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公开(公告)号：US20100041760A1
公开(公告)日：2010-02-18
申请号：US12540780
申请日：2009-08-13
申请人： Jean-Baptiste Blanc , Li Chen , Fariborz Firooznia , Paul Gillespie , Robert Alan Goodnow, JR. , Tai-An Lin , Song Pan , Sung-Sau So , HongYing Yun
发明人： Jean-Baptiste Blanc , Li Chen , Fariborz Firooznia , Paul Gillespie , Robert Alan Goodnow, JR. , Tai-An Lin , Song Pan , Sung-Sau So , HongYing Yun
IPC分类号： A61K31/18 , C07C311/00
CPC分类号： C07D295/08 , C07C311/20 , C07C311/29 , C07C311/43 , C07C317/14 , C07C323/66 , C07C323/67 , C07C2601/02 , C07C2601/08 , C07C2602/10
摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein R1, R2 and R3 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和酯，其中R 1，R 2和R 3在详细描述和权利要求书中定义。 此外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂，可用于治疗与该受体相关的疾病和病症如哮喘。
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公开(公告)号：US20100041713A1
公开(公告)日：2010-02-18
申请号：US12540839
申请日：2009-08-13
申请人： Fariborz Firooznia , Paul Gillespie , Robert Alan Goodnow, JR. , Tai-An Lin , Achyutharao Sidduri , Sung-Sau So , Jenny Tan
发明人： Fariborz Firooznia , Paul Gillespie , Robert Alan Goodnow, JR. , Tai-An Lin , Achyutharao Sidduri , Sung-Sau So , Jenny Tan
IPC分类号： A61K31/18 , C07C311/20 , C07D213/71 , A61K31/4418
CPC分类号： C07C311/29 , C07C311/20 , C07C317/14 , C07C2602/10 , C07D213/34
摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein R1-R4 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和酯，其中R 1 -R 4在详细描述和权利要求书中定义。 此外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂，可用于治疗与该受体相关的疾病和病症如哮喘。
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公开(公告)号：US20090149466A1
公开(公告)日：2009-06-11
申请号：US12328874
申请日：2008-12-05
IPC分类号： A61K31/513 , C07D403/04
CPC分类号： C07D239/47
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗诸如肥胖的疾病。
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14.发明授权公开(公告)号：US07524870B2
公开(公告)日：2009-04-28
申请号：US11283925
申请日：2005-11-21
IPC分类号： C07D401/02 , A61K31/44
CPC分类号： C07C65/24 , C07C51/09 , C07D213/30 , C07D213/61 , C07D213/64 , C07D213/79 , C07D215/06 , C07D215/14 , C07D231/12 , C07D261/08 , C07D277/56 , C07D307/42 , C07D317/54 , C07D319/08 , C07D333/16 , C07D401/12 , C07D409/12 , C07D417/12 , C07C59/66
摘要： The present invention relates to compounds of formula (I) wherein Ar, Ar2, R2, R3, R4, m, p and s are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases that are associated with the activation of the glycogen synthase enzyme, such as diabetes.
摘要翻译： 本发明涉及其中Ar，Ar 2，R 2，R 3，R 4，m，p和s如说明书和权利要求书中所定义的式（I）化合物及其药学上可接受的盐。 该化合物可用于治疗和/或预防与糖原合成酶如糖尿病的活化相关的疾病。
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公开(公告)号：US08163781B2
公开(公告)日：2012-04-24
申请号：US12540804
申请日：2009-08-13
申请人： Jean-Baptiste Blanc , Li Chen , Fariborz Firooznia , Paul Gillespie , Robert Alan Goodnow, Jr. , Yun He , Tai-An Lin , Sung-Sau So , HongYing Yun , Zhenshan Zhang
发明人： Jean-Baptiste Blanc , Li Chen , Fariborz Firooznia , Paul Gillespie , Robert Alan Goodnow, Jr. , Yun He , Tai-An Lin , Sung-Sau So , HongYing Yun , Zhenshan Zhang
IPC分类号： C07D213/62 , A61K31/4412
CPC分类号： C07D213/71 , C07C311/20 , C07C311/29 , C07C317/14 , C07C323/67 , C07C2602/10 , C07D213/34 , C07D409/04
摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein R1-R5, A, B, Q, W, and X are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和酯，其中R1-R5，A，B，Q，W和X在详细描述和权利要求书中定义。 此外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂，可用于治疗与该受体相关的疾病和病症如哮喘。
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公开(公告)号：US20100041714A1
公开(公告)日：2010-02-18
申请号：US12540804
申请日：2009-08-13
申请人： Jean-Baptiste Blanc , Li Chen , Fariborz Firooznia , Paul Gillespie , Robert Alan Goodnow, JR. , Yun He , Tai-An Lin , Sung-Sau So , HongYing Yun , Zhenshan Zhang
发明人： Jean-Baptiste Blanc , Li Chen , Fariborz Firooznia , Paul Gillespie , Robert Alan Goodnow, JR. , Yun He , Tai-An Lin , Sung-Sau So , HongYing Yun , Zhenshan Zhang
IPC分类号： A61K31/4412 , C07C317/14 , C07D213/62 , A61K31/196 , A61P37/08
CPC分类号： C07D213/71 , C07C311/20 , C07C311/29 , C07C317/14 , C07C323/67 , C07C2602/10 , C07D213/34 , C07D409/04
摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein R1-R5, A, B, Q, W, and X are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和酯，其中R1-R5，A，B，Q，W和X在详细描述和权利要求书中定义。 此外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂，可用于治疗与该受体相关的疾病和病症如哮喘。
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公开(公告)号：US08093385B2
公开(公告)日：2012-01-10
申请号：US12180738
申请日：2008-07-28
申请人： Romyr Dominique , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow , Agnieszka Kowalczyk , Qi Qiao , Achyutharao Sidduri
发明人： Romyr Dominique , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow , Agnieszka Kowalczyk , Qi Qiao , Achyutharao Sidduri
IPC分类号： C07D403/00 , C07D231/00 , C07D239/42 , C07C59/40 , A61K31/19 , A61K31/44
CPC分类号： C07C59/68 , C07C217/80 , C07C229/34 , C07C323/56 , C07D209/12 , C07D213/30 , C07D213/61 , C07D215/14 , C07D239/26 , C07D239/54 , C07D317/54 , C07D319/18 , C07D333/20 , C07D405/10 , C07D409/10 , C07D409/14
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, COPD.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如COPD。
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公开(公告)号：US20090054466A1
公开(公告)日：2009-02-26
申请号：US12180738
申请日：2008-07-28
申请人： Romyr Dominique , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow , Agnieszka Kowalczyk , Qi Qiao , Achyutharao Sidduri
发明人： Romyr Dominique , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow , Agnieszka Kowalczyk , Qi Qiao , Achyutharao Sidduri
IPC分类号： A61K31/506 , A61K31/444 , C07D401/10 , A61K31/194 , C07C59/235 , C07D403/10
CPC分类号： C07C59/68 , C07C217/80 , C07C229/34 , C07C323/56 , C07D209/12 , C07D213/30 , C07D213/61 , C07D215/14 , C07D239/26 , C07D239/54 , C07D317/54 , C07D319/18 , C07D333/20 , C07D405/10 , C07D409/10 , C07D409/14
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, COPD
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗诸如COPD的疾病
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公开(公告)号：US20070049632A1
公开(公告)日：2007-03-01
申请号：US11507080
申请日：2006-08-18
申请人： Bruce Banner , Joseph Bilotta , Nader Fotouhi , Paul Gillespie , Robert Goodnow , Matthew Hamilton , Nancy-Ellen Haynes , Agnieszka Kowalczyk , Alexander Mayweg , Michael Myers , Sherrie Pietranico-Cole , Nathan Scott , Kshitij Thakkar , Jefferson Tilley
发明人： Bruce Banner , Joseph Bilotta , Nader Fotouhi , Paul Gillespie , Robert Goodnow , Matthew Hamilton , Nancy-Ellen Haynes , Agnieszka Kowalczyk , Alexander Mayweg , Michael Myers , Sherrie Pietranico-Cole , Nathan Scott , Kshitij Thakkar , Jefferson Tilley
IPC分类号： A61K31/416 , C07D231/54
CPC分类号： C07D231/54
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如II型糖尿病和代谢综合征。
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公开(公告)号：US08188098B2
公开(公告)日：2012-05-29
申请号：US12433921
申请日：2009-05-01
申请人： Shawn David Erickson , Paul Gillespie , Kevin Richard Guertin , Prabha Saba Karnachi , Kyungjin Kim , Chun Ma , Warren William McComas , Sherrie Lynn Pietranico-Cole , Lida Qi , Jefferson Wright Tilley , Qiang Zhang
发明人： Shawn David Erickson , Paul Gillespie , Kevin Richard Guertin , Prabha Saba Karnachi , Kyungjin Kim , Chun Ma , Warren William McComas , Sherrie Lynn Pietranico-Cole , Lida Qi , Jefferson Wright Tilley , Qiang Zhang
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症，例如II型糖尿病。
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