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公开(公告)号：US08825384B2
公开(公告)日：2014-09-02
申请号：US13426304
申请日：2012-03-21
CPC分类号： G01C21/3673 , G01C21/20 , G01C21/32 , G01C21/34
摘要： A navigation system may display a map element represented by a spline including a plurality of vertices. Label coordinate values derived from coordinate values of the plurality of vertices may be retrieved from a database. A label assigned to the map element may be displayed based on the stored label coordinate values. The assigned label may be adapted to the geometric form of at least a portion of the map element.
摘要翻译： 导航系统可以显示由包含多个顶点的样条表示的地图元素。 可以从数据库检索从多个顶点的坐标值导出的标签坐标值。 可以基于存储的标签坐标值来显示分配给地图元素的标签。 分配的标签可以适应于地图元素的至少一部分的几何形式。
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公开(公告)号：US20120245841A1
公开(公告)日：2012-09-27
申请号：US13426304
申请日：2012-03-21
CPC分类号： G01C21/3673 , G01C21/20 , G01C21/32 , G01C21/34
摘要： A navigation system may display a map element represented by a spline including a plurality of vertices. Label coordinate values derived from coordinate values of the plurality of vertices may be retrieved from a database. A label assigned to the map element may be displayed based on the stored label coordinate values. The assigned label may be adapted to the geometric form of at least a portion of the map element.
摘要翻译： 导航系统可以显示由包含多个顶点的样条表示的地图元素。 可以从数据库检索从多个顶点的坐标值导出的标签坐标值。 可以基于存储的标签坐标值来显示分配给地图元素的标签。 分配的标签可以适应于地图元素的至少一部分的几何形式。
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公开(公告)号：US20130002658A1
公开(公告)日：2013-01-03
申请号：US13540070
申请日：2012-07-02
CPC分类号： G01C21/3638 , G06T17/05
摘要： In a database usable for a navigation device, object data units comprising information for a three-dimensional displaying of objects like buildings are provided. At least one of the object data units comprises an adjustable height parameter for adjusting a height of the corresponding object when displayed.
摘要翻译： 在可用于导航装置的数据库中，提供包括用于诸如建筑物的对象的三维显示的信息的对象数据单元。 对象数据单元中的至少一个包括用于在显示时调整相应对象的高度的可调节高度参数。
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公开(公告)号：US09557181B2
公开(公告)日：2017-01-31
申请号：US13458378
申请日：2012-04-27
摘要： A vehicle navigation system has a processing device. The processing device receives entries in a first data structure that are generated and are respectively associated with one tile of a tiling. The processing device may compare a three-dimensional terrain on the respective tile with at least one pre-defined tile pattern. Either an identifier for a pre-defined tile pattern or data describing the terrain on the respective tile may be stored by the processing device in the entry.
摘要翻译： 车辆导航系统具有处理装置。 处理设备接收生成的第一数据结构中的条目，并且分别与平铺的一个瓦片相关联。 处理设备可以将相应瓦片上的三维地形与至少一个预定义的瓦片图案进行比较。 用于预定义瓦片图案的标识符或描述相应瓦片上的地形的数据可以由处理设备存储在条目中。
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15.发明申请METHOD, APPARATUS AND SYSTEM FOR DATA STREAM PROCESSING WITH A PROGRAMMABLE ACCELERATOR 有权用可编程加速器进行数据流处理的方法，装置和系统公开(公告)号：US20140365748A1
公开(公告)日：2014-12-11
申请号：US13993826
申请日：2011-12-29
申请人： Vladimir Ivanov
发明人： Vladimir Ivanov
IPC分类号： G06F9/30
CPC分类号： G06F9/30145 , G06F8/65 , G06F9/30003 , G06F9/3881 , G06F15/7889
摘要： Techniques and mechanisms for programming an accelerator device to enable performance of a data processing algorithm. In an embodiment, an accelerator of a computer platform is programmed based on programming information received from a host processor of the computer platform. In another embodiment, programming of the accelerator is to enable data driven execution of an instruction by a data stream processing engine of the accelerator.
摘要翻译： 用于编程加速器装置以实现数据处理算法的性能的技术和机制。 在一个实施例中，基于从计算机平台的主处理器接收的编程信息来编程计算机平台的加速器。 在另一个实施例中，加速器的编程是使数据驱动的加速器的数据流处理引擎执行指令。
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公开(公告)号：US20110295012A1
公开(公告)日：2011-12-01
申请号：US13197226
申请日：2011-08-03
申请人： Kenneth Alan Simmen , Herman Augustinus De Kock , Pierre Jean-Marie Bernard Raboisson , Lili Hu , Abdellah Tahri , Dominque Louis Nestor Ghislai Surleraux , Karl Magnus Nilsson , Bengt Bertil Samuelsson , Asa Annica Kristina Rosenquist , Vladimir Ivanov , Michael Pelcman , Anna Karin Gertrud Linnea Belfrage , Per-Ola Mikael Johansson , Sandrine Marie Helene Vendeville
发明人： Kenneth Alan Simmen , Herman Augustinus De Kock , Pierre Jean-Marie Bernard Raboisson , Lili Hu , Abdellah Tahri , Dominque Louis Nestor Ghislai Surleraux , Karl Magnus Nilsson , Bengt Bertil Samuelsson , Asa Annica Kristina Rosenquist , Vladimir Ivanov , Michael Pelcman , Anna Karin Gertrud Linnea Belfrage , Per-Ola Mikael Johansson , Sandrine Marie Helene Vendeville
IPC分类号： C07D417/04 , C07C225/22 , C07D277/56
CPC分类号： C07D487/04 , A61K31/427 , A61K31/4709 , A61K31/7056 , A61K38/05 , A61K38/212 , A61K45/06 , A61K47/60 , C07D245/04 , C07D277/56 , C07D401/14 , C07D417/04 , C07D417/14 , C07K5/06139 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393
摘要： Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers, wherein each dashed line represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 is —OR7 or —NH—SO2R8; R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl; R3 is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, or C3-7cycloalkyl; R4 is aryl or Het; n is 3, 4, 5, or 6; R5 is halo, C1-6alkyl, hydroxy, C1-6alkoxy, phenyl, or Het; R6 is C1-6alkoxy or dimethylamino; R7 is hydrogen; aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; R8 is aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; aryl is phenyl optionally substituted with one, two or three substituents; Het is a 5 or 6 membered saturated, partially unsaturated or completely unsaturated heterocyclic ring containing 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, and being optionally substituted with one, two or three substituents; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I). Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.
摘要翻译： 式（I）的HCV复制抑制剂和N-氧化物，盐和立体异构体，其中每个虚线表示任选的双键; X为N，CH，X为双键，C为C; R1是-OR7或-NH-SO2R8; R2是氢，并且其中X是C或CH，R2也可以是C1-6烷基; R 3是氢，C 1-6烷基，C 1-6烷氧基C 1-6烷基或C 3-7环烷基; R4是芳基或Het; n为3,4,5或6; R 5为卤素，C 1-6烷基，羟基，C 1-6烷氧基，苯基或Het; R6是C1-6烷氧基或二甲基氨基; R7是氢; 芳基; Het; 任选被C 1-6烷基取代的C 3-7环烷基; 或任选被C 3-7环烷基，芳基或与Het取代的C 1-6烷基; R8是芳基; Het; 任选被C 1-6烷基取代的C 3-7环烷基; 或任选被C 3-7环烷基，芳基或与Het取代的C 1-6烷基; 芳基是任选被一个，两个或三个取代基取代的苯基; Het是含有1至4个选自氮，氧和硫的杂原子并且任选地被一个，两个或三个取代基取代的5或6元饱和，部分不饱和或完全不饱和的杂环。 含有化合物（I）的药物组合物和制备化合物（I）的方法。 还提供了式（I）的HCV抑制剂与利托那韦的生物可利用组合。
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公开(公告)号：US20090281140A1
公开(公告)日：2009-11-12
申请号：US11632102
申请日：2006-07-28
申请人： Kenneth Alan Simmen , Herman Augustinus De Kock , Pierre Jean-Marie Bernard Raboisson , Lili Hu , Abdellah Tahri , Dominique Louis Nestor Ghislain Surleraux , Karl Magnus Nilsson , Bengt Bertil Samuelson , Åsa Annica Kristina Rosenquist , Vladimir Ivanov , Michael Pelcman , Anna Karin Gertrud Linnea Belfrage , Per-Ola Mikael Johansson , Sandrine Marie Helene Vendeville
发明人： Kenneth Alan Simmen , Herman Augustinus De Kock , Pierre Jean-Marie Bernard Raboisson , Lili Hu , Abdellah Tahri , Dominique Louis Nestor Ghislain Surleraux , Karl Magnus Nilsson , Bengt Bertil Samuelson , Åsa Annica Kristina Rosenquist , Vladimir Ivanov , Michael Pelcman , Anna Karin Gertrud Linnea Belfrage , Per-Ola Mikael Johansson , Sandrine Marie Helene Vendeville
IPC分类号： A61K31/4709 , C07D245/00 , A61P31/12
CPC分类号： C07D487/04 , A61K31/427 , A61K31/4709 , A61K31/7056 , A61K38/05 , A61K38/212 , A61K45/06 , A61K47/60 , C07D245/04 , C07D277/56 , C07D401/14 , C07D417/04 , C07D417/14 , C07K5/06139 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393
摘要： Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers, wherein each dashed line represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 is —OR7, —NH—SO2R8; R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl; R3 is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, C3-7cycloalkyl; R4 is aryl or Het; n is 3, 4, 5, or 6; R5 is halo, C1-6alkyl, hydroxy, C1-6alkoxy, phenyl, or Het; R6 is C1-6alkoxy, or dimethylamino; R7 is hydrogen; aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; R8 is aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; aryl is phenyl optionally substituted with one, two or three substituents; Het is a 5 or 6 membered saturated, partially unsaturated or completely unsaturated heterocyclic ring containing 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, and being optionally substituted with one, two or three substituents; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I). Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.
摘要翻译： 式（I）的HCV复制抑制剂和N-氧化物，盐和立体异构体，其中每个虚线表示任选的双键; X为N，CH，X为双键，C为C; R1是-OR7，-NH-SO2R8; R2是氢，并且其中X是C或CH，R2也可以是C1-6烷基; R 3是氢，C 1-6烷基，C 1-6烷氧基C 1-6烷基，C 3-7环烷基; R4是芳基或Het; n为3,4,5或6; R 5为卤素，C 1-6烷基，羟基，C 1-6烷氧基，苯基或Het; R6是C1-6烷氧基或二甲基氨基; R7是氢; 芳基; Het; 任选被C 1-6烷基取代的C 3-7环烷基; 或任选被C 3-7环烷基，芳基或与Het取代的C 1-6烷基; R8是芳基; Het; 任选被C 1-6烷基取代的C 3-7环烷基; 或任选被C 3-7环烷基，芳基或与Het取代的C 1-6烷基; 芳基是任选被一个，两个或三个取代基取代的苯基; Het是含有1至4个选自氮，氧和硫的杂原子并且任选地被一个，两个或三个取代基取代的5或6元饱和，部分不饱和或完全不饱和的杂环。 含有化合物（I）的药物组合物和制备化合物（I）的方法。 还提供了式（I）的HCV抑制剂与利托那韦的生物可利用组合。
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18.发明申请Method for cleaning a lithographic apparatus module, cleaning arrangement for a lithographic apparatus module and lithographic apparatus comprising the cleaning arrangement 有权用于清洁光刻设备模块的方法，用于光刻设备模块的清洁装置和包括清洁装置的光刻设备公开(公告)号：US20070145296A1
公开(公告)日：2007-06-28
申请号：US11314099
申请日：2005-12-22
申请人： Johannes Freriks , Vadim Banine , Vladimir Ivanov
发明人： Johannes Freriks , Vadim Banine , Vladimir Ivanov
IPC分类号： G03F7/20
CPC分类号： G03F7/70925 , B82Y10/00 , G03F7/70166
摘要： A cleaning arrangement for a lithographic apparatus module may be provided in a collector. The cleaning arrangement includes a hydrogen radical source configured to provide a hydrogen radical containing gas to at least part of the module and a pump configured to pump gas through the module such that a flow speed of the hydrogen radical containing gas provided through at least part of the module is at least 1 m/s. The cleaning arrangement may also include a gas shutter configured to modulate a flow of the hydrogen radical containing gas to at least part of the module, a buffer volume of at least 1 m3 in communication with the module, and a pump configured to provide a gas pressure in the buffer volume between 0.001 mbar (0.1 Pa) and 1 mbar (100 Pa).
摘要翻译： 用于光刻设备模块的清洁装置可以设置在收集器中。 清洁装置包括被配置为向至少部分模块提供含氢自由基气体的氢根源，以及构造成将气体泵送通过模块的泵，使得通过至少部分的至少一部分提供含氢自由基气体的流速 该模块至少为1米/秒。 清洁装置还可以包括配置成将含氢自由基气体的流动调制到模块的至少一部分的气闸，与模块连通的至少1m 3的缓冲体积， 以及配置成在0.001mbar（0.1Pa）和1mbar（100Pa）之间的缓冲体积中提供气体压力的泵。
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19.发明申请Lithographic device, device manufacturing method and device manufactured thereby 有权平版印刷装置，装置制造方法和由此制造的装置公开(公告)号：US20060268246A1
公开(公告)日：2006-11-30
申请号：US11391731
申请日：2006-03-29
申请人： Johannes Jacobs , Vadim Banine , Barrie Brewster , Vladimir Ivanov , Bastiaan Mertens , Johannes Moors , Robert Livesey , Baastiaan Wolschrijn
发明人： Johannes Jacobs , Vadim Banine , Barrie Brewster , Vladimir Ivanov , Bastiaan Mertens , Johannes Moors , Robert Livesey , Baastiaan Wolschrijn
IPC分类号： G03B27/52
CPC分类号： G03F7/70933 , G03F7/70908
摘要： A lithographic apparatus is configured to project a pattern from a patterning device onto a substrate. The apparatus includes a gas purged sealing aperture extending between at least two different zones of the apparatus, and a gas supplier configured to supply the sealing aperture one or more gases selected from a group including hydrogen, deuterium, heavy hydrogen, deuterated hydrogen, and a mixture of argon and hydrogen.
摘要翻译： 光刻设备被配置为将图案从图案形成装置投影到基板上。 该装置包括在装置的至少两个不同区域之间延伸的气体净化密封孔，以及构造成为密封孔提供一种或多种选自包括氢，氘，重氢，氘代氢和 氩和氢的混合物。
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公开(公告)号：US20060104974A1
公开(公告)日：2006-05-18
申请号：US09784950
申请日：2001-02-15
申请人： C. Davis , Russell Blacher , Jose Corvalan , Alan Culwell , Larry Green , Joanne Hales , Nancy Havrilla , Vladimir Ivanov , John Lipani , Qiang Liu , Richard Weber , Xiao-Dong Yang
发明人： C. Davis , Russell Blacher , Jose Corvalan , Alan Culwell , Larry Green , Joanne Hales , Nancy Havrilla , Vladimir Ivanov , John Lipani , Qiang Liu , Richard Weber , Xiao-Dong Yang
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2803 , A61K2039/505 , C07K14/70596 , C07K16/2896 , C07K2317/21 , C07K2317/34 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要： In accordance with the present invention, we have discovered that the molecule CD147 as expressed on certain cells, such as T-cells, B-cells, and/or monocytes, can be utilized for the treatment of a variety of diseases. In particular, we have demonstrated that antibodies that bind to CD147 and that result in the killing of such cells, for example, through the binding of complement, is efficacious in the treatment of diseases. Diseases in which such treatment appears efficacious include, without limitation: graft versus host disease (GVHD), organ transplant rejection diseases (including, without limitation, renal transplant, ocular transplant, and others), cancers (including, without limitation, cancers of the blood (i.e., leukemias and lymphomas), pancreatic, and others), autoimmune diseases, inflammatory diseases, and others.
摘要翻译： 根据本发明，我们发现在诸如T细胞，B细胞和/或单核细胞的某些细胞上表达的分子CD147可用于治疗各种疾病。 特别地，我们已经证明，结合CD147并导致这种细胞的杀伤，例如通过补体结合的抗体在治疗疾病中是有效的。 这种治疗显示有效的疾病包括但不限于：移植物抗宿主病（GVHD），器官移植排斥疾病（包括但不限于肾移植，眼部移植等），癌症（包括但不限于： 血液（即白血病和淋巴瘤），胰腺等），自身免疫疾病，炎性疾病等。
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