modified viral particles obtained from one or more strains of a virus and/or one or more types of virus.
摘要翻译： 本发明涉及一种减少感染性疾病，特别是感染性疾病的发生和严重性的方法，其中在生物流体如血液中发现含有脂质的感染性病毒生物。 本发明使用可用于从含脂质感染性病毒生物体提取脂质的溶剂，从而产生具有降低的感染性和增强的抗原性的改性病毒颗粒。 本发明提供疫苗组合物，其包含具有降低的感染性和增强的抗原性的这些经修饰的病毒颗粒，任选与药学上可接受的载体或免疫刺激剂组合。 将疫苗组合物施用于患者以提供针对含脂质感染性病毒生物体的保护。 本发明的疫苗组合物包括由一种或多种病毒株和/或一种或多种病毒获得的经修饰的病毒颗粒的组合疫苗。
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14.发明申请公开(公告)号：US20050090444A1
公开(公告)日：2005-04-28
申请号：US10996570
申请日：2004-11-23
申请人： Marc Bellotti , H. Brewer , Hassibullah Akeefe , Adam Conner , Timothy Perlman
发明人： Marc Bellotti , H. Brewer , Hassibullah Akeefe , Adam Conner , Timothy Perlman
CPC分类号： G01N33/92 , A61K9/1275 , A61K38/1709 , C07K14/775 , A61K2300/00
摘要： The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.
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15.发明申请Modified viral particles with immunogenic properties and reduced lipid content useful for treating and preventing infectious diseases 失效具有免疫原性和改善的脂质含量的改良的病毒颗粒可用于治疗和预防感染性疾病公开(公告)号：US20050032222A1
公开(公告)日：2005-02-10
申请号：US10873015
申请日：2004-06-21
申请人： Bill Cham , Jo-Ann Maltais , Marc Bellotti
发明人： Bill Cham , Jo-Ann Maltais , Marc Bellotti
CPC分类号： A61K39/292 , A61K39/12 , A61K39/29 , A61K2039/5252 , A61K2039/55566 , A61K2039/57 , A61L2/0011 , A61L2/0088 , A61M1/3486 , C12N7/00 , C12N2730/10134 , C12N2730/10163 , C12N2740/15034 , C12N2740/15063 , C12N2770/20034 , C12N2770/24063 , C12N2770/24334 , C12N2770/24363
摘要： The present invention relates to a method for reducing the occurrence and severity of infectious diseases, especially infectious diseases in which lipid-containing infectious viral organisms are found in biological fluids, such as blood. The present invention employs solvents useful for extracting lipids from the lipid-containing infectious viral organism thereby creating modified viral particles with reduced infectivity and enhanced antigenicity. The present invention provides vaccine compositions, comprising these modified viral particles with reduced infectivity and enhanced antigenicity, optionally combined with a pharmaceutically acceptable carrier or an immunostimulant. The vaccine composition is administered to a patient to provide protection against the lipid-containing infectious viral organism. The vaccine compositions of the present invention include combination vaccines of modified viral particles obtained from one or more strains of a virus and/or one or more types of virus.
摘要翻译： 本发明涉及一种减少感染性疾病，特别是感染性疾病的发生和严重性的方法，其中在生物流体例如血液中发现含有脂质的感染性病毒生物。 本发明使用可用于从含脂质感染性病毒生物体提取脂质的溶剂，从而产生具有降低的感染性和增强的抗原性的改性病毒颗粒。 本发明提供疫苗组合物，其包含具有降低的感染性和增强的抗原性的这些经修饰的病毒颗粒，任选与药学上可接受的载体或免疫刺激剂组合。 将疫苗组合物施用于患者以提供针对含脂质感染性病毒生物体的保护。 本发明的疫苗组合物包括由一种或多种病毒株和/或一种或多种病毒获得的经修饰的病毒颗粒的组合疫苗。
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公开(公告)号：US5836933A
公开(公告)日：1998-11-17
申请号：US666190
申请日：1996-06-19
CPC分类号： A61J1/10
摘要： A parenteral fluid delivery bag having a line set formed integral with the bag, the line set being peelably releasable from the remainder of the bag so as to assume a deployed position adapted to enter into fluid communication with a patient. In an alternate embodiment, a plurality of bags connected by an integrally formed wye-junction are adapted for delivery to a patient and retrieval of fluid from a patient.
摘要翻译： 一种肠胃外流体输送袋，其具有与所述袋一体形成的线组，所述线组可从所述袋的其余部分可剥离地释放，以便呈现适于与患者进行流体连通的展开位置。 在替代实施例中，通过整体形成的Y形接头连接的多个袋适于递送到患者并从患者回收流体。
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公开(公告)号：US4738668A
公开(公告)日：1988-04-19
申请号：US527604
申请日：1983-08-29
CPC分类号： A61M39/16 , A61M2039/1027 , Y10S604/905
摘要： A pair of separate conduits, each having an internal seal zone, may be joined by the method which comprises sealingly joining the ends of the conduits together; thereafter adding an antiseptic into the area of the joined conduits between internal seals formed in the zones; and then opening said internal seals without separating the conduits to permit internal fluid flow through the joined conduits.
摘要翻译： 每个具有内部密封区域的一对单独的导管可以通过包括将导管的端部密封地接合在一起的方法连接; 然后在形成在所述区域中的内部密封件之间的所述连接导管区域中加入防腐剂; 然后打开所述内部密封件而不分离导管，以允许内部流体流过连接的导管。
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公开(公告)号：US4596571A
公开(公告)日：1986-06-24
申请号：US734363
申请日：1985-05-14
申请人： Marc Bellotti , Randy K. Murphey
发明人： Marc Bellotti , Randy K. Murphey
CPC分类号： A61M39/1011 , A61M2039/1066
摘要： A protective shroud for a connection site also strengthens the connection site by restraining movement of the connection site in a manner which would cause its separation. One end of the protective shroud is buttressed to resist yielding in response to forces acting upon the connection site. When an oversized connection site is inserted into the shroud, the shroud provides a camming action which compresses the connection site to a length which securely nests within the shroud.
摘要翻译： 用于连接部位的保护罩还可以通过以使其分离的方式限制连接部位的移动来加强连接部位。 保护罩的一端被支撑以抵抗作用在连接部位上的力的屈服。 当超大的连接部位插入护罩时，护罩提供凸轮动作，将连接部位压缩到安全地嵌套在护罩内的长度。
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公开(公告)号：US4473369A
公开(公告)日：1984-09-25
申请号：US338712
申请日：1982-01-11
CPC分类号： A61M39/1011 , A61M39/16 , A61M39/287 , A61M1/28 , A61M2039/1066 , Y10S604/905
摘要： A system is provided for connection of a transfer spike on the end of a tube with another tube, in which the connection portions may be ultraviolet sterilized prior to connection. Both the spike and the tube for connection communicate with a housing member having a tubular, collapsible sheath member which is ultraviolet transparent. Also, a clamping system may be provided for closing flow through the system.
摘要翻译： 提供了一种系统，用于将管的端部上的传送尖钉与另一个管连接，其中连接部分可以在连接之前被紫外线消毒。 尖头和用于连接的管都与具有紫外透明的管状可折叠护套构件的壳体构件连通。 而且，可以提供夹紧系统来封闭通过系统的流动。
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公开(公告)号：US4141834A
公开(公告)日：1979-02-27
申请号：US851663
申请日：1977-11-15
申请人： Marc Bellotti , William J. Schnell
发明人： Marc Bellotti , William J. Schnell
CPC分类号： A61M1/16 , B01D61/28 , B01D61/32 , Y10S210/929
摘要： An improved valving system is provided in a dialysis system in which the dialysis solution flow path through the dialyzer may be sealed off adjacent the inlet and outlet of the dialyzer, with the pumped dialysis solution being shunted so that the pump and heater do not need to be turned off. As ultrafiltration takes place over a predetermined period of time, it can be directly measured by monitoring the liquid level of a reservoir connected to the sealed portion of the dialysis solution flow path.
摘要翻译： 在透析系统中提供改进的阀门系统，其中通过透析器的透析溶液流动路径可以在透析器的入口和出口附近被密封，泵送的透析溶液被分流，使得泵和加热器不需要 关闭 由于在预定的时间段内进行超滤，所以可以通过监测连接到透析液流路的密封部分的储液器的液面来直接测量。
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