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公开(公告)号：US08173778B2
公开(公告)日：2012-05-08
申请号：US12651145
申请日：2009-12-31
申请人： Osamu Ohara , Takahiro Nagase , Michio Oishi , Hiroshi Yokota , Osamu Kamida
发明人： Osamu Ohara , Takahiro Nagase , Michio Oishi , Hiroshi Yokota , Osamu Kamida
IPC分类号： C07K16/00
CPC分类号： A61K31/7088 , C07K14/4702 , C07K14/82 , G01N33/57446 , G01N33/57484 , G01N2333/4703 , Y10S435/81 , Y10S435/975
摘要： A gene encoding a novel protein that works as a guanine nucleotide exchange factor (GEF) for a Rho family protein being one group of small GTP-binding proteins, namely, a polynucleotide shown by the nucleotide sequence set forth in SEQ ID NO: 1, SEQ ID NO: 3, or SEQ ID NO: 5, or the complementary strand, the equivalents of the polynucleotide, a protein encoded by the polynucleotide, a vector containing the polynucleotide, a transformant containing the vector, an antibody against the protein encoded by the polynucleotide, a method of identifying a compound that inhibits the function of the protein encoded by the polynucleotide and/or the expression of the polynucleotide, a method of determining a disease, a pharmaceutical composition, and a reagent kit are provided.
摘要翻译： 编码作为Rho家族蛋白质的鸟嘌呤核苷酸交换因子（GEF）的新型蛋白质的基因是一组小的GTP结合蛋白，即由SEQ ID NO：1所示的核苷酸序列显示的多核苷酸， SEQ ID NO：3或SEQ ID NO：5，或互补链，多核苷酸的等同物，由多核苷酸编码的蛋白质，含有多核苷酸的载体，含有该载体的转化体， 提供多核苷酸，鉴定抑制多核苷酸编码的蛋白质的功能的化合物的方法和/或多核苷酸的表达，确定疾病的方法，药物组合物和试剂盒的方法。
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12.发明申请Gene encoding a guanmine nucleotide exchange factor and the gene product thereof 失效基因编码鸟苷核苷酸交换因子及其基因产物公开(公告)号：US20070196377A1
公开(公告)日：2007-08-23
申请号：US10594707
申请日：2005-03-29
申请人： Osamu Ohara , Takahiro Nagase , Michi Oishi , Hiroshi Yokota , Osamu Kamida
发明人： Osamu Ohara , Takahiro Nagase , Michi Oishi , Hiroshi Yokota , Osamu Kamida
IPC分类号： A61K48/00 , C12Q1/68 , G01N33/574 , C07H21/04 , C07K16/40 , A61K39/395 , C12P21/06 , C12N9/10
CPC分类号： A61K31/7088 , C07K14/4702 , C07K14/82 , G01N33/57446 , G01N33/57484 , G01N2333/4703 , Y10S435/81 , Y10S435/975
摘要： A gene encoding a novel protein that works as a guanine nucleotide exchange factor (GEF) for a Rho family protein being one group of small GTP-binding proteins, namely, a polynucleotide shown by the nucleotide sequence set forth in SEQ ID NO: 1, SEQ ID NO: 3, or SEQ ID NO: 5, or the complementary strand, the equivalents of the polynucleotide, a protein encoded by the polynucleotide, a vector containing the polynucleotide, a transformant containing the vector, an antibody against the protein encoded by the polynucleotide, a method of identifying a compound that inhibits the function of the protein encoded by the polynucleotide and/or the expression of the polynucleotide, a method of determining a disease, a pharmaceutical composition, and a reagent kit are provided.
摘要翻译： 编码作为Rho家族蛋白质的鸟嘌呤核苷酸交换因子（GEF）的新型蛋白质的基因是一组小的GTP结合蛋白，即由SEQ ID NO：1所示的核苷酸序列显示的多核苷酸， SEQ ID NO：3或SEQ ID NO：5，或互补链，多核苷酸的等同物，由多核苷酸编码的蛋白质，含有多核苷酸的载体，含有该载体的转化体， 提供多核苷酸，鉴定抑制多核苷酸编码的蛋白质的功能的化合物的方法和/或多核苷酸的表达，确定疾病的方法，药物组合物和试剂盒的方法。
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13.发明授权Gene encoding a guanine nucleotide exchange factor and the gene product thereof 失效编码鸟嘌呤核苷酸交换因子的基因及其基因产物公开(公告)号：US07667013B2
公开(公告)日：2010-02-23
申请号：US10594707
申请日：2005-03-29
申请人： Osamu Ohara , Takahiro Nagase , Michio Oishi , Hiroshi Yokota , Osamu Kamida
发明人： Osamu Ohara , Takahiro Nagase , Michio Oishi , Hiroshi Yokota , Osamu Kamida
IPC分类号： C12N15/11
CPC分类号： A61K31/7088 , C07K14/4702 , C07K14/82 , G01N33/57446 , G01N33/57484 , G01N2333/4703 , Y10S435/81 , Y10S435/975
摘要： A gene encoding a novel protein that works as a guanine nucleotide exchange factor (GEF) for a Rho family protein being one group of small GTP-binding proteins, namely, a polynucleotide shown by the nucleotide sequence set forth in SEQ ID NO: 1, SEQ ID NO: 3, or SEQ ID NO: 5, or the complementary strand, the equivalents of the polynucleotide, a protein encoded by the polynucleotide, a vector containing the polynucleotide, a transformant containing the vector, an antibody against the protein encoded by the polynucleotide, a method of identifying a compound that inhibits the function of the protein encoded by the polynucleotide and/or the expression of the polynucleotide, a method of determining a disease, a pharmaceutical composition, and a reagent kit are provided.
摘要翻译： 编码作为Rho家族蛋白质的鸟嘌呤核苷酸交换因子（GEF）的新型蛋白质的基因是一组小的GTP结合蛋白，即由SEQ ID NO：1所示的核苷酸序列显示的多核苷酸， SEQ ID NO：3或SEQ ID NO：5，或互补链，多核苷酸的等同物，由多核苷酸编码的蛋白质，含有多核苷酸的载体，含有该载体的转化体， 提供多核苷酸，鉴定抑制由多核苷酸编码的蛋白质的功能和/或多核苷酸表达的化合物的方法，确定疾病的方法，药物组合物和试剂盒。
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14.发明申请Formation/Elongation of Axon by Inhibiting the Expression or Function of Singar and Application to Nerve Regeneration 有权通过抑制单倍体的表达或功能形成/延伸轴突并应用于神经再生公开(公告)号：US20100267072A1
公开(公告)日：2010-10-21
申请号：US12084242
申请日：2006-10-26
申请人： Naoyuki Inagaki , Tatsuya Mori , Osamu Ohara , Takahiro Nagase
发明人： Naoyuki Inagaki , Tatsuya Mori , Osamu Ohara , Takahiro Nagase
CPC分类号： G01N33/5058 , C12N15/113 , C12N2310/14 , G01N2500/00
摘要： Singar is identified as a novel molecule, whose expression is varied before and after the polarization of a nerve cell, and occurs in the tip of an elongating axon, called a growth cone, which is important for the formation or elongation of an axon. Singar is expressed specifically in the brain and the amount of Singar expression is largely increased in an individual during periods where the formation of axons is increased. It is observed that Singar is highly enriched in the growth cone at the tip of an axon. When the expression of Singar is inhibited in nerve cells in culture, the formation of multiple axons is induced. Thus, the inhibition of Singar can induce axon formation. Therefore, by inhibiting the expression or activity of Singar, it becomes possible to induce or promote the formation or elongation of an axon in a nerve cell.
摘要翻译： Singar被鉴定为一种新颖的分子，其表达在神经细胞的极化之前和之后是变化的，并且发生在延伸轴突的尖端，称为生长锥，其对于轴突的形成或延伸是重要的。 Singar在脑中特异性表达，并且在轴突形成增加期间个体中Singar表达量大大增加。 观察到，Singar在轴突末端的生长锥中高度富集。 当培养中神经细胞中Singar的表达被抑制时，诱导多个轴突的形成。 因此，Singar的抑制可以诱导轴突形成。 因此，通过抑制Singar的表达或活性，可以诱导或促进神经细胞中轴突的形成或延伸。
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公开(公告)号：US07790866B2
公开(公告)日：2010-09-07
申请号：US10535733
申请日：2003-11-20
CPC分类号： C12N9/1048 , C07K14/4748
摘要： The present invention provides: a novel DNA, a carcinoma-associated gene comprising the DNA, a recombinant protein encoded by the DNA, an antibody binding to the protein, an anti-carcinoma agent comprising the antibody, a low-molecular-weight compound binding to the protein, and a screening system. An example of such a novel DNA is a DNA comprising a nucleotide sequence encoding the following polypeptide (a) or (b): (a) a polypeptide, consisting of an amino acid sequence identical to or substantially identical to the amino acid sequence represented by SEQ ID NO: 2; or (b) a polypeptide, consisting of an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 by deletion, substitution, or addition of one or a plurality of amino acids and having biological activity substantially equivalent to the functions of the polypeptide (a).
摘要翻译： 本发明提供：新型DNA，包含DNA的癌相关基因，由DNA编码的重组蛋白，与蛋白结合的抗体，包含抗体的抗癌剂，结合 蛋白质和筛选系统。 这样的新型DNA的实例是包含编码以下多肽（a）或（b）的核苷酸序列的DNA：（a）多肽，由与氨基酸序列相同或基本相同的氨基酸序列组成， SEQ ID NO：2; 或（b）通过缺失，取代或添加一个或多个氨基酸并具有与功能基本相同的生物学活性的由SEQ ID NO：2所示的氨基酸序列衍生的氨基酸序列组成的多肽 的多肽（a）。
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公开(公告)号：US20080262202A1
公开(公告)日：2008-10-23
申请号：US12099513
申请日：2008-04-08
IPC分类号： C07K14/47
CPC分类号： C07K14/47 , A61K2039/505
摘要： The present invention is related to a DNA comprising a nucleotide sequence encoding a polypeptide represented by SEQ ID NO:1 or SEQ ID NO:2. The DNA according to the present invention is highly expressed in prostatic adenocarcinoma and ovarian carcinoma, and is a cancer-associated gene, so that it is possible to inhibit cancer by blocking the binding of the present protein to its ligand. Accordingly, the present antibody is used not only in the detection of the present protein, but also as an agent for the treatment or prevention of cancers such as prostatic adenocarcinoma and ovarian carcinoma.
摘要翻译： 本发明涉及包含编码由SEQ ID NO：1或SEQ ID NO：2表示的多肽的核苷酸序列的DNA。 根据本发明的DNA在前列腺腺癌和卵巢癌中高度表达，并且是癌相关基因，使得可以通过阻断本发明蛋白质与其配体的结合来抑制癌症。 因此，本发明的抗体不仅用于检测本发明的蛋白质，而且用作治疗或预防前列腺腺癌和卵巢癌等癌症的药剂。
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公开(公告)号：US20060160082A1
公开(公告)日：2006-07-20
申请号：US10530880
申请日：2003-10-16
申请人： Osamu Ohara , Takahiro Nagase , Reiko Kikuno
发明人： Osamu Ohara , Takahiro Nagase , Reiko Kikuno
IPC分类号： C12Q1/68 , C07H21/02 , C12P21/06 , C07K14/705 , C07K16/28
CPC分类号： C07K14/47
摘要： A novel DNA comprising a protein-encoding region is directly cloned from cDNA library originating from human adult whole brain and human fetal whole brain, the base sequence thereof is determined, and the functions thereof are identified. A DNA comprising a base sequence encoding the following polypeptide (a) or (b): (a) a polypeptide consisting of an amino acid sequence which is identical or substantially identical with the amino acid sequence represented by SEQ ID No.1, (b) a polypeptide consisting of an amino acid sequence represented by SEQ ID No.1 in which part of amino acids are deleted, substituted or added, and having substantially the same biological activity as the function of the polypeptide (a), recombinant polypeptide encoded by the above DNAs, and protein comprising the polypeptide.
摘要翻译： 从源自人成人全脑和人胎儿全脑的cDNA文库直接克隆包含蛋白质编码区的新型DNA，确定其碱基序列，鉴定其功能。 包含编码以下多肽（a）或（b）的碱基序列的DNA：（a）由与SEQ ID No.1所代表的氨基酸序列相同或基本相同的氨基酸序列组成的多肽 ）由SEQ ID No.1所示的氨基酸序列组成的多肽，其中部分氨基酸缺失，取代或添加，并且具有与多肽（a）的功能基本上相同的生物学活性，由 上述DNA和包含该多肽的蛋白质。
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公开(公告)号：US20090258022A1
公开(公告)日：2009-10-15
申请号：US12013346
申请日：2008-01-11
IPC分类号： A61K39/395 , C07K16/18 , C12N5/06 , G01N33/566 , A61P37/02
CPC分类号： C07K14/705
摘要： A novel gene apparently encoding a transmembrane glycoprotein has been successfully isolated by constructing a cDNA library of 4 kb or above in size from mRNA expressed in human adult brain and analyzing the structures of the cDNAs contained within said library by the shotgun method. The novel gene shows brain-specific expression and the protein encoded by said gene has a typical PDZ binding motif.
摘要翻译： 通过构建人大脑中表达的mRNA的大小为4kb或以上的cDNA文库，并通过霰弹枪法分析所述文库中所含的cDNA的结构，已经成功地分离了显然编码跨膜糖蛋白的新基因。 该新基因显示脑特异性表达，由该基因编码的蛋白具有典型的PDZ结合基序。
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公开(公告)号：US20060275302A1
公开(公告)日：2006-12-07
申请号：US10535733
申请日：2003-11-20
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K14/82 , C07K16/30
CPC分类号： C12N9/1048 , C07K14/4748
摘要： The present invention provides: a novel DNA, a carcinoma-associated gene comprising the DNA, a recombinant protein encoded by the DNA, an antibody binding to the protein, an anti-carcinoma agent comprising the antibody, a low-molecular-weight compound binding to the protein, and a screening system. An example of such a novel DNA is a DNA comprising a nucleotide sequence encoding the following polypeptide (a) or (b): (a) a polypeptide, consisting of an amino acid sequence identical to or substantially identical to the amino acid sequence represented by SEQ ID NO: 2; or (b) a polypeptide, consisting of an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 by deletion, substitution, or addition of one or a plurality of amino acids and having biological activity substantially equivalent to the functions of the polypeptide (a).
摘要翻译： 本发明提供：新型DNA，包含DNA的癌相关基因，由DNA编码的重组蛋白，与蛋白结合的抗体，包含抗体的抗癌剂，结合 蛋白质和筛选系统。 这样的新型DNA的实例是包含编码以下多肽（a）或（b）的核苷酸序列的DNA：（a）多肽，由与氨基酸序列相同或基本相同的氨基酸序列组成， SEQ ID NO：2; 或（b）通过缺失，取代或添加一个或多个氨基酸并具有与功能基本相同的生物学活性的由SEQ ID NO：2所示的氨基酸序列衍生的氨基酸序列组成的多肽 的多肽（a）。
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公开(公告)号：US06716613B1
公开(公告)日：2004-04-06
申请号：US10009332
申请日：2001-12-10
申请人： Noboru Yamaji , Kouichi Nishimura , Kunitake Abe , Osamu Ohara , Takahiro Nagase , Nobuo Nomura
发明人： Noboru Yamaji , Kouichi Nishimura , Kunitake Abe , Osamu Ohara , Takahiro Nagase , Nobuo Nomura
IPC分类号： C12N948
CPC分类号： C12N9/6489 , A61K38/00
摘要： This invention provides a novel metalloprotease having an aggrecanase activity which causes joint diseases, a gene coding for this metalloprotease, a promoter of the above metalloprotease, a method for screening a drug with the use of the above metalloprotease and a pharmaceutical composition for inhibiting degradation of proteoglycans, which comprises as the active ingredient a substance capable of inhibiting the aggrecanase activity of the above metalloprotease.
摘要翻译： 本发明提供了具有引起关节疾病的聚集蛋白聚糖酶活性的新型金属蛋白酶，编码该金属蛋白酶的基因，上述金属蛋白酶的启动子，使用上述金属蛋白酶进行药物筛选的方法和抑制降解的药物组合物 蛋白多糖，其包含作为活性成分的能够抑制上述金属蛋白酶的聚集蛋白聚糖酶活性的物质。
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