摘要:
The present invention relates to a device for the specific selection of target molecules, wherein immobilized capture molecules can be organized in a microarray in the form of spots or lines. In a further aspect the present invention relates to a method of specifically selecting target molecules in a reaction zone, as well as the use of such a device for specifically selecting target molecules, e.g. for target enrichment, or microarray based genome selection (MGS).
摘要:
A microfluidic cartridge for placement onto a parallel pneumatic interface plate of a pneumatic instrument is provided. The cartridge includes a three dimensional fluid channel, in which a fluid is to be transported, a flexible membrane that spans a plane and is part of an outer surface of the cartridge. The three dimensional fluid channel is spatially defined in three dimensions by internal walls of the cartridge and by the flexible membrane. The flexible membrane is in a ground state, when no pressure or vacuum is applied to the flexible membrane. However, the flexible membrane is pneumatically deflectable from the ground state perpendicular to the plane of the flexible membrane in two directions when the cartridge is placed onto the parallel pneumatic interface plate.
摘要:
The present invention provides a biosensor comprising a cartridge for accommodating a fluid sample, the cartridge comprising at least two chambers, wherein each chamber comprises a sensor surface with one or more binding sites. The biosensor further comprises means for generating a magnetic field at the binding sites of the sensor surfaces of the at least two chambers. The biosensor also comprises means for detecting particles accumulated at/and or proximate the binding sites of the sensor surfaces of the at least two chambers. Therein, the magnetic field at the binding sites has a sufficiently large gradient to actuate magnetic label particles towards the binding sites.
摘要:
A detection system combines an excitation radiation source (18) providing excitation radiation (10) to an analysis region of a sample (14) within a substrate (16) having a detection surface, a detector (22) for detecting radiation collected from the analysis region comprising the detection surface of the sample resulting from the excitation, and a magnet arrangement (24) beneath the analysis region of the sample, and stationary with respect to the excitation radiation source and light coupling arrangement, for attracting magnetic beads (15) within the sample to the substrate surface The detection radiation is collected from the detection surface of the substrate, to give an enhanced surface specificity The invention combines the advantages of surface detection with a simple low cost magnetic system for bringing the target to the surface
摘要:
The present invention provides a microf luidic device, for instance for molecular sieving or for detecting a target substance in a sample fluid. The device comprises a first substrate (120) having a substantially flat first surface that is provided with first recesses (124), and a second substrate (128) having a substantially flat second surface that is provided with second recesses (130). At least some of the first recesses are filled with a porous material (114). Alternate first recesses and second recesses form a meandering channel for a sample fluid. The second recesses may be filled with a further porous material. In an embodiment, a capture substance for binding a target substance is arranged in or on the porous material.
摘要:
Micro-fluidic systems comprise components (4), for instance sensors or pump units, which are intended to measure properties of a fluid or exert influence on this fluid, which is conducted in a channel (7). In the present invention, a micro-fluidic system is proposed in which a component (4) is embedded in castjacket material (5), such that a component structure (49) is formed, parallel to which a channel structure (8) is arranged, wherein a channel (7) is incorporated in the channel structure (8). In such a micro-fluidic system, the component can be positioned in relation to the channel in such a manner that a fluid flow with very good flow properties through the channel can be realized.
摘要:
The present invention is directed to an evanescent field induced optical sensor of a transparent polymer substrate coated with a thin transparent polymer waveguide for use as biosensor for detecting biological molecules, wherein the transparent polymer waveguide has a thickness of ≧0.10 μm and ≦0.50 μm and a refractive index nD of 1.39 to 1.79, said transparent polymer waveguide has a coupling grating recess structure for enhancing the coupling of the light wave into said transparent polymer waveguide, the lower surface of said transparent polymer waveguide contacts the transparent polymer substrate, said transparent polymer substrate has a refractive index n of 1.29 to 1.69, wherein the material of said transparent polymer waveguide and said transparent poly-mer substrate is selected such that the difference of the refractive index ΔnD of said transparent polymer waveguide and said transparent polymer substrate is at least Δ n 0.1, the outer upper surface of said polymer waveguide possess specific binding compounds to detect at least one specific chemical and/or biochemical substance or the outer upper surface of said polymer waveguide is covered with a thin noble metal layer.
摘要:
This invention relates to a method of manufacture of a barrier, especially for electronic display devices, comprising the step of co-extruding a melt of at least one inorganic material with a melt of at least one organic material, wherein the at least one inorganic material and the at least one organic material are co-extruded as a continuous sheet.
摘要:
The invention relates to an illumination system comprising an optical waveguide of an optically transparent material having an exit surface and a plurality of end faces, and a light source whose light is coupled into the waveguide via at least one end face of the waveguide. The waveguide further comprises polarizing means for polarizing the light emitted by the light source. The waveguide comprises at least two layers, of which one layer comprises an optically anisotropic material having refractive indices n.sub.e and n.sub.o and the other layer comprises an optically isotropic material having a refractive index n.sub.i, in which one of the refractive indices n.sub.e or n.sub.o is equal to n.sub.i. For the refractive indices, n.sub.e or n.sub.o should be equal or substantially equal to n.sub.i in order that polarization separation occurs at the interface between the isotropic and the anisotropic material. The invention also relates to a flat-panel picture display device including such an illumination system.
摘要:
The invention relates to a micro valve for use in a biosensor, a micro fluidic device, use of such a device, and a micro fluidic element. Biosensors are used for detection of molecules and/or ions, such as protein, drug, DNA, RNA, hormone, glucose, insulin, enzyme, fungus, bacterium, etc., in a biological sample. The sensor can be used for diagnostic application, but for instance also drugs, either therapeutic or abuse, may be detected in for instance blood, urine and saliva.