公开(公告)号：US11878993B2

公开(公告)日：2024-01-23

申请号：US18295770

申请日：2023-04-04

Applicant: Singular Genomics Systems, Inc

Inventor： Ronald Graham ,  Olga Adelfinskaya ,  Megha Cila ,  Rodrigo Rodriguez ,  Abrehet Abdu ,  Eli N. Glezer

IPC: C07H19/14 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q1/6876

CPC classification number: C07H19/14 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q1/6876

Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.

公开(公告)号：US20230242571A1

公开(公告)日：2023-08-03

申请号：US18104690

申请日：2023-02-01

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Zachary Terranova

IPC: C07H23/00 ,  C12Q1/6869

CPC classification number: C07H23/00 ,  C12Q1/6869

Abstract: Disclosed herein, inter alia, are silicon containing cleavable linkers and compounds for use in nucleic acid sequencing.

公开(公告)号：US11697736B2

公开(公告)日：2023-07-11

申请号：US16415700

申请日：2019-05-17

Applicant: SINGULAR GENOMICS SYSTEMS, INC.

Inventor： Ronald Graham ,  Rodrigo Rodriguez

IPC: C09B11/24 ,  C09B69/00 ,  C07F7/08 ,  C07H23/00

CPC classification number: C09B11/24 ,  C07F7/083 ,  C07F7/0803 ,  C07F7/0825 ,  C09B69/008 ,  C07F7/0816 ,  C07H23/00

Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof.

公开(公告)号：US20230160001A1

公开(公告)日：2023-05-25

申请号：US17918072

申请日：2021-05-06

Applicant: Singular Genomics Systems, Inc.

Inventor： Ada Tong ,  Ronald Graham ,  Megha Cila ,  Eli N. Glezer ,  Zachary Terranova

IPC: C12Q1/6869

CPC classification number: C12Q1/6869 ,  C12Q1/6818

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.

公开(公告)号：US20230101281A1

公开(公告)日：2023-03-30

申请号：US17882448

申请日：2022-08-05

Applicant: Singular Genomics Systems, Inc.

Inventor： Megha Cila ,  Ronald Graham ,  Rodrigo Rodriguez

IPC: C09B62/36 ,  C09K11/06 ,  G01N33/58

Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof. In an aspect is provided a monovalent nucleotide or monovalent nucleoside covalently bound to a monovalent form of a compound described herein (e.g., wherein the R13 moiety of a compound described herein has reacted with a bioconjugate reactive group to form a bioconjugate linker thereby covalently bonding the monovalent compound to the monovalent nucleotide or monovalent nucleoside).

公开(公告)号：US20220315614A1

公开(公告)日：2022-10-06

申请号：US17698283

申请日：2022-03-18

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Zachary Terranova

IPC: C07F9/6521

Abstract: Disclosed herein, inter alia, are reducing agents and methods of use thereof.

公开(公告)号：US10738072B1

公开(公告)日：2020-08-11

申请号：US16662781

申请日：2019-10-24

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Olga Adelfinskaya ,  Megha Cila ,  Rodrigo Rodriguez ,  Abrehet Abdu ,  Eli N. Glezer

IPC: C07H19/14 ,  C07H19/10 ,  C12Q1/68 ,  C12Q1/6869

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.

公开(公告)号：US12215124B2

公开(公告)日：2025-02-04

申请号：US16969879

申请日：2019-02-20

Applicant: SINGULAR GENOMICS SYSTEMS, INC.

Inventor： Ronald Graham ,  Andrew Spaventa ,  Eli Glezer

IPC: C07H21/04 ,  C12Q1/6869

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.

公开(公告)号：US12188089B2

公开(公告)日：2025-01-07

申请号：US18439062

申请日：2024-02-12

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Megha Cila

IPC: C12Q1/68 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6874 ,  C12Q1/6876 ,  C12Q1/6806

Abstract: Disclosed herein, inter alia, are methods and cleavable compounds that minimize byproduct formation following cleavage.

公开(公告)号：US20240392348A1

公开(公告)日：2024-11-28

申请号：US18797267

申请日：2024-08-07

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Ronald Graham ,  Michael J. Krause

IPC: C12Q1/6818 ,  C12Q1/6825

Abstract: Disclosed herein, inter alia, are modified nucleotides and methods of using the same in nucleic acid sequencing reactions.