公开(公告)号：US20200017438A1

公开(公告)日：2020-01-16

申请号：US16469255

申请日：2018-01-12

Applicant: Signum Biosciences, Inc.

Inventor： Michael Voronkov ,  Edwardo Perez ,  Jason Healy ,  Jose Fernandez

IPC: C07C275/20 ,  C07D207/16 ,  C07C233/47 ,  C07D221/00 ,  C07D213/80 ,  C07D205/04 ,  C07D239/42 ,  C07D241/28 ,  A61P29/00 ,  A61K9/00

Abstract: The present invention provides compounds useful in treating or preventing inflammation acne, bacterial conditions and promoting the appearance of healthy skin and compositions including these compounds.

公开(公告)号：US20190336561A1

公开(公告)日：2019-11-07

申请号：US16514337

申请日：2019-07-17

Applicant: Signum Biosciences, Inc.

Inventor： Kristen Huber ,  Michael Voronkov ,  Jose Fernandez ,  Karl Rouzard ,  Eduardo Perez ,  Maxwell Stock ,  Jeffry Stock

IPC: A61K36/9066 ,  A61K36/73 ,  A61K36/33 ,  A61K45/06 ,  A61K36/31 ,  A61K36/28 ,  A61K36/235 ,  A61K36/23 ,  A61K36/185 ,  A61K36/14 ,  A61K9/00 ,  A61K8/97 ,  A61K36/87 ,  A61K36/77 ,  A61K36/45 ,  A61K36/52 ,  A61K36/54 ,  A61K36/575 ,  A61K36/71 ,  A61K36/736 ,  A61K36/79 ,  A61Q19/08

Abstract: Compositions containing natural and botanical extracts for use in inhibiting one, two, or three of (a)-(c): (a) demethylation of PP2A by PME-1 methylesterase; (b) formation of free radicals and reactive oxygen species; and/or (c) inflammation. These compositions include an extract of one or more botanicals selected from the group consisting of: juniper berry fruit, schisandra fruit, strawberry fruit, avocado seeds, black raspberry seeds, blueberry seeds, celery seeds, cranberry seeds, fennel seeds, grape seeds, guarana seeds, red raspberry seeds, maca root, goldenseal root, turmeric root, magnolia bark, pygeum bark, red raspberry leaf, almond, cocoa powder, Echinacea angustifolia, prickly pear cactus and walnut.

公开(公告)号：US10314817B2

公开(公告)日：2019-06-11

申请号：US15518755

申请日：2015-10-15

Applicant: Signum Biosciences, Inc.

Inventor： Jeffry Stock ,  Maxwell Stock ,  Michael Voronkov ,  Jose Fernandez ,  Kristen Huber

IPC: A61K31/405 ,  C07D209/16

Abstract: EHT extract including a mixture of late eluting tryptamides and early eluting tryptamides in a weight ratio of at least about 7:1 late eluting tryptamides:early eluting tryptamides, wherein the EHT extract includes at least 30% eicosanoyl-5-hydroxytryptamide, based on the total weight of the tryptamides in the EHT extract.

公开(公告)号：US10314802B2

公开(公告)日：2019-06-11

申请号：US15665922

申请日：2017-08-01

Applicant: Signum Biosciences, Inc.

Inventor： Jeffry B. Stock ,  Maxwell Stock ,  Keshava Rapole ,  Seung-Yub Lee ,  Michael Voronkov ,  Eduardo Perez ,  Joel Gordon ,  Shuyi Chen ,  Jinglong Chen

IPC: A61K31/197 ,  A61K9/00 ,  C07C323/59 ,  C07C335/08 ,  C07C243/34 ,  C07C321/18 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24 ,  C07D207/16 ,  C07D243/34

Abstract: Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

公开(公告)号：US20160361283A1

公开(公告)日：2016-12-15

申请号：US15151221

申请日：2016-05-10

Applicant: SIGNUM BIOSCIENCES, INC.

Inventor： Jeffry B. Stock ,  Maxwell Stock ,  Keshava Rapole ,  Seung-Yub Lee ,  Michael Voronkov ,  Eduardo Perez ,  Joel Gordon ,  Shuyi Chen ,  Jinglong Chen

IPC: A61K31/197 ,  A61K9/00

CPC classification number: A61K31/197 ,  A61K9/0014 ,  C07C243/34 ,  C07C321/18 ,  C07C323/59 ,  C07C335/08 ,  C07C2601/02 ,  C07C2601/14 ,  C07D207/16 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D243/34 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24

Abstract: Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

Abstract translation: 除此之外，本发明提供能够有效调节炎症反应的新型异戊二烯基化合物和包含这些异戊二烯基化合物的药物，化妆品，药​​妆和局部组合物。 本发明的抗炎化合物可用于治疗或预防与炎症相关的疾病或病症。 本发明的促炎症化合物可用于治疗或预防与抑制炎性反应相关的疾病或病症。 因此，本发明还提供了用于治疗或预防与炎症相关的疾病或病症的方法以及可用于治疗或预防与抑制炎性反应相关的疾病或病症的方法。