公开(公告)号：US5885430A

公开(公告)日：1999-03-23

申请号：US726877

申请日：1996-10-04

申请人： John R. Kernan ,  Thomas E. Kane

发明人： John R. Kernan ,  Thomas E. Kane

IPC分类号： G01N27/447 ,  G01N27/26

CPC分类号： G01N27/44704 ,  G01N27/44782

摘要： An automated electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from one side of a plate. The first array of capillary ends are spaced apart in substantially the same manner as the wells of a microtitre tray of standard size. This allows one to simultaneously perform capillary electrophoresis on samples present in each of the wells of the tray. The capillary cartridge has two embodiments. In one embodiment, the second ends of the capillary tubes are also arranged is such an array. In a second embodiment, the second ends communicate with an interior cavity of pressure cell from which solutions, gels and the like may be introduced. The pressure cell allows for applying high pressure to clean out the capillary tubes. An apparatus for performing automated capillary gel electrophoresis using such a cartridge is also disclosed.

摘要翻译： 公开了一种自动电泳系统。 该系统采用具有多个毛细管的毛细管盒。 盒具有从板的一侧突出的第一阵列的毛细管端。 毛细管端部的第一阵列以与标准尺寸的微量托盘的孔基本相同的方式间隔开。 这允许人们同时对存在于托盘的每个孔中的样品进行毛细管电泳。 毛细管盒具有两个实施例。 在一个实施例中，毛细管的第二端也布置为这样的阵列。 在第二实施例中，第二端与压力池的内部空腔连通，可以引入溶液，凝胶等。 压力池允许施加高压以清洁毛细管。 还公开了使用这种盒进行自动毛细管凝胶电泳的装置。

公开(公告)号：US09994714B2

公开(公告)日：2018-06-12

申请号：US14891278

申请日：2014-05-16

申请人： Thomas E. Kane

发明人： Thomas E. Kane ,  Brian A. Jones

IPC分类号： C09B67/08 ,  C09B65/00 ,  C09B67/02 ,  A61K8/25 ,  A61Q1/02 ,  A61K8/02 ,  B05D1/18 ,  B05D7/00 ,  C09D7/12

CPC分类号： C09B67/0007 ,  A61K8/0241 ,  A61K8/25 ,  A61K2800/412 ,  A61K2800/61 ,  A61K2800/651 ,  A61Q1/02 ,  B05D1/18 ,  B05D7/57 ,  B05D7/58 ,  C09B65/00 ,  C09B67/0013 ,  C09B67/0097 ,  C09D7/62

摘要： A pigment particle for use in artist color media comprises a silica containing core particle having pore channels formed therein, at least one colorant present in the pore channels in at least part of the silica particle, and a nonporous silica layer coated over the pore channels. A method of manufacturing colored particles for use in artist color media comprises providing a core silica particle having pore channels formed therein, loading at least one colorant into the pore channels of the particle, and depositing a silica layer over the pore channels using fluorosilicic acid. Another method of manufacturing colored particles for use in artist color media comprises providing a porous silica particle having pore channels formed therein, and depositing a silica layer over the pore channels using a fluorosilicic acid where a colorant is present in the fluorosilicic acid.

公开(公告)号：US20100147692A1

公开(公告)日：2010-06-17

申请号：US12634661

申请日：2009-12-09

申请人： Changsheng Liu ,  Thomas E. Kane ,  Qingbo Li

发明人： Changsheng Liu ,  Thomas E. Kane ,  Qingbo Li

IPC分类号： G01N27/00

CPC分类号： C07K1/26 ,  G01N27/44704 ,  G01N27/44743 ,  G01N27/44782 ,  Y10T436/2575

摘要： An automated capillary zone electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from one side of a plate. The first array of capillary ends is spaced apart in substantially the same manner as the wells of a microtitre tray of standard size. This allows one to simultaneously perform capillary electrophoresis on samples present in each of the wells of the tray. The system includes a stacked, dual carrousel arrangement to eliminate cross-contamination resulting from reuse of the same buffer tray on consecutive executions from electrophoresis. The system also has a container connected to the detection end of the capillaries. The container is provided with valving which facilitate cleaning the capillaries, loading buffer into the capillaries, introducing samples to be electrophoresced into the capillaries, and performing capillary zone electrophoresis on the thus introduced samples.

摘要翻译： 公开了一种自动化毛细管区域电泳系统。 该系统采用具有多个毛细管的毛细管盒。 盒具有从板的一侧突出的第一阵列的毛细管端。 毛细管端部的第一阵列以与标准尺寸的微量滴定塔的孔基本相同的方式间隔开。 这允许人们同时对存在于托盘的每个孔中的样品进行毛细管电泳。 该系统包括堆叠的双转盘装置，以消除由连续的电泳执行中重复使用相同的缓冲盘引起的交叉污染。 该系统还具有连接到毛细管的检测端的容器。 该容器设置有阀，其有助于清洁毛细管，将缓冲液加载到毛细管中，将待电泳的样品引入毛细管中，并在这样引入的样品上进行毛细管区带电泳。

公开(公告)号：US06485783B1

公开(公告)日：2002-11-26

申请号：US09704644

申请日：2000-11-01

申请人： Robert J. Bailey ,  Lisa H. Michael ,  Thomas E. Kane

发明人： Robert J. Bailey ,  Lisa H. Michael ,  Thomas E. Kane

IPC分类号： C23C1606

CPC分类号： C23C28/345 ,  C23C16/4404 ,  C23C16/54 ,  C23C28/321

摘要： A chemical vapor deposition (CVD) system is provided for processing a substrate 110. The system 100 includes a heated muffle 115, a chamber 120 having an injector assembly 130 for introducing chemical vapor to process the substrate 110, and a belt 105 for moving the substrate through the muffle and chamber. The belt 105 has an oxidation-resistant coating 175 to reduce formation of deposits thereon. The coating 175 is particularly useful for resisting formation of chromium oxides on belts made from a chromium-containing alloy. In one embodiment, the oxidation-resistant coating 175 comprises a securely-adhered oxide layer 185 that is substantially free of transition metals. Preferably, the oxidation-resistant coating 175 comprises aluminum oxide. More preferably, the coating 175 comprises an aluminum oxide layer 185 securely adhered over a nickel aluminide layer 180.

摘要翻译： 提供了用于处理衬底110的化学气相沉积（CVD）系统。系统100包括加热的马弗炉115，具有用于引入化学蒸汽以处理衬底110的喷射器组件130的腔室120和用于移动 衬底通过马弗炉和腔室。 带105具有抗氧化涂层175以减少沉积物的形成。 涂层175特别可用于在由含铬合金制成的带上形成铬氧化物。 在一个实施例中，抗氧化涂层175包括基本上不含过渡金属的牢固粘附的氧化物层185。 优选地，抗氧化涂层175包括氧化铝。 更优选地，涂层175包括牢固地粘附在镍铝层180上的氧化铝层185。

公开(公告)号：US06206973B1

公开(公告)日：2001-03-27

申请号：US09480730

申请日：2000-01-06

申请人： Robert J. Bailey ,  Lisa H. Michael ,  Thomas E. Kane

发明人： Robert J. Bailey ,  Lisa H. Michael ,  Thomas E. Kane

IPC分类号： C23C1600

CPC分类号： C23C28/345 ,  C23C16/4404 ,  C23C16/54 ,  C23C28/321

摘要： A chemical vapor deposition (CVD) system is provided for processing a substrate 110. The system 100 includes a heated muffle 115, a chamber 120 having an injector assembly 130 for introducing chemical vapor to process the substrate 110, and a belt 105 for moving the substrate through the muffle and chamber. The belt 105 has an oxidation-resistant coating 175 to reduce formation of deposits thereon. The coating 175 is particularly useful for resisting formation of chromium oxides on belts made from a chromium-containing alloy. In one embodiment, the oxidation-resistant coating 175 comprises a securely-adhered oxide layer 185 that is substantially free of transition metals. Preferably, the oxidation-resistant coating 175 comprises aluminum oxide. More preferably, the coating 175 comprises an aluminum oxide layer 185 securely adhered over a nickel aluminide layer 180.

摘要翻译： 提供了用于处理衬底110的化学气相沉积（CVD）系统。系统100包括加热的马弗炉115，具有用于引入化学蒸汽以处理衬底110的喷射器组件130的腔室120和用于移动 衬底通过马弗炉和腔室。 带105具有抗氧化涂层175以减少沉积物的形成。 涂层175特别可用于在由含铬合金制成的带上形成铬氧化物。 在一个实施例中，抗氧化涂层175包括基本上不含过渡金属的牢固粘附的氧化物层185。 优选地，抗氧化涂层175包括氧化铝。 更优选地，涂层175包括牢固地粘附在镍铝层180上的氧化铝层185。

公开(公告)号：US6063251A

公开(公告)日：2000-05-16

申请号：US866308

申请日：1997-05-30

申请人： Thomas E. Kane ,  John R. Kernan ,  Changsheng Liu ,  Qingbo Li

发明人： Thomas E. Kane ,  John R. Kernan ,  Changsheng Liu ,  Qingbo Li

IPC分类号： G01N27/447

CPC分类号： G01N27/44782

摘要： An automated electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from one side of a plate. The first array of capillary ends are spaced apart in substantially the same manner as the wells of a microtitre tray of standard size. This allows one to simultaneously perform capillary electrophoresis on samples present in each of the wells of the tray. Electrical crosstalk between neighboring capillaries is attenuated using a protective tubing formed from an electrically insulative material. This crosstalk attenuation is provided in the form of sheathing, either around individual capillaries, or around bundles of spaced apart capillaries. Crosstalk attenuation may be enhanced by passing a nonconductive gas or liquid through lumens formed in the protective tubing, in which lumens the capillary tubes are present.

摘要翻译： 公开了一种自动电泳系统。 该系统采用具有多个毛细管的毛细管盒。 盒具有从板的一侧突出的第一阵列的毛细管端。 毛细管端部的第一阵列以与标准尺寸的微量托盘的孔基本相同的方式间隔开。 这允许人们同时对存在于托盘的每个孔中的样品进行毛细管电泳。 使用由电绝缘材料形成的保护管，相邻毛细管之间的电气串扰被衰减。 这种串扰衰减以围绕单个毛细管或围绕分开的毛细管束的护套形式提供。 可以通过使非导电气体或液体通过在保护管中形成的内腔（其中存在毛细管的管腔）来增强串扰衰减。

公开(公告)号：US6027627A

公开(公告)日：2000-02-22

申请号：US105988

申请日：1998-06-29

申请人： Qingbo Li ,  Thomas E. Kane ,  Changsheng Liu ,  Bernard Sonnenschein ,  Michael V. Sharer ,  John R. Kernan

发明人： Qingbo Li ,  Thomas E. Kane ,  Changsheng Liu ,  Bernard Sonnenschein ,  Michael V. Sharer ,  John R. Kernan

IPC分类号： G01N27/447 ,  G01N27/26 ,  G01N27/477

CPC分类号： G01N27/44782

摘要： An automated electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from one side of a plate. The first array of capillary ends are spaced apart in substantially the same manner as the wells of a microtitre tray of standard size. This allows one to simultaneously perform capillary electrophoresis on samples present in each of the wells of the tray. The system includes a stacked, dual carousel arrangement to eliminate cross-contamination resulting from reuse of the same buffer tray on consecutive executions from electrophoresis. The system also has a gel delivery module containing a gel syringe/a stepper motor or a high pressure chamber with a pump to quickly and uniformly deliver gel through the capillary tubes. The system further includes a multi-wavelength beam generator to generate a laser beam which produces a beam with a wide range of wavelengths. An off-line capillary reconditioner thoroughly cleans a capillary cartridge to enable simultaneous execution of electrophoresis with another capillary cartridge. The streamlined nature of the off-line capillary reconditioner offers the advantage of increased system throughput with a minimal increase in system cost.

摘要翻译： 公开了一种自动电泳系统。 该系统采用具有多个毛细管的毛细管盒。 盒具有从板的一侧突出的第一阵列的毛细管端。 毛细管端部的第一阵列以与标准尺寸的微量托盘的孔基本相同的方式间隔开。 这允许人们同时对存在于托盘的每个孔中的样品进行毛细管电泳。 该系统包括堆叠的双转盘装置，以消除由连续的电泳执行中重复使用相同的缓冲盘引起的交叉污染。 该系统还具有含有凝胶注射器/步进电机或具有泵的高压室的凝胶递送模块，以通过毛细管快速均匀地输送凝胶。 该系统还包括多波长光束发生器，以产生产生具有宽波长范围的光束的激光束。 离线毛细管修复器彻底清洁毛细管柱，以便同时执行另一个毛细管柱的电泳。 离线毛细管再生器的流线型性质提供了增加系统吞吐量的优点，同时最小化了系统成本。

公开(公告)号：US5642790A

公开(公告)日：1997-07-01

申请号：US710564

申请日：1996-09-19

申请人： Thomas J. Kane ,  Thomas E. Kane

发明人： Thomas J. Kane ,  Thomas E. Kane

IPC分类号： B60C25/00 ,  F16N7/00 ,  F16N7/12

CPC分类号： F16N7/00 ,  B60C25/0596

摘要： A method and apparatus for applying a lubricant to an object is disclosed. The lubrication apparatus includes a rotatable and cylindrically shaped brush for applying the lubricant to the object, a housing for holding the brush, and a pump for applying the lubricant to the brush located in a chamber positioned below the brush. A vertical slide cylinder moves the brush in a generally vertical direction along the central axis in and out of the chamber, and a horizontal slide cylinder moves the brush in a generally horizontal direction transverse to the central axis to contact the object. The chamber has a sloped chamber cap connected to the top portion of the chamber for collecting lubricant that drips from the brush. The brush is preferably rotated by a motor. The method of applying the lubricant to the object includes the steps of applying the lubricant to the brush in the chamber, moving the brush to a vertical position equal that of the object, moving the brush horizontally to contact the object, and lubricating the object by rotating the object and the brush.

摘要翻译： 公开了一种用于向物体施加润滑剂的方法和装置。 润滑装置包括用于将润滑剂施加到物体的可旋转和圆柱形的刷子，用于保持刷子的壳体和用于将润滑剂施加到位于刷子下方的腔室中的刷子的泵。 垂直滑动缸沿着中心轴线沿着中心轴线大致垂直的方向移动，并且使水平滑动缸沿与中心轴线大致水平的方向移动以接触物体。 该室具有连接到室的顶部的倾斜室盖，用于收集从刷子滴下的润滑剂。 刷子优选地由电动机旋转。 将润滑剂涂敷到物体上的方法包括以下步骤：将润滑剂涂布在室内的刷子上，将刷子移动到与物体相同的垂直位置，使刷子水平移动以接触物体，并通过 旋转物体和刷子。

公开(公告)号：US20160108244A1

公开(公告)日：2016-04-21

申请号：US14891278

申请日：2014-05-16

申请人： Thomas E. Kane

发明人： Thomas E. Kane ,  Brian A. Jones

IPC分类号： C09B67/08 ,  B05D1/18 ,  B05D7/00 ,  C09D7/12

CPC分类号： C09B67/0007 ,  A61K8/0241 ,  A61K8/25 ,  A61K2800/412 ,  A61K2800/61 ,  A61K2800/651 ,  A61Q1/02 ,  B05D1/18 ,  B05D7/57 ,  B05D7/58 ,  C09B65/00 ,  C09B67/0013 ,  C09B67/0097 ,  C09D7/62

摘要： A pigment particle for use in artist color media comprises a silica containing core particle having pore channels formed therein, at least one colorant present in the pore channels in at least part of the silica particle, and a nonporous silica layer coated over the pore channels. A method of manufacturing colored particles for use in artist color media comprises providing a core silica particle having pore channels formed therein, loading at least one colorant into the pore channels of the particle, and depositing a silica layer over the pore channels using fluorosilicic acid. Another method of manufacturing colored particles for use in artist color media comprises providing a porous silica particle having pore channels formed therein, and depositing a silica layer over the pore channels using a fluorosilicic acid where a colorant is present in the fluorosilicic acid.

摘要翻译： 用于艺术家彩色介质的颜料颗粒包括其中形成有孔通道的二氧化硅核心颗粒，存在于至少部分二氧化硅颗粒中的孔通道中的至少一种着色剂和涂覆在孔道上的无孔二氧化硅层。 制造用于艺术家彩色介质的有色颗粒的制造方法包括提供其中形成有孔隙的核心二氧化硅颗粒，将至少一种着色剂加载到颗粒的孔通道中，以及使用氟硅酸在孔道上沉积二氧化硅层。 制造用于艺术家彩色培养基的彩色颗粒的另一种方法包括提供一种其中形成有孔隙通道的多孔二氧化硅颗粒，并使用氟硅酸在氟硅酸中沉积二氧化硅层，其中着色剂存在于氟硅酸中。

公开(公告)号：US20130081484A1

公开(公告)日：2013-04-04

申请号：US13516359

申请日：2010-12-15

申请人： Brian A. Jones ,  Scott L. Grossman ,  Valerie S. Strohm ,  Thomas E. Kane

发明人： Brian A. Jones ,  Scott L. Grossman ,  Valerie S. Strohm ,  Thomas E. Kane

IPC分类号： G01N33/00 ,  B05D1/18 ,  G01K13/00

CPC分类号： G01N33/00 ,  B01L3/50 ,  B01L2200/143 ,  B01L2200/147 ,  B01L2300/0832 ,  B05D1/18 ,  G01K13/00 ,  G01N30/04 ,  G01N2030/126 ,  G01N2030/167

摘要： A container used for chromatographic sample analysis has (a) at least one silica uppermost layer, which is deposited onto the container using a liquid phase deposition process, and, optionally, (b) at least one indicator present in at least part of the at least one silica uppermost layer for visually distinguishing the container from other containers, and/or determining the “use status” of the container, and/or identifying the proper orientation of the container when it is to be put in use, and/or providing a means of decoration, identification, or counterfeit detection. In one preferred embodiment, the indicator is thermochromic. In another preferred embodiment, the indicator is photochromic.

摘要翻译： 用于色谱样品分析的容器具有（a）至少一个二氧化硅最上层，其使用液相沉积工艺沉积到容器上，并且任选地（b）至少一个指示剂存在于至少一部分 至少一个二氧化硅最上层，用于将容器与其他容器视觉上区分开，和/或确定容器的使用状态，和/或在容器被使用时识别容器的正确取向，和/或提供一种装置 的装饰，鉴定或假冒检测。 在一个优选实施方案中，指示剂是热变色的。 在另一个优选实施方案中，指示剂是光致变色的。