利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

150 条记录 (耗时 0.039 秒)

    New7&agr;, 17&agr;-bis-alkylated testosterone derivatives and their use in long-term therapy of androgen-dependent diseases
    13.
    发明授权
    New7&agr;, 17&agr;-bis-alkylated testosterone derivatives and their use in long-term therapy of androgen-dependent diseases 失效
    New7alpha，17α-双烷基化睾酮衍生物及其在长期治疗雄激素依赖性疾病中的应用

    公开(公告)号：US06767903B1

    公开(公告)日：2004-07-27

    申请号：US09869000

    申请日：2001-06-22

    申请人： Arwed Cleve ,  Gerhard Sauer ,  Christoph Huwe ,  Karsten Parczyk ,  Jens Hoffmann ,  Martin Schneider

    发明人： Arwed Cleve ,  Gerhard Sauer ,  Christoph Huwe ,  Karsten Parczyk ,  Jens Hoffmann ,  Martin Schneider

    IPC分类号： A61K3159

    CPC分类号： C07J1/00 ,  C07J5/00

    摘要： The invention relates to new 7&agr;, 17&agr;, 17&bgr;-substituted testosterone derivatives of general formula (I) and their use as pure antiandrogens for the long-term therapy of androgen-dependent diseases, notably for the long-term antiandrogen therapy of prostate carcinoma. In the general formula (I) A is an unbranched C6-C13-alkylene group; B is an oxygen atom, —S(O)p— group, in which p is 0, 1 or 2, an iminocarbonyl group —C(O)N(Y)—, an imino group —N(Y)—, a carbonylimino group —N(Y)C(O)—, a sulfonylimino group —NN(Y)S(O)2—, where Y is a hydrogen atom or a C1-C8-alkyl group, a sulfonyloxy group —OS(O)2—, a dimethylsilyloxy group —O—Si(CH3)2— or a carbonylsulfanyl group —SC(O)— or a bond between A and C or, together with C, a bond between A and D; C is a bond between B and D or, together with B, a bond between A and D or an unbranched C1-C6-alkylene group, a phenylene group, a substituted phenylene group, a five-membered ring or six-membered ring heteroarylene group, a substituted five-membered ring or six-membered ring heteroarylene group or a five-membered ring or six-membered ring heteroarylene group fused with a phenyl ring; and D is a hydrogen atom, a C1-C4-alkyl group, a vinyl group, a C1-C4-alkoxy group, a C1-C4-alkoxycarbonyl group, a bis(C1-C4-alkoxycarbonyl)methyl group, an acetyl(C1-C4-alkoxybonyl)methyl group, a cyan group, a carboxy group, an azide group, a hydroxy group, a halogen atom or a rest of the formula CnFmHo, in which n is 1, 2, 3 or 4, m>1 and m+o=2n+1.

    摘要翻译： 本发明涉及通式（I）的新的7α，17α，17β-取代的睾酮衍生物及其作为用于长期治疗雄激素依赖性疾病的纯抗雄激素的用途，特别是用于前列腺癌的长期抗雄激素治疗。 在通式（I）中，A是无支链的C 6 -C 13 - 亚烷基; B是氧原子，-S（O）对基，其中p是0,1或2，亚氨基羰基-C（O）N（Y） - ，亚氨基-N（Y） - ， 羰基亚氨基-N（Y）C（O） - ，磺酰亚氨基-NN（Y）S（O）2 - ，其中Y是氢原子或C1-C8-烷基，磺酰氧基-OS（O ）2-，二甲基甲硅烷氧基-O-Si（CH 3）2 - 或羰基硫烷基-SSC（O） - 或A和C之间的键，或与C一起形成A和D之间的键; C是B和D之间的键，或者与B一起，A和D之间的键或无支链的C 1 -C 6 - 亚烷基，亚苯基，取代的亚苯基，五元环或六元环亚杂芳基 取代的五元环或六元环亚杂芳基或与苯环稠合的五元环或六元环亚杂芳基; 和D是氢原子，C 1 -C 4烷基，乙烯基，C 1 -C 4 - 烷氧基，C 1 -C 4 - 烷氧基羰基，双（C 1 -C 4 - 烷氧基羰基）甲基，乙酰基（ C 1 -C 4 - 烷氧基羰基）甲基，氰基，羧基，叠氮基，羟基，卤素原子或式C n F m H o的其余部分，其中n为1,2,3或4，m> 1和m + o = 2n + 1。

    METHOD AND SYSTEM FOR PROVIDING DATA ANALYTICS RESULTS
    15.
    发明申请
    METHOD AND SYSTEM FOR PROVIDING DATA ANALYTICS RESULTS 审中-公开
    提供数据分析结果的方法和系统

    公开(公告)号：US20160092820A1

    公开(公告)日：2016-03-31

    申请号：US14864415

    申请日：2015-09-24

    申请人： Alexander Ebel ,  Martin Schneider ,  Sonja Zillner

    发明人： Alexander Ebel ,  Martin Schneider ,  Sonja Zillner

    IPC分类号： G06Q10/06

    CPC分类号： G06Q10/06395 ,  G05B17/02 ,  G05B19/41885 ,  Y02P90/26

    摘要： A system for providing data analytics results for a process performed in an industrial plant includes a knowledge model repository configured to store semantic knowledge models. The system also includes selection unit configured to select at least one analytics application describing semantically at least one process step and at least one parameter required for accomplishing an analytics task. The system includes a processing unit configured to process the selected analytics application and selected instantiated semantic knowledge models to infer at least one storage location of at least one data source of the industrial plant, and an execution engine configured to execute the selected data analytics application using accessed process data provided by the inferred data sources of the industrial plant to generate the data analytics results.

    摘要翻译： 用于为在工厂中执行的处理提供数据分析结果的系统包括被配置为存储语义知识模型的知识模型存储库。 该系统还包括选择单元，其被配置为选择描述语义上至少一个处理步骤的至少一个分析应用程序和完成分析任务所需的至少一个参数。 该系统包括处理单元，该处理单元被配置为处理所选择的分析应用程序和所选择的实例化语义知识模型以推断出工业工厂的至少一个数据源的至少一个存储位置，以及执行引擎，被配置为使用 由工业工厂的推断数据源提供的访问过程数据，以生成数据分析结果。

    Catalyst components for the polymerization of olefins and catalysts therefrom obtained
    17.
    发明授权
    Catalyst components for the polymerization of olefins and catalysts therefrom obtained 有权
    用于烯烃聚合的催化剂组分及其催化剂

    公开(公告)号：US09051400B2

    公开(公告)日：2015-06-09

    申请号：US13516709

    申请日：2010-12-17

    申请人： Friedhelm Gundert ,  Martin Schneider

    发明人： Friedhelm Gundert ,  Martin Schneider

    IPC分类号： C08F4/646 ,  C08F110/02 ,  C08F10/00

    CPC分类号： C08F10/00 ,  C08F110/02 ,  C08F4/6565 ,  C08F4/6567 ,  C08F2500/12 ,  C08F2500/18 ,  C08F2500/24

    摘要： A catalyst component for the polymerization of olefins comprising Mg, Ti and Cl obtained by a process comprising the following steps: a) reacting a precursor of formula MgCl2.mEtOH, wherein m is equal to, or lower than, 1.5 having a porosity due to pores with radius up to 1μ of higher than 0.4 cm3/g with an alcohol of formula RIOH where RI is an alkyl different from ethyl, a cycloalkyl or aryl radical having 3-20 carbon atoms said RIOH being reacted with the said precursor using molar ratio RIOH/Mg ranging from 0.01 to 10; b) reacting the product obtained in (a) with TiCl4 using Ti/Mg molar ratio ranging from 0.01 to 15, c) reacting the product obtained in (b) with a silicon compound of formula RIaRIIbSi(ORIII)4−(a+b) where RI-RIII are linear or branched, cycloalkyl, aryl C1-C20 hydrocarbon groups a and b are integers from 0 to 2.

    摘要翻译： 用于通过包括以下步骤的方法获得的包含Mg，Ti和Cl的烯烃聚合的催化剂组分：a）使式MgCl 2·mEtOH的前体与其反应，其中m等于或低于1.5，由于 其中R1是不同于乙基的烷基，具有3-20个碳原子的环烷基或芳基，所述RIOH与所述前体反应，使用摩尔比，其中半数高达1μs，高于0.4cm 3 / g的孔 RIOH / Mg为0.01〜10; b）将（a）中获得的产物与TiCl 4的摩尔比为0.01至15，c）使（b）中获得的产物与式RIaRIIbSi（ORIII）4-（a + b）的硅化合物反应， ）其中RI-RIII是直链或支链的，环烷基，芳基C1-C20烃基a和b是0-2的整数。