公开(公告)号：US20080200804A1

公开(公告)日：2008-08-21

申请号：US11562262

申请日：2006-11-21

申请人： Andreas Hartlep ,  Christoph Pedain ,  Martin Brady ,  Raghu Raghavan

发明人： Andreas Hartlep ,  Christoph Pedain ,  Martin Brady ,  Raghu Raghavan

IPC分类号： A61B6/00 ,  A61M31/00

CPC分类号： A61M5/14 ,  A61M2005/14292 ,  A61M2210/0693 ,  G06F19/00 ,  G16H40/63 ,  G16H50/50

摘要： A method for determining a backflow of a substance along a track of a delivery device includes: a) obtaining parameters that influence the flow of the fluid or substance; b) acquiring information about delivery data; and c) computing the backflow along the delivery device using the information in steps a) and b).

摘要翻译： 用于确定物质沿输送装置的轨道的回流的方法包括：a）获得影响流体或物质流动的参数; b）获取有关送货数据的信息; 以及c）使用步骤a）和b）中的信息来计算沿输送装置的回流。

公开(公告)号：US20070276340A1

公开(公告)日：2007-11-29

申请号：US11434080

申请日：2006-05-15

申请人： David Poston ,  Raghu Raghavan ,  Martin Brady

发明人： David Poston ,  Raghu Raghavan ,  Martin Brady

IPC分类号： A61M5/32

CPC分类号： A61M25/0026 ,  A61B17/3401 ,  A61B17/3421 ,  A61B2017/3419 ,  A61F2/82 ,  A61F2002/826 ,  A61M25/0021 ,  A61M25/0068 ,  A61M25/0069 ,  A61M25/0074 ,  A61M2025/0042 ,  A61M2025/0096 ,  A61M2025/0681

摘要： A medical device for delivering material through tissue into a defined area of a patient may comprise: a material delivery element through which the material may flow out of a delivery end; the delivery end having an opening that can be inserted through a surface of the tissue; and a sealing system proximal to the delivery end that can extend away from the material delivery element along the surface of the tissue and apply pressure to the tissue after the material delivery element has been inserted through the surface of the tissue. A physical barrier may be provided on the material delivery device to reduce back flow loss of delivered material.

摘要翻译： 用于将材料通过组织输送到患者的限定区域中的医疗装置可以包括：材料递送元件，材料可以通过该材料输送元件从输送端流出; 所述输送端具有能够穿过所述组织的表面插入的开口; 以及靠近输送端的密封系统，其可以沿着组织的表面远离材料输送元件延伸，并且在材料输送元件已经穿过组织的表面插入之后对组织施加压力。 可以在材料输送装置上提供物理屏障以减少输送材料的回流损失。

公开(公告)号：US20050267360A1

公开(公告)日：2005-12-01

申请号：US11115093

申请日：2005-04-26

申请人： Rainer Birkenbach ,  Christoph Pedain ,  Andreas Hartlep ,  Raghu Raghavan ,  Martin Brady

发明人： Rainer Birkenbach ,  Christoph Pedain ,  Andreas Hartlep ,  Raghu Raghavan ,  Martin Brady

IPC分类号： A61B5/05 ,  A61B19/00

CPC分类号： A61B90/36 ,  A61B34/10 ,  A61B34/20 ,  A61B2034/107 ,  A61B2034/2055 ,  A61B2034/2068 ,  A61B2034/2072

摘要： The visualization of procedural guidelines for a medical procedure, in which a medical instrument is shown in an image representation of a body portion including an area in which a medical procedure is to be carried out, wherein, in the vicinity of the functional portion of the instrument, regions or locations are indicated which are of special relevance to the procedure according to established guidelines for said procedure.

摘要翻译： 可视化的医疗程序的程序指南，其中医疗器械被显示在包括要执行医疗程序的区域的身体部位的图像表示中，其中在该功能部分的附近 指示与所述程序的既定指导方针相关的手段，区域或位置。

公开(公告)号：US20140303593A1

公开(公告)日：2014-10-09

申请号：US14229876

申请日：2014-03-29

申请人： Raghu Raghavan ,  Martin Brady

发明人： Raghu Raghavan ,  Martin Brady

IPC分类号： A61M25/10

CPC分类号： A61M25/10 ,  A61M2025/105 ,  A61M2025/1086

摘要： Surgery is performed on a patient with a novel device by: excising tissue from tissue mass within a patient to create a cavity within the tissue mass; inserting a novel device of this invention into the cavity; shaping a flexible expandable component of the device to adjust dimensions on the flexible expandable component; providing a liquid into the component through the liquid input port; and controlling pressure or flow rate of the liquid in the component to move the liquid through the multiple openings and into the cavity. The device has a liquid inlet port, an exterior surface having length, width and depth, and multiple openings in the surface distributed throughout the length, width and depth to act as liquid delivery ports; the exterior surface of the liquid delivery device being shapeable by internal pneumatic pressure or hydraulic pressure to better fit inside dimensions of a surgical cavity; the multiple openings deliver the liquid through the multiple openings.

摘要翻译： 通过以下方式对具有新颖装置的患者进行手术：从患者组织块切除组织以在组织块内形成空腔; 将本发明的新型装置插入空腔中; 使所述装置的柔性可膨胀部件成形以调整所述柔性可膨胀部件上的尺寸; 通过液体输入端口向组件提供液体; 并且控制所述部件中的液体的压力或流速以将所述液体移动通过所述多个开口并进入所述空腔。 该装置具有液体入口，具有长度，宽度和深度的外表面，并且表面上的多个开口分布在整个长度，宽度和深度上以用作液体输送口; 液体输送装置的外表面可以通过内部气动压力或液压成形，以更好地适应手术腔的内部尺寸; 多个开口通过多个开口输送液体。

公开(公告)号：US20140243783A1

公开(公告)日：2014-08-28

申请号：US14046845

申请日：2013-10-04

申请人： Raghu Raghavan ,  Martin Brady

发明人： Raghu Raghavan ,  Martin Brady

IPC分类号： A61M25/10 ,  A61M25/01 ,  A61M5/158 ,  A61M25/00

CPC分类号： A61M5/158 ,  A61M25/02 ,  A61M25/04 ,  A61M25/10 ,  A61M2005/1588 ,  A61M2025/0002 ,  A61M2025/0293 ,  A61M2025/1047 ,  A61M2025/1093 ,  A61M2210/0693

摘要： Interstitial tissue structure is treated with a flowable liquid agent by: providing a delivery cannula having a proximal end and a distal end and an external surface with at least one expandable member located on the external surface of at least one catheter or needle. The delivery cannula is inserted into live tissue, creating a hole in the tissue surrounding the delivery cannula. Contact is made against an inner surface of the hole with contact pressure from the at least one expandable member, said contact pressure establishing a first level of stress in tissue surrounding the hole in the tissue. The expandable member is expanded to increase the contact pressure and provide a second level of stress in the tissue surrounding the hole in the tissue to a second level of stress that is greater than the first level of stress.

摘要翻译： 用可流动的液体试剂处理间质组织结构，方法是：提供具有近端和远端的输送插管和具有位于至少一个导管或针的外表面上的至少一个可扩张构件的外表面。 输送插管插入活组织中，在输送插管周围的组织中产生孔。 接触是通过来自至少一个可膨胀构件的接触压力抵靠孔的内表面制成的，所述接触压力在围绕组织中的孔的组织中建立第一级应力。 可膨胀构件被膨胀以增加接触压力，并且在围绕组织中的孔的组织中提供第二水平的应力至大于第一应力水平的第二水平的应力。

公开(公告)号：US08406850B2

公开(公告)日：2013-03-26

申请号：US13241936

申请日：2011-09-23

申请人： Raghu Raghavan ,  Martin Brady

发明人： Raghu Raghavan ,  Martin Brady

IPC分类号： A61B5/05

CPC分类号： A61K49/06 ,  A61M2005/14292 ,  G01R33/5601 ,  G01R33/56341

摘要： A method for estimating the physiological parameters defining the edema induced upon infusion of fluid from an intraparenchymally placed catheter including; a) acquisition of patient-specific medical data; b) estimation of pertinent tissue microstructure based on the patient-specific medical data and/or generalized information derived or drawn from one or more of the following: experience, literature, modeling, studies, research, analysis; c) acquisition of information about delivery parameters, and/or delivery device geometry, and/or fluid properties; and d) computing a field of values of predicted extracellular volume fraction over the tissue region using the information obtained in (b) and (c). According to a further aspect, a method of infusing or planning and/or monitoring an infusion of a contrast agent such that the distribution of such agent can be detected and observing and/or measuring the backflow length along the catheter track.

摘要翻译： 一种估计生理参数的方法，所述生理参数限定了从实施静脉内放置的导管输注流体时引起的水肿，包括： a）获取患者特定的医疗数据; b）基于患者特定的医学数据和/或从以下一个或多个中得出或得出的一般化信息来估计相关的组织微结构：经验，文献，建模，研究，研究，分析; c）获取关于递送参数和/或递送装置几何形状和/或流体属性的信息; 以及d）使用（b）和（c）中获得的信息计算组织区域上预测的细胞外体积分数的值的场。 根据另一方面，一种输注或规划和/或监测造影剂的输注的方法，使得可以检测这种药剂的分布，并观察和/或测量沿着导管轨迹的回流长度。

公开(公告)号：US08083753B2

公开(公告)日：2011-12-27

申请号：US11873154

申请日：2007-10-16

申请人： Matthew S. Solar ,  Thomas I. Miller ,  John David ,  Raghu Raghavan ,  Martin Brady ,  Gerald W. Mills

发明人： Matthew S. Solar ,  Thomas I. Miller ,  John David ,  Raghu Raghavan ,  Martin Brady ,  Gerald W. Mills

IPC分类号： A61B19/00

CPC分类号： A61B90/11 ,  A61B34/20 ,  A61B34/30 ,  A61B34/70 ,  A61B2034/107 ,  A61B2034/2055 ,  A61B2034/301 ,  A61B2090/374

摘要： A surgical alignment device is disclosed that is controlled remotely through the use of an actuator, where the actuator in turn controls at least one local adjustment device. The alignment device is suited for neurosurgery, although it is not exclusively limited to neurosurgery. The alignment device includes an insertion guide that is coupled to the local adjustment device, the insertion guide being used to guide a device such as a catheter into a patient. The alignment device may also be coupled to a control module such as a microcomputer that controls the orientation of the insertion guide in response to inputs from the surgeon as to a location of interest within the patient.

摘要翻译： 公开了通过使用致动器远程控制的外科对准装置，其中致动器依次控制至少一个局部调节装置。 对准装置适用于神经外科手术，但并不限于神经外科手术。 对准装置包括联接到局部调节装置的插入引导件，插入引导件用于将诸如导管的装置引导到患者体内。 对准装置还可以耦合到诸如微型计算机的控制模块，微型计算机响应于来自外科医生的输入以及患者内感兴趣的位置来控制插入引导件的取向。

公开(公告)号：US07366561B2

公开(公告)日：2008-04-29

申请号：US09825786

申请日：2001-04-04

申请人： Gerald W. Mills ,  Martin Brady ,  Raghu Raghavan ,  John David ,  Thomas I. Miller ,  Matthew S. Solar

发明人： Gerald W. Mills ,  Martin Brady ,  Raghu Raghavan ,  John David ,  Thomas I. Miller ,  Matthew S. Solar

IPC分类号： A61B5/05

CPC分类号： A61B90/11 ,  A61B34/20 ,  A61B34/30 ,  A61B34/70 ,  A61B2034/107 ,  A61B2034/2055 ,  A61B2034/301 ,  A61B2090/374

摘要： A surgical alignment device is shown that is controlled remotely through the use of an actuator, where the actuator in turn controls at least one local adjustment device. The alignment device is suited for neurosurgery, although it is not exclusively limited to neurosurgery. The alignment device includes an insertion guide that is coupled to the local adjustment device, the insertion guide being used to guide a device such as a catheter into a patient. The alignment device may also be coupled to a control module such as a microcomputer that controls the orientation of the insertion guide in response to inputs from the surgeon as to a location of interest within the patient.

摘要翻译： 示出了通过使用致动器远程控制的外科对准装置，其中致动器依次控制至少一个局部调节装置。 对准装置适用于神经外科手术，但并不限于神经外科手术。 对准装置包括联接到局部调节装置的插入引导件，插入引导件用于将诸如导管的装置引导到患者体内。 对准装置还可以耦合到诸如微型计算机的控制模块，微型计算机响应于来自外科医生的输入以及患者内感兴趣的位置来控制插入引导件的取向。

公开(公告)号：US20080039869A1

公开(公告)日：2008-02-14

申请号：US11873154

申请日：2007-10-16

申请人： Gerald Mills ,  Martin Brady ,  Raghu Raghavan ,  John David ,  Thomas Miller ,  Matthew Solar

发明人： Gerald Mills ,  Martin Brady ,  Raghu Raghavan ,  John David ,  Thomas Miller ,  Matthew Solar

IPC分类号： A61B19/00

CPC分类号： A61B90/11 ,  A61B34/20 ,  A61B34/30 ,  A61B34/70 ,  A61B2034/107 ,  A61B2034/2055 ,  A61B2034/301 ,  A61B2090/374

摘要： A surgical alignment device is disclosed that is controlled remotely through the use of an actuator, where the actuator in turn controls at least one local adjustment device. The alignment device is suited for neurosurgery, although it is not exclusively limited to neurosurgery. The alignment device includes an insertion guide that is coupled to the local adjustment device, the insertion guide being used to guide a device such as a catheter into a patient. The alignment device may also be coupled to a control module such as a microcomputer that controls the orientation of the insertion guide in response to inputs from the surgeon as to a location of interest within the patient.

摘要翻译： 公开了通过使用致动器远程控制的外科对准装置，其中致动器依次控制至少一个局部调节装置。 对准装置适用于神经外科手术，但并不限于神经外科手术。 对准装置包括联接到局部调节装置的插入引导件，插入引导件用于将诸如导管的装置引导到患者体内。 对准装置还可以耦合到诸如微型计算机的控制模块，微型计算机响应于来自外科医生的输入以及患者内感兴趣的位置来控制插入引导件的取向。

公开(公告)号：US20120215157A1

公开(公告)日：2012-08-23

申请号：US13208756

申请日：2011-08-12

申请人： James G. Berryman ,  Raghu Raghavan

发明人： James G. Berryman ,  Raghu Raghavan

IPC分类号： A61M37/00 ,  F17D3/01

CPC分类号： A61B8/481 ,  A61B5/4839 ,  A61B8/0816 ,  A61B8/0833 ,  A61B34/73 ,  A61N7/00 ,  G01N29/0654 ,  G01N2291/02836 ,  Y10T137/0391 ,  Y10T137/206

摘要： The present invention provides for a method of controlling mass movement of fluid material within a field of interest comprising using time reversal acoustic focusing. The time reversal acoustic focusing can be is used for simultaneous spatial and temporal focusing of acoustic energy to control the duration of localization and/or direction of movement of material within tissue or liquid within tissue. Both delivery of material and persistence with respect to target locations can be enhanced by focusing of sonic waveforms or transmissions towards targeted areas in a field of interest, such as within a patient.

摘要翻译： 本发明提供一种在感兴趣的领域内控制流体材料的质量移动的方法，包括使用时间反转声聚焦。 时间反转声聚焦可以用于声能的同时空间和时间聚焦以控制在组织内的组织或液体内的材料的定位和/或运动方向的持续时间。 可以通过将声波形或发射集中在感兴趣的领域（例如患者体内）中的目标区域来增强相对于目标位置的物质输送和持久性。