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公开(公告)号：US20170216484A1
公开(公告)日：2017-08-03
申请号：US15491864
申请日：2017-04-19
Applicant: MicroVention, Inc.
Inventor： Gregory M. Cruise , Michael J. Constant , Edward Michael Keeley , Rob Greene , Clayton Harris
CPC classification number: A61L24/06 , A61K49/0442 , A61K49/12 , A61L24/001 , A61L24/0015 , A61L2300/44 , A61L2400/06 , A61L2430/36 , C08L33/08 , C08L33/26
Abstract: Polymeric compositions are described comprising a biocompatible polymer including a biodegradable linkage to a visualization agent and a non-physiological pH solution; wherein the biocompatible polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.
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公开(公告)号：US09486221B2
公开(公告)日：2016-11-08
申请号：US13899357
申请日：2013-05-21
Applicant: MicroVention, Inc.
Inventor： Gregory M. Cruise , Michael J. Constant , Edward Michael Keeley , Terrance T. Tran
CPC classification number: A61B17/12113 , A61B17/12181 , A61B90/39 , A61B2017/00004 , A61B2017/1205 , A61B2090/3966 , A61K49/0404 , A61L24/001 , A61L24/0031 , A61L24/046 , A61L27/16 , A61L27/18 , A61L27/56 , A61L31/048 , A61L31/06 , A61L31/146 , A61L31/18 , A61L2430/36 , C08L39/06 , C08L71/02
Abstract: Described herein are apparatus, compositions, systems and associated methods to occlude structures and malformations with radiopaque hydrogel filaments with delayed controlled rates of expansion permitting the repositioning of the device once inside the structure or malformation. Further described is a device for implantation in an animal comprising a difunctional, low molecular weight ethylenically unsaturated shapeable macromer; an ethylenically unsaturated monomer; and a radiopaque element, wherein said device contains no support members. Methods of forming such devices are also disclosed.
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13.发明申请公开(公告)号：US20140256837A1
公开(公告)日：2014-09-11
申请号：US14254661
申请日：2014-04-16
Applicant: MicroVention, Inc.
Inventor： Gregory M. Cruise , Michael J. Constant
IPC: C08F22/38
CPC classification number: C08F22/385 , A61K9/0024 , A61K49/0457 , A61L31/145
Abstract: Hydrogels are described that expand volumetrically in response to a change in their environment and as well as their methods of manufacture and use.
Abstract translation: 描述了水凝胶，其响应于其环境的变化以及它们的制造和使用方法而以体积方式膨胀。
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公开(公告)号：US20140107251A1
公开(公告)日：2014-04-17
申请号：US14054515
申请日：2013-10-15
Applicant: MicroVention, Inc.
Inventor： Gregory M. Cruise , Michael J. Constant , Edward Michael Keeley , Rob Greene , Clayton Harris
IPC: A61L24/06
CPC classification number: A61L24/06 , A61K49/0442 , A61K49/12 , A61L24/001 , A61L24/0015 , A61L2300/44 , A61L2400/06 , A61L2430/36 , C08L33/08 , C08L33/26
Abstract: Polymeric compositions are described comprising a biocompatible polymer including a biodegradable linkage to a visualization agent and a non-physiological pH solution; wherein the biocompatible polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.
Abstract translation: 描述了包含生物相容性聚合物的聚合物组合物，其包括与可视化试剂和非生理pH溶液的生物可降解连接; 其中所述生物相容性聚合物可溶于非生理pH溶液中，并且在生理pH下不溶。 公开了形成溶液和聚合物的方法以及治疗用途的方法。
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公开(公告)号：US10828388B2
公开(公告)日：2020-11-10
申请号：US16287797
申请日：2019-02-27
Applicant: MicroVention, Inc.
Inventor： Gregory M. Cruise , Michael J. Constant , Edward Michael Keeley , Rob Greene , Clayton Harris
Abstract: Polymeric compositions are described comprising a biocompatible polymer including a biodegradable linkage to a visualization agent and a non-physiological solution; wherein the biocompatible polymer is soluble in the non-physiological solution and insoluble in a physiological solution. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.
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Patent Agency Ranking
公开(公告)号：US20200268789A1
公开(公告)日：2020-08-27
申请号：US16806936
申请日：2020-03-02
Applicant: MicroVention, Inc.
Inventor： Gregory M. Cruise , Michael J. Constant , Joshua Garretson
IPC: A61K31/785 , A61K9/00 , A61K31/78 , A61L24/00 , A61L24/04
Abstract: Compositions are described comprising a polymer; a non-physiological pH solution; and a visualization agent; wherein the polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.
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公开(公告)号：US09724103B2
公开(公告)日：2017-08-08
申请号：US14990676
申请日：2016-01-07
Applicant: MicroVention, Inc.
Inventor： Gregory M. Cruise , Michael J. Constant , Terrance Tran
CPC classification number: A61B17/1219 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/12154 , A61B17/12168 , A61L31/00 , A61L31/022 , A61L31/041 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/145 , A61L31/146 , A61L2400/04 , C08L71/02
Abstract: Devices for the occlusion of body cavities, such as the embolization of vascular aneurysms and the like, and methods for making and using such devices. The devices may be comprised of novel expansile materials, novel infrastructure design, or both. The devices provided are very flexible and enable deployment with reduced or no damage to bodily tissues, conduits, cavities, etceteras.
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公开(公告)号：US09655989B2
公开(公告)日：2017-05-23
申请号：US14736145
申请日：2015-06-10
Applicant: MicroVention, Inc.
Inventor： Gregory M. Cruise , Michael J. Constant , Edward Michael Keeley , Rob Greene , Clayton Harris
CPC classification number: A61L24/06 , A61K49/0442 , A61K49/12 , A61L24/001 , A61L24/0015 , A61L2300/44 , A61L2400/06 , A61L2430/36 , C08L33/08 , C08L33/26
Abstract: Polymeric compositions are described comprising a biocompatible polymer including a biodegradable linkage to a visualization agent and a non-physiological pH solution; wherein the biocompatible polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.
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19.发明授权Acrylic hydrogels with deprotonated amine groups that undergo volumetric expansion in response to changes in environmental pH 有权具有脱质子胺基的丙烯酸水凝胶，其响应于环境pH的变化而经历体积膨胀公开(公告)号：US08734834B2
公开(公告)日：2014-05-27
申请号：US13898250
申请日：2013-05-20
Applicant: MicroVention, Inc.
Inventor： Gregory M. Cruise , Michael J. Constant
IPC: A61F2/02
CPC classification number: C08F22/385 , A61K9/0024 , A61K49/0457 , A61L31/145
Abstract: Hydrogels are described that expand volumetrically in response to a change in their environment and as well as their methods of manufacture and use.
Abstract translation: 水凝胶被描述为响应于其环境的变化以及它们的制造和使用方法而以体积方式膨胀。
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20.发明申请公开(公告)号：US20130274362A1
公开(公告)日：2013-10-17
申请号：US13898250
申请日：2013-05-20
Applicant: MicroVention, Inc.
Inventor： Gregory M. Cruise , Michael J. Constant
IPC: A61L31/14
CPC classification number: C08F22/385 , A61K9/0024 , A61K49/0457 , A61L31/145
Abstract: Hydrogels are described that expand volumetrically in response to a change in their environment and as well as their methods of manufacture and use.
Abstract translation: 水凝胶被描述为响应于其环境的变化以及它们的制造和使用方法而以体积方式膨胀。
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