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公开(公告)号：US08308684B2
公开(公告)日：2012-11-13
申请号：US13102876
申请日：2011-05-06
申请人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton , Lisa Rogers , Joseph Ferraro
发明人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton , Lisa Rogers , Joseph Ferraro
CPC分类号： B05D1/00 , A61F2/82 , A61F2/958 , A61F2250/0067 , A61L29/08 , A61L29/16 , A61L2300/606 , A61M25/1027 , A61M25/1038 , A61M2025/1031 , B05D2259/00 , Y10T29/49
摘要： A non-polymeric or biological coating applied to a radially expandable interventional medical device in a collapsed, wrapped, or folded configuration, the coating applied within at least one fold. Properties of the coating material applied to the medical device are adjusted or varied to result in a desired combination of coverage of the surface of the medical device, drug loading, and coating thickness. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device.
摘要翻译： 以折叠的，包裹的或折叠的形式施加到可径向展开的介入医疗装置的非聚合物或生物涂层，所述涂层施用在至少一个折叠内。 调整或改变施加到医疗装置上的涂层材料的性质，以产生医疗装置的表面，药物负载和涂层厚度的覆盖范围的期望组合。 涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。 治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。
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公开(公告)号：US20110213302A1
公开(公告)日：2011-09-01
申请号：US13102876
申请日：2011-05-06
申请人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton , Lisa Rogers , Joseph Ferraro
发明人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton , Lisa Rogers , Joseph Ferraro
CPC分类号： B05D1/00 , A61F2/82 , A61F2/958 , A61F2250/0067 , A61L29/08 , A61L29/16 , A61L2300/606 , A61M25/1027 , A61M25/1038 , A61M2025/1031 , B05D2259/00 , Y10T29/49
摘要： A non-polymeric or biological coating applied to a radially expandable interventional medical device in a collapsed, wrapped, or folded configuration, the coating applied within at least one fold. Properties of the coating material applied to the medical device are adjusted or varied to result in a desired combination of coverage of the surface of the medical device, drug loading, and coating thickness. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device.
摘要翻译： 以折叠的，包裹的或折叠的形式施加到可径向展开的介入医疗装置的非聚合物或生物涂层，所述涂层施用在至少一个折叠内。 调整或改变施加到医疗装置上的涂层材料的性质，以产生医疗装置的表面，药物负载和涂层厚度的覆盖范围的期望组合。 涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。 治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。
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公开(公告)号：US20060083768A1
公开(公告)日：2006-04-20
申请号：US11238564
申请日：2005-09-28
申请人： Roger Labrecque , Geoffrey Moodie , Suzanne Conroy , Lisa Rogers , Joseph Ferraro , Theodore Karwoski , Steve Herweck , Paul Martakos
发明人： Roger Labrecque , Geoffrey Moodie , Suzanne Conroy , Lisa Rogers , Joseph Ferraro , Theodore Karwoski , Steve Herweck , Paul Martakos
CPC分类号： A61L31/08 , A61F2/07 , A61F2/885 , A61F2/90 , A61F2002/065 , A61F2002/075 , A61L31/10 , A61L31/16 , A61L2300/606 , A61L2300/802
摘要： A method for the provision of a coating on an implantable medical device results in a medical device having a bio-absorbable coating. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a dissolved therapeutic agent component can also be provided. The coated medical device is implantable in a patient to effect controlled delivery of the coating, including the dissolved therapeutic agent, to the patient.
摘要翻译： 在可植入医疗装置上提供涂层的方法导致具有生物可吸收涂层的医疗装置。 涂层包括生物吸收载体组分。 除了生物吸收性载体成分之外，还可以提供溶解的治疗剂成分。 涂覆的医疗装置可植入患者体内以实现对包括溶解的治疗剂在内的包衣的控制递送。
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公开(公告)号：US20140308333A1
公开(公告)日：2014-10-16
申请号：US14252671
申请日：2014-04-14
申请人： Roger Labrecque , Geoffrey Moodie , Joseph F. Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck
发明人： Roger Labrecque , Geoffrey Moodie , Joseph F. Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： A coating material including a bio-absorbable cross-linked material and a cellular uptake inhibitor. The bio-absorbable cross-linked material includes two or more fatty acids cross-linked into a substantially random configuration by ester bonds. The coating material may be adhered to a medical device. A medical device system including a medical device and a coating is also included.
摘要翻译： 包括生物可吸收交联材料和细胞吸收抑制剂的涂层材料。 生物可吸收交联材料包括通过酯键交联成基本上无规构型的两种或更多种脂肪酸。 涂层材料可以粘附到医疗装置。 还包括包括医疗装置和涂层的医疗装置系统。
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公开(公告)号：US08962023B2
公开(公告)日：2015-02-24
申请号：US11236943
申请日：2005-09-28
申请人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Thomas M. Swanick
发明人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Thomas M. Swanick
IPC分类号： A61K9/00 , A61L27/54 , A61F13/02 , A61K9/06 , A61K31/225 , A61K31/355 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/08 , A61L2/20 , A61L27/36 , A61L27/52 , A61L31/00 , A61L31/10 , A61L31/14 , A61F2/06 , B05D3/06
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A method of UV curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can provide anti-adhesion characteristics, in addition to improved healing and anti-inflammatory response. The cross-linked gel is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel derived from at least one fatty acid compound. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent. The curing method can vary the application of UV light in both intensity and duration to achieve a desired amount of cross-linking forming the gel.
摘要翻译： 提供UV固化方法和相应的所得非聚合交联凝胶。 交联凝胶可以与医疗装置结构组合。 除了改善愈合和抗炎反应之外，交联凝胶还可提供抗粘附特性。 交联凝胶通常由天然存在的油或部分天然存在的油形成的油组合物形成，其至少部分固化形成由至少一种脂肪酸化合物衍生的交联凝胶。 此外，油组合物可以包括治疗剂组分，例如药物或其它生物活性剂。 固化方法可以改变UV光在强度和持续时间上的应用，以实现形成凝胶的所需量的交联。
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公开(公告)号：US08858978B2
公开(公告)日：2014-10-14
申请号：US11237263
申请日：2005-09-28
申请人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith M. Faucher , Thomas M. Swanick
发明人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith M. Faucher , Thomas M. Swanick
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A method of curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can provide anti-adhesion characteristics, in addition to improved healing and anti-inflammatory response. The cross-linked gel is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel derived from at least one fatty acid compound. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent. The curing method can vary the application of heat in both temperature and duration to achieve a desired amount of cross-linking forming the gel.
摘要翻译： 提供固化方法和相应的所得非聚合交联凝胶。 交联凝胶可以与医疗装置结构组合。 除了改善愈合和抗炎反应之外，交联凝胶还可提供抗粘附特性。 交联凝胶通常由天然存在的油或部分天然存在的油形成的油组合物形成，其至少部分固化形成由至少一种脂肪酸化合物衍生的交联凝胶。 此外，油组合物可以包括治疗剂组分，例如药物或其它生物活性剂。 固化方法可以在温度和持续时间内改变热量的应用以实现形成凝胶的所需量的交联。
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公开(公告)号：US20070071798A1
公开(公告)日：2007-03-29
申请号：US11525390
申请日：2006-09-22
申请人： Steve Herweck , Thomas Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Keith Faucher , Philip McNamara , Roger Labrecque , Suzanne Conroy , Trevor Carlton
发明人： Steve Herweck , Thomas Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Keith Faucher , Philip McNamara , Roger Labrecque , Suzanne Conroy , Trevor Carlton
IPC分类号： A61K9/70
CPC分类号： B65B55/18 , A61B2017/00004 , A61B2017/320044 , A61B2090/0816 , A61F2/0059 , A61F2/0095 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/14 , A61L2/186 , A61L2/206 , A61L2/208 , A61L31/00 , A61L31/145 , A61L31/148 , A61L2202/24 , B26F1/18 , B29C39/02 , B65B31/04 , Y10T83/0481
摘要： A bio-absorbable stand-alone film is derived at least in part from fatty acids. The bio-absorbable stand-alone film can have anti-adhesive, anti-inflammatory, non-inflammatory, and wound healing properties, and can additionally include one or more therapeutic agents incorporated therein. The stand-alone film has one or more perforations or depressions formed therein. Corresponding methods of making the bio-absorbable stand-alone film with one or more perforations or depressions include molding, cutting, carving, puncturing or otherwise suitable methods to create the perforations or depressions in the bio-absorbable stand-alone film. The resulting stand-alone film is bioabsorbable.
摘要翻译： 生物可吸收的独立膜至少部分地由脂肪酸衍生。 生物吸收性独立膜可以具有抗粘连性，抗炎性，非炎性和伤口愈合性，并且还可以包括一种或多种掺入其中的治疗剂。 独立膜具有形成在其中的一个或多个穿孔或凹陷。 使具有一个或多个穿孔或凹陷的生物吸收性独立薄膜的相应方法包括成型，切割，雕刻，穿刺或以其它方式适当地在生物吸收性独立薄膜中产生穿孔或凹陷的方法。 所得到的独立膜是生物可吸收的。
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公开(公告)号：US20060088596A1
公开(公告)日：2006-04-27
申请号：US11236977
申请日：2005-09-28
申请人： Roger Labrecque , Geoffrey Moodie , Lisa Rogers , Joseph Ferraro , Theodore Karwoski , Steve Herweck , Paul Martakos
发明人： Roger Labrecque , Geoffrey Moodie , Lisa Rogers , Joseph Ferraro , Theodore Karwoski , Steve Herweck , Paul Martakos
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： A method for the provision of a coating on an implantable medical device results in a medical device having a bio-absorbable coating. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a dissolved therapeutic agent component can also be provided. The coated medical device is implantable in a patient to effect controlled delivery of the coating, including the dissolved therapeutic agent, to the patient.
摘要翻译： 在可植入医疗装置上提供涂层的方法导致具有生物可吸收涂层的医疗装置。 涂层包括生物吸收载体组分。 除了生物吸收性载体成分之外，还可以提供溶解的治疗剂成分。 涂覆的医疗装置可植入患者体内以实现对包括溶解的治疗剂在内的包衣的控制递送。
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公开(公告)号：US20060112536A1
公开(公告)日：2006-06-01
申请号：US11250768
申请日：2005-10-14
申请人： Steve Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton , Lisa Rogers , Joseph Ferraro
发明人： Steve Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton , Lisa Rogers , Joseph Ferraro
IPC分类号： B23P17/04
CPC分类号： B05D1/00 , A61F2/82 , A61F2/958 , A61F2250/0067 , A61L29/08 , A61L29/16 , A61L2300/606 , A61M25/1027 , A61M25/1038 , A61M2025/1031 , B05D2259/00 , Y10T29/49
摘要： A non-polymeric or biological coating applied to a radially expandable interventional medical device in a collapsed, wrapped, or folded configuration. Properties of the coating material applied to the medical device are adjusted or varied to result in a desired combination of coverage of the surface of the medical device, drug loading, and coating thickness. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device.
摘要翻译： 以折叠的，包裹的或折叠的构造施加到可径向展开的介入医疗装置的非聚合或生物涂层。 调整或改变施加到医疗装置上的涂层材料的性质，以产生医疗装置的表面，药物负载和涂层厚度的覆盖范围的期望组合。 涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。 治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。
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公开(公告)号：US20060067974A1
公开(公告)日：2006-03-30
申请号：US11236908
申请日：2005-09-28
申请人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck
发明人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： A coated medical device an a method of providing a coating on an implantable medical device result in a medical device having a bio-absorbable coating. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The coated medical device is implantable in a patient to effect controlled delivery of the coating, including the therapeutic agent, to the patient.
摘要翻译： 涂覆的医疗装置是在可植入医疗装置上提供涂层的方法，导致具有生物吸收性涂层的医疗装置。 涂层包括生物吸收载体组分。 除了生物可吸收载体组分之外，还可以提供治疗剂成分。 涂覆的医疗装置可植入患者体内以实现对包括治疗剂在内的涂层的可控输送。
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