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    Clustering of Recorded Patient Neurological Activity to Determine Length of a Neurological Event
    11.
    发明申请
    Clustering of Recorded Patient Neurological Activity to Determine Length of a Neurological Event 有权
    记录患者神经活动以确定神经事件长度的聚类

    公开(公告)号：US20140309614A1

    公开(公告)日：2014-10-16

    申请号：US14262634

    申请日：2014-04-25

    Applicant: Medtronic, Inc.

    Inventor： Mark G. Frei ,  Ivan Osorio ,  Nina M. Graves ,  Scott F. Schaffner ,  Mark T. Rise ,  Jonathon E. Giftakis ,  David L. Carlson

    IPC: A61M5/172 ,  A61N1/36

    CPC classification number: A61M5/1723 ,  A61B5/04001 ,  A61B5/0476 ,  A61B5/4094 ,  A61B5/6843 ,  A61B5/721 ,  A61N1/36025 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/361

    Abstract: Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.

    Abstract translation: 装置和方法检测与神经系统疾病的神经系统事件（例如癫痫发作），与治疗疗法相关联的更新治疗参数相关联的检测簇。 当最大比例超过强度阈值时，检测到簇的出现。 如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联 。 因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。 可以通过提供电刺激，药物输注或组合来提供治疗治疗。 治疗参数可以针对治疗疗法或第n个检测簇的每个第m个连续的应用组进行更新。

    Precision delivery of electrical stimulation
    14.
    发明授权
    Precision delivery of electrical stimulation 有权

    公开(公告)号：US10765869B2

    公开(公告)日：2020-09-08

    申请号：US15848291

    申请日：2017-12-20

    Applicant: Medtronic, Inc.

    Inventor： David L. Carlson ,  Heather D. Orser ,  Dale G. Suilmann ,  Kenneth J. Gutzman ,  Gregory J. Loxtercamp

    IPC: A61N1/36 ,  A61N1/372 ,  A61N1/05 ,  A61B5/04 ,  A61B5/0478 ,  A61N1/08 ,  A61B5/00

    Abstract: An example method for controlling delivery of electrical stimulation therapy includes maintaining, by one or more processors of a medical device configured to deliver electrical stimulation to a patient, a counter tied to a clock used by the medical device to deliver the electrical stimulation to the patient; and obtaining, by the one or more processors, one or more representations of sensed electrical signals for the patient that are referenced to counts of the counter. In this example, the method also includes identifying, based on the one or more representations of the sensed electrical signals for the patient, a count of the counter at which stimulation is to be delivered to the patient; and delivering, by the medical device and to the patient, electrical stimulation based on the identified count of the counter.

    PRECISION DELIVERY OF ELECTRICAL STIMULATION
    15.
    发明申请
    PRECISION DELIVERY OF ELECTRICAL STIMULATION 审中-公开

    公开(公告)号：US20180200523A1

    公开(公告)日：2018-07-19

    申请号：US15848291

    申请日：2017-12-20

    Applicant: Medtronic, Inc.

    Inventor： David L. Carlson ,  Heather D. Orser ,  Dale G. Suilmann ,  Kenneth J. Gutzman ,  Gregory J. Loxtercamp

    IPC: A61N1/36 ,  A61N1/05 ,  A61N1/372

    Abstract: An example method for controlling delivery of electrical stimulation therapy includes maintaining, by one or more processors of a medical device configured to deliver electrical stimulation to a patient, a counter tied to a clock used by the medical device to deliver the electrical stimulation to the patient; and obtaining, by the one or more processors, one or more representations of sensed electrical signals for the patient that are referenced to counts of the counter. In this example, the method also includes identifying, based on the one or more representations of the sensed electrical signals for the patient, a count of the counter at which stimulation is to be delivered to the patient; and delivering, by the medical device and to the patient, electrical stimulation based on the identified count of the counter.

    State machine framework for programming closed-loop algorithms that control the delivery of therapy to a patient by an implantable medical device
    16.
    发明授权
    State machine framework for programming closed-loop algorithms that control the delivery of therapy to a patient by an implantable medical device 有权
    用于编程闭环算法的状态机框架，其通过可植入医疗装置控制对患者的治疗递送

    公开(公告)号：US09079039B2

    公开(公告)日：2015-07-14

    申请号：US13934096

    申请日：2013-07-02

    Applicant: Medtronic, Inc.

    Inventor： David L. Carlson ,  Benjamin P. Isaacson ,  David E. Linde

    IPC: A61N1/36 ,  A61N1/372

    CPC classification number: A61N1/37264 ,  A61N1/3606 ,  A61N1/36139 ,  A61N1/37247

    Abstract: This disclosure describes a state machine framework for programming closed-loop algorithms that control the delivery of therapy to a patient by an implantable medical device (IMD). The state machine framework may use one or more programmable state parameters to define at least part of a structure of a state machine that generates one or more therapy decisions based on one or more sensed states of the patient. The state machine framework may include a state machine runtime environment that executes on an IMD and that is configurable to implement a variety of different state machines depending on programmable state parameters that are received from an external device. The techniques of this disclosure may, in some cases, allow IMD developers and/or users to program, change, and/or download new closed-loop control policy algorithms during the lifespan of the IMD without requiring new firmware code to be downloaded onto the IMD.

    Abstract translation: 本公开描述了用于编程闭环算法的状态机框架，其通过可植入医疗装置（IMD）控制对患者的治疗递送。 状态机框架可以使用一个或多个可编程状态参数来定义基于患者的一个或多个感测状态产生一个或多个治疗决定的状态机的结构的至少一部分。 状态机框架可以包括在IMD上执行并且可配置为根据从外部设备接收的可编程状态参数来实现各种不同状态机的状态机运行时环境。 在某些情况下，本公开的技术可以允许IMD开发者和/或用户在IMD的寿命期间对新的闭环控制策略算法进行编程，改变和/或下载，而不需要将新的固件代码下载到 IMD。

    STIMULATION ELECTRODE SELECTION
    18.
    发明申请
    STIMULATION ELECTRODE SELECTION 有权
    刺激电极选择

    公开(公告)号：US20130197605A1

    公开(公告)日：2013-08-01

    申请号：US13827537

    申请日：2013-03-14

    Applicant: Medtronic, Inc.

    Inventor： David L. Carlson ,  Randy M. Jensen ,  Timothy J. Denison ,  Jianping Wu ,  Gabriela C. Molnar ,  Scott R. Stanslaski ,  William J. Marks

    IPC: A61N1/36

    CPC classification number: A61N1/36067 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/36082 ,  A61N1/36185 ,  A61N1/37247

    Abstract: Bioelectrical signals may be sensed within a brain of a patient with a plurality of sense electrode combinations. A stimulation electrode combination for delivering stimulation to the patient to manage a patient condition may be selected based on the frequency band characteristics of the sensed signals. In some examples, a stimulation electrode combination associated with the sense electrode combination that sensed a bioelectrical brain signal having a relatively highest relative beta band power level may be selected to deliver stimulation therapy to the patient. Other frequency bands characteristics may also be used to select the stimulation electrode combination.

    Abstract translation: 可以在具有多个感测电极组合的患者的脑内感测生物电信号。 可以基于感测信号的频带特性来选择用于将刺激递送给患者以管理患者状况的刺激电极组合。 在一些示例中，可以选择与检测到具有相对较高的相对β带功率水平的生物电脑信号的感测电极组合相关联的刺激电极组合，以向患者传递刺激治疗。 也可以使用其他频带特性来选择刺激电极组合。

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