摘要:
Inverse agonists and antagonists of serotonin receptors are disclosed for use in treating sleep disorders such as insomnia, and specifically sleep maintenance insomnia. The compound increase slow wave sleep, decrease the number of awakenings after sleep onset, and decrease the time awake after sleep onset.
摘要:
The present invention relates to compounds and methods useful as inhibitors of protein kinases, including B-Raf and several receptor tyrosine and cytoplasmic tyrosine kinases. The present invention is directed to new substituted pyrimidinyloxy urea compounds of Formulas II, III and IV and compositions and their application as pharmaceuticals for the treatment of disease. Methods of modulating of protein kinase activity in a human or animal subject are also provided for the treatment diseases such as cancers.
摘要:
Systems for applying or dispensing fluids such as surgical prep solution are disclosed. The applicator includes a barrel portion, container, and/or cap. The barrel portion, container and/or cap comprises elements such that they can be movably located relative to each other prior to activation.
摘要:
A system and method for viewing and ordering wager gaming content utilizes a network server to provide an interface to a user coupled to the network. In one embodiment, the server is an Internet web based server, and the user is a thin client, using an Internet browser to view and select wager gaming content. The web based server may be coupled to an order entry system to facilitate ordering and payment for selected wager gaming content. The order entry system may also be coupled to a content server to provide for downloading of selected wager gaming content.
摘要:
Laminates of having a first outer layer of weatherable film, at least one mid layer, and a second outer layer containing an opacifying quantity of white pigment. The laminates are particularly useful for protecting photovoltaic cells, solar panels, and circuit boards. In photovoltaic cells, the laminates result in increased power generation.
摘要:
Behavioral pharmacological data with the compound of formula (I), a novel and selective 5HT2A/2C receptor inverse agonist, demonstrate in vivo efficacy in models of psychosis and dyskinesias. This includes activity in reversing MK-801 induced locomotor behaviors, suggesting that this compound may be an efficacious anti-psychotic, and activity in an MPTP primate model of dyskinesias, suggesting efficacy as an anti-dyskinesia agent. These data support the hypothesis that 5HT2A/2C receptor inverse agonism may confer antipsychotic and anti-dyskinetic efficacy in humans, and indicate a use of the compound of formula (I) and related agents as novel therapeutics for Parkinson's Disease, related human neurodegenerative diseases, and psychosis.
摘要:
The installation and use of abrasion and corrosion resistant polyolefin and polyolefin blend liners in the production or injection string of a well is shown. The lining is employed for the principal purpose of reducing wear or corrosion on the tubing string or wear on the associated production equipment. In a preferred embodiment of the invention, the polymer liner is characterized by polypropylene material, which is abrasion resistant and which has a coefficient of friction that is lower that the coefficient of friction of metal tubing. Also, disclosed herein are tubular goods and tubular good liners which decrease or eliminate friction and mechanical wear and decrease or eliminate chemical corrosion to the walls of the tubular good. The liners may include a diffusion barrier, an adhesive, and a friction and wear resistant layer.
摘要:
A pumping system including a fluid inlet line and a primary pump for the fluid. The primary pump includes an impeller in an impeller chamber, with the impeller chamber adapted to receive fluid from the inlet line. A suction chamber is above the impeller chamber, with a throttle opening between the impeller chamber and the suction chamber. A priming pump is adapted to draw fluid through the throttle opening into the suction chamber. A fluid path is provided around the impeller chamber and between the inlet line and the suction chamber, with the fluid path having a larger area than the throttle opening and including a float restrictor.
摘要:
An auxiliary reactor for use with a reformer reactor having at least one reaction zone, and including a burner for burning fuel and creating a heated auxiliary reactor gas stream, and heat exchanger for transferring heat from auxiliary reactor gas stream and heat transfer medium, preferably two-phase water, to reformer reaction zone. Auxiliary reactor may include first cylindrical wall defining a chamber for burning fuel and creating a heated auxiliary reactor gas stream, the chamber having an inlet end, an outlet end, a second cylindrical wall surrounding first wall and a second annular chamber there between. The reactor being configured so heated auxiliary reactor gas flows out the outlet end and into and through second annular chamber and conduit which is disposed in second annular chamber, the conduit adapted to carry heat transfer medium and being connectable to reformer reaction zone for additional heat exchange.