公开(公告)号：US20060188563A1

公开(公告)日：2006-08-24

申请号：US10550586

申请日：2003-03-27

申请人： Shuji Sato ,  Takeshi Goto ,  Norifumi Tanida ,  Tatsuya Meno ,  Takaaki Yoshinaga ,  Keishi Yonemura

发明人： Shuji Sato ,  Takeshi Goto ,  Norifumi Tanida ,  Tatsuya Meno ,  Takaaki Yoshinaga ,  Keishi Yonemura

IPC分类号： A61K9/48

CPC分类号： A61K31/513 ,  A61K9/2846 ,  A61K9/2886 ,  A61K31/58

摘要： A medicinal oral preparation to be delivered to the large intestine comprising a core containing a pharmacologically active ingredient, an inner layer containing one or more cationic polymers and an outer layer containing one or more anionic polymers whereby the core is coated, which is designed so that, in a disintegration test successively consisting of a vertical movement for 2 hours in a first solution of pH 1.2, a vertical movement for 2 hours in a second solution of pH 7.4 and a vertical movement in a third solution of pH 6.4, the average disintegration initiation point and the average disintegration completion point each falls within a period from 35 minutes to 130 minutes after starting the vertical movement in the third solution. Namely, a medicinal oral preparation to be delivered to the large intestine, a medicinal oral preparation for treating colon cancer and a medicinal oral preparation for treating colitis which would not disintegrate in the stomach or small intestine but begin to disintegrate after attaining the large intestine and surely complete the disintegration while remaining in the large intestine.

摘要翻译： 一种药物口服制剂，其被输送至大肠，其包含含有药理活性成分的核心，含有一种或多种阳离子聚合物的内层和含有一种或多种阴离子聚合物的外层，其中所述芯被涂覆，其被设计为 在依次由在pH1.2的第一溶液中垂直运动2小时，在pH 7.4的第二溶液中垂直运动2小时和在pH6.4的第三溶液中的垂直运动的崩解测试中，平均分解 起始点和平均崩解完成点各自在第三溶液中开始垂直运动之后的35分钟至130分钟的时间段内。 也就是说，要输送到大肠的药用口服制剂，用于治疗结肠癌的药物口服制剂和用于治疗不会在胃或小肠中分解而在达到大肠后开始分解的结肠炎的药物口服制剂，以及 一定要在大肠的同时完成解体。

公开(公告)号：US20090163597A1

公开(公告)日：2009-06-25

申请号：US12084912

申请日：2006-11-09

申请人： Takeshi Goto ,  Kenji Mori

发明人： Takeshi Goto ,  Kenji Mori

IPC分类号： A61K31/167 ,  A61P29/00

CPC分类号： A61K45/06 ,  A61K9/0009 ,  A61K9/08 ,  A61K31/137 ,  A61K31/167

摘要： A preparation used for iontophoresis in order to absorb a physiologically active substance via the skin or mucosa using electrical driving force and the preparation containing a local anesthetic, epinephrine or its salt, water and chlorobutanol.

摘要翻译： 用于离子电渗疗法的制剂，以便通过电驱动力通过皮肤或粘膜吸收生理活性物质，以及含有局部麻醉剂，肾上腺素或其盐，水和氯丁醇的制剂。

公开(公告)号：US08639175B2

公开(公告)日：2014-01-28

申请号：US12591723

申请日：2009-11-30

申请人： Takeshi Goto

发明人： Takeshi Goto

IPC分类号： G03G15/00 ,  B65H31/00

CPC分类号： G03G15/6576

摘要： A curl correcting unit can be attached in a normal orientation and inverse orientation. In the normal orientation, a sponge roller being on the lower side, a sliding plate is pressed down by a curl-correction-amount adjusting mechanism. When the sliding plate is pressed down, a roller-side plate is lifted up via a link, where the link works as a shaft of a seesaw that connects the sliding plate and the roller-side plate. As a result, the sponge roller moves up and comes into press-contact with a metallic roller. In the inverse orientation, the sponge roller being on the upper side, the roller-side plate is directly pressed down by the curl-correction-amount adjusting mechanism and thereby the sponge roller comes into press-contact with the metallic roller.

摘要翻译： 卷曲校正单元可以以正常取向和反向取向附接。 在正常取向下，海绵辊位于下侧，滑板由卷曲校正量调节机构压下。 当滑动板被按压时，辊侧板通过连杆抬起，链节用作连接滑板和滚子侧板的跷跷板的轴。 结果，海绵辊向上移动并与金属辊压接。 在相反的方向上，海绵辊在上侧，辊侧板被卷曲校正量调节机构直接按压，从而海绵辊与金属辊压接。

公开(公告)号：US08372458B2

公开(公告)日：2013-02-12

申请号：US12616353

申请日：2009-11-11

申请人： Hideo Shidara ,  Junichi Otsuji ,  Kiyotaka Takahashi ,  Takeshi Goto

发明人： Hideo Shidara ,  Junichi Otsuji ,  Kiyotaka Takahashi ,  Takeshi Goto

IPC分类号： A23C19/08

CPC分类号： A01J25/002 ,  A23C19/08 ,  G01N11/162

摘要： Objects of the present invention are to provide a continuous emulsification process and equipment therefor in which exact viscosity is measured inline and production conditions are controlled automatically, and a continuous production method for process cheese type and equipment therefor. The present invention provides a continuous production method for process cheese type in which process cheese type ingredients are agitated and emulsified with any agitation intensity by an agitation bar 4 while heating in the vessel which is applied with fixed back pressure, the process cheese type is flowed and held in a holding pipe 7 for a certain period and thereby the process cheese type is cooled, and then the cooled process cheese type is molded and filled and a process cheese type product 13 is produced, wherein a transducer of an oscillating viscometer is immersed in the process cheese type during holding or after cooling such that the transducer is not directly contacted with the process cheese type; and wherein agitation intensity of the agitation device and/or back pressure applied to the vessel is adjusted such that a detected value of the transducer becomes near a target value which is set in advance, and thereby production conditions are controlled automatically so that the viscosity of the process cheese type during holding or after cooling becomes near a target viscosity.

公开(公告)号：US20110249389A1

公开(公告)日：2011-10-13

申请号：US13165125

申请日：2011-06-21

申请人： Takeshi Goto

发明人： Takeshi Goto

IPC分类号： H05K7/00

CPC分类号： G06F1/1677 ,  G06F1/1616 ,  G06F1/1624 ,  G06F1/1643 ,  G06F1/1681 ,  H04M1/0216 ,  H04M1/0237 ,  Y10S248/917

摘要： A portable information processing apparatus, includes: a body section configured to have an upper face on which a keyboard for inputting information is provided at least; and a display section configured to have an upper face on which a display member for displaying information is provided at least; the display section being mounted for sliding movement between a first position at which the display section is placed in an overlapping relationship at an upper portion of the body section and a second position at which the display section opens the upper portion of the body section, the display section being mounted for tilting up and down movements with respect to the body section when the display section is at the second position.

摘要翻译： 一种便携式信息处理设备，包括：主体部分，至少设置有用于输入信息的键盘的上表面; 以及显示部，被配置为具有至少设置有用于显示信息的显示部件的上表面; 所述显示部被安装用于在所述主体部的上部以显示部以重叠关系放置的第一位置和所述显示部打开所述主体部的上部的第二位置之间滑动， 显示部分被安装用于当显示部分处于第二位置时相对于主体部分上下移动。

公开(公告)号：US08010046B2

公开(公告)日：2011-08-30

申请号：US12105511

申请日：2008-04-18

申请人： Takeshi Goto

发明人： Takeshi Goto

IPC分类号： H04B5/00

CPC分类号： H04B5/0062

摘要： A wireless communication apparatus for demodulating modulated information which is transmitted from a wireless tag so as to read out the modulated information, includes: an antenna which transmits a transmission signal to the wireless tag and receives a signal transmitted from the wireless tag as a reception signal; a demodulator which demodulates the reception signal to output a demodulated signal; a signal output unit which outputs a proportional signal proportional to the transmission signal; and a controller which calculates the proportional signal and the demodulated signal to output an calculated signal, and calculates the calculated signal and the reception signal.

摘要翻译： 一种用于解调从无线标签发送以便读出调制信息的调制信息的无线通信装置，包括：向无线标签发送发送信号并接收从无线标签发送的信号作为接收信号的天线 ; 解调器，其对接收信号进行解调以输出解调信号; 信号输出单元，其输出与所述发送信号成比例的比例信号; 以及控制器，其计算比例信号和解调信号以输出计算出的信号，并计算所计算的信号和接收信号。

公开(公告)号：US07960508B2

公开(公告)日：2011-06-14

申请号：US10477101

申请日：2002-05-10

申请人： Masaki Hirashima ,  Takeshi Naruse ,  Hiroaki Maeda ,  Chikateru Nozaki ,  Takeshi Goto ,  Katsuhiko Akiyama ,  Wataru Hattori

发明人： Masaki Hirashima ,  Takeshi Naruse ,  Hiroaki Maeda ,  Chikateru Nozaki ,  Takeshi Goto ,  Katsuhiko Akiyama ,  Wataru Hattori

IPC分类号： A61K38/00 ,  A61K38/04 ,  A61K38/16 ,  A61K38/10 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00

CPC分类号： C07K14/4747 ,  C07K14/47 ,  G01N33/5014

摘要： A peptide fragment or a series of peptide fragments containing one or more selenocysteine that has a lowered toxicity than selenocystine and that exhibits a cytotoxicity-inhibitory activity. The peptide fragment or a series of peptide fragments according to the present invention has preferably the amino acid sequence from 260th to 362nd amino acid residues from the C-terminal of selenoprotein P, or said amino acid sequence with one or several amino acid residues therein being deleted, substituted or added, or a partial sequence of either of the above amino acid sequences, or an amino acid sequence comprising as a part any of the above amino acid sequences. A screening method for a peptide fragment having the cytotoxicity-inhibitory activity is also provided.

摘要翻译： 含有一种或多种硒代半胱氨酸的肽片段或一系列肽片段，其毒性低于硒代胱氨酸并且具有细胞毒性抑制活性。 根据本发明的肽片段或一系列肽片段优选具有来自硒蛋白P的C末端的第260至第362位氨基酸残基的氨基酸序列，或其中具有一个或几个氨基酸残基的所述氨基酸序列是 缺失，取代或添加，或上述氨基酸序列中的任一个的部分序列，或包含作为上述氨基酸序列之一的氨基酸序列。 还提供了具有细胞毒性抑制活性的肽片段的筛选方法。

公开(公告)号：US07601532B2

公开(公告)日：2009-10-13

申请号：US10947249

申请日：2004-09-23

申请人： Akira Nakagawara ,  Miki Ohira ,  Shin Ishii ,  Takeshi Goto ,  Hiroyuki Kubo ,  Takahiro Hirata ,  Yasuko Yoshida ,  Saichi Yamada

发明人： Akira Nakagawara ,  Miki Ohira ,  Shin Ishii ,  Takeshi Goto ,  Hiroyuki Kubo ,  Takahiro Hirata ,  Yasuko Yoshida ,  Saichi Yamada

IPC分类号： C12M3/00 ,  C12M1/34 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/118

摘要： A microarray for predicting the prognosis of neuroblastoma, wherein the microarray has 25 to 45 probes related to good prognosis, which are hybridized to a gene transcript whose expression is increased in a good prognosis patient with neuroblastoma and are selected from 96 polynucleotides consisting of the nucleotide sequences of SEQ. ID NOs. 1, 5, 6, 14. 16, 17, 19, 22-24, 28, 29, 31, 37, 39, 40, 43, 44, 47-52, 54, 57-60, 62, 64, 65, 67, 68, 72-75, 77, 78, 80-82, 84, 87, 89-91, 94, 100, 103, 112, 113, 118, 120, 129, 130, 132, 136, 138, 142, 144, 145, 148, 150-153, 155, 158-160, 163-165, 169-171, 173, 174, 177, 178, 180-182, 184, 186, 187, 189, 191, 192, 194, 195, 198-200 or their partial continuous sequences or their complementary strands, and 25 to 45 probes related to poor prognosis, which are hybridized to a gene transcript whose expression is increased in a poor prognosis patient with neuroblastoma and are selected from 104 polynucleotides consisting of the nucleotide sequences of SEQ. ID NOs. 2-4, 7-13, 15, 18, 20, 21, 25-27, 30, 32-36, 38, 41, 42, 45, 46, 53, 55, 56, 61, 63, 66, 69-71, 76, 79, 83, 85, 86, 88, 92, 93, 95-99, 101, 102, 104-111, 114-117, 119, 121-128, 131, 133-135, 137, 139-141, 143, 146, 147, 149, 154, 156, 157, 161, 162, 166-168, 172, 175, 176, 179, 183, 185, 188, 190, 193, 196, 197 or their partial continuous sequences or their complementary strands.

摘要翻译： 一种用于预测神经母细胞瘤的预后的微阵列，其中所述微阵列具有与良好预后相关的25至45个探针，其与在具有神经母细胞瘤的良好预后患者中表达增加的基因转录物杂交，并且选自96个由核苷酸 SEQ。 身份证号 1，5，6，14，16，17，19，22-24，28，29，31，37，39，40，43，44，47-52，54，57-60，62，64，65， 67，68，72-75，77，78，80-82，84，87，89-91，94，100，103，112，113，118，120，129，130，132，136，138， 144,145,148,150-153,155,158-160,163-165,169-171,173,174,177,178,180-182,184,186,187,189,191,192,194， 195，198-200或其部分连续序列或其互补链，以及与不良预后相关的25至45个探针，其与在具有神经母细胞瘤的不良预后患者中表达增加的基因转录物杂交，并且选自104个多核苷酸 的SEQ ID NO： 身份证号 2-4，7-13，15，18，20，21，25-27，30，32-36，38，41，42，45，46，53，55，56，61，63，66，69- 71,76,79,83,85,86,88,92,93,95-99,101,102,104-111,114-117,119,121-128,131,133-135,137,139- 141,143,146,147,149,154,156,157,161,162,166-168,172,175,176,179,183,185,188,190,193,196,197或其部分连续序列 或其互补链。

公开(公告)号：US20050270518A1

公开(公告)日：2005-12-08

申请号：US11141393

申请日：2005-06-01

申请人： Hiroyuki Sugawara ,  Takeshi Goto ,  Kounosuke Kitamura ,  Hiroshi Aoyama

发明人： Hiroyuki Sugawara ,  Takeshi Goto ,  Kounosuke Kitamura ,  Hiroshi Aoyama

IPC分类号： H05K1/02 ,  G03B27/32 ,  H05K3/00

CPC分类号： G03B27/32 ,  H05K1/0269 ,  H05K3/0008 ,  H05K3/0026 ,  H05K2201/09781 ,  H05K2201/09918

摘要： A method for determining a position of a reference point in which there is no influence of aberration of a camera lens or the like, but an error caused by a failure in shape of an alignment mark can be reduced. An alignment mark consisting of a plurality of pattern portions (and background portions) centering at a design reference point is provided in advance. Positions of centers of border lines of the patterns are calculated. Obtained coordinate values of the centers are averaged in each axial direction. The averaged coordinate values are regarded as coordinate values of a machining reference point. Thus, even when a defect occurs in any pattern portion, an error caused by the defect is reduced so that the accuracy in machining can be improved.

摘要翻译： 可以减小用于确定在其中没有一个照相机透镜等的像差的影响的参考点的位置的方法，但由在对准标记的形状的失败的错误。 预先设置由以设计基准点为中心的多个图案部分（和背景部分）构成的对准标记。 计算模式边界线中心的位置。 获得的中心坐标值在每个轴向平均。 平均坐标值被认为是加工参考点的坐标值。 因此，即使当在任何图案部分发生缺陷时，由缺陷引起的误差降低，从而可以提高加工精度。

公开(公告)号：US06263270B1

公开(公告)日：2001-07-17

申请号：US08970421

申请日：1997-11-14

申请人： Kunihito Sato ,  Takeshi Goto ,  Yuichi Kubota

发明人： Kunihito Sato ,  Takeshi Goto ,  Yuichi Kubota

IPC分类号： G06F700

CPC分类号： B62D1/28 ,  B60T2201/08 ,  B60T2201/087 ,  B62D6/00 ,  B62D7/159

摘要： A steering control apparatus prevents interference between a steering operation of a driver and a steering control operation of the steering control apparatus by detecting a steering operation so as to decrease an amount of the steering control operation when the steering operation is performed by the driver. A guide line provided on a vehicle moving lane on which the vehicle is moving is recognized so as to set a target position on the vehicle moving lane based on a result of recognition of the guide line. A steering control operation is performed so that the vehicle moves to trace the target position. An amount of each component of a steering operation applied to a steering wheel is detected by a steering angle sensor and a steering torque sensor. An amount of the steering control operation is corrected so that the amount of the steering control operation is decreased in accordance with the amount of each component of the steering operation.

摘要翻译： 转向控制装置通过检测转向操作来防止驾驶员的转向操作和转向控制装置的转向控制操作之间的干扰，以便当驾驶员执行转向操作时减少转向控制操作的量。 识别在车辆移动通道上设置的引导线，以便基于引导线的识别结果在车辆移动通道上设定目标位置。 执行转向控制操作，使得车辆移动以跟踪目标位置。 通过转向角传感器和转向转矩传感器检测施加到方向盘的转向操作的每个部件的量。 对转向控制动作的量进行修正，根据转向操作的各成分的数量，使转向控制动作的数量减少。