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公开(公告)号：US09351964B2
公开(公告)日：2016-05-31
申请号：US13321257
申请日：2010-05-27
申请人： Neil Almstead , Tamil Arasu , Soongyu Choi , Liangxian Cao , Jeffrey Allen Campbell , Donald Corson , Thomas W. Davis , Jason D. Graci , Zhengxian Gu , Peter Seongwoo Hwang , William Lennox , Harry H. Miao , Langdon Miller , Young-Choon Moon , Hongyan Qi , Christopher Trotta , Marla L. Weetall
发明人： Neil Almstead , Tamil Arasu , Soongyu Choi , Liangxian Cao , Jeffrey Allen Campbell , Donald Corson , Thomas W. Davis , Jason D. Graci , Zhengxian Gu , Peter Seongwoo Hwang , William Lennox , Harry H. Miao , Langdon Miller , Young-Choon Moon , Hongyan Qi , Christopher Trotta , Marla L. Weetall
IPC分类号： A01N43/04 , A61K31/44 , A61K45/06 , A61K31/4745 , A61K31/437 , C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , A61K31/44 , A61K31/4745 , A61K45/06 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/401 , Y02A50/463 , Y02A50/465
摘要： Compounds, such as compounds of Formula (I), that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral replication or the production of viral RNA or DNA or viral protein and compositions comprising such Compounds are described. Also described are methods of reducing VEGF using such Compounds and methods for treating cancer and non-neoplastic conditions involving the administration of such Compounds. Further described are methods of inhibiting viral replication or the production of viral RNA or DNA or viral protein using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments.
摘要翻译： 描述了选择性抑制人血管内皮生长因子（VEGF）的病理生成的化合物，例如式（I）的化合物和包含这些化合物的组合物。 描述了抑制病毒复制或产生病毒RNA或DNA或病毒蛋白的化合物和包含这些化合物的组合物。 还描述了使用这些化合物还原VEGF的方法以及用于治疗涉及施用这些化合物的癌症和非肿瘤性病症的方法。 进一步描述的是使用这种用于治疗涉及施用这些化合物的病毒感染的化合物和方法来抑制病毒复制或产生病毒RNA或DNA或病毒蛋白质的方法。 化合物可以作为单一药物治疗或与一种或多种另外的治疗组合施用于需要这种治疗的人。
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公开(公告)号：US6130220A
公开(公告)日：2000-10-10
申请号：US369677
申请日：1999-08-05
申请人： Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Jian Jeffrey Chen , Robert Than Hendricks , Michael Joseph Melnick , Keith Adrian Murray Walker
发明人： Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Jian Jeffrey Chen , Robert Than Hendricks , Michael Joseph Melnick , Keith Adrian Murray Walker
IPC分类号： C07C307/06 , C07D211/36 , C07D213/74 , C07D295/26 , C07D401/04 , C07D401/12 , A61K31/495 , A01N43/42 , C07D279/10 , C07D471/00 , C07D471/02
CPC分类号： C07D295/26 , C07C307/06 , C07D211/36 , C07D213/74 , C07D401/04 , C07D401/12
摘要： This invention relates to sulfamides of formula (I) ##STR1## that are inhibitors of metalloproteases, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
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公开(公告)号：US07868037B2
公开(公告)日：2011-01-11
申请号：US11331180
申请日：2006-01-13
申请人： Gary Mitchell Karp , Peter Seongwoo Hwang , James Jan Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Allan Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell
发明人： Gary Mitchell Karp , Peter Seongwoo Hwang , James Jan Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Allan Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell
IPC分类号： C07D209/10 , A61K31/404
CPC分类号： C07D403/12 , C07D209/14 , C07D209/42 , C07D401/12 , C07D403/10 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
摘要翻译： 本发明提供化合物，药物组合物和使用这些化合物或组合物治疗病毒感染或影响病毒IRES活性的方法。
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公开(公告)号：US07772271B2
公开(公告)日：2010-08-10
申请号：US11653448
申请日：2007-01-16
申请人： Gary Mitchell Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
发明人： Gary Mitchell Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC分类号： C07D209/10 , A61K31/404
CPC分类号： C07D209/30 , C07D209/14 , C07D209/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
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公开(公告)号：US07074939B2
公开(公告)日：2006-07-11
申请号：US11065841
申请日：2005-02-25
IPC分类号： C07D209/36
CPC分类号： C07D209/42 , C07D209/10 , C07D209/30 , C07D209/36
摘要： This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a —CH2—, —O—, —S—, or —S(O)—; and the other substituents are as defined in the specification; or individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents
摘要翻译： 本发明涉及通常为抗炎和止痛化合物的化合物，其由式I表示：其中A为-CH 2 - ， - O - ， - S-或 - 所以）-; 而其它取代基如说明书中所定义; 或各异构体，异构体的混合物及其药学上可接受的盐。 本发明还涉及含有这些化合物的药物组合物及其用作治疗剂的方法
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公开(公告)号：US06867185B2
公开(公告)日：2005-03-15
申请号：US10317451
申请日：2002-12-12
CPC分类号： C07K5/0804 , A61K38/00
摘要： The present invention relates to macrocyclic compounds, methods for making these compounds, pharmaceutical compositions and the therapeutic or prophylactic use of these compounds by administering said compounds to mammals or treat hepatitis C virus (HCV) infection.
摘要翻译： 本发明涉及大环化合物，制备这些化合物的方法，药物组合物以及通过将哺乳动物施用所述化合物或治疗丙型肝炎病毒（HCV）感染来治疗或预防这些化合物的用途。
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公开(公告)号：US06787559B2
公开(公告)日：2004-09-07
申请号：US10267727
申请日：2002-10-09
申请人： Roland Joseph Billledeau , Chris Allen Broka , Jeffrey Allen Campbell , Jian Jeffrey Chen , Sharon Marie Dankwardt , Nancy Delaet , Leslie Ann Robinson , Keith Adrian Murray Walker
发明人： Roland Joseph Billledeau , Chris Allen Broka , Jeffrey Allen Campbell , Jian Jeffrey Chen , Sharon Marie Dankwardt , Nancy Delaet , Leslie Ann Robinson , Keith Adrian Murray Walker
IPC分类号： A61K31445
CPC分类号： C07D235/06 , C07C311/27 , C07D209/08 , C07D209/12 , C07D317/58
摘要： This invention relates to certain sulfonamide derivatives that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
摘要翻译： 本发明涉及某些作为前胶原C-蛋白酶抑制剂的磺酰胺衍生物，含有它们的药物组合物，其使用方法和制备这些化合物的方法。
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公开(公告)号：US06492394B1
公开(公告)日：2002-12-10
申请号：US09469660
申请日：1999-12-22
申请人： Roland Joseph Billledeau , Chris Allen Broka , Jeffrey Allen Campbell , Jian Jeffrey Chen , Sharon Marie Dankwardt , Nancy Delaet , Leslie Ann Robinson , Keith Adrian Murray Walker
发明人： Roland Joseph Billledeau , Chris Allen Broka , Jeffrey Allen Campbell , Jian Jeffrey Chen , Sharon Marie Dankwardt , Nancy Delaet , Leslie Ann Robinson , Keith Adrian Murray Walker
IPC分类号： A61K31445
CPC分类号： C07D235/06 , C07C311/27 , C07D209/08 , C07D209/12 , C07D317/58
摘要： A compound of the Formula (I): wherein Z, R1, R, and Ar2 are as defined in the specification. This invention also relates to sulfonamide compounds of the Formula (I) that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use, and methods for preparing the compounds.
摘要翻译： 式（I）的化合物：其中Z，R1，R和Ar2如说明书中所定义。 本发明还涉及作为原胶原C-蛋白酶抑制剂的式（I）的磺酰胺化合物，含有它们的药物组合物，其用途及其制备方法。
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公开(公告)号：US06872744B2
公开(公告)日：2005-03-29
申请号：US10255891
申请日：2002-09-26
IPC分类号： A61K31/404 , A61P15/06 , A61P19/02 , A61P19/06 , A61P25/28 , A61P29/00 , A61P43/00 , C07D209/10 , C07D209/30 , C07D209/36 , C07D209/42 , A61K31/40
CPC分类号： C07D209/42 , C07D209/10 , C07D209/30 , C07D209/36
摘要： This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a —CH2—, —O—, —S—, or —S(O)—; and the other substituents are as defined in the specification; or individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.
摘要翻译： 本发明涉及通常为抗炎和镇痛化合物的化合物，其由式I表示：其中A为-CH 2 - ， - O - ， - S - 或-S（O） - ; 而其它取代基如说明书中所定义; 或各异构体，异构体的混合物及其药学上可接受的盐。 本发明还涉及含有这些化合物的药物组合物及其用作治疗剂的方法。
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公开(公告)号：US06869964B2
公开(公告)日：2005-03-22
申请号：US10441830
申请日：2003-05-20
IPC分类号： A61K38/55 , A61K31/4709 , A61K38/00 , A61K38/06 , A61P1/16 , A61P31/12 , A61P43/00 , C07D215/20 , C07D215/233 , C07K5/062 , C07K5/078 , C07K5/08 , C07K5/083 , C07D401/02 , A61K31/47
CPC分类号： C07K5/0808 , A61K38/00 , C07K5/06165
摘要： The present invention relates to tripeptide compounds, compositions containing such compounds and methods for using such compounds for the treatment of hepatitis C virus (HCV) infection. In particular, the present invention provides novel tripeptide analogs, pharmaceutical compositions containing such analogs and methods for using these analogs in the treatment of HCV infection.
摘要翻译： 本发明涉及三肽化合物，含有这些化合物的组合物和使用这些化合物治疗丙型肝炎病毒（HCV）感染的方法。 特别地，本发明提供新颖的三肽类似物，含有这些类似物的药物组合物和使用这些类似物治疗HCV感染的方法。
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