GENES OF IL-12p40 SUBUNIT MUTATED FOR IMPROVING THE ACTIVITY OF IL-12 AND USE THEREOF FOR DNA VACCINE ADJUVANT
    11.
    发明申请
    GENES OF IL-12p40 SUBUNIT MUTATED FOR IMPROVING THE ACTIVITY OF IL-12 AND USE THEREOF FOR DNA VACCINE ADJUVANT 有权
    用于改善IL-12活性的IL-12p40亚基基因及其用于DNA疫苗补充剂的用途

    公开(公告)号:US20070269408A1

    公开(公告)日:2007-11-22

    申请号:US11832993

    申请日:2007-08-02

    摘要: The present invention relates to the IL-12p40 subunit mutant gene which can produce IL-12 (interleukin 12) of human and mouse origin with high activity, the expression vector including above mutant gene and the use of them to DNA vaccine adjuvant. Particularly, it relates to IL-12p40 mutant gene which inhibits the secretion of IL-12p40 but normally secretes active IL-12p70 by making mutation at Asn-222 (human) or Asn-220 (mouse) amino acid of IL-12p40, which acts as a competitive inhibitor of active form of IL-12, IL-12p70. Therefore, the IL-12p40 mutant gene of the present invention can be useful for DNA vaccination and gene therapy against various diseases, for example, AIDS, hepatitis C or hepatitis B, cancer, influenza, tuberculosis and malaria, which essentially require cellular immune responses for their therapy.

    摘要翻译: 本发明涉及能够产生具有高活性的人和小鼠来源的IL-12(白细胞介素12)的IL-12p40亚基突变基因,包括上述突变基因的表达载体及其用于DNA疫苗佐剂。 特别涉及抑制IL-12p40分泌的IL-12p40突变基因,但通常在IL-12p40的Asn-222(人)或Asn-220(小鼠))氨基酸上突变而分泌活性IL-12p70, 作为IL-12,IL-12p70活性形式的竞争性抑制剂。 因此,本发明的IL-12p40突变基因可用于针对各种疾病(例如艾滋病,丙型肝炎或乙型肝炎,癌症,流感,结核病和疟疾)的DNA疫苗接种和基因治疗,其基本上需要细胞免疫应答 为他们的治疗。

    Front substrate of plasma display panel and fabricating method thereof
    12.
    发明申请
    Front substrate of plasma display panel and fabricating method thereof 失效
    等离子体显示面板的前基板及其制造方法

    公开(公告)号:US20070196584A1

    公开(公告)日:2007-08-23

    申请号:US11785844

    申请日:2007-04-20

    申请人: Sung Lee

    发明人: Sung Lee

    IPC分类号: B05D7/00

    摘要: Disclosed is a front substrate of a plasma display panel and fabricating method thereof, by which color temperature, color purity, and contrast of PDP are enhanced. The present invention includes an upper dielectric layer containing a colorant therein. And, the present invention includes the step of forming an upper dielectric layer having a colorant added thereto.

    摘要翻译: 公开了一种等离子体显示面板的前基板及其制造方法,通过该方法,提高了PDP的色温,色纯度和对比度。 本发明包括其中含有着色剂的上电介质层。 并且,本发明包括形成添加有着色剂的上电介质层的步骤。

    Microphone and speaker having plate spring structure and speech recognition/synthesizing device using the microphone and the speaker
    13.
    发明申请
    Microphone and speaker having plate spring structure and speech recognition/synthesizing device using the microphone and the speaker 审中-公开
    麦克风和扬声器具有板簧结构和使用麦克风和扬声器的语音识别/合成装置

    公开(公告)号:US20070147650A1

    公开(公告)日:2007-06-28

    申请号:US11635280

    申请日:2006-12-07

    IPC分类号: H04R9/06

    CPC分类号: H04R19/005 H04R2499/11

    摘要: A subminiature microphone and speaker having a plate spring structure and a speech recognition/synthesizing device using the microphone and speaker include frames, vibration plates, plate spring structures, elastic portions connected to the frames and the vibration plates, and sensor units which are disposed at the elastic portions and sense vibration of the vibration plates transmitted to the elastic portions.

    摘要翻译: 具有板簧结构的微型麦克风和扬声器以及使用麦克风和扬声器的语音识别/合成装置包括框架,振动板,板簧结构,连接到框架和振动板的弹性部分,以及传感器单元 振动板的弹性部分和感测振动传递到弹性部分。

    Near-field optical probe based on SOI substrate and fabrication method thereof
    14.
    发明申请
    Near-field optical probe based on SOI substrate and fabrication method thereof 失效
    基于SOI衬底的近场光探针及其制造方法

    公开(公告)号:US20070128854A1

    公开(公告)日:2007-06-07

    申请号:US11633820

    申请日:2006-12-05

    IPC分类号: H01L21/4763

    摘要: Provided is near-field optical probe including: a cantilever arm support portion that is formed of a lower silicon layer of a silicon-on-insulator (SOI) substrate, the cantilever arm support portion having a through hole formed therein at a side of the lower silicon layer; and a cantilever arm forming of a junction oxidation layer pattern and an upper silicon layer pattern on the SOI substrate that are supported on an upper surface of the lower silicon layer and each have a smaller hole than the through hole, a silicon oxidation layer pattern having a tip including an aperture at a vertical end, corresponding with the hole on the upper silicon layer pattern, and an optical transmission prevention layer that is formed on the silicon oxidation layer pattern and does not cover the aperture.

    摘要翻译: 本发明提供的近场光学探针包括:由绝缘体上硅(SOI)衬底的下硅层形成的悬臂支撑部,所述悬臂臂支撑部在其一侧形成有通孔, 下硅层; 以及形成在所述SOI衬底上的结氧化层图案和上硅层图案的悬臂,所述支撑在所述下硅层的上表面上并且具有比所述通孔更小的孔,硅氧化层图案具有 对应于上硅层图案上的孔的垂直端的开孔,以及形成在硅氧化层图案上并且不覆盖该孔的防透光层。

    Reverse-turn mimetics and method relating thereto
    15.
    发明申请
    Reverse-turn mimetics and method relating thereto 有权
    反转模拟物及其相关方法

    公开(公告)号:US20070021425A1

    公开(公告)日:2007-01-25

    申请号:US10826972

    申请日:2004-04-16

    IPC分类号: A61K31/53 C07D487/04

    摘要: Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

    摘要翻译: 公开了模拟生物活性肽和蛋白质的反转转区的二级结构的构象约束化合物。 这种反转模拟结构在广泛的领域中具有实用性,包括用作诊断和治疗剂。 还公开了含有本发明的反转模拟结构的文库以及筛选该文库以鉴定生物活性成员的方法。 本发明还涉及这种化合物用于抑制或治疗由Wnt信号传导途径调节的疾病,例如癌症,特别是结肠直肠癌,与血管成形术,多囊肾病,异常血管生成疾病,类风湿性关节炎疾病,结节性硬化综合征相关的再狭窄 ,阿尔茨海默氏病,过度毛发生长或损失,或溃疡性结肠炎。

    Prism sheet and backlight unit using the same
    16.
    发明申请
    Prism sheet and backlight unit using the same 有权
    棱镜片和背光单元使用相同

    公开(公告)号:US20070002576A1

    公开(公告)日:2007-01-04

    申请号:US11314342

    申请日:2005-12-22

    IPC分类号: B60Q1/26 B60Q1/00

    摘要: A prism sheet capable of achieving an enhancement in light efficiency and viewing angle characteristics and a backlight unit using the prism sheet are disclosed. The prism sheet includes: a condensing film which transmits light incident to the condensing film; a plurality of prism crests on the condensing film having apexes; and a plurality of reflection patterns formed on the condensing film such that each of the reflection patterns faces a boundary of adjacent prism crests associated with the reflection pattern to reflect light incident onto the reflection patterns.

    摘要翻译: 公开了能够实现光效和视角特性提高的棱镜片以及使用该棱镜片的背光单元。 棱镜片包括:透射入射到聚光膜的光的聚光膜; 在聚光膜上具有顶点的多个棱镜峰; 以及形成在聚光膜上的多个反射图案,使得每个反射图案面向与反射图案相关联的相邻棱镜波峰的边界,以反射入射到反射图案上的光。

    Plasma display apparatus and driving method thereof
    17.
    发明申请
    Plasma display apparatus and driving method thereof 审中-公开
    等离子体显示装置及其驱动方法

    公开(公告)号:US20060262044A1

    公开(公告)日:2006-11-23

    申请号:US11265157

    申请日:2005-11-03

    IPC分类号: G09G3/28

    摘要: There is provided a plasma display apparatus and a driving method thereof. The plasma display apparatus includes a plasma display panel; and a scan driver commonly using a voltage source supplying a sustain pulse voltage, a setup bias voltage, a setdown pulse voltage, and a scan pulse voltage among a plurality of driving voltages supplied to a scan electrode of the plasma display panel.

    摘要翻译: 提供了一种等离子体显示装置及其驱动方法。 等离子体显示装置包括等离子体显示面板; 以及扫描驱动器,通常使用提供给等离子体显示面板的扫描电极的多个驱动电压中的维持脉冲电压,设定偏置电压,下降脉冲电压和扫描脉冲电压的电压源。

    Mobile terminal with personal video recorder
    18.
    发明申请
    Mobile terminal with personal video recorder 审中-公开
    带个人录像机的移动终端

    公开(公告)号:US20060252459A1

    公开(公告)日:2006-11-09

    申请号:US11417564

    申请日:2006-05-03

    申请人: Sung Lee

    发明人: Sung Lee

    IPC分类号: H04M1/00

    摘要: A method for controlling recording at a mobile terminal includes receiving a video signal having stream data, determining signal quality of the stream data, and obtaining loss information associated with a lost portion of the stream data responsive to the signal quality. In addition, a mobile terminal includes a receiver for receiving a video signal having stream data. The controller may be configured to determine signal quality of the stream data and obtain loss information associated with a lost portion of the stream data responsive to the signal quality. Alternatively, the mobile terminal includes a controller configured to obtain previously stored loss information, such that the loss information is associated with a lost portion of stream data of a video signal, and a receiver for receiving lost stream data corresponding to the loss information from a video data server responsive to an information request.

    摘要翻译: 一种用于控制移动终端记录的方法包括接收具有流数据的视频信号,确定流数据的信号质量,以及响应信号质量获得与流数据的丢失部分相关联的丢失信息。 此外,移动终端包括用于接收具有流数据的视频信号的接收器。 控制器可以被配置为响应于信号质量来确定流数据的信号质量并且获得与流数据的丢失部分相关联的丢失信息。 或者,移动终端包括被配置为获得预先存储的丢失信息的控制器,使得丢失信息与视频信号的流数据的丢失部分相关联,以及接收器,用于接收对应于来自 响应于信息请求的视频数据服务器。

    Method of forming bit line in semiconductor device
    19.
    发明申请
    Method of forming bit line in semiconductor device 失效
    在半导体器件中形成位线的方法

    公开(公告)号:US20060240673A1

    公开(公告)日:2006-10-26

    申请号:US11401585

    申请日:2006-04-11

    申请人: Sung Lee

    发明人: Sung Lee

    IPC分类号: H01L21/467

    摘要: A method of forming a bit line of a semiconductor device wherein an etch-stop nitride film, a trench oxide film and a hard mask nitride film are formed on a semiconductor substrate. The hard mask nitride film and the trench oxide film are etched to a limited etch thickness of a photo mask. The remaining trench oxide film is etched using the hard mask nitride film as a mask, thus forming a trench. The etch-stop nitride film and the hard mask nitride film are etched on condition that an oxide film has a high selectivity with respect to a nitride film. Accordingly, the loss of a top surface of the trench oxide film can be minimized and a bit line can be formed to have a uniform height. In accordance with the invention, bit line resistance and capacitance variation can be reduced and the reliability of a device can be improved.

    摘要翻译: 一种形成半导体器件的位线的方法,其中在半导体衬底上形成蚀刻停止氮化物膜,沟槽氧化物膜和硬掩模氮化物膜。 将硬掩模氮化物膜和沟槽氧化物膜蚀刻到光掩模的有限蚀刻厚度。 使用硬掩模氮化物膜作为掩模蚀刻剩余的沟槽氧化膜,从而形成沟槽。 在氧化膜相对于氮化物膜具有高选择性的条件下蚀刻蚀刻停止氮化物膜和硬掩模氮化物膜。 因此,可以使沟槽氧化膜的上表面的损失最小化,并且可以形成具有均匀高度的位线。 根据本发明,可以降低位线电阻和电容变化,并且可以提高器件的可靠性。

    Light emitting diode package and fabrication method thereof
    20.
    发明申请
    Light emitting diode package and fabrication method thereof 有权
    发光二极管封装及其制造方法

    公开(公告)号:US20060214178A1

    公开(公告)日:2006-09-28

    申请号:US11320968

    申请日:2005-12-30

    IPC分类号: H01L33/00

    摘要: The present invention provides a light emitting diode (LED) package and the fabrication method thereof. The LED package includes a lower metal layer, and a first silicon layer, a first insulation layer, a second silicon layer, a second insulation layer, and a package electrode pattern formed in their order on the lower metal layer. The LED package also includes a spacer having a cavity, formed on the electrode pattern. The LED package further includes an LED mounted in the cavity by flip-chip bonding to the electrode patterns, and an optical element attached to the upper surface of the spacer.

    摘要翻译: 本发明提供一种发光二极管(LED)封装及其制造方法。 LED封装包括下金属层,以及在下金属层上依次形成的第一硅层,第一绝缘层,第二硅层,第二绝缘层和封装电极图案。 LED封装还包括形成在电极图案上的具有空腔的间隔物。 LED封装还包括通过与电极图案倒装芯片结合而安装在腔中的LED以及附接到间隔件的上表面的光学元件。