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11.发明申请Small molecules for treatment of hypercholesterolemia and related diseases 审中-公开用于治疗高胆固醇血症和相关疾病的小分子公开(公告)号：US20050277690A1
公开(公告)日：2005-12-15
申请号：US11148960
申请日：2005-06-09
Applicant: Jagadish Sircar , Haripada Khatuya , Richard Thomas , Kashinatham Alisala , Victor Vassar , Igor Nikoulin
Inventor： Jagadish Sircar , Haripada Khatuya , Richard Thomas , Kashinatham Alisala , Victor Vassar , Igor Nikoulin
IPC: A61K31/198 , A61K31/405 , C07C237/22 , C07C279/18 , C07D209/16 , C07D257/04
CPC classification number: C07D257/04 , A61K31/198 , A61K31/405 , C07C237/22 , C07C279/18
Abstract: The present invention provides compositions adapted to enhance reverse cholesterol transport in mammals. The compositions are suitable for oral delivery and useful in the treatment and/or prevention of hypercholesterolemia, atherosclerosis and associated cardiovascular diseases.
Abstract translation: 本发明提供适于增强哺乳动物逆向胆固醇转运的组合物。 所述组合物适用于口服递送，并且可用于治疗和/或预防高胆固醇血症，动脉粥样硬化和相关的心血管疾病。
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公开(公告)号：US20050177181A1
公开(公告)日：2005-08-11
申请号：US11025364
申请日：2004-12-29
Applicant: Jonathan Kagan , Mitchell Dann , Greg Fluet , Sayeed Ikramuddin , Paul Swain , Richard Thomas , Gerard Hoffmann , Mary Wilmore
Inventor： Jonathan Kagan , Mitchell Dann , Greg Fluet , Sayeed Ikramuddin , Paul Swain , Richard Thomas , Gerard Hoffmann , Mary Wilmore
CPC classification number: A61B17/00234 , A61B17/0401 , A61B17/0487 , A61B17/06166 , A61B17/1114 , A61B2017/00004 , A61B2017/00296 , A61B2017/00876 , A61B2017/00991 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0454 , A61B2017/0458 , A61B2017/0464 , A61B2017/0496 , A61F2/04 , A61F2/848 , A61F5/0076 , A61F5/0086
Abstract: The present invention provides devices and methods for attachment of an implanted device, such as an artificial stoma device, a gastrointestinal sleeve device or an attachment cuff, within a patient's digestive tract for treatment of obesity. Special surgical fasteners provide a lasting and durable attachment to the gastrointestinal tissue without causing excessive pressure that could result in tissue erosion and detachment of the implanted device. Fastener delivery devices that facilitate peroral placement and deployment of fasteners and secondary devices are also provided. Also described are implantable devices and attachment means that avoid causing excessive pressure within the tissue by having compliance that is compatible with the gastrointestinal tissues where it is attached.
Abstract translation: 本发明提供了用于在患者的消化道内将植入装置（例如人工造口装置，胃肠套筒装置或附件袖带）附接以用于治疗肥胖的装置和方法。 特殊的外科紧固件提供持久且持久的附着到胃肠道组织，而不会引起可能导致植入装置的组织侵蚀和脱离的过大的压力。 还提供了促进紧固件和辅助装置的口腔放置和部署的紧固件输送装置。 还描述了可植入装置和附接装置，其通过具有与其所附接的胃肠组织相容的顺应性来避免在组织内引起过大的压力。
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13.发明申请Phenyloxazolidinones having a C-C bond to 4-8 membered heterocyclic rings 审中-公开具有C-C键与4-8元杂环的苯基恶唑烷酮公开(公告)号：US20050054683A1
公开(公告)日：2005-03-10
申请号：US10470575
申请日：2003-03-22
Applicant: Douglas Hutchinson , Michael Ennis , Robert Hoffman , Richard Thomas , Toni-Jo Poel , Michael Barbachyn , Steven Brickner , David Anderson
Inventor： Douglas Hutchinson , Michael Ennis , Robert Hoffman , Richard Thomas , Toni-Jo Poel , Michael Barbachyn , Steven Brickner , David Anderson
IPC: C07D413/10 , A61K31/00 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/435 , A61K31/4439 , A61K31/445 , A61K31/4462 , A61K31/4465 , A61K31/4523 , A61K31/454 , A61K31/495 , A61K31/55 , A61P31/00 , A61P31/04 , C07D205/04 , C07D223/02 , C07D225/02 , C07D263/20 , C07D277/14 , C07D295/00 , C07D413/02 , C07D413/14 , C07D417/14
CPC classification number: C07D413/10 , C07D413/14 , C07D417/14
Abstract: A process for preparing a compound of the formula I: or pharmaceutical acceptable salts thereof wherein X is —NR1—, —S(O)g—, or —O—; R1 is —H, C1-6 alkyl optionally substituted with one or more —OH, —CN, or halo, or R1 is —(CH2)h-aryl, —COR1-1, —COOR1-2, —CO—(CH2)h—COR1-1, C1-6 alkyl sulfonyl, —SO2—(CH2)h-aryl, or —(CO)i-Het; R2 is —H, C1-6 alkyl, —(CH2)h-aryl, or halo; R3 and R4 are the same or different and are —H or halo; R5 is —H, C1-12 alkyl optionally substituted with one or more halo, C3-12 cycloalkyl, C1-6 alkoxy. The compounds are useful antimicrobial agents.
Abstract translation: 制备式I化合物或其药学上可接受的盐的方法，其中X为-NR 1 - ， - S（O）g - 或-O-; R 1是-H，任选地被一个或多个-OH，-CN或卤素取代的C 1-6烷基，或者R 1是 - （CH 2）h - 芳基，-COR 1 -1，-COOR 1-2，-CO-（CH 2 ）h-COR1-1，C 1-6烷基磺酰基，-SO 2 - （CH 2）h - 芳基或 - （CO）i-Het; R2是-H，C1-6烷基， - （CH2）h-芳基或卤素; R3和R4相同或不同，为-H或卤素; R5是-H，任选被一个或多个卤素取代的C 1-12烷基，C 3-12环烷基，C 1-6烷氧基。 这些化合物是有用的抗微生物剂。
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公开(公告)号：US4658564A
公开(公告)日：1987-04-21
申请号：US815560
申请日：1986-01-02
Applicant: Cecil R. Bell, Jr. , Richard Thomas , Jasper R. London , Walter R. Sizemore
Inventor： Cecil R. Bell, Jr. , Richard Thomas , Jasper R. London , Walter R. Sizemore
CPC classification number: B65B61/20
Abstract: A device for placing articles such as coupons or the like in cartons being conveyed past a work station containing the device. The device includes an upright coupon or the like article supply hopper, a reciprocatory mechanism for inserting the articles into the cartons as they are conveyed past and momentarily stopped adjacent thereto and a reciprocating vacuum or suction mechanism for removing the coupons from the supply hopper and placing them in the path of the inserting mechanism for placement into cartons.
Abstract translation: 用于将诸如优惠券等物品放置在纸箱中的装置被传送通过包含该装置的工作站。 该装置包括一个直立的优惠券或类似的物品供应料斗，一个往复运动的机构，用于当物品被输送过去并且相邻地被停止时将纸张插入到纸箱中;以及一个往复式真空或抽吸机构，用于从供料斗中取出试样并放置 它们在插入机构的路径中放置在纸箱中。
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公开(公告)号：USD870840S1
公开(公告)日：2019-12-24
申请号：US29635162
申请日：2018-01-29
Applicant: Carson Cheng , Michael Cheng , Richard Thomas
Designer： Carson Cheng , Michael Cheng , Richard Thomas
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Patent Agency Ranking
公开(公告)号：USD844734S1
公开(公告)日：2019-04-02
申请号：US29561531
申请日：2016-04-17
Applicant: Carson Cheng , Changan Tian , Richard Thomas
Designer： Carson Cheng , Changan Tian , Richard Thomas
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公开(公告)号：USD826361S1
公开(公告)日：2018-08-21
申请号：US29579246
申请日：2016-09-28
Applicant: Carson Cheng , Changan Tian , Richard Thomas
Designer： Carson Cheng , Changan Tian , Richard Thomas
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公开(公告)号：US09976834B1
公开(公告)日：2018-05-22
申请号：US15650962
申请日：2017-07-16
Applicant: Carson Cheng , Changan Tian , Richard Thomas
Inventor： Carson Cheng , Changan Tian , Richard Thomas
Abstract: A flip up gun sight includes a sight body which includes: a sight housing having a pivotal end; a base member having a right tab and a left tab slidably connected with the pivotal end of the sight housing; a supporting member having a first supporting end pivotally connected with the sight housing, and a second supporting end pivotally connected with the base member; and a locking and folding mechanism which includes a pair of sliding slots formed on the right and left tabs, and a first mounting pin adapted to pivotally connect with the sight housing and sight base member to guide the sight housing for operating between a raised position and a down position.
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公开(公告)号：US09862146B2
公开(公告)日：2018-01-09
申请号：US14126675
申请日：2012-06-15
Applicant: Marco Marcus Matheus Driessen , Michelle Elizabeth Seitz , Paulus Antonius Maria Steeman , John Edmond Southwell , Jigeng Xu , Richard Thomas , Micha Sandor Nicolaas Hubert Mulders
Inventor： Marco Marcus Matheus Driessen , Michelle Elizabeth Seitz , Paulus Antonius Maria Steeman , John Edmond Southwell , Jigeng Xu , Richard Thomas , Micha Sandor Nicolaas Hubert Mulders
CPC classification number: B29C64/106 , B29C64/129 , B29C64/135 , B29C64/40 , B33Y10/00 , B33Y30/00
Abstract: A method and apparatus for additive fabrication which provides a substrate which helps the newly hardened resin layer to separate from the substrate while providing a substrate of appropriate strength and durability. In an embodiment, the substrate is a multi-layer substrate comprising a transport layer and a structural layer, the transport layer comprising a polyolefin or a fluoropolymer, and the structural layer comprising a semi-crystal line thermoplastic polymer.
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公开(公告)号：USD803020S1
公开(公告)日：2017-11-21
申请号：US29581701
申请日：2016-10-20
Applicant: Carson Cheng , Richard Thomas , Jason Michael Cheng
Designer： Carson Cheng , Richard Thomas , Jason Michael Cheng
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