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公开(公告)号：US5464540A
公开(公告)日：1995-11-07
申请号：US165446
申请日：1993-12-09
Applicant: Dwayne T. Friesen , David D. Newbold , Scott B. McCray , Roderick J. Ray
Inventor： Dwayne T. Friesen , David D. Newbold , Scott B. McCray , Roderick J. Ray
IPC: B01D61/36
CPC classification number: B01D61/362
Abstract: There is described a process for the removal of at least one component of a liquid mixture, the basic process comprising directing a liquid mixture against the feed side of a membrane, directing a condensable vapor sweep stream past the permeate side of the membrane in a manner such that the flow of the condensable vapor sweep is substantially countercurrent to the flow of the liquid mixture, thereby transporting at least a portion of at least one component of the liquid mixture from the feed side to the permeate side of the membrane to form a combined permeate side mixture of condensable vapor and at least one transported component.
Abstract translation: 描述了去除液体混合物的至少一种组分的方法，其基本方法包括将液体混合物引导到膜的进料侧，引导可冷凝的蒸气吹扫流以膜的渗透侧流过膜的渗透侧 使得可冷凝蒸汽吹扫的流动基本上与液体混合物的流动逆流，从而将至少一部分液体混合物的组分从进料侧输送到膜的渗透侧，以形成组合 可冷凝蒸汽的渗透侧混合物和至少一个输送组分。
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12.发明授权Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus 有权使用改进的喷雾干燥装置制备均匀喷雾干燥的固体无定形药物分散体的方法公开(公告)号：US06973741B2
公开(公告)日：2005-12-13
申请号：US10766450
申请日：2004-01-27
Applicant: Ronald A. Beyerinck , Heather L. M. Diebele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
Inventor： Ronald A. Beyerinck , Heather L. M. Diebele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
CPC classification number: A61K9/1682 , A61J3/02 , A61K9/146 , A61K9/1652 , A61K9/1694 , A61K31/404 , A61K31/47 , B01J2/04
Abstract: Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-enhancing polymers.
Abstract translation: 传统的喷雾干燥方法通过结合压力喷嘴和扩散板来改善干燥气体的流动和干燥室延伸以增加干燥时间，这样的改进导致药物浓度增强的均匀固体分散体形成 聚合物。
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公开(公告)号：US06623639B2
公开(公告)日：2003-09-23
申请号：US09525580
申请日：2000-03-15
Applicant: Robert P. Barss , Dwayne T. Friesen , Scott B. McCray , Kendall R. Pearson , Roderick J. Ray , Delores R. Sidwell , James B. West
Inventor： Robert P. Barss , Dwayne T. Friesen , Scott B. McCray , Kendall R. Pearson , Roderick J. Ray , Delores R. Sidwell , James B. West
IPC: B01D6908
CPC classification number: B01D67/0093 , B01D67/0006 , B01D67/0011 , B01D69/08 , B01D69/12 , B01D69/125 , B01D71/56 , B01D71/62 , B01D2323/08 , B01D2323/30 , B65D85/812 , B65D2205/02
Abstract: Solvent-resistant polybenzimidazole membranes, methods of making them and crosslinking them and composite membranes and hollow fiber membrane modules from them are disclosed.
Abstract translation: 公开了耐溶剂聚苯并咪唑膜，制备它们并交联它们的方法以及复合膜和中空纤维膜组件。
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公开(公告)号：US5350681A
公开(公告)日：1994-09-27
申请号：US928673
申请日：1992-08-12
Applicant: Guillermo A. Iacobucci , Daniel J. Brose , Roderick J. Ray , Paul van Eikeren
Inventor： Guillermo A. Iacobucci , Daniel J. Brose , Roderick J. Ray , Paul van Eikeren
CPC classification number: C07K5/0613 , C07K1/00 , C07K14/70 , C12M21/18 , C12P21/02 , Y10S530/801
Abstract: The present invention discloses a method for the enzymatic synthesis of a peptide. A protected peptide having a C-terminal carboxylate group or a protected, N-acyl amino acid having an alpha carboxylate group is reacted with a protected peptide having an N-terminal ammonium group or a protected amino acid having an alpha ammonium group in the presence of a condensation enzyme under conditions in which the carboxylate group and the ammonium group condense to form a protected, uncharged, peptide product. This peptide product is transported across a water-immiscible hydrophobic phase into an aqueous product phase and prevented from back diffusing across the water-immiscible hydrophobic phase. The peptide product can be converted, chemically or enzymatically, to a charged species that cannot back diffuse across the water-immiscible phase into the aqueous reaction phase. The water-immiscible hydrophobic phase is an ion rejection membrane separating the aqueous reaction phase from the product phase creating oil/water interfaces with each of the aqueous phases.
Abstract translation: 本发明公开了一种肽合成酶的方法。 具有羧酸C端的保护肽或具有α羧酸酯基团的被保护的N-酰基氨基酸在存在下与具有N-末端铵基或被保护的氨基酸的受保护肽反应 的缩合酶在羧酸酯基和铵基团缩合形成受保护的不带电荷的肽产物的条件下反应。 该肽产物通过水不混溶的疏水相转运到水相产物相中并防止反向扩散穿过与水不混溶的疏水相。 肽产物可以化学或酶促转化成不能通过水不混溶相扩散到水反应相中的带电物质。 水不混溶的疏水相是将水反应相与产物相分离的离子排斥膜，产生与每个水相的油/水界面。
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15.发明授权Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus 有权使用改进的喷雾干燥装置制备均匀喷雾干燥的固体无定形药物分散体的方法公开(公告)号：US08343550B2
公开(公告)日：2013-01-01
申请号：US13165732
申请日：2011-06-21
Applicant: Ronald A. Beyerinck , Heather L. M. Deibele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
Inventor： Ronald A. Beyerinck , Heather L. M. Deibele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
CPC classification number: A61K9/1682 , A61J3/02 , A61K9/146 , A61K9/1652 , A61K9/1694 , A61K31/404 , A61K31/47 , B01J2/04
Abstract: Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-enhancing polymers.
Abstract translation: 传统的喷雾干燥方法通过结合压力喷嘴和扩散板来改善干燥气体的流动和干燥室延伸以增加干燥时间，这样的改进导致药物浓度增强的均匀固体分散体形成 聚合物。
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Patent Agency Ranking
16.发明申请METHOD FOR MAKING HOMOGENEOUS SPRAY-DRIED SOLID AMORPHOUS DRUG DISPERSIONS UTILIZING MODIFIED SPRAY-DRYING APPARATUS 有权使用改性喷雾干燥装置制备均匀喷雾干燥固体非晶态药物分散体的方法公开(公告)号：US20110277339A1
公开(公告)日：2011-11-17
申请号：US13165732
申请日：2011-06-21
Applicant: Ronald A. Beyerinck , Heather L. M. Deibele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
Inventor： Ronald A. Beyerinck , Heather L. M. Deibele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
IPC: F26B3/12
CPC classification number: A61K9/1682 , A61J3/02 , A61K9/146 , A61K9/1652 , A61K9/1694 , A61K31/404 , A61K31/47 , B01J2/04
Abstract: Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-enhancing polymers.
Abstract translation: 传统的喷雾干燥方法通过结合压力喷嘴和扩散板来改善干燥气体的流动和干燥室延伸以增加干燥时间，这样的改进导致药物浓度增强的均匀固体分散体形成 聚合物。
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公开(公告)号：US07736672B2
公开(公告)日：2010-06-15
申请号：US11003664
申请日：2004-12-03
Applicant: Roderick J. Ray , Leah E. Appel , Dwayne Thomas Friesen , Marshall D. Crew , Joshua R. Shockey
Inventor： Roderick J. Ray , Leah E. Appel , Dwayne Thomas Friesen , Marshall D. Crew , Joshua R. Shockey
IPC: A61K9/14
CPC classification number: A61K9/1617 , A61K9/1635 , A61K9/1694
Abstract: A process is described for producing drug-containing multiparticulates with improved stability, characterized by an improvement in one or more of chemical stability, physical stability, or dissolution stability.
Abstract translation: 描述了用于生产具有改进的稳定性的含药多颗粒的方法，其特征在于改进一种或多种化学稳定性，物理稳定性或溶解稳定性。
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公开(公告)号：US4725359A
公开(公告)日：1988-02-16
申请号：US704868
申请日：1985-02-25
Applicant: Roderick J. Ray
Inventor： Roderick J. Ray
CPC classification number: C02F1/16 , B01D53/268 , Y10S55/30
Abstract: A method of and apparatus for obtaining potable water from the exhaust of an internal combustion engine is disclosed essentially comprising separating a water vapor permeate containing water vapor and noncondensable gases from the exhaust by a nonporous nonionic hydrophilic membrane, then separating the water vapor from noncondensable gases by either condensing the water vapor or compressing the entire water vapor permeate followed by condensation of the water vapor contained in the permeate.
Abstract translation: 公开了一种从内燃机的排气中获得饮用水的方法和设备，其基本上包括通过非离子非离子亲水膜从废气中分离含有水蒸气和不凝气体的水蒸气渗透物，然后将水蒸汽与不可冷凝气体 通过冷凝水蒸汽或压缩整个水蒸气渗透物，随后包含在渗透物中的水蒸气冷凝。
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公开(公告)号：US07951403B2
公开(公告)日：2011-05-31
申请号：US11003659
申请日：2004-12-03
Applicant: Dwayne T. Friesen , Marshall D. Crew , Roderick J. Ray , Leah E. Appel
Inventor： Dwayne T. Friesen , Marshall D. Crew , Roderick J. Ray , Leah E. Appel
CPC classification number: A61K9/1617 , A61K9/1635 , A61K9/1694 , A61K31/7052
Abstract: A process for forming drug multiparticulates having improved drug crystallinity is disclosed, comprising modifying a conventional melt-congeal process by adding a volatile cospecies either to the molten mixture or to the process atmosphere, or to both.
Abstract translation: 公开了一种形成具有改善的药物结晶度的药物多颗粒的方法，其包括通过向熔融混合物或加工气氛或两者添加挥发性环氧树脂来改变常规的熔融 - 凝结过程。
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20.发明授权Method for making homogeneous spray-dried solid amorphous drug dispersions using pressure nozzles 有权使用压力喷嘴制备均匀喷雾干燥的固体无定形药物分散体的方法公开(公告)号：US07780988B2
公开(公告)日：2010-08-24
申请号：US10351568
申请日：2003-01-24
Applicant: Ronald A. Beyerinck , Roderick J. Ray , Dan E. Dobry , Dana M. Settell
Inventor： Ronald A. Beyerinck , Roderick J. Ray , Dan E. Dobry , Dana M. Settell
CPC classification number: A61K9/1652 , A61K9/1694
Abstract: Homogeneous solid amorphous dispersions of drugs in concentration-enhancing polymers are formed in desirable larger particle sizes with minimal fines by using an atomizer and process conditions capable of producing droplets having an average diameter of at least 50 microns and a D10 of at least 10 microns.
Abstract translation: 浓缩增强聚合物中药物的均匀固体无定型分散体通过使用雾化器和能够产生平均直径为至少50微米，D10为至少10微米的液滴的工艺条件，以最小的细粉形成期望的较大粒径。
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