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公开(公告)号：US20240383944A1
公开(公告)日：2024-11-21
申请号：US18526685
申请日：2023-12-01
Applicant: Massachusetts Institute of Technology
Inventor： Mark David Simon , Bradley L. Pentelute , Andrea Adamo , Patrick Louis Heider , Klavs F. Jensen
Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.
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公开(公告)号：US11878996B2
公开(公告)日：2024-01-23
申请号：US17127951
申请日：2020-12-18
Applicant: Massachusetts Institute of Technology
Inventor： Mark David Simon , Bradley L. Pentelute , Andrea Adamo , Patrick Louis Heider , Klavs F. Jensen
CPC classification number: C07K1/045 , B01J8/00 , B01J19/00 , B01J19/0053 , C07K1/04 , C07K1/042 , C07K1/061 , C07K1/08
Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.
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公开(公告)号：US20210188899A1
公开(公告)日：2021-06-24
申请号：US17127951
申请日：2020-12-18
Applicant: Massachusetts Institute of Technology
Inventor： Mark David Simon , Bradley L. Pentelute , Andrea Adamo , Patrick Louis Heider , Klavs F. Jensen
Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.
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公开(公告)号：US10889613B2
公开(公告)日：2021-01-12
申请号：US15602056
申请日：2017-05-22
Applicant: Massachusetts Institute of Technology
Inventor： Mark David Simon , Bradley L. Pentelute , Andrea Adamo , Patrick Louis Heider , Klavs F. Jensen
Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.
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公开(公告)号：US09927038B2
公开(公告)日：2018-03-27
申请号：US14420683
申请日：2013-08-09
Applicant: Massachusetts Institute of Technology
Inventor： Andrea Adamo , Alexander P. Clayton , Patrick Louis Heider , Nopphon Weeranoppanant , Klavs F. Jensen
CPC classification number: F16K15/14 , B01L3/502723 , B01L3/502738 , B01L2200/0673 , B01L2200/0684 , B01L2300/0681 , B01L2300/0864 , B01L2300/0874 , B01L2400/0487 , B01L2400/0655 , F16K99/0015 , F16K99/0057 , Y10T137/7793 , Y10T137/87249
Abstract: Pressure control in fluidic systems is generally described. In some cases, a system comprises a fluid-permeable (e.g., liquid-permeable) medium and a pressure regulator. The medium and the pressure regulator can be positioned between a first fluidic channel and a second fluidic channel. The medium is arranged, in certain cases, such that fluid (e.g., liquid) can be transported from the first fluidic channel, through the medium, and into the second fluidic channel. In certain cases, when a first pressure within the first fluidic channel is below a sum of the permeability pressure differential of the medium with respect to the fluid and a second pressure within the second fluidic channel, the fluid is substantially prevented from being transported through an outlet of the first fluidic channel.
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Patent Agency Ranking
公开(公告)号：US20180066012A1
公开(公告)日：2018-03-08
申请号：US15695795
申请日：2017-09-05
Applicant: Massachusetts Institute of Technology
Inventor： Mark David Simon , Bradley L. Pentelute , Andrea Adamo , Patrick Louis Heider , Klavs F. Jensen
Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.
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公开(公告)号：US20160102118A1
公开(公告)日：2016-04-14
申请号：US14853683
申请日：2015-09-14
Applicant: Massachusetts Institute of Technology
Inventor： Mark David Simon , Bradley L. Pentelute , Andrea Adamo , Patrick Louis Heider , Klavs F. Jensen
Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.
Abstract translation: 通常描述用于进行固相肽合成的系统和方法。 固相肽合成是将已经固定在固体支持物上的肽加入氨基酸残基的已知方法。 在某些实施方案中，本发明的系统和方法可用于快速进行固相肽合成，同时保持高产率。 某些实施方案涉及可用于以减少进行固相肽合成所需时间量的方式加热，运输和/或混合试剂的方法和系统。
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公开(公告)号：US20160031931A1
公开(公告)日：2016-02-04
申请号：US14776870
申请日：2014-02-24
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： Mark David Simon , Bradley L. Pentelute , Andrea Adamo , Patrick Louis Heider , Klavs F. Jensen
Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.
Abstract translation: 通常描述用于进行固相肽合成的系统和方法。 固相肽合成是将已经固定在固体支持物上的肽加入氨基酸残基的已知方法。 在某些实施方案中，本发明的系统和方法可用于快速进行固相肽合成，同时保持高产率。 某些实施方案涉及可用于以减少进行固相肽合成所需时间量的方式加热，运输和/或混合试剂的方法和系统。
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公开(公告)号：US20230174572A1
公开(公告)日：2023-06-08
申请号：US17747952
申请日：2022-05-18
Applicant: Massachusetts Institute of Technology
Inventor： Dale Arlington Thomas, III , Alexander James Mijalis , Bradley L. Pentelute , Mark David Simon , Andrea Adamo , Patrick Louis Heider , Klavs F. Jensen
CPC classification number: C07K1/084 , B01J19/24 , C07K1/045 , C07K7/06 , C07K14/47 , C07K14/60 , C07K14/61 , C07K14/62 , B01J2219/24
Abstract: Methods and system for solid phase peptide synthesis are provided. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. New amino acid residues are added via a coupling reaction between an activated amino acid and an amino acid residue of the immobilized peptide. Amino acids may be activated using, e.g., a base and an activating agent. Certain inventive concepts, described herein, relate to methods and systems for the activation of amino acids. These systems and methods may allow for fewer side reactions and a higher yield compared to conventional activation techniques as well as the customization of the coupling reaction on a residue-by-residue basis without the need for costly and/or complex processes.
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公开(公告)号：US11185839B2
公开(公告)日：2021-11-30
申请号：US16098333
申请日：2017-05-02
Applicant: Massachusetts Institute of Technology
Inventor： Andrea Adamo , Dale Arlington Thomas, III , Klavs F. Jensen , Timothy F. Jamison , Aaron A. Bedermann , Kosisochukwu C. Aroh
Abstract: The instant disclosure is related to fluidic distributors, fluidic systems, and associated methods and articles. Certain embodiments are related to fluidic distributors that comprise bays including fluidic connections with relative positions that substantially correspond to each other. In some embodiments, a fluidic distributor may comprise bays with electrical interfaces with relative positions that substantially correspond to each other.
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