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公开(公告)号：US11879841B2
公开(公告)日：2024-01-23
申请号：US17497827
申请日：2021-10-08
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid , Paul E. Glenn , Lawrence C. West , Benjamin Cipriany , Keith G. Fife
IPC: G01N21/64 , C12Q1/6874
CPC classification number: G01N21/6408 , C12Q1/6874 , G01N21/648 , G01N21/6428 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2201/0446 , G01N2201/062
Abstract: Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.
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12.发明授权公开(公告)号：US10712274B2
公开(公告)日：2020-07-14
申请号：US15974826
申请日：2018-05-09
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid
IPC: G01N21/00 , G01N21/64 , C12Q1/6874 , G01N21/77 , B01L3/00 , C12Q1/6869
Abstract: An active-source-pixel, integrated device capable of performing biomolecule detection and/or analysis, such as single-molecule nucleic acid sequencing, is described. An active pixel of the integrated device includes a sample well into which a sample to be analyzed may diffuse, an excitation source for providing excitation energy to the sample well, and a sensor configured to detect emission from the sample. The sensor may comprise two or more segments that produce a set of signals that are analyzed to differentiate between and identify tags that are attached to, or associated with, the sample. Tag differentiation may be spectral and/or temporal based. Identification of the tags may be used to detect, analyze, and/or sequence the biomolecule.
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公开(公告)号：US10533945B2
公开(公告)日：2020-01-14
申请号：US15808940
申请日：2017-11-10
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid , Benjamin Cipriany , Jack Jewell , Lawrence C. West , Michael Ferrigno , Paul E. Glenn , Adam Ezra Cohen , Anthony Bellofiore
IPC: G01N21/64 , C12Q1/6874 , G01N21/77 , C12Q1/6869 , B01L3/00
Abstract: Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.
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公开(公告)号：US10371634B2
公开(公告)日：2019-08-06
申请号：US15882776
申请日：2018-01-29
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid , Paul E. Glenn , Lawrence C. West , Benjamin Cipriany , Keith G. Fife
IPC: G01N21/64 , C12Q1/6874
Abstract: Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.
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15.发明授权公开(公告)号：US10288565B2
公开(公告)日：2019-05-14
申请号：US15641949
申请日：2017-07-05
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid , Lawrence C. West , Keith G. Fife , Benjamin Cipriany , Farshid Ghasemi
IPC: G01N21/64 , C12Q1/6874 , C12Q1/6869
Abstract: System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes at least one waveguide configured to propagate excitation energy to the sample wells from a region of the integrated device configured to couple with an excitation energy source. A pixel may also include at least one element for directing the emission energy towards a sensor within the pixel. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device. One of multiple markers distinguishable by temporal parameters of the emission energy may label the sample and configuration of the sensor within a pixel may allow for detection of a temporal parameter associated with the marker labeling the sample.
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Patent Agency Ranking
公开(公告)号：US09921157B2
公开(公告)日：2018-03-20
申请号：US14821686
申请日：2015-08-07
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid , Paul E. Glenn , Lawrence C. West , Benjamin Cipriany , Keith G. Fife
CPC classification number: G01N21/6408 , C12Q1/6874 , G01N21/6428 , G01N21/6452 , G01N21/648 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2201/0446 , G01N2201/062
Abstract: Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.
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17.发明申请公开(公告)号：US20160084761A1
公开(公告)日：2016-03-24
申请号：US14821688
申请日：2015-08-07
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid , Lawrence C. West , Keith G. Fife , Benjamin Cipriany , Farshid Ghasemi
CPC classification number: G01N21/6408 , C12Q1/6869 , C12Q1/6874 , G01N21/6428 , G01N21/6454 , G01N21/648 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6463 , G01N2201/0696 , G01N2201/08 , G01N2201/12
Abstract: System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes at least one waveguide configured to propagate excitation energy to the sample wells from a region of the integrated device configured to couple with an excitation energy source. A pixel may also include at least one element for directing the emission energy towards a sensor within the pixel. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device. One of multiple markers distinguishable by temporal parameters of the emission energy may label the sample and configuration of the sensor within a pixel may allow for detection of a temporal parameter associated with the marker labeling the sample.
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18.发明授权公开(公告)号：US12123834B2
公开(公告)日：2024-10-22
申请号：US16900008
申请日：2020-06-12
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid
IPC: B01L3/00 , C12Q1/6869 , C12Q1/6874 , G01N21/64 , G01N21/77
CPC classification number: G01N21/6486 , B01L3/5085 , C12Q1/6869 , C12Q1/6874 , G01N21/64 , G01N21/645 , G01N21/6452 , G01N21/648 , G01N21/7743 , G01N21/7746 , B01L2200/12 , B01L2300/0829 , B01L2300/0887 , B01L2300/0893 , B01L2300/168 , C12Q2521/101 , C12Q2525/101 , C12Q2537/157 , C12Q2563/107 , C12Q2565/607 , G01N2021/6419 , G01N2021/6441 , G01N2021/6478 , G01N2201/02 , G01N2201/06113 , G01N2201/0612 , G01N2201/062 , G01N2201/068 , G01N2201/125 , Y10T29/49016 , C12Q1/6874 , C12Q2521/101 , C12Q2525/101 , C12Q2537/157 , C12Q2563/107 , C12Q2565/607
Abstract: An active-source-pixel, integrated device capable of performing biomolecule detection and/or analysis, such as single-molecule nucleic acid sequencing, is described. An active pixel of the integrated device includes a sample well into which a sample to be analyzed may diffuse, an excitation source for providing excitation energy to the sample well, and a sensor configured to detect emission from the sample. The sensor may comprise two or more segments that produce a set of signals that are analyzed to differentiate between and identify tags that are attached to, or associated with, the sample. Tag differentiation may be spectral and/or temporal based. Identification of the tags may be used to detect, analyze, and/or sequence the biomolecule.
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19.发明申请公开(公告)号：US20200088639A1
公开(公告)日：2020-03-19
申请号：US16688728
申请日：2019-11-19
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid , Lawrence C. West , Keith G. Fife , Benjamin Cipriany , Farshid Ghasemi
IPC: G01N21/64 , C12Q1/6869 , C12Q1/6874
Abstract: System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes at least one waveguide configured to propagate excitation energy to the sample wells from a region of the integrated device configured to couple with an excitation energy source. A pixel may also include at least one element for directing the emission energy towards a sensor within the pixel. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device. One of multiple markers distinguishable by temporal parameters of the emission energy may label the sample and configuration of the sensor within a pixel may allow for detection of a temporal parameter associated with the marker labeling the sample.
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20.发明申请公开(公告)号：US20190383737A1
公开(公告)日：2019-12-19
申请号：US16442206
申请日：2019-06-14
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Benjamin Cipriany , Faisal R. Ahmad , Joseph D. Clark , Daniel B. Frier , Michael Ferrigno , Mel Davey , Tom Thurston , Brett J. Gyarfas , Todd Rearick , Jeremy Christopher Jordan
Abstract: Instrument control and data acquisition in advanced analytic systems that utilize optical pulses for sample analysis are described. Clocking signals for data acquisition, data processing, communication, and/or other data handling functionalities can be derived from an on-board pulsed optical source, such as a passively mode-locked laser. The derived clocking signals can operate in combination with one or more clocking signals from a stable oscillator, so that instrument operation and data handling can tolerate interruptions in operation of the pulsed optical source.
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