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公开(公告)号：US6013019A
公开(公告)日：2000-01-11
申请号：US55484
申请日：1998-04-06
CPC分类号： A61M29/02 , A61F2/95 , A61N5/1002 , A61F2002/9517 , A61F2210/0095 , A61M2025/018 , A61M2025/1013 , A61M2025/1079 , A61M2025/1081
摘要： The temporary radioisotope stent catheter system of the present invention includes a temporary radioisotope stent that is situated at a distal portion of two, co-axially situated, thin-walled tubes. The catheter system can be delivered into a vessel of a human body either as a stand-alone device or it can be used in conjunction with an elongated cylindrical sheath which is a form of delivery catheter. If used as a stand-alone device, the temporary radioisotope stent is first percutaneously advanced through a guiding catheter and is then placed at the site of a stenotic dilatation. An operating means located at a proximal portion of the catheter system is then used to increase the diameter of the temporary radioisotope stent to be approximately equal to the inside diameter of the dilated stenosis. The temporary radioisotope stent is then retained at that position for an irradiation time period that is determined by the level of radioactivity of the stent, by the diameter of the dilated stenosis, and by the dose of radiation that is prescribed for application to that portion of the artery. At the conclusion of the irradiation time period, the operating means at the proximal portion of the catheter system is used to decrease the diameter of the temporary radioisotope stent to its minimum value, and then the catheter system is removed from the patient's body.
摘要翻译： 本发明的临时放射性同位素支架导管系统包括临时放射性同位素支架，其位于两个同轴位置的薄壁管的远端部分。 导管系统可以作为独立装置输送到人体的容器中，或者可以与作为输送导管形式的细长圆柱形护套一起使用。 如果用作独立装置，则临时放射性同位素支架首先通过引导导管经皮前进，然后放置在狭窄扩张部位。 然后使用位于导管系统的近端部分的操作装置将临时放射性同位素支架的直径增加到近似等于扩张狭窄的内径。 然后将临时放射性同位素支架保持在该位置，以照射时间段，其由支架的放射性水平，扩张的狭窄的直径以及通过施用于该部分的 动脉。 在照射时间段结束时，使用导管系统的近端部分的操作装置将临时放射性同位素支架的直径减小到其最小值，然后将导管系统从患者体内移除。
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公开(公告)号：US5938689A
公开(公告)日：1999-08-17
申请号：US70974
申请日：1998-05-01
CPC分类号： A61N1/0529 , A61N1/0534 , A61N1/36185 , A61N1/36064 , A61N1/36075
摘要： Disclosed herein are several unique configurations of electrodes for stimulation of brain tissue. Specifically, a configuration of electrodes is disclosed that has at least one electrode on the brain's surface and at least one additional electrode located deep within the tissue of the brain. It is envisioned that all such electrodes would be located in close proximity to a particular region of the brain such as an epileptic focus. It is further envisioned that several brain surface electrodes would be used in conjunction with several deep brain electrodes. Specifically, it is envisioned that all surface electrodes would be electrically joined together and all deep electrodes would be electrically joined together. In this way, when a source of electrical current is connected to those electrodes, a particular region of the brain could be surrounded by a "curtain" of electrical current that can be used to depolarize neurons at the perimeter of the region so as to prevent any electrical signal originating in that region from being transmitted beyond that region to the rest of the brain. Sub-surface electrodes placed between 1 and 10 mm below the brain's surface could also be used with either brain surface electrodes or deep brain electrodes.
摘要翻译： 本文公开了用于刺激脑组织的电极的几种独特配置。 具体地，公开了在脑的表面上具有至少一个电极和位于脑的组织内的至少一个另外的电极的电极的构造。 可以设想，所有这样的电极将位于紧邻脑的特定区域，例如癫痫焦点。 进一步设想，几个脑表面电极将与几个深层脑电极结合使用。 具体地，可以想象所有的表面电极将被电连接在一起，并且所有的深电极将被电连接在一起。 以这种方式，当电流源连接到那些电极时，脑的特定区域可以被电流的“窗帘”所包围，可以用于在该区域的周边去极化神经元，以防止 源自该区域的任何电信号都不会传播到超出该区域的大脑的其余部分。 放置在脑表面下方1至10毫米之间的子表面电极也可用于脑表面电极或深脑电极。
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13.发明授权Radioisotope stent with increased radiation field strength at the ends of the stent 失效放射性同位素支架在支架末端具有增加的辐射场强度
公开(公告)号：US5840009A
公开(公告)日：1998-11-24
申请号：US567138
申请日：1995-12-05
CPC分类号： A61F2/82 , A61N5/1002 , A61F2210/0095
摘要： Disclosed is a radioisotope stent that has increased radioactivity at the end regions of the stent as compared to the stent's central region. To minimize the neointimal hyperplasia that may exist to a greater extent at the ends of a stent that is implanted into an artery of a human body, the amount of radioactivity placed at or near the ends of the stent should be increased as compared to the amount of radioactivity over the remainder of the stent. It is an additional object of this invention to increase the radiation field at the end of a radioisotope stent by placing additional metal surfaces at the ends of the stent so as to have additional surfaces onto which a radioisotope can be placed.
摘要翻译： 公开了一种放射性同位素支架，其与支架的中心区域相比在支架的端部区域具有增加的放射性。 为了最小化可能在植入人体动脉的支架的末端更大程度地存在的新内膜增生，应该增加放置在支架端部或附近的放射性量， 放射性超过支架的其余部分。 本发明的另一个目的是通过在支架的端部放置额外的金属表面以增加可以放置放射性同位素的附加表面来增加放射性同位素支架末端的辐射场。
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14.发明授权Balloon angioplasty catheter with enhanced capability to penetrate a tight arterial stenosis 失效球囊血管成形术导管具有增强穿透紧张性动脉狭窄的能力
公开(公告)号：US5830227A
公开(公告)日：1998-11-03
申请号：US840788
申请日：1997-04-16
CPC分类号： A61M25/0068 , A61M25/104 , A61M2025/0183 , A61M2025/1004 , A61M2025/1056 , A61M2025/1093 , A61M2029/025 , A61M25/008
摘要： The present invention is a balloon angioplasty catheter that combines a catheter shaft having increased pushability with an elongated, gradually tapered, highly flexible, lubricity coated, distal tip that is specifically designed to penetrate through a tight stenosis. The distal end of the tip is formed as a very thin-walled, tapered, frustrum of a cone that is capable of following a guide wire through even the most tortuous coronary arteries. The proximal end of the tip has a diameter that is equal to or slightly larger than the diameter of an angioplasty balloon that is wrapped around a catheter shaft at a distal section of the balloon angioplasty catheter. One embodiment of the invention includes a thin-walled tube located at the proximal end of the distal tip which extends over the distal end of the angioplasty balloon. This design can prevent the distal end of the wrapped pre-deployed balloon from engaging the arterial wall as it is pushed through a tight stenosis. The balloon angioplasty catheter can be designed with the capability for either or both a rapid exchange or over-the-wire mode.
摘要翻译： 本发明是一种球囊血管成形术导管，其将具有增加的推动性的导管轴与细长的逐渐变细的，高度柔性的润滑性涂层的远侧末端组合，该尖端被专门设计成穿过狭窄狭窄。 尖端的远端形成为非常薄壁的锥形锥体，其能够跟随导丝通过甚至最曲折的冠状动脉。 尖端的近端具有等于或略大于在球囊血管成形术导管的远端部分处缠绕导管轴的血管成形术球囊的直径的直径。 本发明的一个实施例包括位于远侧末梢的近端处的薄壁管，其在血管成形术气囊的远端上延伸。 这种设计可以防止被包裹的预先展开的球囊的远端在紧张的狭窄被推动时与动脉壁接合。 球囊血管成形术导管可以被设计成具有快速交换或线上模式中的一种或两者的能力。
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公开(公告)号：US5643312A
公开(公告)日：1997-07-01
申请号：US202128
申请日：1994-02-25
CPC分类号： A61F2/844 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2002/825 , A61F2002/91533 , A61F2002/9155 , A61F2210/0019
摘要： The present invention provides for an expandable stent (1) for use in an artery or other vessel of a human body which forms a plurality of spaced apart generally circular rings (2). The stent structure (1) maintains patency of a vessel within which the stent (1) is inserted and is formed by a plurality of closed and generally circular rings (2) where the plane of each ring (2) is substantially parallel to the plane of an adjacent ring (2). The rings (2) have a common longitudinal axis generally perpendicular to the plane of each ring (2) with the longitudinal axis passing through the geometric center of each of the rings (2). A plurality of elongated wire structures forming longitudinals (4T, 4B, 4R, 4L) are fixedly secured to the rings (2) and extend in a direction generally parallel to the longitudinal axis of the rings (2). The stent (1) formed of the generally circular rings (2) optimizes hoop strength and minimizes elastic recoil of a vessel into which the stent (1) is inserted.
摘要翻译： 本发明提供一种用于人体的动脉或其他血管的可扩张支架（1），其形成多个间隔开的大致圆环（2）。 支架结构（1）保持支架（1）插入其中的容器的通畅性并且由多个闭合且大致圆形的环（2）形成，其中每个环（2）的平面基本上平行于平面 的相邻环（2）。 环（2）具有大致垂直于每个环（2）的平面的公共纵向轴线，纵向轴线穿过每个环（2）的几何中心。 形成纵骨（4T，4B，4R，4L）的多个细长线结构固定地固定到环（2）上并且沿大致平行于环（2）的纵向轴线的方向延伸。 由大致圆形环（2）形成的支架（1）优化环箍强度并使插入支架（1）的容器的弹性反冲最小化。
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16.发明授权Integrated dual-function catheter system and method for balloon angioplasty and stent delivery 失效集成双功能导管系统和球囊血管成形术和支架输送的方法
公开(公告)号：US5634928A
公开(公告)日：1997-06-03
申请号：US647294
申请日：1996-05-09
CPC分类号： A61M25/104 , A61F2/95 , A61F2/958 , A61F2/0095 , A61F2002/9517 , A61F2210/0019 , A61F2250/0098 , A61M2025/0006 , A61M29/02
摘要： An integrated catheter system utilizes a balloon angioplasty catheter placed through a central passageway of a stent delivery catheter to enable balloon angioplasty and stent delivery to be accomplished with a single device. The integrated catheter system is able to perform dilatation of an arterial stenosis, placement of the stent at the site of the stenosis and then the angioplasty catheter balloon can be used to further embed the stent into the arterial wall. Balloon angioplasty, stent placement and stent embedding into the arterial wall are all accomplished while the catheter's angioplasty balloon remains situated at the site of the stenosis. A conically shaped distal portion of the stent delivery catheter allows stent placement over the deflated balloon after balloon angioplasty even when intimal dissection causes an intimal flap to be pushed inwardly against the deflated balloon. A proximal portion of the integrated catheter system employs longitudinal motion constraining spacers to prevent the stent from being inadvertently positioned beyond the distal end of the balloon. The balloon of the balloon angioplasty catheter can be readily advanced through tortuous coronary arteries because the distal end of the stent delivery catheter can be placed back by 0.5 to 20 cm from the balloons proximal end during insertion. Thus, the stiffness of the stent and the stent delivery catheter do not add stiffness to the distal portion of the balloon angioplasty catheter, which stiffness can prevent catheter advancement through such tortuous vessels.
摘要翻译： 集成的导管系统利用通过支架输送导管的中心通道放置的球囊血管成形术导管，以实现球囊血管成形术和用单个装置实现支架输送。 综合导管系统能够进行动脉狭窄的扩张，将支架放置在狭窄部位，然后血管成形术导管球囊可用于进一步将支架嵌入动脉壁。 气囊血管成形术，支架置入和支架嵌入动脉壁都是完成的，而导管的血管成形术球囊保持位于狭窄部位。 支架输送导管的锥形远端部分允许支架放置在球囊血管成形术之后的放气球上，即使当内膜解剖术使得内膜被向内压靠在放气气囊上时。 集成导管系统的近端部分采用纵向运动约束间隔物，以防止支架被无意地定位在气囊远端之外。 球囊血管成形术导管的球囊可以通过曲折的冠状动脉容易地前进，因为支架输送导管的远端可以在插入期间放置回离球囊近端0.5至20cm。 因此，支架和支架输送导管的刚度不会增加球囊血管成形术导管的远端部分的刚度，该刚度可以防止导管通过这种曲折的血管前进。
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公开(公告)号：US5306259A
公开(公告)日：1994-04-26
申请号：US926271
申请日：1992-08-10
CPC分类号： A61B17/3403 , A61B17/3401 , A61M25/065 , A61B2017/00907 , A61M25/0693
摘要： This invention is directed to a vascular access needle (20) for insertion of a sharpened end of a needle (28) into the lumen of a blood vessel. The vascular access needle (20) includes both a hollow needle (28) and an elongated cylindrical body (22) having respective central passageway lumen (27) and capillary lumen (26) extending through the entire vascular access needle (20). The elongated cylindrical body includes a planar angled surface (21) which plane is oriented parallel to the plane of the needle distal opening (29), which provides the capability for proper orientation of the needle (28) for insertion into the blood vessel lumen. The elongated cylindrical body (22) further includes a pair of parallel flat surfaces (23) for stabilization and proper orientation of the needle distal opening (29) when inserting into the blood vessel lumen. Further, the elongated cylindrical body (22) is formed of a substantially transparent material composition in order to allow the user to view the displacement of the blood therein subsequent to insertion within the blood vessel lumen.
摘要翻译： 本发明涉及一种用于将针（28）的尖锐末端插入血管内腔的血管通路针（20）。 血管通路针（20）包括中空针（28）和细长的圆柱体（22），其具有延伸穿过整个血管通路针（20）的各自的中心通道腔（27）和毛细血管腔（26）。 细长的圆柱体包括平面成角度的表面（21），该平面定向成平行于针远端开口（29）的平面，这提供了针（28）的适当取向用于插入血管内腔的能力。 细长圆柱体（22）还包括一对平行的平坦表面（23），用于在插入血管内腔时稳定和适当地定位针远端开口（29）。 此外，细长圆柱体（22）由基本上透明的材料组合物形成，以便允许使用者在插入血管内腔之后观察其中血液的位移。
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公开(公告)号：US08454677B2
公开(公告)日：2013-06-04
申请号：US12007289
申请日：2008-01-09
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2002/91525 , A61F2002/91541 , A61F2002/91558 , A61F2002/91583 , A61F2210/0076 , A61F2230/0013 , A61F2250/0032 , A61F2250/0036 , A61F2250/0098
摘要： A stent in the form of a thin-walled, multi-cellular tubular structure is provided. The tubular structure has a longitudinal axis and the stent includes a plurality of circumferential sets of strut members. Each set of the strut members is longitudinally displaced from each other and connected to each other by longitudinally extending links. Each set of the strut members forms a closed and cylindrical portion of the stent. Further, each set of the strut members includes a plurality of connected curve sections and diagonal sections. The sets of the strut members further include end sets of strut members located at each end of the stent and central sets of strut members located between the end sets of the strut members. The diagonal sections of the end sets of the strut members have a center portion and two ends.
摘要翻译： 提供了薄壁多孔管状结构形式的支架。 管状结构具有纵向轴线，并且支架包括多个圆周组的支柱构件。 每组支柱构件彼此纵向移位并通过纵向延伸的连杆相互连接。 每组支柱构件形成支架的闭合和圆柱形部分。 此外，每组支柱构件包括多个连接的曲线部分和对角线部分。 支柱构件的组还包括位于支架的每个端部处的支柱构件的端组和位于支柱构件的端部组之间的支柱构件的中心组。 支柱构件的端部组的对角部分具有中心部分和两端。
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公开(公告)号：US20130079746A1
公开(公告)日：2013-03-28
申请号：US13431526
申请日：2012-03-27
CPC分类号： A61M25/01 , A61M25/0012 , A61M25/005 , A61M25/0108 , A61M25/02 , A61M25/0662 , A61M39/0606 , A61M2025/0266 , A61M2025/028 , A61M2025/0286 , B21C37/042
摘要： A thin-walled introducer sheath is described. In some embodiments, the introducer sheath includes structural support components, such as wires, used in connection with a polymeric inner coating, a polymeric outer coating, or both. Further, in some embodiments, the wire components are annealed to reduce cold-work-related stresses and hardness. Use of annealed components may enable a reduction in the thickness of the polymeric outer coating in some applications.
摘要翻译： 描述了薄壁导引鞘。 在一些实施例中，引入器护套包括与聚合物内涂层，聚合物外涂层或两者结合使用的结构支撑部件，例如导线。 此外，在一些实施例中，将线材部件退火以减少与冷加工有关的应力和硬度。 在一些应用中，退火组分的使用可以使聚合物外涂层的厚度减小。
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公开(公告)号：US08244338B2
公开(公告)日：2012-08-14
申请号：US12320948
申请日：2009-02-10
IPC分类号： A61B5/0402
CPC分类号： A61B5/0472 , A61B5/0006 , A61B5/0031 , A61B5/02405 , A61B5/02455 , A61B5/04012 , A61B5/042 , A61B5/0432 , A61B5/044 , A61B5/0452 , A61B5/413 , A61B5/686 , A61B5/746 , A61N1/025 , A61N1/37211 , A61N1/37247
摘要： A system for cardiac event detection over varying time scales includes implanted electrical leads forming a portion of an implanted cardiotracker and external equipment including external alarm mechanisms and a physicians programmer. The cardiac event detection system monitors the degradation of a patient's cardiovascular condition from one or more causes. A processor computes the electrical signals of a heart signal parameter's average value over a time period for a multiplicity of heart rate ranges. The electrical signals are stored and information transmitted to external equipment.
摘要翻译： 用于在不同时间尺度上进行心脏事件检测的系统包括形成植入式心脏呼吸器的一部分的植入电引线和包括外部警报机构和医生程序员的外部设备。 心脏事件检测系统从一个或多个原因监测患者心血管疾病的恶化。 处理器在多个心率范围内计算心脏信号参数在一段时间内的平均值的电信号。 电信号被存储，信息传输到外部设备。
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