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    METHODS OF TREATING CANCER USING COMPOSITIONS COMPRISING PERILLYL ALCOHOL DERIVATIVE
    11.
    发明申请
    METHODS OF TREATING CANCER USING COMPOSITIONS COMPRISING PERILLYL ALCOHOL DERIVATIVE 有权

    公开(公告)号：US20220096464A1

    公开(公告)日：2022-03-31

    申请号：US17390292

    申请日：2021-07-30

    Applicant: NeOnc Technologies, Inc.

    Inventor： Thomas CHEN

    IPC: A61K31/495 ,  A61K47/55 ,  A61K47/54

    Abstract: A method for treating brain metastases of a cancer in a mammal includes administering to the mammal a therapeutically effective amount of a perillyl alcohol carbamate, such as TMZ-POH. The brain metastases can be originated or spread from breast cancer. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent, such as a chemotherapeutic agent. The chemotherapeutic agents that may be used in the present invention include a DNA alkylating agent, a topoisomerase inhibitor, an endoplasmic reticulum stress inducing agent, a platinum compound, an antimetabolite, an enzyme inhibitor, and a receptor antagonist.

    PHARMACEUTICAL COMPOSITIONS COMPRISING MONOTERPENES
    13.
    发明申请
    PHARMACEUTICAL COMPOSITIONS COMPRISING MONOTERPENES 有权
    包含单体的药物组合物

    公开(公告)号：US20150368173A1

    公开(公告)日：2015-12-24

    申请号：US14817286

    申请日：2015-08-04

    Applicant: NEONC Technologies, Inc.

    Inventor： Thomas CHEN ,  DANIEL LEVIN ,  SATISH PUPPALI

    IPC: C07C29/88 ,  C07C201/12 ,  C07C67/14 ,  C07C201/16

    CPC classification number: C07C29/92 ,  A61K31/045 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07B2200/07 ,  C07C29/78 ,  C07C29/86 ,  C07C29/88 ,  C07C67/14 ,  C07C201/12 ,  C07C201/16 ,  C07C2601/16 ,  C07C33/14 ,  C07C205/57 ,  C07C69/76 ,  C07C69/92

    Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

    Abstract translation: 本发明提供纯化大于约98.5％（w / w）的单萜或倍半萜的方法。 该方法包括衍生单萜（或倍半萜烯）以产生单萜（或倍半萜烯）衍生物，分离单萜（或倍半萜烯）衍生物和从衍生物中释放单萜（或倍半萜烯）的步骤。 包括本发明范围的药物组合物是包含纯度大于约98.5％（w / w）的单萜（或倍半萜烯）的药物组合物。 纯化的单萜可用于治疗癌症等疾病。 本单萜（或倍半萜烯）可以单独施用，或者可以与辐射或其它治疗剂如化学治疗剂共同施用。

    METHODS AND DEVICES FOR USING ISOPERILLYL ALCOHOL
    14.
    发明申请
    METHODS AND DEVICES FOR USING ISOPERILLYL ALCOHOL 有权
    使用异丙醇的方法和装置

    公开(公告)号：US20150359754A1

    公开(公告)日：2015-12-17

    申请号：US14833210

    申请日：2015-08-24

    Applicant: NEONC TECHNOLOGIES INC.

    Inventor： Thomas CHEN ,  Daniel Levin ,  Satish Pupalli ,  Daniel Anthony Dickman

    IPC: A61K31/045 ,  A61N5/10 ,  A61K47/48 ,  A61K45/06 ,  A61K31/325

    CPC classification number: A61K31/045 ,  A61K31/05 ,  A61K31/165 ,  A61K31/325 ,  A61K31/4015 ,  A61K31/415 ,  A61K31/4188 ,  A61K45/06 ,  A61K47/54 ,  A61K47/55 ,  A61N5/10 ,  C07B2200/07 ,  C07C271/22 ,  C07D207/26 ,  C07D231/12 ,  C07D487/04 ,  A61K2300/00

    Abstract: The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of an isomer or analog of monoterpene or sesquiterpene (or its derivative), such as an isoperillyl alcohol. The present invention also provides for a method of treating a disease comprising the step of administering to a patient a therapeutically effective amount of a derivative of an isomer or analog of monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The derivative may be an isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

    Abstract translation: 本发明提供了治疗诸如癌症的疾病的方法，包括向患者施用治疗有效量的单萜烯或倍半萜烯（或其衍生物）的异构体或类似物，例如异环戊醇。 本发明还提供了治疗疾病的方法，其包括向患者施用治疗有效量的单萜或倍半萜的异构体或类似物的衍生物，例如异哌环醇氨基甲酸酯的步骤。 衍生物可以是与治疗剂如化学治疗剂缀合的异环戊醇。 给药途径可以变化，包括吸入，鼻内，口服，透皮，静脉内，皮下或肌内注射。

    PHARMACEUTICAL COMPOSITIONS COMPRISING MONOTERPENES
    17.
    发明申请
    PHARMACEUTICAL COMPOSITIONS COMPRISING MONOTERPENES 有权

    公开(公告)号：US20210130271A1

    公开(公告)日：2021-05-06

    申请号：US17123365

    申请日：2020-12-16

    Applicant: NEONC Technologies, Inc.

    Inventor： Thomas CHEN ,  Daniel LEVIN ,  Satish PUPPALI

    IPC: C07C29/92 ,  A61K31/045 ,  C07C201/16 ,  C07C201/12 ,  C07C67/14 ,  C07C29/88 ,  C07C29/86 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07C29/78

    Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

    METHODS OF TREATING CANCER USING COMPOSITIONS COMPRISING PERILLYL ALCOHOL DERIVATIVE
    18.
    发明申请
    METHODS OF TREATING CANCER USING COMPOSITIONS COMPRISING PERILLYL ALCOHOL DERIVATIVE 审中-公开

    公开(公告)号：US20200230132A1

    公开(公告)日：2020-07-23

    申请号：US16722816

    申请日：2019-12-20

    Applicant: NeOnc Technologies, Inc.

    Inventor： Thomas CHEN

    IPC: A61K31/495 ,  A61K47/55 ,  A61K47/54

    Abstract: A method for treating brain metastases of a cancer in a mammal includes administering to the mammal a therapeutically effective amount of a perillyl alcohol carbamate, such as TMZ-POH. The brain metastases can be originated or spread from breast cancer. The penllyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent, such as a chemotherapeutic agent. The chemotherapeutic agents that may be used in the present invention include a DNA alkylating agent, a topoisomerase inhibitor, an endoplasmic reticulum stress inducing agent, a platinum compound, an antimetabolite, an enzyme inhibitor, and a receptor antagonist.

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