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11.发明授权公开(公告)号：US06915678B2
公开(公告)日：2005-07-12
申请号：US10422713
申请日：2003-04-25
申请人： Maximilian Fleischer , Hans Meixner , Bernhard Ostrick , Roland Pohle , Elfriede Simon , Martin Zimmer
发明人： Maximilian Fleischer , Hans Meixner , Bernhard Ostrick , Roland Pohle , Elfriede Simon , Martin Zimmer
IPC分类号： G01N27/414 , G01N33/00 , G01N7/00 , H01L23/58
CPC分类号： G01N33/0039 , G01N27/4143 , Y02A50/247
摘要： An ozone sensor has an ozone-sensitive layer containing an ozone-sensitive material which is encapsulated in a polymer or in a polymer mixture or is coated by at least one polymer or polymer mixture. Advantages result from a longer service life of the ozone-sensitive materials which, because of their high hygroscopic properties, would not be stable without encapsulation or coating. Furthermore, a polymer matrix can be selectively used as a filter or in order to eliminate interfering influences.
摘要翻译： 臭氧传感器具有包含臭氧敏感材料的臭氧敏感层，其被包封在聚合物或聚合物混合物中或被至少一种聚合物或聚合物混合物涂覆。 优点是由于其具有高吸湿性能的臭氧敏感材料的使用寿命更长，在不进行包封或涂覆的情况下将不稳定。 此外，聚合物基质可以选择性地用作过滤器或为了消除干扰影响。
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12.发明申请Method For Measuring Gases And/Or Minimizing Cross-Sensitivities In Fet-Based Gas Sensors 有权用于测量气体和/或最小化基于气体传感器的交叉敏感性的方法公开(公告)号：US20080016949A1
公开(公告)日：2008-01-24
申请号：US11587173
申请日：2005-04-22
申请人： Maximillian Fleischer , Uwe Lampe , Hans Meixner , Roland Pohle , Elfriede Simon
发明人： Maximillian Fleischer , Uwe Lampe , Hans Meixner , Roland Pohle , Elfriede Simon
CPC分类号： G01N27/4143 , G01N33/006
摘要： A gas sensor based on a field effect transistor (“FET”) evaluates both a change in work function of a gas-sensitive layer of the FET and a change in the capacitance of the layer. Thus, two physically independent signals are read from the gas-sensitive layer, each signal representing a sensitivity to a different gas. This reduces the effect of cross-sensitivities; that is, of one gas on the target gas. The underlying physical mechanisms, the first causing a change in the work function in a reaction with gases and the second causing a change in the capacitance of the sensitive layer, are widely different. Because of this, the two parameters demonstrate different gas sensitivities. If the reactions to both gases are known, the effect of the interfering gas on the sensor signal can be compensated for, and with this the concentration of the target gas can be determined.
摘要翻译： 基于场效应晶体管（“FET”）的气体传感器评估FET的气敏层的功函数变化和层的电容变化。 因此，从气体敏感层读取两个物理独立的信号，每个信号表示对不同气体的敏感性。 这降低了交叉敏感性的影响; 也就是目标气体上的一种气体。 潜在的物理机制，首先引起与气体反应的功函数的变化，第二个导致敏感层的电容变化的物理机制是不同的。 因此，这两个参数表现出不同的气体敏感性。 如果对两种气体的反应是已知的，则可以补偿干扰气体对传感器信号的影响，并且可以确定目标气体的浓度。
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公开(公告)号：US20080274559A1
公开(公告)日：2008-11-06
申请号：US11629550
申请日：2005-06-13
CPC分类号： G01N33/0054 , Y02A50/246 , Y10T436/175383
摘要： The invention relates to a gas sensor which is used to detect ammonia by detecting and evaluating conductivity variations on semi-conductive metal oxides, comprising: a substrate, a gas sensitive layer made of a semi-conductive metal oxide, a catalytic filter which is disposed in front of the metal oxide, said filter being used to convert ammonia, contained in the measuring gas, into a NO/NO2 mixture or to only NO2, measuring electrodes which are arranged on the surface of the substrate in order to detect conductivity variations in the semi-conductive metal oxide which is at least sensitive to NO/NO2, a controllable electric heating device which is used to adjust predetermined temperatures at least for the semi-conductive metal oxide, whereby the formed NO/NO2 can be guided to the metal oxide and the content of ammonia in the measuring gas can be determined from the NO/NO2-measurement by means of the semi-conductive metal oxide.
摘要翻译： 本发明涉及一种用于通过检测和评估半导电金属氧化物的导电率变化来检测氨的气体传感器，包括：基板，由半导体金属氧化物制成的气敏层，设置在催化过滤器 在金属氧化物的前面，所述过滤器用于将包含在测量气体中的氨转化为NO / NO 2混合物或仅将NO2测量电极设置在衬底的表面上，以便检测电导率变化 至少对NO / NO2敏感的半导体金属氧化物，至少用于半导体金属氧化物调节预定温度的可控电加热装置，由此所形成的NO / NO 2可被引导到金属 氧化物，测定气体中的氨的含量可以通过半导体金属氧化物从NO / NO 2测定中求出。
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14.发明授权Device and method for the quantitative determination of nitrogen oxides in exhaled air and application thereof 有权用于定量测定呼出空气中氮氧化物的装置和方法及其应用公开(公告)号：US07704214B2
公开(公告)日：2010-04-27
申请号：US10476444
申请日：2002-04-30
CPC分类号： G01N33/497 , A61B5/082 , A61B5/097 , G01N27/4143 , G01N33/0013 , G01N33/0037 , Y02A50/245
摘要： A volumetric flow of an analyte, including exhaled air, is fed to a gas sensor unit by used of gas flow device, which can include various sensors for the determination of nitrogen oxides. An oxidation catalyst is used when using an NO2 sensor, which converts nitrogen monoxide to nitrogen dioxide and the gas sensor unit measures the content of nitrogen dioxide. The nitrogen monoxide content is calculated from the nitrogen dioxide content. In order to eliminate cross-sensitivity moisture and ethanol are also measured. The device can be applied to the determination of nitrogen monoxide content of exhaled air.
摘要翻译： 包括呼出空气的分析物的体积流量通过使用气流装置供给到气体传感器单元，其可以包括用于测定氮氧化物的各种传感器。 当使用将一氧化氮转化为二氧化氮的NO 2传感器使用氧化催化剂时，气体传感器单元测量二氧化氮的含量。 一氧化氮含量由二氧化氮含量计算。 为了消除交叉敏感性，也测量了水分和乙醇。 该装置可用于测定呼出空气中的一氧化氮含量。
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公开(公告)号：US20080038749A1
公开(公告)日：2008-02-14
申请号：US10588493
申请日：2005-01-27
IPC分类号： G01N33/53
CPC分类号： G01N33/5438
摘要： A biosensor for detecting an antigen using an antigen/antibody coupling includes: a silicon substrate, at least one interdigital electrode pair structure that is located on the silicon substrate, the electrode pair being interspaced at a maximum distance of 1.0 μm; a counter-electrode on the silicon substrate; a reference electrode; a first layer of protein, covering at least the interdigital electrode structure; a selective second protein layer applied to the first layer and containing a capture antibody selected specifically with respect to the antigen of interest and to which the antigen can be coupled. A sensor signal can be read on the interdigital electrode structure, if the antigen is coupled to the capture antibody by way of a sample to be analysed that comes into contact with the biosensor and a redox reactive molecule is enzymatically released on the sensor surface by an enzyme-marked detection antibody likewise coupled to the antigen.
摘要翻译： 用于使用抗原/抗体偶联检测抗原的生物传感器包括：硅衬底，位于硅衬底上的至少一个叉指电极对结构，电极对以1.0μm的最大距离进行间隔; 在硅衬底上的对电极; 参考电极; 蛋白质的第一层，至少覆盖指状电极结构; 选择性第二蛋白质层，其施加到第一层并且含有相对于感兴趣的抗原特异性选择的抗体可以偶联的捕获抗体。 如果抗原通过与生物传感器接触的待分析样品与捕获抗体偶联，并且氧化还原反应性分子在传感器表面上被酶促释放，则可以在叉指电极结构上读取传感器信号 同样与抗原偶联的酶标记检测抗体。
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公开(公告)号：US20050176067A1
公开(公告)日：2005-08-11
申请号：US11049953
申请日：2005-02-04
IPC分类号： C12M1/34 , G01N33/53 , G01N33/537 , G01N33/543 , G01N33/68
CPC分类号： G01N33/5438 , G01N33/6854
摘要： A biosensor is for detecting an allergen-specific immunoglobulin E (IgE) via antigen/antibody coupling. The biosensor includes a silicon substrate and at least one interdigital electrode pair structure applied to the silicon substrate with a gap between the electrode pairs of a maximum of 1.0 μm. A counter electrode is further applied to the silicon substrate. The biosensor also includes a reference electrode. Additionally, coatings are included on the biosensor. A first coat is made from protein coating at least the interdigital electrode structure; a selective second coat is made from protein applied over the first coat, the second coat containing a selected captor antibody; and a third coat is applied over the first coat, which contains the allergen which can couple to the captor antibody. A sensor signal can be readout at the interdigital electrode structure, if an allergen-specific immunoglobulin E (IgE) from a sample of a human blood serum in contact with a biosensor couples to the allergen present on the sensor surface. Further, an enzymatic release of a redox reactive molecule takes place on the sensor surface via an enzyme-marked detection antibody similarly coupled to the allergen-specific immumoglobulin E (IgE).
摘要翻译： 生物传感器用于通过抗原/抗体偶联检测变应原特异性免疫球蛋白E（IgE）。 生物传感器包括硅衬底和至少一个指状硅电极对结构，其中电极对之间的间隙最大为1.0μm。 另外将对电极施加到硅衬底上。 生物传感器还包括参比电极。 另外，生物传感器上也包含涂层。 第一层由蛋白质涂层至少形成叉指电极结构; 选择性第二层由在第一层上施用的蛋白质制成，第二层包含选定的捕获抗体; 并且第三层涂覆在第一层上，其含有可以偶联到捕获体抗体的变应原。 如果来自与生物传感器接触的人血清样品的变应原特异性免疫球蛋白E（IgE）与存在于传感器表面上的变应原相耦合，则可以在叉指电极结构处读出传感器信号。 此外，通过类似地与变应原特异性免疫球蛋白E（IgE）偶联的酶标记的检测抗体，在传感器表面上发生氧化还原反应性分子的酶促释放。
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公开(公告)号：US07851202B2
公开(公告)日：2010-12-14
申请号：US10588493
申请日：2005-01-27
CPC分类号： G01N33/5438
摘要： A biosensor for detecting an antigen using an antigen/antibody coupling includes: a silicon substrate, at least one interdigital electrode pair structure that is located on the silicon substrate, the electrode pair being interspaced at a maximum distance of 1.0 μm; a counter-electrode on the silicon substrate; a reference electrode; a first layer of protein, covering at least the interdigital electrode structure; a selective second protein layer applied to the first layer and containing a capture antibody selected specifically with respect to the antigen of interest and to which the antigen can be coupled. A sensor signal can be read on the interdigital electrode structure, if the antigen is coupled to the capture antibody by way of a sample to be analyzed that comes into contact with the biosensor and a redox reactive molecule is enzymatically released on the sensor surface by an enzyme-marked detection antibody likewise coupled to the antigen.
摘要翻译： 用于使用抗原/抗体偶联检测抗原的生物传感器包括：硅衬底，位于硅衬底上的至少一个叉指电极对结构，电极对间隔1.0μm的最大距离; 在硅衬底上的对电极; 参考电极; 蛋白质的第一层，至少覆盖指状电极结构; 选择性第二蛋白质层，其施加到第一层并且含有相对于感兴趣的抗原特异性选择的抗体可以偶联的捕获抗体。 如果抗原通过与生物传感器接触的待分析样品与捕获抗体偶联，并且氧化还原反应性分子在传感器表面上被酶促释放，则可以在叉指电极结构上读取传感器信号 同样与抗原偶联的酶标记检测抗体。
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18.发明申请Fet-based sensor for detecting reducing gases or alcohol, and associated production and operation method 审中-公开用于检测还原气体或酒精的基于Fet的传感器，以及相关的生产和操作方法公开(公告)号：US20070181426A1
公开(公告)日：2007-08-09
申请号：US11587070
申请日：2005-04-21
申请人： Maximilian Fleischer , Gabor Kiss , Hans Meixner , Uwe Lampe
发明人： Maximilian Fleischer , Gabor Kiss , Hans Meixner , Uwe Lampe
CPC分类号： G08B17/117 , G01N27/4141
摘要： An FET-based gas sensor includes at least one field-effect transistor and at least one gas-sensitive layer and a reference layer. Any changes in work function occurring when materials of the layers are exposed to a gas are used to trigger the field-effect structures. The gas-sensitive layer includes a metal oxide having an oxidation catalyst on its surface and accessible to the measured gas.
摘要翻译： 基于FET的气体传感器包括至少一个场效应晶体管和至少一个气体敏感层和参考层。 用于暴露于气体的层的材料发生的作用函数的任何变化被用于触发场效应结构。 气敏层包括其表面上具有氧化催化剂的金属氧化物，并且可被测量的气体接近。
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19.发明申请FET-BASED SENSOR FOR DETECTING REDUCING GASES OR ALCOHOL, AND ASSOCIATED PRODUCTION AND OPERATIONG METHOD 审中-公开用于检测降低气体或酒精的基于FET的传感器，以及相关的生产和操作方法公开(公告)号：US20090127100A1
公开(公告)日：2009-05-21
申请号：US12330955
申请日：2008-12-09
申请人： Maximilian Fleischer , Gabor Kiss , Hans Meixner , Uwe Lampe
发明人： Maximilian Fleischer , Gabor Kiss , Hans Meixner , Uwe Lampe
IPC分类号： C23C14/16
CPC分类号： G08B17/117 , G01N27/4141
摘要： An FET-based gas sensor includes at least one field-effect transistor and at least one gas-sensitive layer and a reference layer. Any changes in work function occurring when materials of the layers are exposed to a gas are used to trigger the field-effect structures. The gas-sensitive layer includes a metal oxide having an oxidation catalyst on its surface and accessible to the measured gas.
摘要翻译： 基于FET的气体传感器包括至少一个场效应晶体管和至少一个气体敏感层和参考层。 用于暴露于气体的层的材料发生的作用函数的任何变化被用于触发场效应结构。 气敏层包括其表面上具有氧化催化剂的金属氧化物，并且可被测量的气体接近。
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20.发明申请公开(公告)号：US20060163483A1
公开(公告)日：2006-07-27
申请号：US10559261
申请日：2004-06-08
IPC分类号： G01J5/02
CPC分类号： B64D37/32 , G01N21/3504 , G01N21/39
摘要： The invention relates to a device for monitoring the oxygen concentration in an aircraft tank. The device includes an absorption measuring section equipped with a laser or laser diode (6), a photodiode (7), a temperature sensor (8) and a reflector (5) for carrying out laser spectroscopy on a gas volume to be measured inside the tank. The conducting components of the device are positioned outside the tank and its reflector (5) is positioned in the tank in the gas volume to be measured, the components and reflector being optically coupled by a window (3) that is situated in the tank wall (2). The absorption measuring section is mainly located in the chamber containing the gas to be measured.
摘要翻译： 本发明涉及一种用于监测飞机罐中的氧气浓度的装置。 该装置包括配备有激光或激光二极管（6），光电二极管（7），温度传感器（8）和反射器（5）的吸收测量部分，用于在待测量的气体体积上进行激光光谱 坦克。 装置的导电部件位于罐外部，其反射器（5）在待测量的气体体积中定位在罐中，部件和反射器通过位于罐壁中的窗口（3）光学耦合 （2）。 吸收测量部分主要位于包含要测量气体的腔室中。
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