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公开(公告)号：US09000146B2
公开(公告)日：2015-04-07
申请号：US13470251
申请日：2012-05-11
申请人： Janelle J. Bruinsma , Michael J. Domanico , Graham P. Lidgard , Hongzhi Zou , William G. Weisburg , Hemanth D. Shenoi , James P. Light, II
发明人： Janelle J. Bruinsma , Michael J. Domanico , Graham P. Lidgard , Hongzhi Zou , William G. Weisburg , Hemanth D. Shenoi , James P. Light, II
CPC分类号： C12Q1/6806 , B01D33/15 , B01D33/155 , B01L3/00 , B01L3/5021 , B03C1/30 , B04B3/00 , C12N15/1006 , C12N15/1013 , C12N15/1017 , C12Q1/6886 , C12Q2600/158 , C12Q2600/16 , Y10T436/143333
摘要： Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for extracting multiple DNA targets from a human stool sample with, for example, methods employing spin filtration techniques.
摘要翻译： 本文提供了与分离核酸有关的技术。 特别地，该技术涉及用于从例如使用旋转过滤技术的方法从人粪便样品中提取多个DNA靶标的方法和试剂盒。
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公开(公告)号：US09637792B2
公开(公告)日：2017-05-02
申请号：US13364978
申请日：2012-02-02
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6827 , C12Q1/6858 , C12Q2600/154 , C12Q2521/331 , C12Q2523/125 , C12Q2563/159
摘要： The present invention relates to methods and compositions for determination of and uses of specific methylation patterns indicative of adenoma and carcinoma. In particular, the invention relates to analysis of defined CpG loci that are coordinately methylated in DNAs from cancer and adenoma samples, methods for identifying coordinately methylated loci, and methods of using analysis of coordinately methylated loci in one or more marker regions in the design of assays for adenoma and cancer.
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公开(公告)号：US20120196756A1
公开(公告)日：2012-08-02
申请号：US13364978
申请日：2012-02-02
CPC分类号： C12Q1/6886 , C12Q1/6827 , C12Q1/6858 , C12Q2600/154 , C12Q2521/331 , C12Q2523/125 , C12Q2563/159
摘要： The present invention relates to methods and compositions for determination of and uses of specific methylation patterns indicative of adenoma and carcinoma. In particular, the invention relates to analysis of defined CpG loci that are coordinately methylated in DNAs from cancer and adenoma samples, methods for identifying coordinately methylated loci, and methods of using analysis of coordinately methylated loci in one or more marker regions in the design of assays for adenoma and cancer.
摘要翻译： 本发明涉及用于确定和使用指示腺瘤和癌症的特异性甲基化模式的方法和组合物。 特别地，本发明涉及在来自癌症和腺瘤样品的DNA中配位甲基化的定义的CpG基因座的分析，用于鉴定配位甲基化位点的方法以及在设计中的一个或多个标记区域中使用配位甲基化位点分析的方法 腺瘤和癌症检测。
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公开(公告)号：US09211112B2
公开(公告)日：2015-12-15
申请号：US13587552
申请日：2012-08-16
申请人： Graham P. Lidgard , Michael J. Domanico , Keith Fourrier , James P. Light, II , Scott Castanon , Keith Kopitzke
发明人： Graham P. Lidgard , Michael J. Domanico , Keith Fourrier , James P. Light, II , Scott Castanon , Keith Kopitzke
CPC分类号： A61B10/0038 , B01L3/50825 , G01N1/38
摘要： Provided herein is technology relating to collecting and preparing samples. For example, the technology relates particularly, but not exclusively, to devices, systems, and kits that allow a subject to collect and prepare a sample for analysis.
摘要翻译： 本文提供了与收集和制备样品相关的技术。 例如，该技术尤其涉及但不排他地涉及允许受试者收集和准备用于分析的样品的装置，系统和试剂盒。
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公开(公告)号：US08808990B2
公开(公告)日：2014-08-19
申请号：US13469999
申请日：2012-05-11
IPC分类号： G01N33/53 , C07H1/08 , G01N33/574
CPC分类号： C12Q1/6806 , G01N33/5308 , G01N33/57419
摘要： Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for serial extraction of multiple DNA targets from a human stool sample.
摘要翻译： 本文提供了与分离核酸有关的技术。 特别地，该技术涉及用于从人粪便样品中连续提取多个DNA靶标的方法和试剂盒。
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公开(公告)号：US20130211286A1
公开(公告)日：2013-08-15
申请号：US13587552
申请日：2012-08-16
申请人： Graham P. Lidgard , Michael J. Domanico , Keith Fourrier , James P. Light, II , Scott Castanon , Keith Kopitzke
发明人： Graham P. Lidgard , Michael J. Domanico , Keith Fourrier , James P. Light, II , Scott Castanon , Keith Kopitzke
IPC分类号： A61B10/00
CPC分类号： A61B10/0038 , B01L3/50825 , G01N1/38
摘要： Provided herein is technology relating to collecting and preparing samples. For example, the technology relates particularly, but not exclusively, to devices, systems, and kits that allow a subject to collect and prepare a sample for analysis.
摘要翻译： 本文提供了与收集和制备样品相关的技术。 例如，该技术尤其涉及但不排他地涉及允许受试者收集和准备用于分析的样品的装置，系统和试剂盒。
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公开(公告)号：US20120288867A1
公开(公告)日：2012-11-15
申请号：US13469999
申请日：2012-05-11
CPC分类号： C12Q1/6806 , G01N33/5308 , G01N33/57419
摘要： Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for extracting multiple DNA targets from human stool samples.
摘要翻译： 本文提供了与分离核酸有关的技术。 特别地，该技术涉及从人粪便样品中提取多个DNA靶标的方法和试剂盒。
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公开(公告)号：US5882876A
公开(公告)日：1999-03-16
申请号：US483924
申请日：1995-06-07
申请人： Gary Toukatly , Graham P. Lidgard
发明人： Gary Toukatly , Graham P. Lidgard
IPC分类号： G01N33/574 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K48/00 , A61P35/00 , C07H21/04 , C07K14/435 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/30 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , C12R1/19 , G01N33/48 , G01N33/53
摘要： Disclosed are genetic sequences and their encoded amino acid sequences for two interior nuclear matrix proteins useful as markers of malignant cell types. Primary and secondary structure analysis of the proteins is presented as well as means for their recombinant production, and compositions and methods for the use of these markers in clinical assays and cancer therapies.
摘要翻译： 公开了用作两种内部核基质蛋白的遗传序列及其编码的氨基酸序列，其用作恶性细胞类型的标志物。 本发明提供了蛋白质的一级和二级结构分析以及其重组生产的方法，以及在临床测定和癌症治疗中使用这些标记物的组合物和方法。
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公开(公告)号：US5698439A
公开(公告)日：1997-12-16
申请号：US470950
申请日：1995-06-06
申请人： Gary Toukatly , Graham P. Lidgard
发明人： Gary Toukatly , Graham P. Lidgard
IPC分类号： G01N33/574 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K48/00 , A61P35/00 , C07H21/04 , C07K14/435 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/30 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , C12R1/19 , C12N1/20
摘要： Disclosed are genetic sequences and their encoded amino acid sequences for two interior nuclear matrix proteins useful as markers of malignant cell types. Primary and secondary structure analysis of the proteins is presented as well as means for their recombinant production, and compositions and methods for the use of these markers in clinical assays and cancer therapies.
摘要翻译： 公开了用作两种内部核基质蛋白的遗传序列及其编码的氨基酸序列，其用作恶性细胞类型的标志物。 本发明提供了蛋白质的一级和二级结构分析以及其重组生产的方法，以及在临床测定和癌症治疗中使用这些标记物的组合物和方法。
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公开(公告)号：US4447528A
公开(公告)日：1984-05-08
申请号：US291354
申请日：1981-08-10
IPC分类号： G01N33/564 , A61K39/00 , G01N33/566 , G01N33/82 , G01N33/58 , G01N33/50
CPC分类号： G01N33/82 , Y10S435/975 , Y10S436/804
摘要： A radioassay procedure and reagent kit therefor for detecting auto blocking antibody, such as auto blocking antibody which interferes with the complexation of intrinsic factor with vitamin B.sub.12. A receptor, i.e., intrinsic factor, is immobilized on a support and the amount of ligand, i.e., vitamin B.sub.12, capable of binding therewith in the presence of a biological fluid sample is determined.
摘要翻译： 一种用于检测自身阻断抗体的自动阻断抗体的放射性检测方法及其试剂盒，其阻碍内在因子与维生素B12的复合。 将受体（即固有因子）固定在载体上，并确定能够在生物流体样品存在下与其结合的配体（即维生素B12）的量。
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