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    Utilization of electrode spatial arrangements for characterizing cardiac conduction conditions
    13.
    发明申请
    Utilization of electrode spatial arrangements for characterizing cardiac conduction conditions 有权
    利用电极空间布置来表征心脏传导条件

    公开(公告)号：US20160045133A1

    公开(公告)日：2016-02-18

    申请号：US14782134

    申请日：2014-05-07

    Applicant: ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC.

    Inventor： Ram K. Balachandran ,  D. Curtis Deno

    IPC: A61B5/042 ,  A61B18/14 ,  A61B5/00 ,  A61B5/06 ,  A61B5/0452

    CPC classification number: A61B5/0422 ,  A61B5/0452 ,  A61B5/061 ,  A61B5/062 ,  A61B5/7203 ,  A61B5/7239 ,  A61B18/1492 ,  A61B34/20 ,  A61B2017/00039 ,  A61B2017/00044 ,  A61B2017/00053 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61B2034/2051 ,  A61B2034/2053 ,  A61B2218/002

    Abstract: A system and method are provided for determining electrophysiological data. The system comprises an electronic control unit that is configured to receive electrical signals from a set of electrodes, receive position and orientation data for the set of electrodes from a mapping system, compensate for position and orientation artifacts of the set of electrodes, compose cliques of a subset of neighboring electrodes in the set of electrodes, determine catheter orientation independent information of a target tissue, and output the orientation independent information to a display. The method comprising receiving electrogram data for a set of electrodes (80), compensating for artifacts in sensor positions in the mapping system (81), resolving the bipolar signals into a 3D vector electrogram in the mapping system coordinates (82), manipulating observed unipolar voltage signals and the tangent component of the e-field to estimate the conduction velocity vector (83), and outputting the catheter orientation independent information (84).

    Abstract translation: 提供了一种用于确定电生​​理数据的系统和方法。 该系统包括电子控制单元，其被配置为从一组电极接收电信号，从映射系统接收用于该组电极的位置和取向数据，补偿该组电极的位置和取向伪像， 电极组中的相邻电极的子集，确定目标组织的导管取向独立信息，并将取向独立信息输出到显示器。 该方法包括接收用于一组电极（80）的电描记图数据，补偿映射系统（81）中的传感器位置中的伪像，将双极性信号解析为映射系统坐标（82）中的3D矢量电描记图，操纵观察到的单极性 电压信号和电场的切线分量来估计传导速度矢量（83），并输出导管取向独立信息（84）。

    Laplacian and Tikhonov regularization for voltage mapping with a medical device
    15.
    发明授权
    Laplacian and Tikhonov regularization for voltage mapping with a medical device 有权

    公开(公告)号：US10049771B2

    公开(公告)日：2018-08-14

    申请号：US13839074

    申请日：2013-03-15

    Applicant: St. Jude Medical, Atrial Fibrillation Division, Inc.

    Inventor： Eric Jon Voth ,  D. Curtis Deno ,  Lev Abramovich Koyrakh ,  Braden Eliason

    IPC: G16H50/50 ,  A61B5/0402 ,  A61B5/042

    Abstract: An embodiment of a method for solving the inverse problem of electrophysiology and determining a voltage distribution on a surface of a tissue may comprise receiving a plurality of voltages collected by a plurality of electrodes adjacent to the surface, discretizing the problem using a Finite Element Method (FEM) or a Boundary Element Method (BEM), introducing one or more regularization terms to an error minimization formulation, and solving, by a processor, the voltage distribution according to the plurality of voltages and according to the regularization terms. The regularization terms may comprise one or more of a Laplacian smoothness operator, a Tikhonov regularization matrix, a confidence matrix, and a linear operator that interpolates the plurality of electrode voltages to the tissue voltage distribution.

    ELECTROPHYSIOLOGY LABORATORY SYSTEM FOR USE WITH MAGNETIC RESONANCE IMAGING SYSTEMS
    17.
    发明申请
    ELECTROPHYSIOLOGY LABORATORY SYSTEM FOR USE WITH MAGNETIC RESONANCE IMAGING SYSTEMS 审中-公开
    用于磁共振成像系统的电生理实验室系统

    公开(公告)号：US20150119690A1

    公开(公告)日：2015-04-30

    申请号：US14396008

    申请日：2013-03-15

    Applicant: St. Jude Medical, Atrial Fibrillation Division, Inc.

    Inventor： D. Curtis Deno ,  Jeffrey A. Schweitzer

    IPC: A61B5/06 ,  A61B5/0205 ,  A61B5/00 ,  A61B18/14 ,  A61N1/05 ,  A61N1/36 ,  G01R33/28 ,  A61B5/042

    CPC classification number: A61B5/063 ,  A61B5/02055 ,  A61B5/042 ,  A61B5/0422 ,  A61B5/055 ,  A61B5/6852 ,  A61B5/7203 ,  A61B18/1492 ,  A61B2018/00577 ,  A61B2034/2051 ,  A61B2090/374 ,  A61B2562/18 ,  A61N1/05 ,  A61N1/36 ,  G01R33/285 ,  G01R33/3685

    Abstract: An electrophysiological laboratory system comprises a subsystem configured to perform diagnostic and/or therapeutic functions, a medical device, and an interface module disposed therebetween. The medical device comprises a shaft having proximal and distal portions, high- and low-impedance electrical pathways disposed within the shaft, and an electrode disposed at the distal portion of the shaft and electrically coupled to one or both of the high- and low-impedance electrical pathways. The electrode is configured to perform diagnostic and/or therapy delivery functions. The interface module comprises a high-impedance channel configured to couple the high-impedance pathway of the medical device to the subsystem, and to attenuate magnetic resonance RF and gradient field pulses generated by the MRI system. The interface module further comprises a low-impedance channel configured to couple the low- impedance pathway of the medical device to the subsystem.

    Abstract translation: 电生理实验室系统包括被配置为执行诊断和/或治疗功能的子系统，医疗设备和设置在其间的接口模块。 医疗装置包括具有近端部分和远端部分的轴，设置在轴内的高阻抗电路和低阻抗电通路，以及设置在轴的远端部分并电耦合到高压和低压侧中的一个或两者的电极， 阻抗电路。 电极被配置为执行诊断和/或治疗递送功能。 接口模块包括被配置为将医疗设备的高阻抗路径耦合到子系统的高阻抗通道，并且衰减由MRI系统产生的磁共振RF和梯度场脉冲。 接口模块还包括被配置为将医疗设备的低阻抗路径耦合到子系统的低阻抗通道。

    SYSTEM AND METHOD FOR ASSESSING EFFECTIVE DELIVERY OF ABLATION THERAPY
    19.
    发明申请
    SYSTEM AND METHOD FOR ASSESSING EFFECTIVE DELIVERY OF ABLATION THERAPY 有权

    公开(公告)号：US20220338922A1

    公开(公告)日：2022-10-27

    申请号：US17721349

    申请日：2022-04-14

    Applicant: St. Jude Medical, Atrial Fibrillation Division Inc

    Inventor： D. Curtis Deno ,  Stephan P. Miller

    IPC: A61B18/14 ,  A61B5/00 ,  A61B5/06 ,  A61B90/00

    Abstract: A system and method for assessing effective delivery of ablation therapy to a tissue in a body is provided. A three-dimensional anatomical map of the tissue is generated and displayed with the map defining a corresponding volume. An index is generated corresponding to a location within the volume with the index indicative of a state of ablation therapy at the location. The index may be derived from one or more factors such as the duration an ablation electrode is present at the location, the amount of energy provided, the degree of electrical coupling between an ablation electrode and the tissue at the location and temperature. A visual characteristic (e.g., color intensity) of a portion of the anatomical map corresponding to the location is then altered responsive to the index.

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