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11.发明授权Peptide-forming enzyme gene, peptide-forming enzyme, and peptide producing method 失效肽形成酶基因，肽形成酶和肽生产方法公开(公告)号：US07618796B2
公开(公告)日：2009-11-17
申请号：US11589842
申请日：2006-10-31
IPC分类号： C12P21/02
CPC分类号： C12P21/02 , C07K5/06026 , C12N9/48
摘要： The present invention provides a method for producing dipeptide using inexpensively acquirable starting materials by an industrially advantageous and simple pathway. Dipeptide is produced from L-amino acid ester and L-amino acid using a culture of microbes having the ability to produce a dipeptide from an L-amino acid ester and an L-amino acid, using microbial cells isolated from the culture, or a treated microbial cell product of the microbe.
摘要翻译： 本发明提供了通过工业上有利且简单的途径使用廉价可获得的原料生产二肽的方法。 使用从培养物分离的微生物细胞，使用从L-氨基酸酯和L-氨基酸产生二肽的微生物培养物，由L-氨基酸酯和L-氨基酸产生二肽，或 处理微生物细菌产物。
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公开(公告)号：US20060263861A1
公开(公告)日：2006-11-23
申请号：US11419522
申请日：2006-05-22
CPC分类号： C12P13/04 , C12N9/1014
摘要： A method for producing β-hydroxy amino acid and its optically-active isomer is provided. The β-hydroxy amino acid is produced by reacting a predetermined D-α-amino acid and 5,10-methylene tetrahydrofolic acid in the presence of an enzyme derived from a microorganism belonging to the genera Paracoccus, Aminobacter, or Ensifer.
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公开(公告)号：US07745182B2
公开(公告)日：2010-06-29
申请号：US12345922
申请日：2008-12-30
CPC分类号： C12P13/04 , C12N9/1014
摘要： A method for producing β-hydroxy amino acid and its optically-active isomer is provided. The β-hydroxy amino acid is produced by reacting a predetermined D-α-amino acid and 5,10-methylene tetrahydrofolic acid in the presence of an enzyme derived from a microorganism belonging to the genera Paracoccus, Aminobacter, or Ensifer.
摘要翻译： 提供了一种生产β-羟基氨基酸及其光学活性异构体的方法。 β-羟基氨基酸通过使预定的D-α-氨基酸和5,10-亚甲基四氢叶酸在衍生自属于副球菌属，氨基杆菌属或Ensifer属的微生物的酶存在下反应来制备。
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公开(公告)号：US07556947B2
公开(公告)日：2009-07-07
申请号：US12345887
申请日：2008-12-30
CPC分类号： C12P13/04 , C12N9/1014
摘要： A method for producing β-hydroxy amino acid and its optically-active isomer is provided. The β-hydroxy amino acid is produced by reacting a predetermined D-α-amino acid and 5,10-methylene tetrahydrofolic acid in the presence of an enzyme derived from a microorganism belonging to the genera Paracoccus, Aminobacter, or Ensifer.
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15.发明申请Recombinant DNA having hydantoinase gene and carbamylase gene and process for producing amino acid 审中-公开具有乙内酰脲酶基因和氨基甲酰酶基因的重组DNA及其生产氨基酸的方法公开(公告)号：US20050112729A1
公开(公告)日：2005-05-26
申请号：US10961116
申请日：2004-10-12
摘要： The object of the present invention is to prepare a recombinant DNA efficiently co-expressing genes of enzymes such as HHase, and to produce an amino acid efficiently from hydantoin by utilizing such a recombinant DNA. The present invention provides a recombinant DNA having base sequences encoding the following gene regions (I) and (II) incorporated therein in a predetermined direction and in a predetermined order to produce an amino acid efficiently: (I) a gene region containing a base sequence encoding a hydantoinase gene and a trp promoter sequence located upstream of the base sequence encoding the hydantoinase gene regulating expression of the hydantoinase gene, and (II) a gene region containing a base sequence encoding a carbamylase gene and a trp promoter sequence located upstream of the base sequence encoding the carbamylase gene regulating expression of the carbamylase gene.
摘要翻译： 本发明的目的是制备有效共同表达诸如HHase的酶的基因的重组DNA，并通过利用这种重组DNA从乙内酰脲有效地产生氨基酸。 本发明提供一种具有编码下述基因区（I）和（II）的碱基序列的重组DNA，其特征在于，在规定的方向和规定的顺序中并入其中，以有效地产生氨基酸：（I）含有碱基序列 编码乙内酰脲酶基因和位于编码修饰乙内酰脲酶基因表达的乙内酰脲酶基因的碱基序列上游的trp启动子序列，以及（II）含有编码氨基甲酰化酶基因的碱基序列和位于上游的trp启动子序列的基因区域 编码调节氨基甲酰酶基因表达的氨基甲酰酶基因的碱基序列。
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公开(公告)号：US07851187B2
公开(公告)日：2010-12-14
申请号：US11942873
申请日：2007-11-20
CPC分类号： C12N9/1014 , C12P13/06 , C12Y201/02001
摘要： The present invention provides a new method for producing serine derivatives and their optically-activated derivatives in a convenient manner. In the presence of an enzyme, an L-α-amino acid of formula (I): (in the formula (I), R1 is a hydrocarbon group) is reacted with an aldehyde of formula (II): (in the formula (II), R2 is a hydrocarbon) to produce an L-serine derivative of formula (III). .
摘要翻译： 本发明提供了以方便的方式制备丝氨酸衍生物及其光活性衍生物的新方法。 在酶的存在下，式（I）:(式（I）中的R 1为烃基）的式（I）的L-α-氨基酸与式（II）的醛反应：（在式 II），R 2为烃），得到式（III）的L-丝氨酸衍生物。 。
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17.发明申请公开(公告)号：US20090112019A1
公开(公告)日：2009-04-30
申请号：US12345922
申请日：2008-12-30
IPC分类号： C07C227/16
CPC分类号： C12P13/04 , C12N9/1014
摘要： A method for producing β-hydroxy amino acid and its optically-active isomer is provided. The β-hydroxy amino acid is produced by reacting a predetermined D-α-amino acid and 5,10-methylene tetrahydrofolic acid in the presence of an enzyme derived from a microorganism belonging to the genera Paracoccus, Aminobacter, or Ensifer.
摘要翻译： 提供了生产β-羟基氨基酸及其光学活性异构体的方法。 β羟基氨基酸是通过使预定的D-α-氨基酸和5,10-亚甲基四氢叶酸在衍生自属于副球菌属，氨基杆菌属或Ensifer属的微生物的酶存在下反应生成的。
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公开(公告)号：US20090170171A1
公开(公告)日：2009-07-02
申请号：US11942873
申请日：2007-11-20
CPC分类号： C12N9/1014 , C12P13/06 , C12Y201/02001
摘要： The present invention provides a new method for producing serine derivatives and their optically-activated derivatives in a convenient manner. In the presence of an enzyme, an L-α-amino acid of formula (I): (in the formula (I), R1 is a hydrocarbon group) is reacted with an aldehyde of formula (II): (in the formula (II), R2 is a hydrocarbon) to produce an L-serine derivative of formula (III).
摘要翻译： 本发明提供了以方便的方式制备丝氨酸衍生物及其光活性衍生物的新方法。 在酶的存在下，式（I）:(式（I）中的R 1为烃基）的式（I）的L-α-氨基酸与式（II）的醛反应：（在式 II），R 2为烃），得到式（III）的L-丝氨酸衍生物。
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公开(公告)号：US20050214912A1
公开(公告)日：2005-09-29
申请号：US11091892
申请日：2005-03-29
申请人： Hiroyuki Nozaki , Kunihiko Watanabe
发明人： Hiroyuki Nozaki , Kunihiko Watanabe
CPC分类号： C12P13/225
摘要： A method for producing an optically active amino acid comprising contacting a 5-substituted hydantoin with a group of enzymes including both a hydantoinase and a carbamoylase, wherein the method is carried out in an aqueous solution with a dissolved oxygen concentration of 1.5 ppm or less. Optically active amino acids such as D-tyrosine may be produced with high efficiency.
摘要翻译： 一种光学活性氨基酸的制造方法，其特征在于，将5-取代的乙内酰脲与包括乙内酰脲酶和氨甲酰基酶的酶组合，其中所述方法在溶解氧浓度为1.5ppm以下的水溶液中进行。 可以高效率地生产D-酪氨酸等光活性氨基酸。
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公开(公告)号：US20090111150A1
公开(公告)日：2009-04-30
申请号：US12345887
申请日：2008-12-30
IPC分类号： C12P13/04
CPC分类号： C12P13/04 , C12N9/1014
摘要： A method for producing β-hydroxy amino acid and its optically-active isomer is provided. The β-hydroxy amino acid is produced by reacting a predetermined D-α-amino acid and 5,10-methylene tetrahydrofolic acid in the presence of an enzyme derived from a microorganism belonging to the genera Paracoccus, Aminobacter, or Ensifer.
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