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    Cardiac resynchronization therapy optimization based on intracardiac impedance and heart sounds
    12.
    发明授权
    Cardiac resynchronization therapy optimization based on intracardiac impedance and heart sounds 有权
    基于心内阻抗和心脏声音的心脏再同步治疗优化

    公开(公告)号：US09387330B2

    公开(公告)日：2016-07-12

    申请号：US14158533

    申请日：2014-01-17

    Applicant: Medtronic, Inc.

    Inventor： Todd M. Zielinski ,  Yong Kyun Cho ,  Douglas Hettrick ,  Xusheng Zhang

    IPC: A61N1/00 ,  A61N1/368 ,  A61N1/365 ,  A61B5/053

    CPC classification number: A61N1/36585 ,  A61B5/0535 ,  A61B5/0538 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3686

    Abstract: Methods and/or devices used in delivering cardiac resynchronization therapy based on a plurality of device parameters (e.g., A-V delay, V-V delay, etc.) are optimized by setting a device parameter based on selection data. The selection data may be acquired by acquiring temporal fiducial points (e.g., heart sounds) associated with at least a part of a systolic portion of at least one cardiac cycle and/or temporal fiducial points associated with at least a part of a diastolic portion of the at least one cardiac cycle for each of a plurality of electrode vector configurations, and extracting measurements from the intracardiac impedance signal acquired for each of a plurality of electrode vector configurations based on the temporal fiducial points. The acquired selection data may be scored and used to optimize the device parameter.

    Abstract translation: 通过基于选择数据设置设备参数来优化基于多个设备参数（例如，A-V延迟，V-V延迟等）递送心脏再同步治疗的方法和/或设备。 选择数据可以通过获取与至少一个心动周期的收缩期部分的至少一部分相关联的时间基准点（例如，心音）和/或与至少一个心动周期的舒张部分的至少一部分相关联的时间基准点来获取 所述至少一个心脏周期用于多个电极向量配置中的每一个，并且基于所述时间基准点从针对多个电极向量配置中的每一个获取的心脏内阻抗信号提取测量值。 可以对所获取的选择数据进行评分并用于优化设备参数。

    DETECTION OF INFECTION IN A PATIENT
    14.
    发明申请
    DETECTION OF INFECTION IN A PATIENT 有权

    公开(公告)号：US20220211331A1

    公开(公告)日：2022-07-07

    申请号：US17645433

    申请日：2021-12-21

    Applicant: Medtronic, Inc.

    Inventor： Holly S. Norman ,  Douglas A. Hettrick ,  Mark J. Phelps ,  Shantanu Sarkar ,  Todd M. Zielinski

    IPC: A61B5/00 ,  A61B5/053 ,  A61B5/01 ,  A61B5/11 ,  A61B5/08 ,  A61B5/024 ,  A61B5/021 ,  A61B5/145 ,  G16H50/30

    Abstract: This disclosure is directed to techniques for identifying a medical condition, such as an infection and/or a disease, from sensor data indicative of physiological parameters. In some examples, one example technique for identifying the medical condition includes process sensor data comprising data indicative of a plurality of physiological parameters for a patient comprising an impedance parameter, computing an index based upon values corresponding to at least two of the physiological parameters and based upon a comparison between the index and prediction criterion, generating, for display, output data corresponding to the comparison results, wherein the output data indicates a prediction of the medical condition in the patient if the comparison results indicate satisfaction of the prediction criterion.

    FLUID STATUS DETECTION FROM A CARDIAC ELECTRICAL SIGNAL AND IMPEDANCE SIGNAL
    16.
    发明申请
    FLUID STATUS DETECTION FROM A CARDIAC ELECTRICAL SIGNAL AND IMPEDANCE SIGNAL 审中-公开

    公开(公告)号：US20200030612A1

    公开(公告)日：2020-01-30

    申请号：US16521963

    申请日：2019-07-25

    Applicant: Medtronic, Inc.

    Inventor： Zhendong Song ,  Todd M. Zielinski ,  Brian B. Lee

    IPC: A61N1/365 ,  A61B5/042 ,  A61B5/00 ,  A61B5/0456 ,  A61B5/11

    Abstract: A medical device is configured to generate fluid status signal data of a patient by determining impedance metrics from an impedance signal, determining cardiac electrical signal amplitudes from a cardiac electrical signal and determining a calibration relationship between the impedance metrics and cardiac electrical signal amplitudes. The medical device generates a fluid status signal data by adjusting cardiac electrical signal amplitudes according to the determined calibration relationship. The fluid status signal data may be displayed or monitored for detecting a change in the patient's fluid status.

    Cardiac resynchronization therapy optimization based on intracardiac impedance
    19.
    发明授权
    Cardiac resynchronization therapy optimization based on intracardiac impedance 有权
    基于心内阻抗的心脏再同步治疗优化

    公开(公告)号：US09199086B2

    公开(公告)日：2015-12-01

    申请号：US14158516

    申请日：2014-01-17

    Applicant: Medtronic, Inc.

    Inventor： Todd M. Zielinski ,  Yong Kyun Cho ,  Douglas Hettrick ,  Xusheng Zhang

    IPC: A61N1/00 ,  A61N1/368 ,  A61N1/365

    CPC classification number: A61N1/368 ,  A61N1/36521 ,  A61N1/3682

    Abstract: Methods and/or devices used in delivering cardiac resynchronization therapy based on a plurality of device parameters (e.g., A-V delay, V-V delay, etc.) are optimized by setting a device parameter based on selection data. The selection data may be acquired by acquiring temporal fiducial points (e.g., heart sounds) associated with at least a part of a systolic portion of at least one cardiac cycle and/or temporal fiducial points associated with at least a part of a diastolic portion of the at least one cardiac cycle for each of a plurality of electrode vector configurations, and extracting measurements from the intracardiac impedance signal acquired for each of a plurality of electrode vector configurations based on the temporal fiducial points. The acquired selection data may be scored and used to optimize the device parameter.

    Abstract translation: 通过基于选择数据设置设备参数来优化基于多个设备参数（例如，A-V延迟，V-V延迟等）递送心脏再同步治疗的方法和/或设备。 选择数据可以通过获取与至少一个心动周期的收缩期部分的至少一部分相关联的时间基准点（例如，心音）和/或与至少一个心动周期的舒张部分的至少一部分相关联的时间基准点来获取 所述至少一个心脏周期用于多个电极向量配置中的每一个，并且基于所述时间基准点从针对多个电极向量配置中的每一个获取的心脏内阻抗信号提取测量值。 可以对所获取的选择数据进行评分并用于优化设备参数。

    Use of thoracic and extra-thoracic impedance for diagnostic monitoring
    20.
    发明授权
    Use of thoracic and extra-thoracic impedance for diagnostic monitoring 有权
    使用胸外阻抗进行诊断监测

    公开(公告)号：US08868185B2

    公开(公告)日：2014-10-21

    申请号：US13686359

    申请日：2012-11-27

    Applicant: Medtronic, Inc.

    Inventor： Todd M. Zielinski ,  Douglas A. Hettrick ,  Yong K. Cho ,  Eduardo N. Warman ,  Paul A. Sobotka

    IPC: A61N1/368 ,  A61N1/365 ,  A61M27/00

    CPC classification number: A61N1/36507 ,  A61B5/0537 ,  A61B5/085 ,  A61M27/00 ,  A61N1/3627 ,  A61N1/36521

    Abstract: A medical device and associated method for delivery of a cardiac therapy that includes determining a first impedance signal along a thoracic electrode vector extending within a portion of a thoracic cavity, determining a second impedance signal along an extra-thoracic electrode vector extending outside the thoracic cavity, comparing first amplitude measurements corresponding to the first impedance signals and second amplitude measurements corresponding to the second impedance signals, comparing first slope measurements corresponding to the first impedance signals and second slope measurements corresponding to the second impedance signals, and determining delivery of the cardiac therapy in response to the comparing.

    Abstract translation: 一种用于递送心脏疗法的医疗装置和相关联的方法，其包括沿着在胸腔的一部分内延伸的胸部电极矢量确定第一阻抗信号，沿着延伸到胸腔外部的胸外电极矢量确定第二阻抗信号 比较对应于第一阻抗信号的第一振幅测量值和对应于第二阻抗信号的第二振幅测量值，比较对应于第一阻抗信号的第一斜率测量值和对应于第二阻抗信号的第二斜率测量值，以及确定心脏治疗 响应比较。

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