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11.&agr;-and &bgr;-amino acid hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors 失效
标题翻译: 可用作逆转录病毒蛋白酶抑制剂的α-和β-氨基酸羟乙基氨基磺酰脲衍生物公开(公告)号:US06403585B1
公开(公告)日:2002-06-11
申请号:US09731911
申请日:2000-12-08
申请人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
发明人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
IPC分类号: A61K31535
CPC分类号: C07D213/42 , C07C307/06 , C07D215/48 , C07D215/50 , C07D215/54 , C07D235/06 , C07D239/38 , C07D307/85 , C07K5/06026 , C07K5/06139 , C07K5/06191
摘要: &agr;- and &bgr;-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译: α-和β-氨基酸羟乙基氨基磺酰脲衍生物化合物作为逆转录病毒蛋白酶抑制剂是有效的,特别是作为HIV蛋白酶的抑制剂。
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12.&agr;- and &bgr;-amino acid hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors 失效
标题翻译: 可用作逆转录病毒蛋白酶抑制剂的α-和β-氨基酸羟乙基氨基磺酰脲衍生物公开(公告)号:US06211176B1
公开(公告)日:2001-04-03
申请号:US09345739
申请日:1999-07-01
申请人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
发明人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
IPC分类号: A61K31535
CPC分类号: C07D213/42 , C07C307/06 , C07D215/48 , C07D215/50 , C07D215/54 , C07D235/06 , C07D239/38 , C07D307/85 , C07K5/06026 , C07K5/06139 , C07K5/06191
摘要: &agr;- and &bgr;-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译: α-和β-氨基酸羟乙基氨基磺酰脲衍生物化合物作为逆转录病毒蛋白酶抑制剂是有效的,特别是作为HIV蛋白酶的抑制剂。
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公开(公告)号:US5510349A
公开(公告)日:1996-04-23
申请号:US471898
申请日:1995-06-07
申请人: John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Ko-Chung Lin , Michael L. Vazquez , Richard A. Mueller , Kathryn L. Reed , Robert M. Heintz , Michael Clare , John N. Freskos , Eric T. Sun
发明人: John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Ko-Chung Lin , Michael L. Vazquez , Richard A. Mueller , Kathryn L. Reed , Robert M. Heintz , Michael Clare , John N. Freskos , Eric T. Sun
IPC分类号: A61K31/17 , A61K31/195 , A61K31/197 , A61K31/216 , A61K31/27 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K38/00 , C07C213/00 , C07C213/02 , C07C213/08 , C07C215/28 , C07C269/06 , C07C271/16 , C07C271/20 , C07C271/22 , C07C275/14 , C07C275/18 , C07C275/22 , C07C275/24 , C07C275/28 , C07C311/47 , C07C317/44 , C07C317/50 , C07C323/60 , C07C329/06 , C07C335/08 , C07C335/12 , C07D213/81 , C07D215/48 , C07D215/50 , C07D215/54 , C07D217/26 , C07D235/06 , C07D235/24 , C07D239/38 , C07D241/44 , C07D295/13 , C07D295/15 , C07D303/36 , C07D307/85 , C07D401/12 , C07K5/02 , C07K5/06 , C07K5/078
CPC分类号: C07K5/06191 , A61K31/17 , A61K31/195 , A61K31/197 , A61K31/216 , A61K31/27 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , C04B35/632 , C07C213/00 , C07C213/02 , C07C213/08 , C07C269/06 , C07C271/20 , C07C271/22 , C07C275/14 , C07C275/18 , C07C275/22 , C07C275/24 , C07C275/28 , C07C311/47 , C07C317/44 , C07C317/50 , C07C323/60 , C07C329/06 , C07C335/08 , C07C335/12 , C07D213/81 , C07D215/48 , C07D215/50 , C07D215/54 , C07D217/26 , C07D235/06 , C07D235/24 , C07D239/38 , C07D241/44 , C07D295/13 , C07D295/15 , C07D303/36 , C07D307/85 , C07D401/12 , C07K5/0207 , C07K5/021 , C07K5/06026 , C07K5/06139 , A61K38/00 , C07B2200/07 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要: Urea-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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14.Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors 失效
标题翻译: 用作逆转录病毒蛋白酶抑制剂的琥珀酰氨基羟基氨基磺酰脲衍生物公开(公告)号:US07199158B2
公开(公告)日:2007-04-03
申请号:US11183230
申请日:2005-07-18
申请人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
发明人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
IPC分类号: C07C311/00 , A61K31/18
CPC分类号: C07D213/42 , C07C307/06 , C07C2601/02 , C07C2601/14 , C07D207/16 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/088 , C07D295/13 , C07D295/185 , C07D303/36
摘要: Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula: wherein R1–R6, R7, R7′, R8, R30–R34, X′, Y, Y′, t, x, and n are as defined herein, are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译: 下式的琥珀酰氨基羟基氨基磺酰脲衍生物:
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15.Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors 失效
标题翻译: 用作逆转录病毒蛋白酶抑制剂的琥珀酰氨基羟基氨基磺酰脲衍生物公开(公告)号:US06951886B2
公开(公告)日:2005-10-04
申请号:US10315254
申请日:2002-12-10
申请人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
发明人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
IPC分类号: C07C307/06 , C07D207/16 , C07D213/42 , C07D295/088 , C07D295/13 , C07D295/185 , C07D521/00 , C07C311/00 , A61K31/18
CPC分类号: C07D213/42 , C07C307/06 , C07C2601/02 , C07C2601/14 , C07D207/16 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/088 , C07D295/13 , C07D295/185 , C07D303/36
摘要: Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula: wherein the substituents are as defined in the specification, are effective as retroviral protease inhibitors and in particular as inhibitors of HIV protease.
摘要翻译: 下式的琥珀酰氨基羟基氨基磺酰脲衍生物:其中取代基如说明书中所定义,作为逆转录病毒蛋白酶抑制剂,特别是作为HIV蛋白酶的抑制剂是有效的。
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16..alpha.- and .beta.-amino acid hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors 失效
标题翻译: 可用作逆转录病毒蛋白酶抑制剂的α-和β-氨基酸羟乙基氨基磺酰脲衍生物公开(公告)号:US6022872A
公开(公告)日:2000-02-08
申请号:US709069
申请日:1996-09-06
申请人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
发明人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
IPC分类号: C07C307/06 , C07D213/42 , C07D215/48 , C07D215/50 , C07D215/54 , C07D235/06 , C07D239/38 , C07D307/85 , C07K5/06 , C07K5/078 , A61K31/535 , C07D215/38 , C07D235/26 , C07D239/02
CPC分类号: C07D213/42 , C07C307/06 , C07D215/48 , C07D215/50 , C07D215/54 , C07D235/06 , C07D239/38 , C07D307/85 , C07K5/06026 , C07K5/06139 , C07K5/06191
摘要: .alpha.- and .beta.-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译: α-和β-氨基酸羟乙基氨基磺酰脲衍生物化合物作为逆转录病毒蛋白酶抑制剂是有效的,特别是作为HIV蛋白酶的抑制剂。
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17.Sulfonylalkanoylamino hydroxyethylamino sulfamic acids useful as retroviral protease inhibitors 失效
标题翻译: 用作逆转录病毒蛋白酶抑制剂的磺酰基烷酰氨基羟基氨基氨基磺酸公开(公告)号:US5583132A
公开(公告)日:1996-12-10
申请号:US379645
申请日:1995-02-02
申请人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
发明人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
IPC分类号: A61K31/18 , A61P31/12 , C07C317/44 , C07C307/02 , A61K31/40 , A61K31/535
CPC分类号: C07C317/46 , C07C317/44 , C07D213/42 , C07D213/76 , C07D295/13 , C07D295/26 , C07D307/66 , C07D333/36 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要: Sulfonylalkanoylamino hydroxyethylamino sulfamic acid compounds which are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译: PCT No.PCT / US93 / 10461 Sec。 371日期:1995年2月2日 102(e)1995年2月2日PCT PCT 1993年10月29日PCT公布。 第WO94 / 10136号公报 日期1994年5月11日作为逆转录病毒蛋白酶抑制剂有效的磺酰基烷酰氨基羟基氨基氨基磺酸化合物,特别是作为HIV蛋白酶抑制剂。
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公开(公告)号:US5578606A
公开(公告)日:1996-11-26
申请号:US968712
申请日:1992-10-30
申请人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
发明人: Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
IPC分类号: C07C307/06 , C07D213/42 , C07D215/48 , C07D215/50 , C07D215/54 , C07D235/06 , C07D239/38 , C07D307/85 , C07K5/06 , C07K5/078 , C07D401/12 , A61K31/47 , A61K31/505 , A61K31/54 , C07D413/12 , C07D417/12
CPC分类号: C07D213/42 , C07C307/06 , C07D215/48 , C07D215/50 , C07D215/54 , C07D235/06 , C07D239/38 , C07D307/85 , C07K5/06026 , C07K5/06139 , C07K5/06191
摘要: .alpha.- and .beta.-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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公开(公告)号:US08551988B2
公开(公告)日:2013-10-08
申请号:US12814964
申请日:2010-06-14
申请人: DiZhong Chen , Hong Yan Song , Eric T. Sun , Niefang Yu , Yong Zou
发明人: DiZhong Chen , Hong Yan Song , Eric T. Sun , Niefang Yu , Yong Zou
IPC分类号: A61K31/535 , A61K31/44 , C07D235/00 , C07D413/00 , C07D401/00
CPC分类号: A61K31/4184 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5377 , C04B35/632 , C07D235/06 , C07D235/08 , C07D235/14 , C07D235/18 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/02 , C07D403/06 , C07D409/04 , C07D413/02 , G01N33/5011 , G01N33/6875 , Y02A50/409 , Y02A50/411 , Y02A50/414
摘要: The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).
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公开(公告)号:US08153632B2
公开(公告)日:2012-04-10
申请号:US12093867
申请日:2006-11-15
申请人: Stephanie Blanchard , Cheng Hsia Angeline Lee , Harish Kumar Mysore Nagaraj , Anders Poulsen , Eric T. Sun , Yee Ling Evelyn Tan , Anthony Deodaunia William
发明人: Stephanie Blanchard , Cheng Hsia Angeline Lee , Harish Kumar Mysore Nagaraj , Anders Poulsen , Eric T. Sun , Yee Ling Evelyn Tan , Anthony Deodaunia William
IPC分类号: A61K31/495 , C07D491/00
CPC分类号: A61K31/519 , A61K31/5377 , C07D498/06 , C07D498/08 , C07D498/16 , C07D498/18 , C07D515/16 , C07D515/18
摘要: The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to oxygen linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumors and cancers as well as other disorders or conditions related to or associated with kinases.
摘要翻译: 本发明涉及可用作抗增殖剂的嘧啶化合物。 更具体地,本发明涉及氧连接和取代的嘧啶化合物,其制备方法,含有这些化合物的药物组合物和这些化合物在治疗增殖性疾病中的用途。 这些化合物可用作治疗许多增殖性疾病(包括肿瘤和癌症)以及与激酶相关或与激酶相关的其它病症或病症的药物。
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