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102 条记录 (耗时 0.066 秒)

    Diagnostics and Therapeutics for Diseases Associated With Vasoactive Intestinal Peptide Receptor 1 (Vpac1)
    12.
    发明申请
    Diagnostics and Therapeutics for Diseases Associated With Vasoactive Intestinal Peptide Receptor 1 (Vpac1) 审中-公开
    血管活性肠肽受体1（Vpac1）相关疾病诊断与治疗

    公开(公告)号：US20090004193A1

    公开(公告)日：2009-01-01

    申请号：US11658129

    申请日：2005-07-09

    申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

    发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

    IPC分类号： A61K39/395 ,  G01N33/566 ,  G01N33/68 ,  A61K31/711 ,  A61P35/00 ,  A61P11/00 ,  A61P17/00 ,  A61P25/00 ,  A61P21/00 ,  A61P19/00 ,  A61P3/00 ,  A61P9/00 ,  A61K38/02 ,  C12Q1/68 ,  A61K31/7105

    CPC分类号： G01N33/566 ,  G01N33/74 ,  G01N2333/726 ,  G01N2500/04

    摘要： The invention provides a human VPAC1 which is associated with the cardiovascular diseases, cancer, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of VPAC1 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与心血管疾病，癌症，皮肤病，内分泌疾病，代谢疾病，炎症，胃肠疾病，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经系统疾病和泌尿系疾病有关的人VPAC1。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，癌症，皮肤病，内分泌疾病，代谢疾病，炎症，胃肠疾病，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经系统疾病和泌尿系统疾病 疾病 本发明还涉及结合和/或活化或抑制VPAC1的活性的化合物以及包含这些化合物的药物组合物。

    Diagnostics and Therapeutics for Diseases Associated with Putative Cysteine Protease 1 (Prs1)
    14.
    发明申请
    Diagnostics and Therapeutics for Diseases Associated with Putative Cysteine Protease 1 (Prs1) 审中-公开
    与推定半胱氨酸蛋白酶1（Prs1）相关的疾病诊断与治疗

    公开(公告)号：US20070269807A1

    公开(公告)日：2007-11-22

    申请号：US10588207

    申请日：2005-01-22

    申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Holger Summer ,  Ralf Thiele

    发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Holger Summer ,  Ralf Thiele

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/37 ,  C12N9/641 ,  G01N2500/10

    摘要： The invention provides a human PRSC1 which is associated with the cardiovascular diseases, cancer, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PRSC1 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与心血管疾病，癌症，内分泌疾病，代谢疾病，炎症，胃肠病，血液疾病，呼吸系统疾病，神经系统疾病和泌尿系疾病相关的人PRSC1。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，癌症，内分泌疾病，代谢疾病，炎症，胃肠疾病，血液疾病，呼吸系统疾病，神经疾病和泌尿疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制PRSC1的活性的化合物以及包含这些化合物的药物组合物。

    Diagnostics and Therapeutics for Diseases Associated with Tripeptidyl-Peptidase 2(Tpp2)
    15.
    发明申请
    Diagnostics and Therapeutics for Diseases Associated with Tripeptidyl-Peptidase 2(Tpp2) 审中-公开
    与三肽基肽酶2（Tpp2）相关的疾病的诊断和治疗

    公开(公告)号：US20070258973A1

    公开(公告)日：2007-11-08

    申请号：US10586492

    申请日：2005-01-19

    申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Holger Summer

    发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Holger Summer

    IPC分类号： A61K31/7105 ,  A61K38/02 ,  A61K38/43 ,  A61K39/395 ,  A61P43/00 ,  C12Q1/68 ,  G01N33/53

    CPC分类号： G01N33/57449 ,  C12Q1/37 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57438 ,  G01N33/57442 ,  G01N33/57446 ,  G01N33/6893 ,  G01N33/6896 ,  G01N2500/00

    摘要： The invention provides a human TPP2 which is associated with the cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, gastroenterological diseases, cancer, inflammation, hematological diseases, respiratory diseases, muscle-skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, gastroenterological diseases, cancer, inflammation, hematological diseases, respiratory diseases, muscle-skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of TPP2 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与心血管疾病，皮肤病，内分泌疾病，代谢疾病，胃肠疾病，癌症，炎症，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经系统疾病和泌尿系疾病有关的人类TPP2。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，内分泌疾病，代谢疾病，胃肠疾病，癌症，炎症，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经系统疾病的化合物的化合物和 泌尿系疾病 本发明还涉及结合和/或活化或抑制TPP2活性的化合物以及包含这些化合物的药物组合物。

    Diagnostics and therapeutics for diseases associated with kallikrein 13 (klk13)
    16.
    发明申请
    Diagnostics and therapeutics for diseases associated with kallikrein 13 (klk13) 审中-公开
    与激肽释放酶13（klk13）相关疾病的诊断和治疗

    公开(公告)号：US20070191296A1

    公开(公告)日：2007-08-16

    申请号：US10569438

    申请日：2004-08-17

    申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Stefanie Polej

    发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Stefanie Polej

    IPC分类号： A61K48/00 ,  C12Q1/68 ,  G01N33/574 ,  A61K39/395

    CPC分类号： G01N33/6872 ,  G01N2333/96455

    摘要： The invention provides a human KLK13 which is associated with the hematological diseases, neurological diseases, metabolic diseases, endocrinological diseases, dermatological diseases, gastroenterological diseases, urological diseases, cancer disorders and inflammation. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological diseases, neurological diseases, metabolic diseases, endocrinological diseases, dermatological diseases, gastroenterological diseases, urological diseases, cancer disorders and inflammation. The invention also features compounds which bind to and/or activate or inhibit the activity of KLK13 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与血液疾病，神经疾病，代谢疾病，内分泌疾病，皮肤病，肠胃病，泌尿科疾病，癌症病症和炎症有关的人类KLK13。 本发明还提供了用于鉴定可用于治疗或预防血液疾病，神经疾病，代谢疾病，内分泌疾病，皮肤病学，胃肠疾病，泌尿科疾病，癌症病症和炎症的化合物的测定。 本发明还涉及结合和/或活化或抑制KLK13活性的化合物以及包含这些化合物的药物组合物。

    Diagnostics and therapeutics for diseases associated with aminopeptidase-like 1 (npepl1)
    17.
    发明申请
    Diagnostics and therapeutics for diseases associated with aminopeptidase-like 1 (npepl1) 审中-公开
    与氨基肽酶样1（npepl1）相关的疾病的诊断和治疗

    公开(公告)号：US20070166715A1

    公开(公告)日：2007-07-19

    申请号：US10575361

    申请日：2004-10-02

    申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

    发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

    IPC分类号： C12Q1/68 ,  C12Q1/37

    CPC分类号： C12N9/48 ,  G01N33/573

    摘要： The invention provides a human NPEPL1 which is associated with the cardiovascular diseases, cancer, dermatological diseases, gastroenterological diseases, metabolic diseases, inflammation, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer, dermatological diseases, gastroenterological diseases, metabolic diseases, inflammation, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of NPEPL1 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与心血管疾病，癌症，皮肤病，胃肠疾病，代谢疾病，炎症，血液疾病，呼吸系统疾病，神经系统疾病和泌尿系疾病有关的人NPEPL1。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，癌症，皮肤病，胃肠疾病，代谢疾病，炎症，血液疾病，呼吸系统疾病，神经疾病和泌尿系疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制NPEPL1的活性的化合物以及包含这些化合物的药物组合物。

    Diagnostics and therapeutics for diseases associated with endothelial differentiation, sphingolipid g-protein-coupled receptor 6(edg6)
    18.
    发明申请
    Diagnostics and therapeutics for diseases associated with endothelial differentiation, sphingolipid g-protein-coupled receptor 6(edg6) 审中-公开
    与内皮分化有关的疾病的诊断和治疗，鞘脂g-蛋白偶联受体6（edg6）

    公开(公告)号：US20070141571A1

    公开(公告)日：2007-06-21

    申请号：US10550327

    申请日：2004-03-17

    申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

    发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

    IPC分类号： C12Q1/68 ,  G01N33/53

    CPC分类号： G01N33/6893 ,  G01N33/721 ,  G01N33/74 ,  G01N2405/08 ,  G01N2500/00

    摘要： The invention provides a human EDG6 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, hematological disorders, respiratory diseases, neurological disorders, urological disorders, thrombocytopenia and myeloma. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, hematological disorders, respiratory diseases, neurological disorders, urological disorders, thrombocytopenia and myeloma. The invention also features compounds which bind to and/or activate or inhibit the activity of EDG6 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与心血管疾病，胃肠和肝脏疾病，炎性疾病，血液病症，呼吸系统疾病，神经障碍，尿路疾病，血小板减少症和骨髓瘤相关的人类EDG6。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，胃肠和肝脏疾病，炎性疾病，血液病症，呼吸系统疾病，神经障碍，泌尿系统疾病，血小板减少症和骨髓瘤的化合物的测定。 本发明还涉及结合和/或活化或抑制EDG6活性的化合物以及包含这些化合物的药物组合物。

    Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 85 (gpr85)
    19.
    发明申请
    Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 85 (gpr85) 审中-公开
    与g蛋白偶联受体85（gpr85）相关疾病的诊断和治疗

    公开(公告)号：US20070071753A1

    公开(公告)日：2007-03-29

    申请号：US10576792

    申请日：2004-10-19

    申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Holger Summer

    发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Holger Summer

    IPC分类号： A61K48/00 ,  A61K38/55 ,  G01N33/567 ,  G01N33/574 ,  A61K39/395

    CPC分类号： G01N33/566 ,  G01N33/57423 ,  G01N33/57449 ,  G01N33/6896 ,  G01N2021/6439 ,  G01N2333/726

    摘要： The invention provides a human GPR85 which is associated with the cardiovascular disorders, hematological disorders, inflammatory diseases, metabolic diseases, neurological disorders, urological disorders, respiratory diseases, cancer disorders and reproduction disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, hematological disorders, inflammatory diseases, metabolic diseases, neurological disorders, urological disorders, respiratory diseases, cancer disorders and reproduction disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of GPR85 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与心血管疾病，血液病，炎性疾病，代谢疾病，神经障碍，泌尿系统疾病，呼吸系统疾病，癌症病症和繁殖障碍有关的人GPR85。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，血液病症，炎性疾病，代谢疾病，神经障碍，泌尿系统疾病，呼吸系统疾病，癌症病症和繁殖障碍的化合物的测定。 本发明还涉及结合和/或活化或抑制GPR85活性的化合物以及包含这些化合物的药物组合物。

    Diagnostics and therapeutics for diseases associated with g-protein coupled receptor adipor2 (adipor2)
    20.
    发明申请
    Diagnostics and therapeutics for diseases associated with g-protein coupled receptor adipor2 (adipor2) 审中-公开
    与g-蛋白偶联受体adipor2（adipor2）相关疾病的诊断和治疗

    公开(公告)号：US20070053913A1

    公开(公告)日：2007-03-08

    申请号：US10572882

    申请日：2004-09-16

    申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

    发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

    IPC分类号： A61K39/395 ,  G01N33/53 ,  A61K48/00

    CPC分类号： A61K39/39558 ,  G01N33/6893 ,  G01N2333/726 ,  G01N2500/00 ,  G01N2800/32

    摘要： The invention provides a human AdipoR2 which is associated with the cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, inflammation, neurological diseases, urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, inflammation, neurological diseases, urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of AdipoR2 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与心血管疾病，皮肤病，胃肠病，癌症，血液疾病，呼吸系统疾病，炎症，神经系统疾病，泌尿系疾病有关的人AdipoR2。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，胃肠疾病，癌症，血液疾病，呼吸系统疾病，炎症，神经疾病，泌尿系疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制AdipoR2的活性的化合物以及包含这些化合物的药物组合物。